Research graph
References from Crosstalk between ubiquitination and other post-translational modifications in cardiovascular diseases. Local targets link to admitted publications; unresolved targets remain external evidence.
Global Burden of Cardiovascular Diseases and Risk Factors, 1990–2019
10.1016/j.jacc.2020.11.010 · 2020 · External reference
A Brief Review of Cardiovascular Diseases, Associated Risk Factors and Current Treatment Regimes
10.2174/1381612825666190925163827 · 2019 · External reference
Cardiovascular disease in the Eastern Mediterranean region: epidemiology and risk factor burden
10.1038/nrcardio.2017.138 · 2018 · External reference
The worldwide environment of cardiovascular disease: prevalence, diagnosis, therapy, and policy issues: a report from the American College of Cardiology
10.1016/j.jacc.2012.11.002 · 2012 · External reference
Worldwide Exposures to Cardiovascular Risk Factors and Associated Health Effects: Current Knowledge and Data Gaps
10.1161/circulationaha.115.008718 · 2016 · External reference
Epidemiology of cardiovascular disease in China: current features and implications
10.1038/s41569-018-0119-4 · 2019 · External reference
Proteomics of the heart
10.1152/physrev.00026.2023 · 2024 · External reference
Control of protein stability by post-translational modifications
10.1038/s41467-023-35795-8 · 2023 · External reference
Crosstalk between lysine methylation and phosphorylation of ATG16L1 dictates the apoptosis of hypoxia/reoxygenation-induced cardiomyocytes
10.1080/15548627.2017.1389357 · 2018 · External reference
Post-translational protein modifications in antigen recognition and autoimmunity
10.1016/s1471-4906(01)01976-7 · 2001 · External reference
Chemical and Biochemical Perspectives of Protein Lysine Methylation
10.1021/acs.chemrev.8b00008 · 2018 · External reference
A comprehensive compilation of SUMO proteomics
10.1038/nrm.2016.81 · 2016 · External reference
Machine learning empowers phosphoproteome prediction in cancers
10.1093/bioinformatics/btz639 · 2020 · External reference
Cellular and molecular biology of posttranslational modifications in cardiovascular disease
10.1016/j.biopha.2024.117374 · 2024 · External reference
Insights into the post-translational modifications in heart failure
10.1016/j.arr.2024.102467 · 2024 · External reference
Isolation of a polypeptide that has lymphocyte-differentiating properties and is probably represented universally in living cells
10.1073/pnas.72.1.11 · 1975 · External reference
Nobel committee tags ubiquitin for distinction
10.1016/j.neuron.2005.01.019 · 2005 · External reference
The Ubiquitin System
10.1146/annurev.biochem.67.1.425 · 1998 · External reference
The ubiquitination machinery of the ubiquitin system
10.1199/tab.0174 · 2014 · External reference
Ubiquitination and deubiquitination in the regulation of epithelial-mesenchymal transition in cancer: Shifting gears at the molecular level
10.1016/j.bbamcr.2022.119261 · 2022 · External reference
USP25 Ameliorates Pathological Cardiac Hypertrophy by Stabilizing SERCA2a in Cardiomyocytes
10.1161/circresaha.122.321849 · 2023 · External reference
E3 Ubiquitin ligase NEDD4 family-regulatory network in cardiovascular disease
10.7150/ijbs.48437 · 2020 · External reference
Selective targeting of ubiquitination and degradation of PARP1 by E3 ubiquitin ligase WWP2 regulates isoproterenol-induced cardiac remodeling
10.1038/s41418-020-0523-2 · 2020 · External reference
Roles of Cullin-RING Ubiquitin Ligases in Cardiovascular Diseases
10.3390/biom12030416 · 2022 · External reference
Small molecules as modulators of the proteostasis machinery: Implication in cardiovascular diseases
10.1016/j.ejmech.2023.116030 · 2024 · External reference
Targeting WWP1 ameliorates cardiac ischemic injury by suppressing KLF15-ubiquitination mediated myocardial inflammation
10.7150/thno.77694 · 2023 · External reference
The age of crosstalk: phosphorylation, ubiquitination, and beyond
10.1016/j.molcel.2007.11.019 · 2007 · External reference
Phosphorylation regulates cullin-based ubiquitination in tumorigenesis
10.1016/j.apsb.2020.09.007 · 2021 · External reference
