Contact and support
Need help, have a question, or want to contact the ResearchHub team?
© 2026 ResearchHub. Built for responsible scholarly connection.
Research graph
References from The Promise and Challenge of Induced Pluripotent Stem Cells for Cardiovascular Applications. Local targets link to admitted publications; unresolved targets remain external evidence.
Transplantation of living nuclei from blastula cells into enucleated frogs’ eggs
10.1073/pnas.38.5.455 · 1952 · External reference
Sexually mature individuals of Xenopus laevis from the transplantation of single somatic nuclei
10.1038/182064a0 · 1958 · External reference
Nuclear reprogramming of somatic cells after fusion with human embryonic stem cells
10.1126/science.1116447 · 2005 · External reference
Nuclear reprogramming of somatic cells by in vitro hybridization with ES cells
10.1016/s0960-9822(01)00459-6 · 2001 · External reference
Nuclear reprogramming and pluripotency
10.1038/nature04955 · 2006 · External reference
Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors
10.1016/j.cell.2006.07.024 · 2006 · External reference
Generation of germline-competent induced pluripotent stem cells
10.1038/nature05934 · 2007 · External reference
Induction of pluripotent stem cells from adult human fibroblasts by defined factors
10.1016/j.cell.2007.11.019 · 2007 · External reference
Induced pluripotent stem cell lines derived from human somatic cells
10.1126/science.1151526 · 2007 · External reference
In vitro reprogramming of fibroblasts into a pluripotent ES-cell-like state
10.1038/nature05944 · 2007 · External reference
Reprogramming of human somatic cells to pluripotency with defined factors
10.1038/nature06534 · 2008 · External reference
Efficient and rapid generation of induced pluripotent stem cells from human keratinocytes
10.1038/nbt.1503 · 2008 · External reference
Derivation of induced pluripotent stem cells from human peripheral blood T lymphocytes
10.1371/journal.pone.0011373 · 2010 · External reference
Generation of induced pluripotent stem cells from human blood
10.1182/blood-2009-02-204800 · 2009 · External reference
Generation of induced pluripotent stem cells from human cord blood using OCT4 and SOX2
10.1016/j.stem.2009.09.008 · 2009 · External reference
Human amniotic mesenchymal stem cell-derived induced pluripotent stem cells may generate a universal source of cardiac cells
10.1089/scd.2011.0435 · 2012 · External reference
Direct reprogramming of human neural stem cells by OCT4
10.1038/nature08436 · 2009 · External reference
Feeder-free derivation of induced pluripotent stem cells from adult human adipose stem cells
10.1073/pnas.0908450106 · 2009 · External reference
Generation of human induced pluripotent stem cells from urine samples
10.1038/nprot.2012.115 · 2012 · External reference
Generation of functional murine cardiac myocytes from induced pluripotent stem cells
10.1161/circulationaha.108.778795 · 2008 · External reference
Directed and systematic differentiation of cardiovascular cells from mouse induced pluripotent stem cells
10.1161/circulationaha.108.769562 · 2008 · External reference
Feasibility, safety, and therapeutic efficacy of human induced pluripotent stem cell-derived cardiomyocyte sheets in a porcine ischemic cardiomyopathy model
2012 · External reference
Functional consequences of human induced pluripotent stem cell therapy: myocardial ATP turnover rate in the in vivo swine heart with postinfarction remodeling
10.1161/circulationaha.112.000641 · 2013 · External reference
Intramyocardial injection of pig pluripotent stem cells improves left ventricular function and perfusion: a study in a porcine model of acute myocardial infarction
10.1371/journal.pone.0066688 · 2013 · External reference
Effect of human donor cell source on differentiation and function of cardiac induced pluripotent stem cells
10.1016/j.jacc.2014.04.056 · 2014 · External reference
Characterization of human induced pluripotent stem cell-derived retinal pigment epithelium cell sheets aiming for clinical application
10.1016/j.stemcr.2013.12.007 · 2014 · External reference
Rethinking differentiation: stem cells, regeneration, and plasticity
10.1016/j.cell.2014.02.041 · 2014 · External reference
Concise review: drug discovery in the age of the induced pluripotent stem cell
