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References from Neuronal Na+ Channels Are Integral Components of Pro-Arrhythmic Na+/Ca2+ Signaling Nanodomain That Promotes Cardiac Arrhythmias During β-Adrenergic Stimulation. Local targets link to admitted publications; unresolved targets remain external evidence.
Systematic review of the incidence of sudden cardiac death in the United States
10.1016/j.jacc.2010.09.064 · 2011 · External reference
Casq2 deletion causes sarcoplasmic reticulum volume increase, premature Ca2+ release, and catecholaminergic polymorphic ventricular tachycardia
2006 · External reference
Mutations in the cardiac ryanodine receptor gene (hRyR2) underlie catecholaminergic polymorphic ventricular tachycardia
10.1161/01.cir.103.2.196 · 2001 · External reference
Mechanisms of abnormal calcium homeostasis in mutations responsible for catecholaminergic polymorphic ventricular tachycardia
10.1161/01.res.0000258468.31815.42 · 2007 · External reference
Dysfunctional ryanodine receptors in the heart: new insights into complex cardiovascular diseases
10.1016/j.yjmcc.2013.03.005 · 2013 · External reference
Intra-sarcoplasmic reticulum Ca2+ oscillations are driven by dynamic regulation of ryanodine receptor function by luminal Ca2+ in cardiomyocytes
10.1113/jphysiol.2009.175547 · 2009 · External reference
Ryanodine receptor luminal Ca2+ regulation: swapping calsequestrin and channel isoforms
10.1016/j.bpj.2009.07.030 · 2009 · External reference
Regulation of ryanodine receptors by calsequestrin: effect of high luminal Ca2+ and phosphorylation
10.1529/biophysj.104.051441 · 2005 · External reference
Luminal Ca2+ regulation of single cardiac ryanodine receptors: insights provided by calsequestrin and its mutants
10.1085/jgp.200709907 · 2008 · External reference
Store-dependent deactivation: cooling the chain-reaction of myocardial calcium signaling
10.1016/j.yjmcc.2012.10.008 · 2013 · External reference
Abnormal interactions of calsequestrin with the ryanodine receptor calcium release channel complex linked to exercise-induced sudden cardiac death
10.1161/01.res.0000220647.93982.08 · 2006 · External reference
New roles of calsequestrin and triadin in cardiac muscle
10.1113/jphysiol.2009.172098 · 2009 · External reference
Calsequestrin 2 deletion shortens the refractoriness of Ca2+ release and reduces rate-dependent Ca2+-alternans in intact mouse hearts
10.1016/j.yjmcc.2011.09.020 · 2012 · External reference
Decreased RyR2 refractoriness determines myocardial synchronization of aberrant Ca2+ release in a genetic model of arrhythmia
10.1073/pnas.1300052110 · 2013 · External reference
Molecular basis of catecholaminergic polymorphic ventricular tachycardia
10.1016/j.hrthm.2008.09.013 · 2009 · External reference
Clinical phenotype and functional characterization of CASQ2 mutations associated with catecholaminergic polymorphic ventricular tachycardia
10.1161/circulationaha.106.623793 · 2006 · External reference
Update of the guidelines on sudden cardiac death of the European Society of Cardiology
10.1016/s0195-0668x(02)00809-6 · 2003 · External reference
β-adrenergic stimulation increases the intra-sarcoplasmic reticulum Ca2+ threshold for Ca2+ wave generation
10.1113/jphysiol.2012.236117 · 2012 · External reference
Role of RyR2 phosphorylation in heart failure and arrhythmias: controversies around ryanodine receptor phosphorylation in cardiac disease
10.1161/circresaha.114.300568 · 2014 · External reference
The Cardiac Arrhythmia Pilot Study
10.1016/0002-9149(86)90958-6 · 1986 · External reference
Flecainide therapy reduces exercise-induced ventricular arrhythmias in patients with catecholaminergic polymorphic ventricular tachycardia
10.1016/j.jacc.2011.01.026 · 2011 · External reference
Power and pitfalls of using transgenic mice to optimize therapy for CPVT—a need for prospective placebo-controlled clinical trials in genetic arrhythmia disorders
