Research graph
References from Evidence of Glycolysis Up-Regulation and Pyruvate Mitochondrial Oxidation Mismatch During Mechanical Unloading of the Failing Human Heart. Local targets link to admitted publications; unresolved targets remain external evidence.
2009 focused update incorporated into the ACC/AHA 2005 Guidelines for the Diagnosis and Management of Heart Failure in Adults: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines
10.1016/j.jacc.2008.11.013 · 2009 · External reference
Left ventricular assist device and drug therapy for the reversal of heart failure
10.1056/nejmoa053063 · 2006 · External reference
Reversal of severe heart failure with a continuous-flow left ventricular assist device and pharmacological therapy: a prospective study
10.1161/circulationaha.109.933960 · 2011 · External reference
Bridge to recovery: understanding the disconnect between clinical and biological outcomes
10.1161/circulationaha.111.040261 · 2012 · External reference
The failing heart—an engine out of fuel
10.1056/nejmra063052 · 2007 · External reference
Ventricular assist device implantation corrects myocardial lipotoxicity, reverses insulin resistance, and normalizes cardiac metabolism in patients with advanced heart failure
10.1161/circulationaha.111.060889 · 2012 · External reference
Mechanical unloading promotes myocardial energy recovery in human heart failure
10.1161/circgenetics.113.000404 · 2014 · External reference
Myocardial atrophy and chronic mechanical unloading of the failing human heart: implications for cardiac assist device-induced myocardial recovery
10.1016/j.jacc.2014.05.073 · 2014 · External reference
Changes in citric acid cycle flux and anaplerosis antedate the functional decline in isolated rat hearts utilizing acetoacetate
10.1172/jci115008 · 1991 · External reference
Mitochondrial energetics in the heart in obesity-related diabetes: direct evidence for increased uncoupled respiration and activation of uncoupling proteins
10.2337/db07-0481 · 2007 · External reference
Simultaneous quantification of mitochondrial DNA copy number and deletion ratio: a multiplex real-time PCR assay
10.1038/srep03887 · 2014 · External reference
Cardiac, skeletal, and smooth muscle mitochondrial respiration: are all mitochondria created equal?
10.1152/ajpheart.00227.2014 · 2014 · External reference
Impact of mechanical unloading on microvasculature and associated central remodeling features of the failing human heart
10.1016/j.jacc.2010.04.019 · 2010 · External reference
Myocardial substrate metabolism in the normal and failing heart
10.1152/physrev.00006.2004 · 2005 · External reference
Energy metabolism in the normal and failing heart: potential for therapeutic interventions
10.1023/a:1015320423577 · 2002 · External reference
Altered myocardial fatty acid and glucose metabolism in idiopathic dilated cardiomyopathy
10.1016/s0735-1097(02)01967-8 · 2002 · External reference
Metabolic remodelling of the failing heart: beneficial or detrimental?
10.1093/cvr/cvn282 · 2009 · External reference
Left ventricular assist device effects on metabolic substrates in the failing heart
10.1371/journal.pone.0060292 · 2013 · External reference
The failing heart relies on ketone bodies as a fuel
10.1161/circulationaha.115.017355 · 2016 · External reference
Evidence for intramyocardial disruption of lipid metabolism and increased myocardial ketone utilization in advanced human heart failure
10.1161/circulationaha.115.017545 · 2016 · External reference
Defective DNA replication impairs mitochondrial biogenesis in human failing hearts
10.1161/circresaha.109.212753 · 2010 · External reference
Mitochondrial function in heart muscle from patients with idiopathic dilated cardiomyopathy
10.1016/s0008-6363(99)00388-0 · 2000 · External reference
Freshly isolated mitochondria from failing human hearts exhibit preserved respiratory function
10.1016/j.yjmcc.2013.12.029 · 2014 · External reference
Dysfunction of mitochondrial respiratory chain complex I in human failing myocardium is not due to disturbed mitochondrial gene expression
10.1016/s0735-1097(02)02600-1 · 2002 · External reference
Improvement of myocardial mitochondrial function after hemodynamic support with left ventricular assist devices in patients with heart failure
10.1016/s0022-5223(98)70136-9 · 1998 · External reference
Left ventricular assist device implantation augments nitric oxide dependent control of mitochondrial respiration in failing human hearts
10.1016/s0735-1097(00)00948-7 · 2000 · External reference
Energy metabolic reprogramming in the hypertrophied and early stage failing heart: a multisystems approach
10.1161/circheartfailure.114.001469 · 2014 · External reference
Cardiac anaplerosis in health and disease: food for thought
10.1093/cvr/cvr055 · 2011 · External reference
The key role of anaplerosis and cataplerosis for citric acid cycle function
10.1074/jbc.r200006200 · 2002 · External reference
Substrate-enzyme competition attenuates upregulated anaplerotic flux through malic enzyme in hypertrophied rat heart and restores triacylglyceride content: attenuating upregulated anaplerosis in hypertrophy
10.1161/circresaha.108.189951 · 2009 · External reference
Metabolic fingerprint of ischaemic cardioprotection: importance of the malate-aspartate shuttle
10.1093/cvr/cvr051 · 2011 · External reference
Metabolic adaptation of the hypertrophied heart: role of the malate/aspartate and alpha-glycerophosphate shuttles
10.1006/jmcc.2000.1257 · 2000 · External reference
Magnitude and time course of changes induced by continuous-flow left ventricular assist device unloading in chronic heart failure: insights into cardiac recovery
10.1016/j.jacc.2013.01.072 · 2013 · External reference
Exercise prevents cardiac injury and improves mitochondrial biogenesis in advanced diabetic cardiomyopathy with PGC-1alpha and Akt activation
10.1159/000374021 · 2015 · External reference
Exercise training boosts eNOS-dependent mitochondrial biogenesis in mouse heart: role in adaptation of glucose metabolism
10.1152/ajpendo.00617.2013 · 2014 · External reference
Myocardial reloading after extracorporeal membrane oxygenation alters substrate metabolism while promoting protein synthesis
10.1161/jaha.113.000106 · 2013 · External reference
Patient-controlled conditioning for left ventricular assist device-induced myocardial recovery
10.1016/j.athoracsur.2014.07.058 · 2015 · External reference
Ventricular reconditioning and pump explantation in patients supported by continuous-flow left ventricular assist devices
10.1016/j.healun.2014.09.015 · 2015 · External reference