10.5966/sctm.2013-0162 · 2014 · External reference
Induced pluripotent stem cells for post-myocardial infarction repair: remarkable opportunities and challenges
10.1161/circresaha.114.300556 · 2014 · External reference
Repair of acute myocardial infarction by human stemness factors induced pluripotent stem cells
10.1161/circulationaha.109.865154 · 2009 · External reference
Cardiac tumorigenic potential of induced pluripotent stem cells in an immunocompetent host with myocardial infarction
10.2217/rme.10.103 · 2011 · External reference
Direct evaluation of myocardial viability and stem cell engraftment demonstrates salvage of the injured myocardium
10.1161/circresaha.116.304668 · 2015 · External reference
Intramyocardial transplantation of undifferentiated rat induced pluripotent stem cells causes tumorigenesis in the heart
10.1371/journal.pone.0019012 · 2011 · External reference
Transplantation of undifferentiated murine embryonic stem cells in the heart: teratoma formation and immune response
10.1096/fj.06-6769com · 2007 · External reference
Dual in vivo magnetic resonance evaluation of magnetically labeled mouse embryonic stem cells and cardiac function at 1.5 T
10.1002/mrm.20702 · 2006 · External reference
Reprogramming of skeletal myoblasts for induction of pluripotency for tumor-free cardiomyogenesis in the infarcted heart
10.1161/circresaha.110.240010 · 2011 · External reference
Cardiac progenitors derived from reprogrammed mesenchymal stem cells contribute to angiomyogenic repair of the infarcted heart
10.1007/s00395-012-0301-5 · 2012 · External reference
Chemically defined generation of human cardiomyocytes
10.1038/nmeth.2999 · 2014 · External reference
Abstract 19831: in vivo molecular imaging of human pluripotent stem cell-derived cardiomyocytes in a murine myocardial injury model via a safe harbor integration of a reporter gene
10.1161/circ.130.suppl_2.19831 · 2014 · External reference
Efficient non-viral reprogramming of myoblasts to stemness with a single small molecule to generate cardiac progenitor cells
10.1371/journal.pone.0023667 · 2011 · External reference
Induced pluripotent stem cell (iPSC)-derived Flk-1 progenitor cells engraft, differentiate, and improve heart function in a mouse model of acute myocardial infarction
10.1093/eurheartj/ehr166 · 2011 · External reference
Reduced collagen deposition in infarcted myocardium facilitates induced pluripotent stem cell engraftment and angiomyogenesis for improvement of left ventricular function
10.1016/j.jacc.2011.06.062 · 2011 · External reference
Molecular strategy to reduce in vivo collagen barrier promotes entry of NCX1 positive inducible pluripotent stem cells (iPSC(NCX1+)) into ischemic (or injured) myocardium
10.1371/journal.pone.0070023 · 2013 · External reference
Stem cell therapy for vascular regeneration: adult, embryonic, and induced pluripotent stem cells
10.1161/circulationaha.109.881441 · 2010 · External reference
Clinical trials of adult stem cell therapy for peripheral artery disease
10.14797/mdcj-9-4-201 · 2013 · External reference
Modulating the vascular response to limb ischemia: angiogenic and cell therapies
10.1161/circresaha.115.303565 · 2015 · External reference
Rationale and design for PACE: patients with intermittent claudication injected with ALDH bright cells
10.1016/j.ahj.2014.07.021 · 2014 · External reference
Diabetes and vessel wall remodelling: from mechanistic insights to regenerative therapies
10.1093/cvr/cvn039 · 2008 · External reference
Endothelial progenitor cells for postnatal vasculogenesis
10.1152/ajpcell.00330.2003 · 2004 · External reference
Generating induced pluripotent stem cell derived endothelial cells and induced endothelial cells for cardiovascular disease modelling and therapeutic angiogenesis
10.1016/j.ijcard.2015.06.038 · 2015 · External reference
Hematopoietic and endothelial differentiation of human induced pluripotent stem cells
10.1634/stemcells.2008-0922 · 2009 · External reference
Induction and isolation of vascular cells from human induced pluripotent stem cells—brief report
10.1161/atvbaha.108.182162 · 2009 · External reference
Attenuation of hind-limb ischemia in mice with endothelial-like cells derived from different sources of human stem cells
10.1371/journal.pone.0057876 · 2013 · External reference
