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References from Chemotherapeutic Efficacy of Phosphodiesterase Inhibitors in Chagasic Cardiomyopathy. Local targets link to admitted publications; unresolved targets remain external evidence.
Unresolved reference
2010 · External reference
The United States Trypanosoma cruzi Infection Study: evidence for vector-borne transmission of the parasite that causes Chagas disease among United States blood donors
10.1111/j.1537-2995.2012.03581.x · 2012 · External reference
An estimate of the burden of Chagas disease in the United States
10.1086/605091 · 2009 · External reference
Chagas disease in Spain, the United States and other non-endemic countries
10.1016/j.actatropica.2009.07.019 · 2010 · External reference
Trypanosoma cruzi and Chagas' disease in the United States
10.1128/cmr.00005-11 · 2011 · External reference
Chagas disease
10.1016/s0140-6736(10)60061-x · 2010 · External reference
Pharmacological interventions for treating heart failure in patients with chagas cardiomyopathy
10.1002/14651858.cd009077.pub2 · 2012 · External reference
Global economic burden of Chagas disease: a computational simulation model
10.1016/s1473-3099(13)70002-1 · 2013 · External reference
Early regulation of profibrotic genes in primary human cardiac myocytes by Trypanosoma cruzi
10.1371/journal.pntd.0003747 · 2016 · External reference
Developments in the management of chagasic cardiomyopathy
10.1586/14779072.2015.1103648 · 2015 · External reference
Oxidative stress in Chagas disease
10.1155/2009/190354 · 2009 · External reference
Phenyl-alpha-tert-butyl-nitrone and benzonidazole treatment controlled the mitochondrial oxidative stress and evolution of cardiomyopathy in chronic chagasic rats
10.1016/j.jacc.2010.02.030 · 2010 · External reference
MnSODtg mice control myocardial inflammatory and oxidative stress and remodeling responses elicited in chronic Chagas disease
2013 · External reference
Cyclic GMP signaling in cardiovascular pathophysiology and therapeutics
10.1016/j.pharmthera.2009.02.009 · 2009 · External reference
Role of cyclic GMP-dependent protein kinase in the contractile response to exogenous nitric oxide in rat cardiac myocytes
10.1113/jphysiol.2001.014126 · 2002 · External reference
Cyclic GMP-dependent signaling in cardiac myocytes
10.1253/circj.cj-12-0664 · 2012 · External reference
Phosphodiesterases and cardiac cGMP: evolving roles and controversies
10.1016/j.tips.2011.02.019 · 2011 · External reference
Phosphodiesterases and cyclic GMP regulation in heart muscle
2012 · External reference
Sustained soluble guanylate cyclase stimulation offsets nitric-oxide synthase inhibition to restore acute cardiac modulation by sildenafil
10.1124/jpet.108.137422 · 2008 · External reference
Cytosolic Ca2+-induced apoptosis in rat cardiomyocytes via mitochondrial NO-cGMP-protein kinase G pathway
10.1124/jpet.112.198176 · 2013 · External reference
Sildenafil (Viagra) attenuates ischemic cardiomyopathy and improves left ventricular function in mice
10.1152/ajpheart.ajpheart.91438.2007 · 2008 · External reference
High-frequency speckle tracking echocardiography in the assessment of left ventricular function and remodeling after murine myocardial infarction
10.1152/ajpheart.00553.2013 · 2014 · External reference
NADPH oxidase inhibition ameliorates Trypanosoma cruzi-induced myocarditis during Chagas disease
10.1002/path.2975 · 2011 · External reference
Mitochondrial generation of reactive oxygen species is enhanced at the Q(o) site of the complex III in the myocardium of Trypanosoma cruzi-infected mice: beneficial effects of an antioxidant
10.1007/s10863-008-9184-4 · 2008 · External reference
OGDHL is a modifier of AKT-dependent signaling and NF-kappaB function
10.1371/journal.pone.0048770 · 2012 · External reference
Profiling gene transcription reveals a deficiency of mitochondrial oxidative phosphorylation in Trypanosoma cruzi-infected murine hearts: implications in chagasic myocarditis development
10.1016/s0925-4439(03)00060-7 · 2003 · External reference
TcVac3 induced control of Trypanosoma cruzi infection and chronic myocarditis in mice
2013 · External reference
Mitochondrial complex III defects contribute to inefficient respiration and ATP synthesis in the myocardium of Trypanosoma cruzi-infected mice
10.1089/ars.2008.2418 · 2010 · External reference
Protein oxidation and peroxidation
10.1042/bj20151227 · 2016 · External reference
