References

Prevalence of diagnosed atrial fibrillation in adults: national implications for rhythm management and stroke prevention: the anticoagulation and risk factors in atrial fibrillation (atria) study

10.1001/jama.285.18.2370 · 2001 · External reference

Mechanisms of thrombogenesis in atrial fibrillation: Virchow’s triad revisited

10.1016/s0140-6736(09)60040-4 · 2009 · External reference

Oral anticoagulants for stroke prevention in atrial fibrillation: current status, special situations, and unmet needs

10.1016/s0140-6736(15)60245-8 · 2015 · External reference

Thrombin as a multi-functional enzyme. Focus on in vitro and in vivo effects

10.1160/th10-11-0711 · 2011 · External reference

The cardiovascular actions of protease-activated receptors

10.1124/mol.104.003103 · 2005 · External reference

The roles of proteinase-activated receptors in the vascular physiology and pathophysiology

10.1161/01.atv.0000251995.73307.2d · 2007 · External reference

Signaling properties and functions of two distinct cardiomyocyte protease-activated receptors

10.1161/01.res.86.10.1054 · 2000 · External reference

Protease-activated receptor-1 contributes to cardiac remodeling and hypertrophy

10.1161/circulationaha.107.692764 · 2007 · External reference

Spironolactone reduces fibrosis of dilated atria during heart failure in rats with myocardial infarction

10.1093/eurheartj/ehi478 · 2005 · External reference

Dabigatran and thrombin modulate electrophysiological characteristics of pulmonary vein and left atrium

10.1161/circep.112.971556 · 2012 · External reference

Myocardial cell death in fibrillating and dilated human right atria

10.1016/s0735-1097(99)00382-4 · 1999 · External reference

Promotion of atrial fibrillation by heart failure in dogs atrial remodeling of a different sort

10.1161/01.cir.100.1.87 · 1999 · External reference

Atrial remodeling and atrial fibrillation: recent advances and translational perspectives

10.1016/j.jacc.2014.02.555 · 2014 · External reference

Chronic hemodynamic overload of the atria is an important factor for gap junction remodeling in human and rat hearts

10.1016/j.cardiores.2006.06.016 · 2006 · External reference

Role for microRNA-21 in atrial profibrillatory fibrotic remodeling associated with experimental postinfarction heart failure

10.1161/circep.112.973214 · 2012 · External reference

Effects of the direct thrombin inhibitor dabigatran and its orally active prodrug, dabigatran etexilate, on thrombus formation and bleeding time in rats

10.1160/th07-02-0113 · 2007 · External reference

S35972, a direct-acting thrombin inhibitor with high oral bioavailability and antithrombotic efficacy

10.1111/j.1538-7836.2011.04286.x · 2011 · External reference

The effect of dabigatran plasma concentrations and patient characteristics on the frequency of ischemic stroke and major bleeding in atrial fibrillation patients: The RE-LY trial (Randomized Evaluation of Long-Term Anticoagulation Therapy)

10.1016/j.jacc.2013.07.104 · 2014 · External reference

Characterization of thrombin-bound dabigatran effects on protease-activated receptor-1 expression and signaling in vitro

10.1124/mol.114.096446 · 2015 · External reference

Matricellular proteins in cardiac adaptation and disease

10.1152/physrev.00008.2011 · 2012 · External reference

Cardiac fibrosis in patients with atrial fibrillation: mechanisms and clinical implications

10.1016/j.jacc.2015.06.1313 · 2015 · External reference

Alpha-myosin heavy chain isoform and atrial size in patients with various types of mitral valve dysfunction: a quantitative study

10.1016/s0735-1097(87)80303-0 · 1987 · External reference

Thrombin and protease-activated receptors (PARs) in atherothrombosis

10.1160/th07-08-0481 · 2008 · External reference

Calcineurin/NFAT coupling participates in pathological, but not physiological, cardiac hypertrophy

10.1161/01.res.0000109415.17511.18 · 2004 · External reference

NF-κB regulates thrombin-induced ICAM-1 gene expression in cooperation with NFAT by binding to the intronic NF-κB site in the ICAM-1 gene

10.1152/physiolgenomics.00012.2009 · 2009 · External reference

Protein kinase C-related kinase and ROCK are required for thrombin-induced endothelial cell permeability downstream from Gα12/13 and Gα11/q

10.1074/jbc.m803880200 · 2008 · External reference

Involvement of protein kinase C and RhoA in protease-activated receptor 1–mediated F-actin reorganization and cell growth in rat cardiomyocytes

10.1254/jphs.10197fp · 2011 · External reference

Activation of the calcineurin signaling pathway induces atrial hypertrophy during atrial fibrillation

10.1007/s00018-005-5353-3 · 2006 · External reference

Dabigatran, a direct thrombin inhibitor, blocks differentiation of normal fibroblasts to a myofibroblast phenotype and demonstrates anti-fibrotic effects on scleroderma lung fibroblasts

10.1002/art.24935 · 2009 · External reference

What is all that thrombin for?

10.1046/j.1538-7836.2003.00298.x · 2003 · External reference

Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation

10.1016/0092-8674(91)90261-v · 1991 · External reference

Thrombomodulin as a model of molecular mechanisms that modulate protease specificity and function at the vessel surface

10.1096/fasebj.9.10.7615164 · 1995 · External reference

Coagulation factor Xa induces an inflammatory signalling by activation of protease-activated receptors in human atrial tissue

10.1016/j.ejphar.2013.09.006 · 2013 · External reference

Dabigatran versus warfarin in patients with atrial fibrillation: an analysis of patients undergoing cardioversion

10.1161/circulationaha.110.977546 · 2011 · External reference

RE-CIRCUIT study–randomized evaluation of dabigatran etexilate compared to warfarin in pulmonary vein ablation: assessment of an uninterrupted periprocedural anticoagulation strategy

10.1016/j.amjcard.2014.10.002 · 2015 · External reference

10.1002/ejhf.266

10.1002/ejhf.266 · 2015 · External reference

Protease-activated receptor-1 mediates thrombin-induced persistent sodium current in human cardiomyocytes

10.1124/mol.107.043182 · 2008 · External reference

Altered Na+ currents in atrial fibrillation: effects of ranolazine on arrhythmias and contractility in human atrial myocardium

10.1016/j.jacc.2009.12.055 · 2010 · External reference