Research graph
References from Comparative Efficacy of Treatments for Resistant or Uncontrolled Hypertension. Local targets link to admitted publications; unresolved targets remain external evidence.
Worldwide trends in hypertension prevalence and progress in treatment and control from 1990 to 2019: a pooled analysis of 1201 population-representative studies with 104 million participants
10.1016/s0140-6736(21)01330-1 · 2021 · External reference
Randomized controlled trials of blood pressure lowering in hypertension
10.1161/circresaha.116.303641 · 2015 · External reference
2024 ESC guidelines for the management of elevated blood pressure and hypertension
10.1093/eurheartj/ehae178 · 2024 · External reference
10.1016/j.jacc.2025.05.007
10.1016/j.jacc.2025.05.007 · 2025 · External reference
The PRISMA extension statement for reporting of systematic reviews incorporating network meta-analyses of health care interventions: checklist and explanations
10.7326/m14-2385 · 2015 · External reference
Searching one or two databases was insufficient for meta-analysis of observational studies
10.1016/j.jclinepi.2005.03.004 · 2005 · External reference
New dual endothelin receptor antagonist aprocitentan in hypertension: a systematic review and meta-analysis
10.1016/j.cpcardiol.2023.101686 · 2023 · External reference
Effects of catheter-based renal denervation in hypertension: a systematic review and meta-analysis
10.1161/circulationaha.124.069709 · 2024 · External reference
Efficacy and safety of aldosterone synthase inhibitors for hypertension: a meta-analysis of randomized controlled trials and systematic review
10.1161/hypertensionaha.124.23962 · 2025 · External reference
Aldosterone-targeted therapies: early implementation in resistant hypertension and chronic kidney disease
10.1093/eurheartj/ehaf225 · 2025 · External reference
Chapter 11: Undertaking network meta-analyses [last updated October 2019]
2024 · External reference
Checking consistency in mixed treatment comparison meta-analysis
10.1002/sim.3767 · 2010 · External reference
Consistency and inconsistency in network meta-analysis: concepts and models for multi-arm studies
10.1002/jrsm.1044 · 2012 · External reference
Contour-enhanced meta-analysis funnel plots help distinguish publication bias from other causes of asymmetry
10.1016/j.jclinepi.2007.11.010 · 2008 · External reference
RoB 2: a revised tool for assessing risk of bias in randomised trials
10.1136/bmj.l4898 · 2019 · External reference
CINeMA: an approach for assessing confidence in the results of a network meta-analysis
10.1371/journal.pmed.1003082 · 2020 · External reference
A network meta-analysis of clinical management strategies for treatment-resistant hypertension: making optimal use of the evidence
10.1007/s11606-017-4000-7 · 2017 · External reference
A systematic review and meta-analysis of all sham and placebo controlled trials for resistant hypertension
10.1016/j.ejim.2023.04.021 · 2023 · External reference
Efficacy of pharmacological and interventional treatment for resistant hypertension: a network meta-analysis
10.1093/cvr/cvad165 · 2024 · External reference
Effects of aldosterone on the vasculature
10.1161/01.hyp.0000201443.63240.a7 · 2006 · External reference
The unrecognized prevalence of primary aldosteronism
10.7326/m20-0065 · 2020 · External reference
Cardiovascular events and target organ damage in primary aldosteronism compared with essential hypertension: a systematic review and meta-analysis
10.1016/s2213-8587(17)30319-4 · 2018 · External reference
Spironolactone versus placebo, bisoprolol, and doxazosin to determine the optimal treatment for drug-resistant hypertension (PATHWAY-2): a randomised, double-blind, crossover trial
10.1016/s0140-6736(15)00257-3 · 2015 · External reference
A meta-analysis of add-on use of spironolactone in patients with resistant hypertension
10.1016/j.ijcard.2016.12.158 · 2017 · External reference
Effect of mineralocorticoid antagonists on blood pressure lowering
10.1097/hjh.0000000000001671 · 2018 · External reference
Blood pressure lowering for prevention of cardiovascular disease and death: a systematic review and meta-analysis
10.1016/s0140-6736(15)01225-8 · 2016 · External reference
Relationship between clinic and ambulatory blood pressure and mortality: an observational cohort study in 59 124 patients
10.1016/s0140-6736(23)00733-x · 2023 · External reference
Comparison of the aldosterone-blocking agents eplerenone and spironolactone
10.1002/clc.20324 · 2008 · External reference
Steroidal and non-steroidal mineralocorticoid receptor antagonists in cardiorenal medicine
10.1093/eurheartj/ehaa736 · 2021 · External reference
Physiology in perspective: the Wisdom of the body. Neural control of the kidney
10.1152/ajpregu.00258.2005 · 2005 · External reference
Patient-level pooled analysis of endovascular ultrasound renal denervation or a sham procedure 6 months after medication escalation: the RADIANCE clinical trial program
10.1161/circulationaha.123.066941 · 2024 · External reference
Alcohol-mediated renal denervation in patients with hypertension in the absence of antihypertensive medications
10.4244/eij-d-23-00088 · 2023 · External reference
Endovascular ultrasound renal denervation to treat hypertension (RADIANCE-HTN SOLO): a multicentre, international, single-blind, randomised, sham-controlled trial
10.1016/s0140-6736(18)31082-1 · 2018 · External reference
Endovascular ultrasound renal denervation to treat hypertension
10.1001/jama.2023.0713 · 2023 · External reference
Renal denervation in the management of hypertension in adults. A clinical consensus statement of the ESC council on hypertension and the European Association of Percutaneous Cardiovascular Interventions (EAPCI)
10.1093/eurheartj/ehad054 · 2023 · External reference
Aldosterone synthase inhibition for hypertension
10.1056/nejme2511533 · 2025 · External reference
Ultrasound renal denervation for hypertension resistant to a triple medication pill (RADIANCE-HTN TRIO): a randomised, multicentre, single-blind, sham-controlled trial
10.1016/s0140-6736(21)00788-1 · 2021 · External reference
Decreasing the effects of aldosterone. in resistant hypertension — a success story
10.1056/nejme2216143 · 2023 · External reference
Safety and efficacy of steroidal mineralocorticoid receptor antagonists in patients with kidney failure requiring dialysis: a systematic review and meta-analysis of randomised controlled trials
10.1016/s0140-6736(25)01153-5 · 2025 · External reference
Aldosterone synthase inhibition with lorundrostat for uncontrolled hypertension
10.1001/jama.2023.16029 · 2023 · External reference
Psychological and psychosocial interventions for treatment-resistant schizophrenia: a systematic review and network meta-analysis
10.1016/s2215-0366(24)00136-6 · 2024 · External reference
Measuring the multiple domains of medication nonadherence: findings from a Delphi survey of adherence experts
10.1093/tbm/ibz133 · 2021 · External reference
Patient perceptions, motivations and barriers to treatment adherence in hypertension: results of a questionnaire-based survey in five European countries
10.1080/08037051.2025.2513434 · 2025 · External reference
Genetic and epigenetic mechanisms regulating blood pressure and kidney dysfunction
10.1161/hypertensionaha.124.22072 · 2024 · External reference