Engineering vascular tissue with functional smooth muscle cells derived from human iPS cells and nanofibrous scaffolds
10.1016/j.biomaterials.2014.07.011 · 2014 · External reference
Multimodal evaluation of in vivo magnetic resonance imaging of myocardial restoration by mouse embryonic stem cells
10.1016/j.jtcvs.2007.12.053 · 2008 · External reference
Multimodality evaluation of the viability of stem cells delivered into different zones of myocardial infarction
10.1161/circimaging.108.767343 · 2008 · External reference
Magnetic resonance imaging overestimates ferumoxide-labeled stem cell survival after transplantation in the heart
10.1161/circulationaha.107.732073 · 2008 · External reference
Cell therapy for heart failure: a comprehensive overview of experimental and clinical studies, current challenges, and future directions
10.1161/circresaha.113.300219 · 2013 · External reference
Imaging survival and function of transplanted cardiac resident stem cells
10.1016/j.jacc.2008.12.036 · 2009 · External reference
“String theory” of c-kit(pos) cardiac cells: a new paradigm regarding the nature of these cells that may reconcile apparently discrepant results
10.1161/circresaha.116.305557 · 2015 · External reference
Bone marrow cells regenerate infarcted myocardium
10.1038/35070587 · 2001 · External reference
Chimerism of the transplanted heart
10.1056/nejmoa012081 · 2002 · External reference
Evidence that human cardiac myocytes divide after myocardial infarction
10.1056/nejm200106073442303 · 2001 · External reference
Myocyte proliferation in end-stage cardiac failure in humans
10.1073/pnas.95.15.8801 · 1998 · External reference
Multilineage potential of adult human mesenchymal stem cells
10.1126/science.284.5411.143 · 1999 · External reference
Isolation and expansion of adult cardiac stem cells from human and murine heart
10.1161/01.res.0000147315.71699.51 · 2004 · External reference
Embryonic stem cell lines derived from human blastocysts
10.1126/science.282.5391.1145 · 1998 · External reference
Evidence for cardiomyocyte renewal in humans
10.1126/science.1164680 · 2009 · External reference
c-kit+ cells minimally contribute cardiomyocytes to the heart
10.1038/nature13309 · 2014 · External reference
Isolation of putative progenitor endothelial cells for angiogenesis
10.1126/science.275.5302.964 · 1997 · External reference
Bone marrow origin of endothelial progenitor cells responsible for postnatal vasculogenesis in physiological and pathological neovascularization
10.1161/01.res.85.3.221 · 1999 · External reference
Embryonic stem cell-derived endothelial cells engraft into the ischemic hindlimb and restore perfusion
10.1161/atvbaha.110.202796 · 2010 · External reference
Copy number variation and selection during reprogramming to pluripotency
10.1038/nature09871 · 2011 · External reference
Hotspots of aberrant epigenomic reprogramming in human induced pluripotent stem cells
10.1038/nature09798 · 2011 · External reference
Genetic heterogeneity of induced pluripotent stem cells: results from 24 clones derived from a single C57BL/6 mouse
10.1371/journal.pone.0120585 · 2015 · External reference
Dynamic changes in the copy number of pluripotency and cell proliferation genes in human ESCs and iPSCs during reprogramming and time in culture
10.1016/j.stem.2010.12.003 · 2011 · External reference
Stem cells cruise to clinic
10.1038/494413a · 2013 · External reference
Epigenetic memory in induced pluripotent stem cells
10.1038/nature09342 · 2010 · External reference
The promise of induced pluripotent stem cells in research and therapy
10.1038/nature10761 · 2012 · External reference
Generation of induced pluripotent stem cells without Myc from mouse and human fibroblasts
10.1038/nbt1374 · 2008 · External reference
A comparison of non-integrating reprogramming methods
10.1038/nbt.3070 · 2015 · External reference
Stage-specific optimization of activin/nodal and BMP signaling promotes cardiac differentiation of mouse and human pluripotent stem cell lines
10.1016/j.stem.2010.12.008 · 2011 · External reference
Efficient and scalable purification of cardiomyocytes from human embryonic and induced pluripotent stem cells by VCAM1 surface expression
10.1371/journal.pone.0023657 · 2011 · External reference
Directed cardiomyocyte differentiation from human pluripotent stem cells by modulating Wnt/β-catenin signaling under fully defined conditions
