Research graph
References from Multi-omics profiling reveals molecular features of visceral adiposity in autonomous cortisol secretion. Local targets link to admitted publications; unresolved targets remain external evidence.
Adrenal Incidentaloma
10.1210/endrev/bnaa008 · 2020 · External reference
Approach to the Patient With Adrenal Incidentaloma
10.1210/clinem/dgab512 · 2021 · External reference
European Society of Endocrinology clinical practice guidelines on the management of adrenal incidentalomas, in collaboration with the European Network for the Study of Adrenal Tumors
10.1093/ejendo/lvad066 · 2023 · External reference
Complications of Cushing’s syndrome: state of the art
10.1016/s2213-8587(16)00086-3 · 2016 · External reference
Age-dependent and sex-dependent disparity in mortality in patients with adrenal incidentalomas and autonomous cortisol secretion: an international, retrospective, cohort study
10.1016/s2213-8587(22)00100-0 · 2022 · External reference
Mild autonomous cortisol secretion: pathophysiology, comorbidities and management approaches
10.1038/s41574-024-00984-y · 2024 · External reference
Changes of computed tomography-based body composition after adrenalectomy in patients with endogenous hypercortisolism
10.1111/cen.13902 · 2019 · External reference
Autonomous cortisol secretion in adrenal incidentalomas and increased visceral fat accumulation during follow-up
10.1111/cen.13408 · 2017 · External reference
Abnormal body composition in patients with adrenal adenomas
10.1530/eje-21-0458 · 2021 · External reference
Adipose tissue: between the extremes
10.15252/embj.201696206 · 2017 · External reference
Association of visceral adipose tissue with incident myocardial infarction in older men and women: the Health, Aging and Body Composition Study
10.1093/aje/kwh281 · 2004 · External reference
Visceral fat is an independent predictor of all-cause mortality in men
10.1038/oby.2006.43 · 2006 · External reference
Active Cushing Disease Is Characterized by Increased Adipose Tissue Macrophage Presence
10.1210/jc.2018-02552 · 2019 · External reference
Unique Gene Expression Signature in Periadrenal Adipose Tissue Identifies a High Blood Pressure Group in Patients With Cushing Syndrome
10.1161/hypertensionaha.123.21185 · 2023 · External reference
Glucocorticoid-induced Fingerprints on Visceral Adipose Tissue Transcriptome and Epigenome
10.1210/clinem/dgab662 · 2022 · External reference
Gene expression changes in subcutaneous adipose tissue due to Cushing’s disease
10.1530/jme-15-0119 · 2015 · External reference
Increased oxidative stress, inflammation and fibrosis in perirenal adipose tissue of patients with cortisol-producing adenoma
10.1080/21623945.2019.1690834 · 2019 · External reference
Increased Adipocyte Size, Macrophage Infiltration, and Adverse Local Adipokine Profile in Perirenal Fat in Cushing’s Syndrome
10.1002/oby.21887 · 2017 · External reference
Adipocyte GR Inhibits Healthy Adipose Expansion Through Multiple Mechanisms in Cushing Syndrome
10.1210/en.2018-01029 · 2019 · External reference
Deconstructing the roles of glucocorticoids in adipose tissue biology and the development of central obesity
10.1016/j.bbadis.2013.05.029 · 2014 · External reference
Adipose tissue in cortisol excess: What Cushing’s syndrome can teach us?