Erectile dysfunction drugs and oxidative stress in the liver of male rats
10.1016/j.toxrep.2015.06.002 · 2015 · External reference
Nitric oxide synthase and cyclic GMP signaling in cardiac myocytes: from contractility to remodeling
10.1016/j.yjmcc.2011.07.029 · 2012 · External reference
Enhanced activities and gene expression of phosphodiesterase types 3 and 4 in pressure-induced congestive heart failure
10.1007/s003800200032 · 2002 · External reference
Gene expression analysis in mitochondria from chagasic mice: alterations in specific metabolic pathways
10.1042/bj20040356 · 2004 · External reference
Mechanisms of Trypanosoma cruzi persistence in Chagas disease
10.1111/j.1462-5822.2012.01764.x · 2012 · External reference
Pathogenesis of Chagas disease: time to move on
10.2741/e495 · 2012 · External reference
Current and future treatment of pulmonary hypertension
10.1358/dot.2012.48.2.1703662 · 2012 · External reference
Phosphodiesterase type 5 is highly expressed in the hypertrophied human right ventricle, and acute inhibition of phosphodiesterase type 5 improves contractility
10.1161/circulationaha.106.655266 · 2007 · External reference
Differential expression of PDE5 in failing and nonfailing human myocardium
10.1161/circheartfailure.111.961706 · 2012 · External reference
Chronic inhibition of cyclic GMP phosphodiesterase 5A prevents and reverses cardiac hypertrophy
10.1038/nm1175 · 2005 · External reference
Trypanosoma cruzi infection disturbs mitochondrial membrane potential and ROS production rate in cardiomyocytes
10.1016/j.freeradbiomed.2009.08.008 · 2009 · External reference
Impaired mitochondrial respiratory chain and bioenergetics during chagasic cardiomyopathy development
10.1016/j.bbadis.2004.03.005 · 2004 · External reference
Increased oxidative stress is correlated with mitochondrial dysfunction in chagasic patients
10.1016/j.freeradbiomed.2006.04.009 · 2006 · External reference
Peroxisome proliferator-activated receptor-gamma coactivator 1 alpha (PGC-1 alpha): transcriptional coactivator and metabolic regulator
10.1210/er.2002-0012 · 2003 · External reference
Integration of metabolism and inflammation by lipid-activated nuclear receptors
10.1038/nature07202 · 2008 · External reference
Heart mitochondrial DNA and enzyme changes during early human development
10.1023/a:1007031919298 · 2000 · External reference
Oxidative stress regulates left ventricular PDE5 expression in the failing heart
10.1161/circulationaha.109.906818 · 2010 · External reference
Sildenafil inhibits the formation of superoxide and the expression of gp47 NAD[P]H oxidase induced by the thromboxane A2 mimetic, U46619, in corpus cavernosal smooth muscle cells
10.1111/j.1464-410x.2005.05643.x · 2005 · External reference
The role of parasite persistence in pathogenesis of Chagas heart disease
10.1111/j.1365-3024.2009.01108.x · 2009 · External reference
Cardiac myosin autoimmunity in acute chagas' heart disease
10.1128/iai.69.9.5643-5649.2001 · 2001 · External reference
A cardiac myosin-specific autoimmune response is induced by immunization with Trypanosoma cruzi proteins
10.1128/iai.72.6.3410-3417.2004 · 2004 · External reference
Chagas heart disease pathogenesis: one mechanism or many?
10.2174/156652408785748004 · 2008 · External reference
Cardiac oxidized antigens are targets of immune recognition by antibodies and potential molecular determinants in Chagas disease pathogenesis
10.1371/journal.pone.0028449 · 2012 · External reference
Modulating sarco(endo)plasmic reticulum Ca2+ ATPase 2 (SERCA2) activity: cell biological implications
10.1016/j.ceca.2005.06.033 · 2005 · External reference
Metabolomic quantitative trait loci (mQTL) mapping implicates the ubiquitin proteasome system in cardiovascular disease pathogenesis
10.1371/journal.pgen.1005553 · 2015 · External reference
Chronic inhibition of cGMP-specific phosphodiesterase 5 suppresses endoplasmic reticulum stress in heart failure
10.1111/bph.12346 · 2013 · External reference
Roles of cGMP-dependent protein kinase I (cGKI) and PDE5 in the regulation of Ang II-induced cardiac hypertrophy and fibrosis
10.1073/pnas.1414364111 · 2014 · External reference
The emperor's new clothes: PDE5 and the heart
10.1371/journal.pone.0118664 · 2015 · External reference
cGMP-hydrolytic activity and its inhibition by sildenafil in normal and failing human and mouse myocardium
10.1124/jpet.109.154468 · 2009 · External reference