Research graph
References from 4-Phenylbutyric acid activates an NF-κB-Egr-1 axis to control myoblast proliferation and ECM gene expression. Local targets link to admitted publications; unresolved targets remain external evidence.
Regulation of Proliferation and Differentiation of Myoblasts Derived from Adult Mouse Skeletal Muscle by Specific Isoforms of PDGF
10.1083/jcb.111.4.1623 · 1990 · External reference
Organoid culture promotes dedifferentiation of mouse myoblasts into stem cells capable of complete muscle regeneration
10.1038/s41587-024-02344-7 · 2025 · External reference
Muscle Satellite Cell Heterogeneity and Self-Renewal
10.3389/fcell.2014.00001 · 2014 · External reference
Activated Muscle Satellite Cells Chase Ghosts
10.1016/j.stem.2016.01.008 · 2016 · External reference
Intrinsic and Extrinsic Mechanisms Regulating Satellite Cell Function
10.1242/dev.114223 · 2015 · External reference
10.1186/scrt27 · 2010 · Admitted local publication
Muscular Dystrophies and Cancer Cachexia: Similarities in Chronic Skeletal Muscle Degeneration
10.3390/jfmk2040039 · 2017 · External reference
Satellite Cells in Muscular Dystrophy - Lost in Polarity
10.1016/j.molmed.2016.04.002 · 2016 · External reference
Alterations of Lysine Acetylation Profile in Murine Skeletal Muscles Upon Exercise
10.3389/fnagi.2022.859313 · 2022 · External reference
Concise Review: Epigenetic Regulation of Myogenesis in Health and Disease
10.5966/sctm.2015-0266 · 2016 · External reference
Control of muscle development by dueling HATs and HDACs
2001 · External reference
Chromatin state distribution of residue-specific histone acetylation in early myoblast differentiation
10.1186/s40537-022-00667-3 · 2022 · External reference
Epigenetic regulation of satellite cell fate during skeletal muscle regeneration
10.1186/s13395-020-00259-w · 2021 · External reference
Loci-specific histone acetylation profiles associated with transcriptional coactivator p300 during early myoblast differentiation
10.1080/15592294.2018.1489659 · 2018 · External reference
Stepwise acetyltransferase association and histone acetylation at the Myod1 locus during myogenic differentiation
10.1038/srep02390 · 2013 · External reference
Class I Histone Deacetylases Sequentially Interact with MyoD and pRb during Skeletal Myogenesis
10.1016/s1097-2765(01)00373-2 · 2001 · External reference
Loss of HDAC11 accelerates skeletal muscle regeneration in mice
10.1111/febs.15468 · 2021 · External reference
HDAC Inhibitors as Pharmacological Treatment for Duchenne Muscular Dystrophy: A Discovery Journey from Bench to Patients
10.1016/j.molmed.2024.01.007 · 2024 · External reference
The Therapeutic Effects of 4-phenylbutyric Acid in Maintaining Proteostasis
10.1016/j.biocel.2015.01.015 · 2015 · External reference
Ammonia control in children with urea cycle disorders (UCDs); Phase 2 comparison of sodium phenylbutyrate and glycerol phenylbutyrate
10.1016/j.ymgme.2011.04.013 · 2011 · External reference
4-PBA prevents pressure overload-induced myocardial hypertrophy and interstitial fibrosis by attenuating endoplasmic reticulum stress
10.1016/j.cbi.2015.09.025 · 2015 · External reference
4-Phenylbutyric acid protects against neuronal cell death by primarily acting as a chemical chaperone rather than histone deacetylase inhibitor
10.1016/j.bmcl.2013.08.001 · 2013 · External reference
Chemical chaperones reduce endoplasmic reticulum stress and prevent mutant HFE aggregate formation
10.1074/jbc.m702672200 · 2007 · External reference
In vitro pharmacologic restoration of CFTR-mediated chloride transport with sodium 4-phenylbutyrate in cystic fibrosis epithelial cells containing ΔF08-CFTR
10.1172/jci119788 · 1997 · External reference
A Pilot Clinical Trial of Oral Sodium 4-Phenylbutyrate (Buphenyl) in F508-Homozygous Cystic Fibrosis Patients Partial Restoration of Nasal Epithelial CFTR Function
10.1164/ajrccm.157.2.9706088 · 1998 · External reference
The chemical chaperone 4-phenylbutyric acid rescues molecular cell defects of COL3A1 mutations that cause vascular Ehlers Danlos Syndrome
2025 · External reference
4-Phenylbutyrate restores localization and membrane repair to human dysferlin mutations
10.1016/j.isci.2021.103667 · 2022 · External reference
4-phenylbutyrate exerts stage-specific effects on cardiac differentiation via HDAC inhibition
2021 · External reference
4-phenylbutyric acid promotes migration of gastric cancer cells by histone deacetylase inhibition-mediated IL-8 upregulation
10.1080/15592294.2019.1700032 · 2020 · External reference
Phenylbutyrate—a pan-HDAC inhibitor—suppresses proliferation of glioblastoma LN-229 cell line
10.1007/s13277-015-3781-8 · 2016 · External reference
HDAC Inhibitors: Targets for Tumor Therapy, Immune Modulation and Lung Diseases
10.1016/j.tranon.2021.101312 · 2022 · External reference
Insulin Stimulates Mitochondrial Fusion and Function in Cardiomyocytes via the Akt- mTOR-NFkB-Opa-1 Signaling Pathway
10.2337/db13-0340 · 2013 · External reference
Sodium phenylbutyrate controls neuroinflammatory and antioxidant activities and protects dopaminergic neurons in mouse models of Parkinson’s disease
10.1371/journal.pone.0038113 · 2012 · External reference
