Research graph
References from The Gibbs free energy landscape based on liver metabolome revealed thermodynamic robustness against fasting and obesity. Local targets link to admitted publications; unresolved targets remain external evidence.
The Regulation of Glycolysis and Gluconeogenesis in Animal Tissues
10.1146/annurev.bi.37.070168.001341 · 1968 · External reference
Quantitation of Hepatic Glycogenolysis And Gluconeogenesis in Fasting Humans With 13 C NMR
10.1126/science.1948033 · 1991 · External reference
Regulation of glucose production by the liver
10.1146/annurev.nutr.19.1.379 · 1999 · External reference
Regulation of hepatic glucose uptake and storage in vivo
10.3945/an.112.002089 · 2012 · External reference
Regulation of glucose metabolism from a liver-centric perspective
10.1038/emm.2015.122 · 2016 · External reference
Gluconeogenesis and the Cori cycle in 12-20-and 40-h-fasted humans
1998 · External reference
Trans-omic analysis reveals obesity-associated dysregulation of inter-organ metabolic cycles between the liver and skeletal muscle
10.1016/j.isci.2021.102217 · 2021 · External reference
Structural robustness and temporal vulnerability of the starvation-responsive metabolic network in healthy and obese mouse liver
10.1126/scisignal.ads2547 · 2025 · External reference
The pathogenesis of insulin resistance: integrating signaling pathways and substrate flux
10.1172/jci77812 · 2016 · External reference
Obesity dysregulates fasting-induced changes in glucagon secretion
10.1530/joe-19-0201 · 2019 · External reference
Integrated Liver and Plasma Proteomics in Obese Mice Reveals Complex Metabolic Regulation
10.1016/j.mcpro.2022.100207 · 2022 · External reference
Trans-omic analysis reveals opposite metabolic dysregulation between feeding and fasting in liver associated with obesity
10.1016/j.isci.2024.109121 · 2024 · External reference
Increased rate of gluconeogenesis in type II diabetes mellitus. A 13C nuclear magnetic resonance study
10.1172/jci115997 · 1992 · External reference
Mechanism by which metformin reduces glucose production in type 2 diabetes
10.2337/diabetes.49.12.2063 · 2000 · External reference
Quantitative contributions of gluconeogenesis to glucose production during fasting in type 2 diabetes mellitus
10.1053/meta.2001.19422 · 2001 · External reference
Regulation of Net Hepatic Glycogenolysis and Gluconeogenesis during Exercise: Impact of Type 1 Diabetes
10.1210/jc.2004-0408 · 2004 · External reference
Regulation of hepatic glucose metabolism in health and disease
10.1038/nrendo.2017.80 · 2017 · External reference
Diabetes Patients Requiring Glucose-Lowering Therapy and Nondiabetics With a Prior Myocardial Infarction Carry the Same Cardiovascular Risk
10.1161/circulationaha.107.720847 · 2008 · External reference
Diabetes and modifiable risk factors for cardiovascular disease: the prospective Million Women Study
10.1007/s10654-008-9298-3 · 2008 · External reference
Interorgan metabolic crosstalk in human insulin resistance
10.1152/physrev.00015.2017 · 2018 · External reference
Recommendations for terminology and databases for biochemical thermodynamics
10.1016/j.bpc.2011.03.007 · 2011 · External reference
Unresolved reference
2011 · External reference
Ion suppression in mass spectrometry
10.1373/49.7.1041 · 2003 · External reference
MIRACLE: mass isotopomer ratio analysis of U-13C-labeled extracts. A new method for accurate quantification of changes in concentrations of intracellular metabolites
10.1002/bit.10907 · 2004 · External reference
Quantitative metabolomics for dynamic metabolic engineering using stable isotope labeled internal standards mixture (SILIS)
10.1016/j.jbiosc.2021.09.009 · 2022 · External reference
Absolute metabolite concentrations and implied enzyme active site occupancy in Escherichia coli
10.1038/nchembio.186 · 2009 · External reference
An in vivo data-driven framework for classification and quantification of enzyme kinetics and determination of apparent thermodynamic data
10.1016/j.ymben.2011.02.005 · 2011 · External reference