10.1016/j.bcp.2024.116137 · 2024 · External reference
Visceral fat accumulation and postdexamethasone serum cortisol levels in patients with adrenal incidentaloma
10.1210/jc.2012-4276 · 2013 · External reference
The Steroid Profile of Adrenal Incidentalomas: Subtyping Subjects With High Cardiovascular Risk
10.1210/jc.2019-00365 · 2019 · External reference
Steroid Profiling by LC-MS/MS in Nonsecreting and Subclinical Cortisol-Secreting Adrenocortical Adenomas
10.1210/jc.2015-1992 · 2015 · External reference
Association of adrenal steroids with metabolomic profiles in patients with primary and endocrine hypertension
10.3389/fendo.2024.1370525 · 2024 · External reference
Adrenal steroid metabolites and bone status in patients with adrenal incidentalomas and hypercortisolism
10.1016/j.ebiom.2023.104733 · 2023 · External reference
Lipid remodeling of adipose tissue in metabolic health and disease
10.1038/s12276-023-01071-4 · 2023 · External reference
decoupleR: ensemble of computational methods to infer biological activities from omics data
10.1093/bioadv/vbac016 · 2022 · External reference
WGCNA: an R package for weighted correlation network analysis
10.1186/1471-2105-9-559 · 2008 · External reference
Fast R Functions for Robust Correlations and Hierarchical Clustering
10.18637/jss.v046.i11 · 2012 · External reference
Rare and common genetic determinants of metabolic individuality and their effects on human health
10.1038/s41591-022-02046-0 · 2022 · External reference
MRC IEU UK Biobank GWAS pipeline version 1
2017 · External reference
Multiomics analysis unveils the cellular ecosystem with clinical relevance in aldosterone-producing adenomas with KCNJ5 mutations
10.1073/pnas.2421489122 · 2025 · External reference
Deoxycorticosterone inactivation by AKR1C3 in human mineralocorticoid target tissues
10.1016/j.mce.2005.10.024 · 2006 · External reference
Agonistic and antagonistic properties of progesterone metabolites at the human mineralocorticoid receptor
10.1530/eje.0.1460789 · 2002 · External reference
Mineralocorticoid receptor in adipocytes and macrophages: A promising target to fight metabolic syndrome
10.1016/j.steroids.2014.05.001 · 2014 · External reference
Myeloid mineralocorticoid receptor controls macrophage polarization and cardiovascular hypertrophy and remodeling in mice
10.1172/jci41080 · 2010 · External reference
Modulation of 11β-hydroxysteroid dehydrogenase as a strategy to reduce vascular inflammation
10.1007/s11883-013-0320-1 · 2013 · External reference
The glucocorticoid receptor: cause of or cure for obesity?
10.1152/ajpendo.00478.2015 · 2016 · External reference
Aldosterone promotes autoimmune damage by enhancing Th17-mediated immunity
10.4049/jimmunol.0802886 · 2010 · External reference
Aldosterone, Inflammation, Immune System, and Hypertension
10.1093/ajh/hpaa137 · 2021 · External reference
Paradoxical resistance to high-fat diet-induced obesity and altered macrophage polarization in mineralocorticoid receptor-overexpressing mice
10.1152/ajpendo.00323.2013 · 2014 · External reference
The Mineralocorticoid Receptor Plays a Crucial Role in Macrophage Development and Function
10.1210/endocr/bqad127 · 2023 · External reference
The balance between gluco- and mineralo-corticoid action critically determines inflammatory adipocyte responses
10.1677/joe-09-0292 · 2010 · External reference
Changes in abdominal subcutaneous adipose tissue phenotype following menopause is associated with increased visceral fat mass
10.1038/s41598-021-94189-2 · 2021 · External reference
Estrogen receptor inhibits mineralocorticoid receptor transcriptional regulatory function
10.1210/en.2014-1270 · 2014 · External reference
Ceramides – Lipotoxic Inducers of Metabolic Disorders
10.1016/j.tem.2015.07.006 · 2015 · External reference
Inhibition of Ceramide Synthesis Ameliorates Glucocorticoid-Saturated-Fat-and Obesity-Induced Insulin Resistance
10.1016/j.cmet.2007.01.002 · 2007 · External reference
Structural basis of the mechanism and inhibition of a human ceramide synthase
10.1038/s41594-024-01414-3 · 2025 · External reference
Adipose Fatty Acid Binding Protein Promotes Saturated Fatty Acid-Induced Macrophage Cell Death through Enhancing Ceramide Production
10.4049/jimmunol.1601403 · 2017 · External reference
Macrophage-specific de Novo Synthesis of Ceramide Is Dispensable for Inflammasome-driven Inflammation and Insulin Resistance in Obesity
10.1074/jbc.m115.680199 · 2015 · External reference