4-phenylbutyric acid increases GLUT4 gene expression through suppression of HDAC5 but not endoplasmic reticulum stress
10.1159/000362967 · 2014 · External reference
An integrated encyclopedia of DNA elements in the human genome
10.1038/nature11247 · 2012 · External reference
NF-B Signaling: A Tale of Two Pathways in Skeletal Myogenesis
10.1152/physrev.00040.2009 · 2010 · External reference
Interplay of IKK/NF-κB signaling in macrophages and myofibers promotes muscle degeneration in Duchenne muscular dystrophy
10.1172/jci30556 · 2007 · External reference
IKK/NF-κB regulates skeletal myogenesis via a signaling switch to inhibit differentiation and promote mitochondrial biogenesis
10.1083/jcb.200707179 · 2008 · External reference
NF-B Controls Cell Growth and Differentiation through Transcriptional Regulation of Cyclin D1
10.1128/mcb.19.8.5785 · 1999 · External reference
Muscle wasting in fasting requires activation of NF-κB and inhibition of AKT/Mechanistic target of rapamycin (mTOR) by the protein acetylase, GCN5
10.1074/jbc.m115.685164 · 2015 · External reference
Muscle inflammation is regulated by NF-κB from multiple cells to control distinct states of wasting in cancer cachexia
10.1016/j.celrep.2024.114925 · 2024 · External reference
Muscle Regeneration: Cellular and Molecular Events
2009 · External reference
Induction of Sirt1 by mechanical stretch of skeletal muscle through the early response factor EGR1 triggers an antioxidative response
10.1074/jbc.m110.149153 · 2011 · External reference
Extracellular matrix: an important regulator of cell functions and skeletal muscle development
10.1186/s13578-021-00579-4 · 2021 · External reference
Gene expression profiling in limb-girdle muscular dystrophy 2A
10.1371/journal.pone.0003750 · 2008 · External reference
Comparative Transcriptomic Profiling in Patients Affected by Duchenne and Becker Muscular Dystrophies: A Focus on ECM Genes Dysregulation
10.3390/ijms26146594 · 2025 · External reference
Increased collagen cross-linking is a signature of dystrophin-deficient muscle
10.1002/mus.24998 · 2016 · External reference
PDGFRα signalling promotes fibrogenic responses in collagen-producing cells in Duchenne muscular dystrophy
10.1002/path.4801 · 2016 · External reference
The basement membrane/basal lamina of skeletal muscle
10.1074/jbc.r200027200 · 2003 · External reference
Extracellular Matrix: Brick and Mortar in the Skeletal Muscle Stem Cell Niche
10.3389/fcell.2022.1056523 · 2022 · External reference
Extracellular deposition of matrilin-2 controls the timing of the myogenic program during muscle regeneration
2014 · External reference
Secretome profiling of primary human skeletal muscle cells
10.1016/j.bbapap.2013.08.004 · 2014 · External reference
In-depth analysis of the secretome identifies three major independent secretory pathways in differentiating human myoblasts
10.1016/j.jprot.2012.09.008 · 2012 · External reference
A synaptic nidogen: Developmental regulation and role of nidogen-2 at the neuromuscular junction
10.1186/1749-8104-3-24 · 2008 · External reference
Mitofusins and OPA1 Mediate Sequential Steps in Mitochondrial Membrane Fusion
10.1091/mbc.e09-03-0252 · 2009 · External reference
PGC-1α: key regulator of mitochondrial biogenesis and cellular differentiation in metabolic and regenerative tissues
10.1186/s13578-025-01519-2 · 2025 · External reference
The Alleviative Effect of Sodium Butyrate on Dexamethasone-Induced Skeletal Muscle Atrophy
10.1002/cbin.70003 · 2025 · External reference
Treatment of spinal muscular atrophy by sodium butyrate
10.1073/pnas.171105098 · 2001 · External reference
Epigenetic Regulators Modulate Muscle Damage in Duchenne Muscular Dystrophy Model
2017 · External reference
SeqinR 1.0-2: a contributed package to the R project for statistical computing devoted to biological sequences retrieval and analysis. In: Structural Approaches to Sequence Evolution: Molecules, Networks, Populations
2007 · External reference
clusterProfiler: an R package for comparing biological themes among gene clusters
10.1089/omi.2011.0118 · 2012 · External reference
org.Mm.eg.db: Genome wide annotation for Mouse. R package version 3.21.0
2025 · External reference
KEGGREST: Client-side REST access to the Kyoto Encyclopedia of Genes and Genomes (KEGG). R package version 1.48.1
2025 · External reference
GO.db: A set of annotation maps describing the entire Gene Ontology. R package version 3.21.0.
2025 · External reference
Unresolved reference
2016 · External reference
Unresolved reference
2023 · External reference
Unresolved reference
2019 · External reference
VennDiagram: a package for the generation of highly-customizable Venn and Euler diagrams in R
10.1186/1471-2105-12-35 · 2011 · External reference
Analysis of relative gene expression data using real-time quantitative PCR and the 2-ΔΔCT method
10.1006/meth.2001.1262 · 2001 · External reference
Orchestrating high-throughput genomic analysis with Bioconductor
10.1038/nmeth.3252 · 2015 · External reference
Gene ontology: tool for the unification of biology. The Gene Ontology Consortium
10.1038/75556 · 2000 · External reference
KEGG: Kyoto Encyclopedia of Genes and Genomes
10.1093/nar/28.1.27 · 2000 · External reference