Protein Language: Post-Translational Modifications Talking to Each Other
10.1016/j.tplants.2018.09.004 · 2018 · External reference
Cross-talk between BCKDK-mediated phosphorylation and STUB1-dependent ubiquitination degradation of BCAT1 promotes GBM progression
10.1016/j.canlet.2024.216849 · 2024 · External reference
An inventory of crosstalk between ubiquitination and other post-translational modifications in orchestrating cellular processes
10.1016/j.isci.2023.106276 · 2023 · External reference
N(6)-methyladenosine-modified USP13 induces pro-survival autophagy and imatinib resistance via regulating the stabilization of autophagy-related protein 5 in gastrointestinal stromal tumors
10.1038/s41418-022-01107-8 · 2023 · External reference
USP5 Promotes Ripretinib Resistance in Gastrointestinal Stromal Tumors by MDH2 Deubiquition
10.1002/advs.202401171 · 2024 · External reference
Complex regulatory mechanisms mediated by the interplay of multiple post-translational modifications
10.1016/j.sbi.2017.10.013 · 2018 · External reference
Combinatorial regulation of a signal-dependent activator by phosphorylation and acetylation
10.1073/pnas.1420389111 · 2014 · External reference
Control of MEF2 transcriptional activity by coordinated phosphorylation and sumoylation
10.1074/jbc.m509471200 · 2006 · External reference
The origins of protein phosphorylation
10.1038/ncb0502-e127 · 2002 · External reference
Dissecting the role of protein phosphorylation: a chemical biology toolbox
10.1039/d1cs00991e · 2022 · External reference
Bestrophin3 Deficiency in Vascular Smooth Muscle Cells Activates MEKK2/3-MAPK Signaling to Trigger Spontaneous Aortic Dissection
10.1161/circulationaha.122.063029 · 2023 · External reference
Mechanisms of aortic dissection: From pathological changes to experimental and in silico models
10.1016/j.pmatsci.2024.101363 · 2025 · External reference
Small proline-rich protein 2B drives stress-dependent p53 degradation and fibroblast proliferation in heart failure
10.1073/pnas.1717423115 · 2018 · External reference
PINK1-phosphorylated mitofusin 2 is a Parkin receptor for culling damaged mitochondria
10.1126/science.1231031 · 2013 · External reference
ERK/RSK-mediated phosphorylation of Y-box binding protein-1 aggravates diabetic cardiomyopathy by suppressing its interaction with deubiquitinase OTUB1
10.1016/j.jbc.2022.101989 · 2022 · External reference
Blocking MG53(S255) Phosphorylation Protects Diabetic Heart From Ischemic Injury
10.1161/circresaha.122.321055 · 2022 · External reference
CaMKII-delta9 promotes cardiomyopathy through disrupting UBE2T-dependent DNA repair
10.1038/s41556-019-0380-8 · 2019 · External reference
TRIM24 is an insulin-responsive regulator of P-bodies
10.1038/s41467-022-31735-0 · 2022 · External reference
AMPKalpha2 Protects Against the Development of Heart Failure by Enhancing Mitophagy via PINK1 Phosphorylation
10.1161/circresaha.117.312317 · 2018 · External reference
siRNA nanoparticle targeting Usp20 lowers lipid levels and ameliorates metabolic syndrome in mice
10.1016/j.jlr.2024.100626 · 2024 · External reference
JOSD2 mediates isoprenaline-induced heart failure by deubiquitinating CaMKIIdelta in cardiomyocytes
10.1007/s00018-023-05037-7 · 2024 · External reference
Knocking out USP7 attenuates cardiac fibrosis and endothelial-to-mesenchymal transition by destabilizing SMAD3 in mice with heart failure with preserved ejection fraction
10.7150/thno.97767 · 2024 · External reference
The E3 Ligase TRIM16 Is a Key Suppressor of Pathological Cardiac Hypertrophy
10.1161/circresaha.121.318866 · 2022 · External reference
The Ubiquitin-Like SUMO System and Heart Function: From Development to Disease
10.1161/circresaha.115.307730 · 2016 · External reference
Ubiquitin-like Protein Conjugation: Structures, Chemistry, and Mechanism
10.1021/acs.chemrev.6b00737 · 2018 · External reference
Signalling mechanisms and cellular functions of SUMO
10.1038/s41580-022-00500-y · 2022 · External reference
USP7/HAUSP: A SUMO deubiquitinase at the heart of DNA replication
10.1002/bies.201600096 · 2016 · External reference