10.1016/j.hrthm.2010.07.028 · 2010 · External reference
Flecainide prevents catecholaminergic polymorphic ventricular tachycardia in mice and humans
10.1038/nm.1942 · 2009 · External reference
Inhibition of Na+ channels ameliorates arrhythmias in a drug-induced model of Andersen-Tawil syndrome
10.1016/j.hrthm.2012.10.005 · 2013 · External reference
Flecainide reduces Ca(2+) spark and wave frequency via inhibition of the sarcolemmal sodium current
10.1093/cvr/cvt012 · 2013 · External reference
Neuronal Na+ channel blockade suppresses arrhythmogenic diastolic Ca2+ release
10.1093/cvr/cvu262 · 2015 · External reference
The binding of saxitoxin and tetrodotoxin to excitable tissue
10.1007/bfb0037088 · 1977 · External reference
The Na+ channel in mammalian cardiac cells. Two kinds of tetrodotoxin receptors in rat heart membranes
10.1016/s0021-9258(18)32127-6 · 1983 · External reference
A mutant of TTX-resistant cardiac sodium channels with TTX-sensitive properties
10.1126/science.256.5060.1202 · 1992 · External reference
Distinct subcellular localization of different sodium channel alpha and beta subunits in single ventricular myocytes from mouse heart
10.1161/01.cir.0000121421.61896.24 · 2004 · External reference
Localization of sodium channel subtypes in mouse ventricular myocytes using quantitative immunocytochemistry
10.1016/j.yjmcc.2013.08.004 · 2013 · External reference
Subcellular heterogeneity of sodium current properties in adult cardiac ventricular myocytes
10.1016/j.hrthm.2011.07.016 · 2011 · External reference
Unexpected structural and functional consequences of the R33Q homozygous mutation in cardiac calsequestrin: a complex arrhythmogenic cascade in a knock in mouse model
10.1161/circresaha.108.171660 · 2008 · External reference
Alternating membrane potential/calcium interplay underlies repetitive focal activity in a genetic model of calcium-dependent atrial arrhythmias
10.1113/jphysiol.2014.280784 · 2015 · External reference
Doxycycline inducible expression of SERCA2a improves calcium handling and reverts cardiac dysfunction in pressure overload-induced cardiac hypertrophy
10.1152/ajpheart.00428.2004 · 2004 · External reference
Ryanodine receptor phosphorylation by calcium/calmodulin-dependent protein kinase II promotes life-threatening ventricular arrhythmias in mice with heart failure
10.1161/circulationaha.110.982298 · 2010 · External reference
Cx43 associates with Na(v)1.5 in the cardiomyocyte perinexus
10.1007/s00232-012-9465-z · 2012 · External reference
The inflammasome promotes adverse cardiac remodeling following acute myocardial infarction in the mouse
10.1073/pnas.1108586108 · 2011 · External reference
Genetic ablation of ryanodine receptor 2 phosphorylation at Ser-2808 aggravates Ca(2+)-dependent cardiomyopathy by exacerbating diastolic Ca2+ release
10.1113/jphysiol.2013.264689 · 2014 · External reference
Voltage-gated sodium channel isoform-specific effects of pompilidotoxins
10.1111/j.1742-4658.2009.07533.x · 2010 · External reference
A β(IV)-spectrin/CaMKII signaling complex is essential for membrane excitability in mice
10.1172/jci43621 · 2010 · External reference
Ca2+/calmodulin-dependent protein kinase II (CaMKII) regulates cardiac sodium channel NaV1.5 gating by multiple phosphorylation sites
10.1074/jbc.m111.322537 · 2012 · External reference
Molecular changes in neurons in multiple sclerosis: altered axonal expression of Nav1.2 and Nav1.6 sodium channels and Na+/Ca2+ exchanger
10.1073/pnas.0402765101 · 2004 · External reference
In silico docking reveals possible Riluzole binding sites on Nav1.6 sodium channel: implications for amyotrophic lateral sclerosis therapy
10.1016/j.jtbi.2012.09.004 · 2012 · External reference
μ-conotoxins that differentially block sodium channels NaV1.1 through 1.8 identify those responsible for action potentials in sciatic nerve
