Research graph
References from Myeloperoxidase Inhibition Improves Ventricular Function and Remodeling After Experimental Myocardial Infarction. Local targets link to admitted publications; unresolved targets remain external evidence.
Left ventricular remodeling after myocardial infarction: pathophysiology and therapy
10.1161/01.cir.101.25.2981 · 2000 · External reference
Left ventricular remodeling in the post-infarction heart: a review of cellular, molecular mechanisms, and therapeutic modalities
10.1007/s10741-010-9181-7 · 2011 · External reference
Sudden death in patients with myocardial infarction and left ventricular dysfunction, heart failure, or both
10.1056/nejmoa043938 · 2005 · External reference
Contemporary trends in heart failure with reduced and preserved ejection fraction after myocardial infarction: a community study
10.1093/aje/kwt109 · 2013 · External reference
Long-term trends in the incidence of heart failure after myocardial infarction
10.1161/circulationaha.108.784215 · 2008 · External reference
Primary angioplasty versus intravenous thrombolytic therapy for acute myocardial infarction: a quantitative review of 23 randomised trials
10.1016/s0140-6736(03)12113-7 · 2003 · External reference
National trends in heart failure hospitalization after acute myocardial infarction for Medicare beneficiaries: 1998–2010
10.1161/circulationaha.113.003668 · 2013 · External reference
Potential novel pharmacological therapies for myocardial remodelling
10.1093/cvr/cvn317 · 2009 · External reference
Leukocyte behavior in atherosclerosis, myocardial infarction, and heart failure
10.1126/science.1230719 · 2013 · External reference
Activatable magnetic resonance imaging agent reports myeloperoxidase activity in healing infarcts and noninvasively detects the antiinflammatory effects of atorvastatin on ischemia-reperfusion injury
10.1161/circulationaha.107.756510 · 2008 · External reference
Myeloperoxidase-rich Ly-6C+ myeloid cells infiltrate allografts and contribute to an imaging signature of organ rejection in mice
10.1172/jci42304 · 2010 · External reference
Myeloperoxidase and cardiovascular disease
10.1161/01.atv.0000163262.83456.6d · 2005 · External reference
Myeloperoxidase and plasminogen activator inhibitor 1 play a central role in ventricular remodeling after myocardial infarction
10.1084/jem.20021426 · 2003 · External reference
Hypochlorous acid oxygenates the cysteine switch domain of pro-matrilysin (MMP-7): a mechanism for matrix metalloproteinase activation and atherosclerotic plaque rupture by myeloperoxidase
10.1074/jbc.m106958200 · 2001 · External reference
Myeloperoxidase-generated oxidants modulate left ventricular remodeling but not infarct size after myocardial infarction
10.1161/circulationaha.105.542340 · 2005 · External reference
Myeloperoxidase: a useful biomarker for cardiovascular disease risk stratification?
10.1373/clinchem.2009.126029 · 2009 · External reference
Association between myeloperoxidase levels and risk of coronary artery disease
10.1001/jama.286.17.2136 · 2001 · External reference
Myeloperoxidase serum levels predict risk in patients with acute coronary syndromes
10.1161/01.cir.0000090690.67322.51 · 2003 · External reference
Prognostic value of myeloperoxidase in patients with chest pain
10.1056/nejmoa035003 · 2003 · External reference
PF-1355, a mechanism-based myeloperoxidase inhibitor, prevents immune complex vasculitis and anti-glomerular basement membrane glomerulonephritis
10.1124/jpet.114.221788 · 2015 · External reference
Discovery of 2-(6-(5-Chloro-2-methoxyphenyl)-4-oxo-2-thioxo-3,4-dihydropyrimidin-1(2H)-yl)acet amide (PF-06282999): a highly selective mechanism-based myeloperoxidase inhibitor for the treatment of cardiovascular diseases
10.1021/acs.jmedchem.5b00963 · 2015 · External reference
Measuring myeloperoxidase activity in biological samples
10.1371/journal.pone.0067976 · 2013 · External reference
Myeloperoxidase: the good, the bad, and the ugly
10.2174/157339510791111691 · 2010 · External reference
Myeloperoxidase: friend and foe
10.1189/jlb.1204697 · 2005 · External reference
Myeloperoxidase is required for neutrophil extracellular trap formation: implications for innate immunity
10.1182/blood-2010-06-290171 · 2011 · External reference
Demyelinating diseases: myeloperoxidase as an imaging biomarker and therapeutic target
10.1148/radiol.12111593 · 2012 · External reference
Tracking the inflammatory response in stroke in vivo by sensing the enzyme myeloperoxidase
10.1073/pnas.0803945105 · 2008 · External reference
The healing myocardium sequentially mobilizes two monocyte subsets with divergent and complementary functions
10.1084/jem.20070885 · 2007 · External reference
Impaired infarct healing in atherosclerotic mice with Ly-6C(hi) monocytosis
10.1016/j.jacc.2009.08.089 · 2010 · External reference
Ly-6Chigh monocytes depend on nr4a1 to balance both inflammatory and reparative phases in the infarcted myocardium
10.1161/circresaha.114.303204 · 2014 · External reference
MARCOing monocytes for elimination
10.1126/scitranslmed.3008448 · 2014 · External reference
Neutrophils orchestrate post-myocardial infarction healing by polarizing macrophages towards a reparative phenotype
10.1093/eurheartj/ehw002 · 2016 · External reference
Myeloperoxidase attracts neutrophils by physical forces
10.1182/blood-2010-05-284513 · 2011 · External reference
Serum myeloperoxidase levels independently predict endothelial dysfunction in humans
10.1161/01.cir.0000140262.20831.8f · 2004 · External reference
Myeloperoxidase-generated reactive nitrogen species convert LDL into an atherogenic form in vitro
10.1172/jci5549 · 1999 · External reference
Apolipoprotein A-I is a selective target for myeloperoxidase-catalyzed oxidation and functional impairment in subjects with cardiovascular disease
10.1172/jci200421109 · 2004 · External reference
The myeloperoxidase product hypochlorous acid oxidizes HDL in the human artery wall and impairs ABCA1-dependent cholesterol transport
10.1073/pnas.0405292101 · 2004 · External reference
Prognostic value and echocardiographic determinants of plasma myeloperoxidase levels in chronic heart failure
10.1016/j.jacc.2007.02.053 · 2007 · External reference
Activation of polymorphonuclear neutrophils in patients with impaired left ventricular function
10.1016/j.freeradbiomed.2007.07.016 · 2007 · External reference
Myeloperoxidase: a target for new drug development?
10.1038/sj.bjp.0707358 · 2007 · External reference