The SUMO pathway is essential for nuclear integrity and chromosome segregation in mice
10.1016/j.devcel.2005.10.007 · 2005 · External reference
Sumo E2 enzyme UBC9 is required for efficient protein quality control in cardiomyocytes
10.1161/circresaha.115.304760 · 2014 · External reference
UBC9-Mediated Sumoylation Favorably Impacts Cardiac Function in Compromised Hearts
10.1161/circresaha.115.308268 · 2016 · External reference
Evaluation of the activity and substrate specificity of the human SENP family of SUMO proteases
10.1016/j.bbamcr.2015.10.020 · 2016 · External reference
Greater Celandine hepatotoxicity: a clinical review
10.1016/s1665-2681(19)31408-5 · 2012 · External reference
SUMO-specific proteases and isopeptidases of the SENP family at a glance
10.1242/jcs.211904 · 2018 · External reference
SENP3-regulated Nodal signaling plays a potential role in cardiac left-right asymmetry development
10.1016/j.ijbiomac.2024.133294 · 2024 · External reference
Cardiac-targeted PIASy gene silencing mediates deSUMOylation of caveolin-3 and prevents ischemia/reperfusion-induced Nav1.5 downregulation and ventricular arrhythmias
2022 · External reference
Uncovering the SUMOylation and ubiquitylation crosstalk in human cells using sequential peptide immunopurification
10.1038/ncomms14109 · 2017 · External reference
Converging Small Ubiquitin-like Modifier (SUMO) and Ubiquitin Signaling: Improved Methodology Identifies Co-modified Target Proteins
10.1074/mcp.tir117.000152 · 2017 · External reference
A CK2 and SUMO-dependent, PML NB-involved regulatory mechanism controlling BLM ubiquitination and G-quadruplex resolution
10.1038/s41467-023-41705-9 · 2023 · External reference
SERCA2a: a key protein in the Ca(2+) cycle of the heart failure
10.1007/s10741-019-09873-3 · 2020 · External reference
The war against heart failure: the Lancet lecture
10.1016/s0140-6736(14)61889-4 · 2015 · External reference
SUMO1-dependent modulation of SERCA2a in heart failure
10.1038/nature10407 · 2011 · External reference
SENP2-mediated SERCA2a deSUMOylation increases calcium overload in cardiomyocytes to aggravate myocardial ischemia/reperfusion injury
10.1097/cm9.0000000000002757 · 2023 · External reference
Rg3 promotes the SUMOylation of SERCA2a and corrects cardiac dysfunction in heart failure
10.1016/j.phrs.2021.105843 · 2021 · External reference
Deubiquitinase JOSD2 improves calcium handling and attenuates cardiac hypertrophy and dysfunction by stabilizing SERCA2a in cardiomyocytes
10.1038/s44161-023-00313-y · 2023 · External reference
FGF21 protects against doxorubicin-induced cardiotoxicity by inhibiting connexin 43 ubiquitination
10.1016/j.freeradbiomed.2023.09.033 · 2023 · External reference
Downregulation of cardiac PIASy inhibits Cx43 SUMOylation and ameliorates ventricular arrhythmias in a rat model of myocardial ischemia/reperfusion injury
10.1097/cm9.0000000000002618 · 2023 · External reference
TRIM21 deficiency protects against atrial inflammation and remodeling post myocardial infarction by attenuating oxidative stress
10.1016/j.redox.2023.102679 · 2023 · External reference
Role of acetylation in doxorubicin-induced cardiotoxicity
10.1016/j.redox.2021.102089 · 2021 · External reference
Ginsenoside Rb2 inhibits p300-mediated SF3A2 acetylation at lysine 10 to promote Fscn1 alternative splicing against myocardial ischemic/reperfusion injury
10.1016/j.jare.2023.12.012 · 2024 · External reference
50 years of protein acetylation: from gene regulation to epigenetics, metabolism and beyond
10.1038/nrm3931 · 2015 · External reference
Role of SIRT1 in Modulating Acetylation of the Sarco-Endoplasmic Reticulum Ca(2+)-ATPase in Heart Failure
10.1161/circresaha.118.313865 · 2019 · External reference
Regulation of acetylation of histone deacetylase 2 by p300/CBP-associated factor/histone deacetylase 5 in the development of cardiac hypertrophy
10.1161/circresaha.114.303429 · 2014 · External reference
Acetylation of VGLL4 Regulates Hippo-YAP Signaling and Postnatal Cardiac Growth
10.1016/j.devcel.2016.09.005 · 2016 · External reference