Metabolite concentrations, fluxes and free energies imply efficient enzyme usage
10.1038/nchembio.2077 · 2016 · External reference
An upper limit on Gibbs energy dissipation governs cellular metabolism
10.1038/s42255-018-0006-7 · 2019 · External reference
Identification of localized and distributed bottlenecks in metabolic pathways
1993 · External reference
Genome-Scale Thermodynamic Analysis of Escherichia coli Metabolism
10.1529/biophysj.105.071720 · 2006 · External reference
A genome-scale metabolic reconstruction for Escherichia coli K-12 MG1655 that accounts for 1260 ORFs and thermodynamic information
10.1038/msb4100155 · 2007 · External reference
Thermodynamics-based metabolic flux analysis
10.1529/biophysj.106.093138 · 2007 · External reference
Network thermodynamics in the post-genomic era
10.1016/j.mib.2010.03.001 · 2010 · External reference
Quantitative assessment of thermodynamic constraints on the solution space of genome-scale metabolic models
10.1016/j.bpj.2013.06.011 · 2013 · External reference
Reaction lumping in metabolic networks for application with thermodynamic metabolic flux analysis
10.1038/s41598-021-87643-8 · 2021 · External reference
Thermodynamic limitations of PHB production from formate and fructose in Cupriavidus necator
10.1016/j.ymben.2022.08.005 · 2022 · External reference
Glycolytic strategy as a tradeoff between energy yield and protein cost
10.1073/pnas.1215283110 · 2013 · External reference
Steady-State Metabolite Concentrations Reflect a Balance between Maximizing Enzyme Efficiency and Minimizing Total Metabolite Load
10.1371/journal.pone.0075370 · 2013 · External reference
Pathway Thermodynamics Highlights Kinetic Obstacles in Central Metabolism
10.1371/journal.pcbi.1003483 · 2014 · External reference
The Protein Cost of Metabolic Fluxes: Prediction from Enzymatic Rate Laws and Cost Minimization
10.1371/journal.pcbi.1005167 · 2016 · External reference
The control of flux
1973 · External reference
A linear steady-state treatment of enzymatic chains. General properties, control and effector strength
10.1111/j.1432-1033.1974.tb03318.x · 1974 · External reference
Thermodynamic constraints on the regulation of metabolic fluxes
10.1074/jbc.ra118.004372 · 2018 · External reference
Is distance from equilibrium a good indicator for a reaction’s flux control?
10.1016/j.biosystems.2023.104988 · 2023 · External reference
Global loss of metabolic responsiveness and elevated enzyme in leptin deficient obese mice during starvation
10.1038/s41540-026-00678-3 · 2026 · External reference
Quantitative metabolome analysis using capillary electrophoresis mass spectrometry
10.1021/pr034020m · 2003 · External reference
Analysis of nucleotides by pressure-assisted capillary electrophoresis-mass spectrometry using silanol mask technique
10.1016/j.chroma.2007.05.054 · 2007 · External reference
Obese, a new mutation in the house mouse
10.1093/oxfordjournals.jhered.a106073 · 1950 · External reference
The physiology of obese-hyperglycemic mice [ob/ob mice]
10.1100/tsw.2007.117 · 2007 · External reference
eQuilibrator 3.0: a database solution for thermodynamic constant estimation
10.1093/nar/gkab1106 · 2022 · External reference
BRENDA, the ELIXIR core data resource in 2021: new developments and updates
10.1093/nar/gkaa1025 · 2021 · External reference
Modular rate laws for enzymatic reactions: thermodynamics, elasticities and implementation
10.1093/bioinformatics/btq141 · 2010 · External reference
A note on the kinetics of enzyme action: A decomposition that highlights thermodynamic effects
10.1016/j.febslet.2013.07.028 · 2013 · External reference
Co-response analysis: a new experimental strategy for metabolic control analysis
10.1006/jtbi.1996.0176 · 1996 · External reference
Multidimensional Optimality of Microbial Metabolism
10.1126/science.1216882 · 2012 · External reference
A scalable algorithm to explore the Gibbs energy landscape of genome-scale metabolic networks
10.1371/journal.pcbi.1002562 · 2012 · External reference
multiTFA: a Python package for multi-variate thermodynamics-based flux analysis
10.1093/bioinformatics/btab151 · 2021 · External reference
