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References from Dual functions of NPC1L1 for cholesterol transport: Cholesterol capture and regulation of inner-leaflet cholesterol accessibility. Local targets link to admitted publications; unresolved targets remain external evidence.
Associations between Lifestyle-Related Diseases and Transporters Involved in Intestinal Absorption and Biliary Excretion of Cholesterol
10.1248/bpb.b17-00690 · 2018 · External reference
Niemann-Pick C1 Like 1 protein is critical for intestinal cholesterol absorption
10.1126/science.1093131 · 2004 · External reference
The target of ezetimibe is Niemann-Pick C1-Like 1 (NPC1L1)
10.1073/pnas.0500269102 · 2005 · External reference
Flotillins play an essential role in Niemann-Pick C1-like 1-mediated cholesterol uptake
10.1073/pnas.1014434108 · 2011 · External reference
The small GTPase Cdc42 interacts with Niemann-Pick C1-like 1 (NPC1L1) and controls its movement from endocytic recycling compartment to plasma membrane in a cholesterol-dependent manner
10.1074/jbc.m111.270199 · 2011 · External reference
The clathrin adaptor Numb regulates intestinal cholesterol absorption through dynamic interaction with NPC1L1
10.1038/nm.3417 · 2014 · External reference
Bile acids-mediated intracellular cholesterol transport promotes intestinal cholesterol absorption and NPC1L1 recycling
10.1038/s41467-023-42179-5 · 2023 · External reference
Niemann-Pick C1-like 1 overexpression facilitates ezetimibe-sensitive cholesterol and beta-sitosterol uptake in CaCo-2 cells
10.1124/jpet.106.114181 · 2007 · External reference
Cholesterol-regulated translocation of NPC1L1 to the cell surface facilitates free cholesterol uptake
10.1074/jbc.m511123200 · 2006 · External reference
The N-terminal domain of NPC1L1 protein binds cholesterol and plays essential roles in cholesterol uptake
10.1074/jbc.m111.244475 · 2011 · External reference
Ezetimibe-sensitive cholesterol uptake by NPC1L1 protein does not require endocytosis
10.1091/mbc.e16-03-0154 · 2016 · External reference
Aster-dependent nonvesicular transport facilitates dietary cholesterol uptake
10.1126/science.adf0966 · 2023 · External reference
Cryo-EM structures of NPC1L1 reveal mechanisms of cholesterol transport and ezetimibe inhibition
10.1126/sciadv.abb1989 · 2020 · External reference
Structural insights into the mechanism of human NPC1L1-mediated cholesterol uptake
10.1126/sciadv.abg3188 · 2021 · External reference
Three pools of plasma membrane cholesterol and their relation to cholesterol homeostasis
10.7554/elife.02882 · 2014 · External reference
Nonvesicular cholesterol transport in physiology
10.1172/jci188127 · 2025 · External reference
Coordination of inter-organelle communication and lipid fluxes by OSBP-related proteins
10.1016/j.plipres.2022.101146 · 2022 · External reference
Domain 4 (D4) of Perfringolysin O to Visualize Cholesterol in Cellular Membranes-The Update
10.3390/s17030504 · 2017 · External reference
The rate of transmembrane movement of cholesterol in the human erythrocyte
10.1016/s0021-9258(19)69200-8 · 1981 · External reference
Sterols are mainly in the cytoplasmic leaflet of the plasma membrane and the endocytic recycling compartment in CHO cells
10.1091/mbc.e08-07-0785 · 2009 · External reference
Comment on ‘Orthogonal lipid sensors identify transbilayer asymmetry of plasma membrane cholesterol’
10.7554/elife.38493 · 2018 · External reference
Orthogonal lipid sensors identify transbilayer asymmetry of plasma membrane cholesterol
10.1038/nchembio.2268 · 2017 · External reference
Cell membranes sustain phospholipid imbalance via cholesterol asymmetry
10.1016/j.cell.2025.02.034 · 2025 · External reference
Complementary probes reveal that phosphatidylserine is required for the proper transbilayer distribution of cholesterol
10.1242/jcs.164715 · 2015 · External reference
Visualization of accessible cholesterol using a GRAM domain-based biosensor
10.1038/s41467-023-42498-7 · 2023 · External reference
NPC1L1 Facilitates Sphingomyelin Absorption and Regulates Diet-Induced Production of VLDL/LDL-associated S1P
10.3390/nu12092641 · 2020 · External reference
Visualization of the heterogeneous membrane distribution of sphingomyelin associated with cytokinesis, cell polarity, and sphingolipidosis
10.1096/fj.13-247585 · 2015 · External reference
NPC1L1 is a key regulator of intestinal vitamin K absorption and a modulator of warfarin therapy
10.1126/scitranslmed.3010329 · 2015 · External reference
Modulating NPC1L1 to Potentiate PARP Inhibitor-Induced Ferroptosis and Immune Response in Triple-Negative Breast Cancer
10.3390/pharmaceutics17050554 · 2025 · External reference
ABCA1 and cholesterol transfer protein Aster-A promote an asymmetric cholesterol distribution in the plasma membrane
10.1016/j.jbc.2022.102702 · 2022 · External reference
ABCG1 has a critical role in mediating cholesterol efflux to HDL and preventing cellular lipid accumulation
10.1016/j.cmet.2005.01.002 · 2005 · External reference
The gene encoding ATP-binding cassette transporter 1 is mutated in Tangier disease
10.1038/11914 · 1999 · External reference
Mutations in ABC1 in Tangier disease and familial high-density lipoprotein deficiency
10.1038/11905 · 1999 · External reference
Tangier disease is caused by mutations in the gene encoding ATP-binding cassette transporter 1
10.1038/11921 · 1999 · External reference
Structural basis of sterol recognition by human hedgehog receptor PTCH1
10.1126/sciadv.aaw6490 · 2019 · External reference
Patched 1 reduces the accessibility of cholesterol in the outer leaflet of membranes
10.7554/elife.70504 · 2021 · External reference
Wnt signaling and hepatocarcinogenesis: molecular targets for the development of innovative anticancer drugs
10.1016/j.jhep.2013.07.001 · 2013 · External reference
Localization and role of NPC1L1 in cholesterol absorption in human intestine
10.1194/jlr.m600174-jlr200 · 2006 · External reference
Hepatic Niemann-Pick C1-like 1 regulates biliary cholesterol concentration and is a target of ezetimibe
10.1172/jci30060 · 2007 · External reference
The role of NPC1L1 in cancer
2022 · External reference
Ezetimibe inhibits the migration and invasion of triple-negative breast cancer cells by targeting TGFbeta2 and EMT
10.1002/2211-5463.13797 · 2024 · External reference
Niemann-pick C1-like 1 mediates alpha-tocopherol transport
10.1124/mol.107.043034 · 2008 · External reference
Transporters for the Intestinal Absorption of Cholesterol, Vitamin E, and Vitamin K
10.5551/jat.rv16007 · 2017 · External reference
Cellpose: a generalist algorithm for cellular segmentation
10.1038/s41592-020-01018-x · 2021 · External reference
Fiji: an open-source platform for biological-image analysis
10.1038/nmeth.2019 · 2012 · External reference
In-vitro characterization of the six clustered variants of NPC1L1 observed in cholesterol low absorbers
10.1097/fpc.0b013e3283327925 · 2009 · External reference