Reversible Notch1 acetylation tunes proliferative signalling in cardiomyocytes
10.1093/cvr/cvx228 · 2018 · External reference
Review: Acetylation mechanisms and targeted therapies in cardiac fibrosis
10.1016/j.phrs.2023.106815 · 2023 · External reference
Lysine acetyltransferases and lysine deacetylases as targets for cardiovascular disease
10.1038/s41569-019-0235-9 · 2020 · External reference
Lysine acetylation and cancer: A proteomics perspective
10.1016/j.jprot.2016.10.003 · 2017 · External reference
Epigenetic histone acetylation modifiers in vascular remodelling: new targets for therapy in cardiovascular disease
10.1093/eurheartj/ehn603 · 2009 · External reference
Inhibition of acetylation of histones 3 and 4 attenuates aortic valve calcification
2019 · External reference
Mfn2/Hsc70 Complex Mediates the Formation of Mitochondria-Lipid Droplets Membrane Contact and Regulates Myocardial Lipid Metabolism
10.4028/b-7tthnx · 2024 · External reference
Cardiac injury activates STING signaling via upregulating SIRT6 in macrophages after myocardial infarction
10.1016/j.lfs.2024.122474 · 2024 · External reference
Histone deacetylase 3 suppresses the expression of SHP-1 via deacetylation of DNMT1 to promote heart failure
10.1016/j.lfs.2021.119552 · 2022 · External reference
Myocardial ischaemia-reperfusion injury and cardioprotection in perspective
10.1038/s41569-020-0403-y · 2020 · External reference
STUB1 is acetylated by KAT5 and alleviates myocardial ischemia-reperfusion injury through LATS2-YAP-beta-catenin axis
10.1038/s42003-024-06086-9 · 2024 · External reference
Emergence of hydrogen sulfide as an endogenous gaseous signaling molecule in cardiovascular disease
10.1161/circresaha.114.300505 · 2014 · External reference
Hydrogen sulfide-based therapeutics: exploiting a unique but ubiquitous gasotransmitter
10.1038/nrd4433 · 2015 · External reference
HDAC6: A Novel Histone Deacetylase Implicated in Pulmonary Arterial Hypertension
10.1038/s41598-017-04874-4 · 2017 · External reference
Tubastatin A suppresses renal fibrosis via regulation of epigenetic histone modification and Smad3-dependent fibrotic genes
10.1016/j.vph.2015.04.006 · 2015 · External reference
Rational design and simple chemistry yield a superior, neuroprotective HDAC6 inhibitor, tubastatin A
10.1021/ja102758v · 2010 · External reference
Histone deacetylase 6 inhibitor tubastatin A attenuates angiotensin II-induced hypertension by preventing cystathionine gamma-lyase protein degradation
10.1016/j.phrs.2019.104281 · 2019 · External reference
Restoration of mutant hERG stability by inhibition of HDAC6
10.1016/j.yjmcc.2018.01.009 · 2018 · External reference
Poly(ADP-ribose) polymerase 1 (PARP1) in atherosclerosis: from molecular mechanisms to therapeutic implications
10.1002/med.21300 · 2014 · External reference
Poly(ADP-ribose) Polymerase (PARP) and PARP Inhibitors: Mechanisms of Action and Role in Cardiovascular Disorders
10.1007/s12012-018-9462-2 · 2018 · External reference
Deacetylation-dependent regulation of PARP1 by SIRT2 dictates ubiquitination of PARP1 in oxidative stress-induced vascular injury
10.1016/j.redox.2021.102141 · 2021 · External reference
Endothelial to Mesenchymal Transition in Cardiovascular Disease: JACC State-of-the-Art Review
10.1016/j.jacc.2018.09.089 · 2019 · External reference
Cardiac fibrosis: Cell biological mechanisms, molecular pathways and therapeutic opportunities
10.1016/j.mam.2018.07.001 · 2019 · External reference
SIRT1 mediates the inhibitory effect of Dapagliflozin on EndMT by inhibiting the acetylation of endothelium Notch1
10.1186/s12933-023-02040-x · 2023 · External reference
Investigators, Dapagliflozin in Patients with Heart Failure and Reduced Ejection Fraction
10.1056/nejmoa1911303 · 2019 · External reference
Histone methylation: a dynamic mark in health, disease and inheritance
10.1038/nrg3173 · 2012 · External reference
Arginine methylation of METTL14 promotes RNA N(6)-methyladenosine modification and endoderm differentiation of mouse embryonic stem cells
10.1038/s41467-021-24035-6 · 2021 · External reference
Protein Arginine Methyltransferases in Cardiovascular and Neuronal Function