10.1038/nprot.2012.150 · 2013 · External reference
Generation of highly purified human cardiomyocytes from peripheral blood mononuclear cell-derived induced pluripotent stem cells
10.1371/journal.pone.0126596 · 2015 · External reference
Human induced pluripotent stem cell-derived endothelial cells exhibit functional heterogeneity
2013 · External reference
Contractility of single cardiomyocytes differentiated from pluripotent stem cells depends on physiological shape and substrate stiffness
10.1073/pnas.1508073112 · 2015 · External reference
Immunogenicity of induced pluripotent stem cells
10.1038/nature10135 · 2011 · External reference
Transplanted terminally differentiated induced pluripotent stem cells are accepted by immune mechanisms similar to self-tolerance
10.1038/ncomms4903 · 2014 · External reference
Negligible immunogenicity of terminally differentiated cells derived from induced pluripotent or embryonic stem cells
10.1038/nature11807 · 2013 · External reference
Lack of immune response to differentiated cells derived from syngeneic induced pluripotent stem cells
10.1016/j.stem.2013.01.006 · 2013 · External reference
Toward the development of a global induced pluripotent stem cell library
10.1016/j.stem.2013.08.003 · 2013 · External reference
Generating an iPSC bank for HLA-matched tissue transplantation based on known donor and recipient HLA types
10.1016/j.stem.2012.07.014 · 2012 · External reference
A more efficient method to generate integration-free human iPS cells
10.1038/nmeth.1591 · 2011 · External reference
The role of human leukocyte antigen matching in the development of multiethnic “haplobank” of induced pluripotent stem cell lines
10.1002/stem.772 · 2012 · External reference
Therapeutic potential of appropriately evaluated safe-induced pluripotent stem cells for spinal cord injury
10.1073/pnas.0910106107 · 2010 · External reference
Twelve years' experience with national sharing of HLA-matched cadaveric kidneys for transplantation
10.1056/nejm200010123431504 · 2000 · External reference
Tumorigenicity as a clinical hurdle for pluripotent stem cell therapies
10.1038/nm.3267 · 2013 · External reference
Efficient generation of transgene-free human induced pluripotent stem cells (iPSCs) by temperature-sensitive Sendai virus vectors
10.1073/pnas.1103509108 · 2011 · External reference
Engineering patient-specific valves using stem cells generated from skin biopsy specimens
10.1016/j.athoracsur.2014.04.075 · 2014 · External reference
“Transdifferentiation” of C6 glial cells in culture
10.1126/science.6102413 · 1980 · External reference
Direct reprogramming of fibroblasts into functional cardiomyocytes by defined factors
10.1016/j.cell.2010.07.002 · 2010 · External reference
In vivo reprogramming of murine cardiac fibroblasts into induced cardiomyocytes
10.1038/nature11044 · 2012 · External reference
Heart repair by reprogramming non-myocytes with cardiac transcription factors
10.1038/nature11139 · 2012 · External reference
Recent advances in direct cardiac reprogramming
10.1016/j.gde.2015.09.004 · 2015 · External reference
Labor pains of new technology: direct cardiac reprogramming
10.1161/circresaha.112.271445 · 2012 · External reference
Direct reprogramming of fibroblasts into endothelial cells capable of angiogenesis and reendothelialization in tissue-engineered vessels
10.1073/pnas.1205526109 · 2012 · External reference
Activation of innate immunity is required for efficient nuclear reprogramming
10.1016/j.cell.2012.09.034 · 2012 · External reference
Transdifferentiation of human fibroblasts to endothelial cells: role of innate immunity
10.1161/circulationaha.113.007394 · 2015 · External reference
Disease-specific induced pluripotent stem cells
10.1016/j.cell.2008.07.041 · 2008 · External reference
Patient-specific induced pluripotent stem-cell models for long-QT syndrome
10.1056/nejmoa0908679 · 2010 · External reference
Patient-specific induced pluripotent stem-cell-derived models of LEOPARD syndrome
10.1038/nature09005 · 2010 · External reference
Patient-specific induced pluripotent stem cells as a model for familial dilated cardiomyopathy
10.1126/scitranslmed.3003552 · 2012 · External reference
Microfluidic organs-on-chips
10.1038/nbt.2989 · 2014 · External reference