Energy metabolism in the liver
10.1002/j.2040-4603.2014.tb00548.x · 2014 · External reference
Four key steps control glycolytic flux in mammalian cells
10.1016/j.cels.2018.06.003 · 2018 · External reference
Control of gluconeogenesis in rat liver cells. Flux control coefficients of the enzymes in the gluconeogenic pathway in the absence and presence of glucagon
10.1042/bj2370379 · 1986 · External reference
Stimulation by glucose of gluconeogenesis in hepatocytes isolated from starved rats
10.1042/bj2450661 · 1987 · External reference
Unraveling principles of thermodynamics for genome-scale metabolic networks using graph neural networks
2025 · External reference
Near-equilibrium glycolysis supports metabolic homeostasis and energy yield
10.1038/s41589-019-0364-9 · 2019 · External reference
Spatiotemporal compartmentalization of hepatic NADH and NADPH metabolism
10.1074/jbc.tm117.000258 · 2018 · External reference
Substrate channeling: Molecular bases
10.1002/bmb.2003.494031040239 · 2003 · External reference
Substrate channeling of oxalacetate in solid-state complexes of malate dehydrogenase and citrate synthase
10.1016/s0021-9258(18)95694-2 · 1985 · External reference
Krebs cycle metabolon: structural evidence of substrate channeling revealed by cross-linking and mass spectrometry
10.1002/anie.201409336 · 2015 · External reference
Enzyme-enzyme interaction in the chloroplast: glyceraldehyde-3-phosphate dehydrogenase, triose phosphate isomerase and aldolase
10.1007/bf00201381 · 1995 · External reference
A glycolytic metabolon in Saccharomyces cerevisiae is stabilized by F-actin
10.1111/febs.12387 · 2013 · External reference
A multi-tissue type genome-scale metabolic network for analysis of whole-body systems physiology
10.1186/1752-0509-5-180 · 2011 · External reference
Pyruvate carboxylase activity in the heart and skeletal muscles of the rat. Evidence for a stimulating effect of exercise
1994 · External reference
Pyruvate carboxylase is expressed in human skeletal muscle
10.1016/j.bbrc.2010.08.102 · 2010 · External reference
Consistent Estimation of Gibbs Energy Using Component Contributions
10.1371/journal.pcbi.1003098 · 2013 · External reference
Minimization of intermediate concentrations as a suggested optimality principle for biochemical networks: I. Theoretical analysis
10.1007/bf00160470 · 1991 · External reference
Unresolved reference
External reference
Unresolved reference
2009 · External reference
Quantitative assignment of reaction directionality in a multicompartmental human metabolic reconstruction
10.1016/j.bpj.2012.02.032 · 2012 · External reference
Effect of murine strain on metabolic pathways of glucose production after brief or prolonged fasting
10.1152/ajpendo.00601.2004 · 2005 · External reference
Elevated TCA cycle function in the pathology of diet-induced hepatic insulin resistance and fatty liver
10.1194/jlr.m023382 · 2012 · External reference
Mass spectrometry-based microassay of (2)H and (13)C plasma glucose labeling to quantify liver metabolic fluxes in vivo
10.1152/ajpendo.00003.2015 · 2015 · External reference
In vivo estimates of liver metabolic flux assessed by 13C-propionate and 13C-lactate are impacted by tracer recycling and equilibrium assumptions
10.1016/j.celrep.2020.107986 · 2020 · External reference
Glycerol not lactate is the major net carbon source for gluconeogenesis in mice during both short and prolonged fasting
10.1016/j.molmet.2019.11.005 · 2020 · External reference
Sources of plasma glucose and liver glycogen in fasted ob/ob mice
10.1007/s00592-005-0201-3 · 2005 · External reference
Unresolved reference
1930 · External reference
Unresolved reference
External reference
Kinetic trans-omic analysis reveals key regulatory mechanisms for insulin-regulated glucose metabolism in adipocytes
10.1016/j.isci.2020.101479 · 2020 · External reference
Parameter balancing in kinetic models of cell metabolism
10.1021/jp108764b · 2010 · External reference
UniProt: The universal protein knowledgebase in 2023
10.1093/nar/gkac1052 · 2023 · External reference