10.1007/s12035-019-01850-z · 2020 · External reference
Histone lysine methylation and congenital heart disease: From bench to bedside (Review)
10.3892/ijmm.2017.3115 · 2017 · External reference
The emerging role of asymmetric dimethylarginine as a novel cardiovascular risk factor
10.1016/s0008-6363(03)00500-5 · 2003 · External reference
The dual methyltransferase METTL13 targets N terminus and Lys55 of eEF1A and modulates codon-specific translation rates
10.1038/s41467-018-05646-y · 2018 · External reference
METTL13 Methylation of eEF1A Increases Translational Output to Promote Tumorigenesis
10.1016/j.cell.2018.11.038 · 2019 · External reference
Mettl13 protects against cardiac contractile dysfunction by negatively regulating C-Cbl-mediated ubiquitination of SERCA2a in ischemic heart failure
10.1007/s11427-022-2351-1 · 2023 · External reference
Role of sevoflurane in myocardial ischemia-reperfusion injury via the ubiquitin-specific protease 22/lysine-specific demethylase 3A axis
10.1080/21655979.2022.2062535 · 2022 · External reference
Maternal Exposure to High-Fat Diet Induces Long-Term Derepressive Chromatin Marks in the Heart
10.3390/nu12010181 · 2020 · External reference
Methylation of H3-lysine 79 is mediated by a new family of HMTases without a SET domain
10.1016/s0960-9822(02)00901-6 · 2002 · External reference
Histone Methyltransferase Dot1L Contributes to RIPK1 Kinase-Dependent Apoptosis in Cerebral Ischemia/Reperfusion
10.1161/jaha.121.022791 · 2021 · External reference
Research progress on post-translational modification of proteins and cardiovascular diseases
10.1038/s41420-023-01560-5 · 2023 · External reference
O-glycosylation regulates ubiquitination and degradation of the anti-inflammatory protein A20 to accelerate atherosclerosis in diabetic ApoE-null mice
10.1371/journal.pone.0014240 · 2010 · External reference
Overexpression of p53 due to excess protein O-GlcNAcylation is associated with coronary microvascular disease in type 2 diabetes
10.1093/cvr/cvz216 · 2020 · External reference
Modification of p53 with O-linked N-acetylglucosamine regulates p53 activity and stability
10.1038/ncb1470 · 2006 · External reference
Coenzyme Q10 Mitigates Myocardial Infarction by Modulating HDAC4 O-GlcNAcylation
10.1002/biof.70085 · 2026 · External reference
RhoBTB1 protects against hypertension and arterial stiffness by restraining phosphodiesterase 5 activity
10.1172/jci123462 · 2019 · External reference
Cullin-associated and neddylation-dissociated 1 protein (CAND1) governs cardiac hypertrophy and heart failure partially through regulating calcineurin degradation
10.1016/j.phrs.2022.106284 · 2022 · External reference
Protein neddylation and its role in health and diseases
10.1038/s41392-024-01800-9 · 2024 · External reference
Allosteric activation of the RNF146 ubiquitin ligase by a poly(ADP-ribosyl)ation signal
10.1038/nature13826 · 2015 · External reference
Modulation of poly(ADP-ribose) polymerase-1 (PARP-1)-mediated oxidative cell injury by ring finger protein 146 (RNF146) in cardiac myocytes
10.2119/molmed.2014.00102 · 2014 · External reference
The Methods Employed in Mass Spectrometric Analysis of Posttranslational Modifications (PTMs) and Protein-Protein Interactions (PPIs)
10.1007/978-3-030-15950-4_10 · 2019 · External reference
CRISPR-Cas guides the future of genetic engineering
10.1126/science.aat5011 · 2018 · External reference
Recent advances in predicting and modeling protein-protein interactions
10.1016/j.tibs.2023.03.003 · 2023 · External reference
10.1016/j.csbj.2017.03.004 · 2017 · Admitted local publication
Post-translational modifications of proteins in cardiovascular diseases examined by proteomic approaches
10.1111/febs.17108 · 2025 · External reference
Targeting protein modifications in metabolic diseases: molecular mechanisms and targeted therapies
10.1038/s41392-023-01439-y · 2023 · External reference
Targeted Therapy in Cardiovascular Disease: A Precision Therapy Era
2021 · External reference
CRISPR/Cas9 therapeutics: progress and prospects
10.1038/s41392-023-01309-7 · 2023 · External reference