Metabolic Syndrome is Associated with Ceramide Accumulation in Visceral Adipose Tissue of Women with Morbid Obesity
10.1002/oby.22405 · 2019 · External reference
Obesity-induced CerS6-dependent C16:0 ceramide production promotes weight gain and glucose intolerance
10.1016/j.cmet.2014.08.002 · 2014 · External reference
Macrophage VLDLR mediates obesity-induced insulin resistance with adipose tissue inflammation
10.1038/s41467-017-01232-w · 2017 · External reference
Endogenous cortisol excess confers a unique lipid signature and metabolic network
10.1007/s00109-021-02076-0 · 2021 · External reference
Cer(d18:1/16:0) as a biomarkers for acute coronary syndrome in Chinese populations
2025 · External reference
Ceramides and risk of major adverse cardiovascular events: A meta-analysis of longitudinal studies
10.1016/j.jacl.2020.01.005 · 2020 · External reference
Presence of brown adipocytes in retroperitoneal fat from patients with benign adrenal tumors: relationship with outdoor temperature
10.1210/jc.2012-3535 · 2013 · External reference
Characterization of brown adipose tissue in the human perirenal depot
10.1002/oby.20765 · 2014 · External reference
Cardiometabolic comorbidities and cardiovascular events in “non-functioning” adrenal incidentalomas: a systematic review and meta-analysis
10.1007/s40618-024-02440-0 · 2024 · External reference
Wide-scope targeted analysis of bioactive lipids in human plasma by LC/MS/MS
10.1016/j.jlr.2023.100492 · 2024 · External reference
A single-cell atlas of human and mouse white adipose tissue
10.1038/s41586-022-04518-2 · 2022 · External reference
Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2
10.1186/s13059-014-0550-8 · 2014 · External reference
MetaboAnalyst 6.0: towards a unified platform for metabolomics data processing, analysis and interpretation
10.1093/nar/gkae253 · 2024 · External reference
Unresolved reference
External reference
Accurate estimation of cell composition in bulk expression through robust integration of single-cell information
10.1038/s41467-020-15816-6 · 2020 · External reference
Adiposoft: automated software for the analysis of white adipose tissue cellularity in histological sections
10.1194/jlr.d023788 · 2012 · External reference
QuPath: Open source software for digital pathology image analysis
10.1038/s41598-017-17204-5 · 2017 · External reference
The MR-Base platform supports systematic causal inference across the human phenome
10.7554/elife.34408 · 2018 · External reference
Detection of widespread horizontal pleiotropy in causal relationships inferred from Mendelian randomization between complex traits and diseases
10.1038/s41588-018-0099-7 · 2018 · External reference
Using clusterProfiler to characterize multiomics data
10.1038/s41596-024-01020-z · 2024 · External reference
Functional macrophage cell lines transformed by Abelson leukemia virus
10.1016/0092-8674(78)90101-0 · 1978 · External reference
The diagnosis of Cushing’s syndrome: an Endocrine Society Clinical Practice Guideline
10.1210/jc.2008-0125 · 2008 · External reference
Management of adrenal incidentalomas: European Society of Endocrinology Clinical Practice Guideline in collaboration with the European Network for the Study of Adrenal Tumors
10.1530/eje-16-0467 · 2016 · External reference
Contraception for Women Aged over 40 Years
2017 · External reference
Muscle and bone mass in middle-aged women: role of menopausal status and physical activity
10.1002/jcsm.12547 · 2020 · External reference
Plasma Steroid Profiling Between Patients With and Without Diabetes Mellitus in Nonfunctioning Adrenal Incidentalomas
10.1210/jendso/bvae140 · 2024 · External reference
Defects in the H3t Gene Cause an Increase in Leydig Cells With Impaired Spermatogenesis in Mice
10.1111/gtc.13182 · 2025 · External reference
PDZD8-deficient mice accumulate cholesteryl esters in the brain as a result of impaired lipophagy
10.1016/j.isci.2022.105612 · 2022 · External reference
Widely-targeted quantitative lipidomics method by supercritical fluid chromatography triple quadrupole mass spectrometry [S]
10.1194/jlr.d083014 · 2018 · External reference
Reference intervals for the urinary steroid metabolome: The impact of sex, age, day and night time on human adult steroidogenesis
10.1371/journal.pone.0214549 · 2019 · External reference
The new NHGRI-EBI Catalog of published genome-wide association studies (GWAS Catalog)
10.1093/nar/gkw1133 · 2017 · External reference