Modeling the mitochondrial cardiomyopathy of Barth syndrome with induced pluripotent stem cell and heart-on-chip technologies
10.1038/nm.3545 · 2014 · External reference
An induced pluripotent stem cell model of hypoplastic left heart syndrome (HLHS) reveals multiple expression and functional differences in HLHS-derived cardiac myocytes
10.5966/sctm.2013-0105 · 2014 · External reference
Target identification and mechanism of action in chemical biology and drug discovery
10.1038/nchembio.1199 · 2013 · External reference
Large-scale screening using familial dysautonomia induced pluripotent stem cells identifies compounds that rescue IKBKAP expression
10.1038/nbt.2435 · 2012 · External reference
Refining the human iPSC-cardiomyocyte arrhythmic risk assessment model
10.1093/toxsci/kft205 · 2013 · External reference
Screening drug-induced arrhythmia [corrected] using human induced pluripotent stem cell-derived cardiomyocytes and low-impedance microelectrode arrays
2013 · External reference
Prediction of interindividual differences in hepatic functions and drug sensitivity by using human iPS-derived hepatocytes
10.1073/pnas.1413481111 · 2014 · External reference
Functional vascular endothelium derived from human induced pluripotent stem cells
10.1016/j.stemcr.2013.06.007 · 2013 · External reference
iPSC disease modeling
10.1126/science.1227682 · 2012 · External reference
Developing optofluidic technology through the fusion of microfluidics and optics
10.1038/nature05060 · 2006 · External reference
High-throughput single-molecule optofluidic analysis
10.1038/nmeth.1569 · 2011 · External reference
Microfluidic heart on a chip for higher throughput pharmacological studies
10.1039/c3lc50350j · 2013 · External reference
Ensembles of engineered cardiac tissues for physiological and pharmacological study: heart on a chip
10.1039/c1lc20557a · 2011 · External reference
Modeling supravalvular aortic stenosis syndrome with human induced pluripotent stem cells
10.1161/circulationaha.112.116996 · 2012 · External reference
Identification of a new modulator of the intercalated disc in a zebrafish model of arrhythmogenic cardiomyopathy
10.1126/scitranslmed.3008008 · 2014 · External reference
Generation of patient-specific induced pluripotent stem cell-derived cardiomyocytes as a cellular model of arrhythmogenic right ventricular cardiomyopathy
10.1093/eurheartj/ehs226 · 2013 · External reference
Studying arrhythmogenic right ventricular dysplasia with patient-specific iPSCs
10.1038/nature11799 · 2013 · External reference
Abnormal calcium handling properties underlie familial hypertrophic cardiomyopathy pathology in patient-specific induced pluripotent stem cells
10.1016/j.stem.2012.10.010 · 2013 · External reference
Neurons and cardiomyocytes derived from induced pluripotent stem cells as a model for mitochondrial defects in Friedreich's ataxia
2013 · External reference
Human Pompe disease-induced pluripotent stem cells for pathogenesis modeling, drug testing and disease marker identification
10.1093/hmg/ddr424 · 2011 · External reference
Cell model of catecholaminergic polymorphic ventricular tachycardia reveals early and delayed afterdepolarizations
10.1371/journal.pone.0044660 · 2012 · External reference
Dantrolene rescues arrhythmogenic RYR2 defect in a patient-specific stem cell model of catecholaminergic polymorphic ventricular tachycardia
10.1002/emmm.201100194 · 2012 · External reference
Cardiomyocytes generated from CPVTD307H patients are arrhythmogenic in response to β-adrenergic stimulation
10.1111/j.1582-4934.2011.01476.x · 2012 · External reference
Modeling of catecholaminergic polymorphic ventricular tachycardia with patient-specific human-induced pluripotent stem cells
10.1016/j.jacc.2012.02.066 · 2012 · External reference
Modelling the long QT syndrome with induced pluripotent stem cells
10.1038/nature09747 · 2011 · External reference
Model for long QT syndrome type 2 using human iPS cells demonstrates arrhythmogenic characteristics in cell culture
10.1242/dmm.008409 · 2012 · External reference
Drug evaluation in cardiomyocytes derived from human induced pluripotent stem cells carrying a long QT syndrome type 2 mutation
10.1093/eurheartj/ehr073 · 2011 · External reference
Using induced pluripotent stem cells to investigate cardiac phenotypes in Timothy syndrome
10.1038/nature09855 · 2011 · External reference