10.1073/pnas.1107027108 · 2011 · External reference
The TTX metabolite 4,9-anhydro-TTX is a highly specific blocker of the Na(v1.6) voltage-dependent sodium channel
10.1152/ajpcell.00070.2007 · 2007 · External reference
Evidence for a role of Nav1.6 in facilitating increases in neuronal hyperexcitability during epileptogenesis
10.1152/jn.00383.2013 · 2013 · External reference
Combined Na(+)/Ca(2+) exchanger and L-type calcium channel block as a potential strategy to suppress arrhythmias and maintain ventricular function
10.1161/circep.113.000322 · 2013 · External reference
Scn1b deletion leads to increased tetrodotoxin-sensitive sodium current, altered intracellular calcium homeostasis and arrhythmias in murine hearts
10.1113/jphysiol.2014.277699 · 2015 · External reference
Contribution of sodium channel neuronal isoform Nav1.1 to late sodium current in ventricular myocytes from failing hearts
10.1113/jphysiol.2014.278259 · 2015 · External reference
Prolongation of action potential duration and QT interval during epilepsy linked to increased contribution of neuronal sodium channels to cardiac late Na+ current: a potential mechanism for sudden death in epilepsy
10.1161/circep.114.002693 · 2015 · External reference
Na+ currents are required for efficient excitation-contraction coupling in rabbit ventricular myocytes: a possible contribution of neuronal Na+ channels
10.1113/jphysiol.2010.194688 · 2010 · External reference
Localization of cardiac sodium channels in caveolin-rich membrane domains: regulation of sodium current amplitude
10.1161/hh0402.105177 · 2002 · External reference
Tubulin polymerization disrupts cardiac β-adrenergic regulation of late INa
10.1093/cvr/cvu120 · 2014 · External reference
Beta2-adrenergic receptor redistribution in heart failure changes cAMP compartmentation
10.1126/science.1185988 · 2010 · External reference
Caveolin-3 regulates compartmentation of cardiomyocyte beta2-adrenergic receptor-mediated cAMP signaling
10.1016/j.yjmcc.2013.12.003 · 2014 · External reference
State-dependent trapping of flecainide in the cardiac sodium channel
10.1113/jphysiol.2004.065003 · 2004 · External reference
An unexpected role for brain-type sodium channels in coupling of cell surface depolarization to contraction in the heart
10.1073/pnas.261705699 · 2002 · External reference
Electrophysiological properties of two axonal sodium channels, Nav1.2 and Nav1.6, expressed in mouse spinal sensory neurones
10.1113/jphysiol.2005.083089 · 2005 · External reference
Functional properties and differential neuromodulation of Na(v)1.6 channels
10.1016/j.mcn.2008.05.009 · 2008 · External reference
Mass spectrometry-based identification of native cardiac Nav1.5 channel α subunit phosphorylation sites
10.1021/pr300702c · 2012 · External reference
Suppression of spontaneous ca elevations prevents atrial fibrillation in calsequestrin 2-null hearts
10.1161/circep.113.000994 · 2014 · External reference
Recent advances in the molecular pathophysiology of atrial fibrillation
10.1172/jci46315 · 2011 · External reference
Short communication: flecainide exerts an antiarrhythmic effect in a mouse model of catecholaminergic polymorphic ventricular tachycardia by increasing the threshold for triggered activity
10.1161/circresaha.111.247338 · 2011 · External reference
“Ryanopathy”: causes and manifestations of RyR2 dysfunction in heart failure
10.1093/cvr/cvt024 · 2013 · External reference
Proarrhythmic response to sodium channel blockade. Theoretical model and numerical experiments
10.1161/01.cir.84.3.1364 · 1991 · External reference
Mortality and morbidity in patients receiving encainide, flecainide, or placebo. The Cardiac Arrhythmia Suppression Trial
10.1056/nejm199103213241201 · 1991 · External reference
Calcium-induced release of calcium from the cardiac sarcoplasmic reticulum
10.1152/ajpcell.1983.245.1.c1 · 1983 · External reference