Research graph
References from A scalable, high-throughput glue perturbation screening platform for molecular glue discovery. Local targets link to admitted publications; unresolved targets remain external evidence.
Development of targeted protein degradation therapeutics
10.1038/s41589-019-0362-y · 2019 · External reference
Small molecule innate immune modulators in cancer therapy
10.3389/fimmu.2024.1395655 · 2024 · External reference
Haven’t got a glue: Protein surface variation for the design of molecular glue degraders
10.1016/j.chembiol.2021.04.009 · 2021 · External reference
Structure of the DDB1-CRBN E3 ubiquitin ligase in complex with thalidomide
10.1038/nature13527 · 2014 · External reference
Anticancer sulfonamides target splicing by inducing RBM39 degradation via recruitment to DCAF15
10.1126/science.aal3755 · 2017 · External reference
Unveiling the hidden interactome of CRBN molecular glues
10.1038/s41467-025-62099-w · 2025 · External reference
Chemo-proteomics exploration of HDAC degradability by small molecule degraders
10.1016/j.chembiol.2021.07.002 · 2021 · External reference
Comparative analysis of biophysical methods for monitoring protein proximity induction in the development of small molecule degraders
10.1016/j.bbagen.2023.130398 · 2023 · External reference
Selective and Potent Molecular Glue Degraders for NIMA-Related Kinase 7
2025 · External reference
Development of Oral, Potent, and Selective CK1α Degraders for AML Therapy
10.1021/jacsau.4c00762 · 2024 · External reference
Overcoming IMiD resistance in T-cell lymphomas through potent degradation of ZFP91 and IKZF1
10.1182/blood.2021014701 · 2022 · External reference
Discovery of a VHL molecular glue degrader of GEMIN3 by Picowell RNA-seq
2025 · External reference
A Next Generation Connectivity Map: L1000 Platform and the First 1,000,000 Profiles
10.1016/j.cell.2017.10.049 · 2017 · External reference
DRUG-seq for miniaturized high-throughput transcriptome profiling in drug discovery
10.1038/s41467-018-06500-x · 2018 · External reference
DRUG-seq Provides Unbiased Biological Activity Readouts for Neuroscience Drug Discovery
10.1021/acschembio.1c00920 · 2022 · External reference
Transcriptome-based chemical screens identify CDK8 as a common barrier in multiple cell reprogramming systems
2023 · External reference
CC-90009: A Cereblon E3 Ligase Modulating Drug That Promotes Selective Degradation of GSPT1 for the Treatment of Acute Myeloid Leukemia
10.1021/acs.jmedchem.0c01489 · 2021 · External reference
Selective CK1α degraders exert antiproliferative activity against a broad range of human cancer cell lines
10.1038/s41467-024-44698-1 · 2024 · External reference
Lenalidomide induces ubiquitination and degradation of CK1α in del(5q) MDS
10.1038/nature14610 · 2015 · External reference
Lenalidomide causes selective degradation of IKZF1 and IKZF3 in multiple myeloma cells
10.1126/science.1244851 · 2014 · External reference
BMS-986397, a First-in-Class Molecular Glue Degrader of Casein Kinase 1α (CK1α) for the Treatment of Acute Myeloid Leukemia (AML) and High-Risk Myelodysplastic Syndrome (HR-MDS) Harboring Functional TP53
10.1182/blood-2024-209924 · 2024 · External reference
MYC induces CDK4/6 inhibitors resistance by promoting pRB1 degradation
10.1038/s41467-024-45796-w · 2024 · External reference
The integrated stress response: From mechanism to disease
10.1126/science.aat5314 · 2020 · External reference
GDF15 is a dynamic biomarker of the integrated stress response in the central nervous system
10.1111/cns.14600 · 2024 · External reference
CC-90009, a novel cereblon E3 ligase modulator, targets acute myeloid leukemia blasts and leukemia stem cells
10.1182/blood.2020008676 · 2021 · External reference
Ribosome Collisions Trigger General Stress Responses to Regulate Cell Fate
10.1016/j.cell.2020.06.006 · 2020 · External reference
Degradation of GSPT1 causes TP53-independent cell death in leukemia while sparing normal hematopoietic stem cells
10.1172/jci153514 · 2022 · External reference
Molecular glues for protein-protein interactions: Progressing toward a new dream
10.1016/j.chembiol.2024.04.002 · 2024 · External reference
Targeted protein degradation: from mechanisms to clinic
10.1038/s41580-024-00729-9 · 2024 · External reference
Genome-Wide and Functional Annotation of Human E3 Ubiquitin Ligases Identifies MULAN, a Mitochondrial E3 that Regulates the Organelle’s Dynamics and Signaling
2008 · External reference
edgeR v4: powerful differential analysis of sequencing data with expanded functionality and improved support for small counts and larger datasets
10.1093/nar/gkaf018 · 2025 · External reference
Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2
10.1186/s13059-014-0550-8 · 2014 · External reference
clusterProfiler 4.0: A universal enrichment tool for interpreting omics data
2021 · External reference
Using clusterProfiler to characterize multiomics data
10.1038/s41596-024-01020-z · 2024 · External reference
Comparative analysis of biophysical methods for monitoring protein proximity induction in the development of small molecule degraders
10.1016/j.bbagen.2023.130398 · ExternalCitation · doi-reference
A Next Generation Connectivity Map: L1000 Platform and the First 1,000,000 Profiles
10.1016/j.cell.2017.10.049 · ExternalCitation · doi-reference
Ribosome Collisions Trigger General Stress Responses to Regulate Cell Fate
10.1016/j.cell.2020.06.006 · ExternalCitation · doi-reference
Haven’t got a glue: Protein surface variation for the design of molecular glue degraders
10.1016/j.chembiol.2021.04.009 · ExternalCitation · doi-reference
Chemo-proteomics exploration of HDAC degradability by small molecule degraders
10.1016/j.chembiol.2021.07.002 · ExternalCitation · doi-reference
Molecular glues for protein-protein interactions: Progressing toward a new dream
10.1016/j.chembiol.2024.04.002 · ExternalCitation · doi-reference
CC-90009: A Cereblon E3 Ligase Modulating Drug That Promotes Selective Degradation of GSPT1 for the Treatment of Acute Myeloid Leukemia
10.1021/acs.jmedchem.0c01489 · ExternalCitation · doi-reference
DRUG-seq Provides Unbiased Biological Activity Readouts for Neuroscience Drug Discovery
10.1021/acschembio.1c00920 · ExternalCitation · doi-reference
Development of Oral, Potent, and Selective CK1α Degraders for AML Therapy
10.1021/jacsau.4c00762 · ExternalCitation · doi-reference
Structure of the DDB1-CRBN E3 ubiquitin ligase in complex with thalidomide
10.1038/nature13527 · ExternalCitation · doi-reference
Lenalidomide induces ubiquitination and degradation of CK1α in del(5q) MDS
10.1038/nature14610 · ExternalCitation · doi-reference
DRUG-seq for miniaturized high-throughput transcriptome profiling in drug discovery
10.1038/s41467-018-06500-x · ExternalCitation · doi-reference
Selective CK1α degraders exert antiproliferative activity against a broad range of human cancer cell lines
10.1038/s41467-024-44698-1 · ExternalCitation · doi-reference
MYC induces CDK4/6 inhibitors resistance by promoting pRB1 degradation
10.1038/s41467-024-45796-w · ExternalCitation · doi-reference
Unveiling the hidden interactome of CRBN molecular glues
10.1038/s41467-025-62099-w · ExternalCitation · doi-reference
Targeted protein degradation: from mechanisms to clinic
10.1038/s41580-024-00729-9 · ExternalCitation · doi-reference
Development of targeted protein degradation therapeutics
10.1038/s41589-019-0362-y · ExternalCitation · doi-reference
Using clusterProfiler to characterize multiomics data
10.1038/s41596-024-01020-z · ExternalCitation · doi-reference
edgeR v4: powerful differential analysis of sequencing data with expanded functionality and improved support for small counts and larger datasets
10.1093/nar/gkaf018 · ExternalCitation · doi-reference
GDF15 is a dynamic biomarker of the integrated stress response in the central nervous system
10.1111/cns.14600 · ExternalCitation · doi-reference
Lenalidomide causes selective degradation of IKZF1 and IKZF3 in multiple myeloma cells
10.1126/science.1244851 · ExternalCitation · doi-reference
Anticancer sulfonamides target splicing by inducing RBM39 degradation via recruitment to DCAF15
10.1126/science.aal3755 · ExternalCitation · doi-reference
The integrated stress response: From mechanism to disease
10.1126/science.aat5314 · ExternalCitation · doi-reference
Degradation of GSPT1 causes TP53-independent cell death in leukemia while sparing normal hematopoietic stem cells
10.1172/jci153514 · ExternalCitation · doi-reference
BMS-986397, a First-in-Class Molecular Glue Degrader of Casein Kinase 1α (CK1α) for the Treatment of Acute Myeloid Leukemia (AML) and High-Risk Myelodysplastic Syndrome (HR-MDS) Harboring Functional TP53
10.1182/blood-2024-209924 · ExternalCitation · doi-reference
CC-90009, a novel cereblon E3 ligase modulator, targets acute myeloid leukemia blasts and leukemia stem cells
10.1182/blood.2020008676 · ExternalCitation · doi-reference
Overcoming IMiD resistance in T-cell lymphomas through potent degradation of ZFP91 and IKZF1
10.1182/blood.2021014701 · ExternalCitation · doi-reference
Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2
10.1186/s13059-014-0550-8 · ExternalCitation · doi-reference
Small molecule innate immune modulators in cancer therapy
10.3389/fimmu.2024.1395655 · ExternalCitation · doi-reference
