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References from An Oral Selective Alpha-1A Adrenergic Receptor Agonist Prevents Doxorubicin Cardiotoxicity. Local targets link to admitted publications; unresolved targets remain external evidence.
Cardiac alpha1-adrenergic receptors: novel aspects of expression, signaling mechanisms, physiologic function, and clinical importance
10.1124/pr.112.007203 · 2014 · External reference
Alpha 1-adrenergic receptor responses in alpha 1AB-AR knockout mouse hearts suggest the presence of alpha 1D-AR
10.1152/ajpheart.00441.2002 · 2003 · External reference
The alpha-1D is the predominant alpha-1-adrenergic receptor in human epicardial coronary arteries
10.1016/j.jacc.2009.05.056 · 2009 · External reference
Targeted alpha(1A)-adrenergic receptor overexpression induces enhanced cardiac contractility but not hypertrophy
10.1161/hh1601.095912 · 2001 · External reference
alpha1A- but not alpha1B-adrenergic receptors precondition the ischemic heart by a staurosporine-sensitive, chelerythrine-insensitive mechanism
10.1016/j.cardiores.2004.10.009 · 2005 · External reference
Transgenic alpha1A-adrenergic activation limits post-infarct ventricular remodeling and dysfunction and improves survival
10.1016/j.cardiores.2006.06.015 · 2006 · External reference
Overexpression of cardiomyocyte alpha1a-adrenergic receptors attenuates postinfarct remodeling by inducing angiogenesis through heterocellular signaling
10.1161/atvbaha.115.305919 · 2015 · External reference
Genetic enhancement of ventricular contractility protects against pressure-overload-induced cardiac dysfunction
10.1016/j.yjmcc.2004.07.010 · 2004 · External reference
Major cardiovascular events in hypertensive patients randomized to doxazosin vs chlorthalidone: the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT)
10.1001/jama.283.15.1967 · 2000 · External reference
Pharmacological characteristics of Ro 115-1240, a selective alpha1A/1L-adrenoceptor partial agonist: a potential therapy for stress urinary incontinence
10.1111/j.1464-410x.2004.04577.x · 2004 · External reference
A randomized crossover study to evaluate Ro 115-1240, a selective alpha1A/1L-adrenoceptor partial agonist in women with stress urinary incontinence
10.1111/j.1464-410x.2004.04560.x · 2004 · External reference
An alpha-1A-adrenergic receptor subtype agonist prevents cardiomyopathy without increasing blood pressure (abstr)
10.1161/circ.118.suppl_18.s_533-b · 2008 · External reference
An alpha1A-adrenergic-extracellular signal-regulated kinase survival signaling pathway in cardiac myocytes
10.1161/circulationaha.106.664862 · 2007 · External reference
A molecular MRI probe to detect treatment of cardiac apoptosis in vivo
10.1002/mrm.22876 · 2011 · External reference
Cardiac function in 5-year survivors of childhood cancer: a long-term follow-up study
10.1001/archinternmed.2010.233 · 2010 · External reference
Cancer therapy-related cardiac dysfunction and heart failure: part 1: definitions, pathophysiology, risk factors, and imaging
10.1161/circheartfailure.115.002661 · 2016 · External reference
New insights into doxorubicin-induced cardiotoxicity: the critical role of cellular energetics
10.1016/j.yjmcc.2006.06.009 · 2006 · External reference
Recent advances in the discovery of alpha1-adrenoceptor agonists
10.2174/156802607779318217 · 2007 · External reference
Differentiation of rat myocytes in single cell cultures with and without proliferating nonmyocardial cells. Cross-striations, ultrastructure, and chronotropic response to isoproterenol
10.1161/01.res.50.1.101 · 1982 · External reference
The alpha1A-adrenergic receptor subtype mediates increased contraction of failing right ventricular myocardium
10.1152/ajpheart.00042.2015 · 2015 · External reference
Comparison between alpha-1 adrenoceptor-mediated and beta adrenoceptor-mediated inotropic components elicited by norepinephrine in failing human ventricular muscle
10.1016/s0022-3565(24)36448-1 · 1997 · External reference
Transcriptional integration of mitochondrial biogenesis
10.1016/j.tem.2012.06.006 · 2012 · External reference
Sexual dimorphism of doxorubicin-mediated cardiotoxicity: potential role of energy metabolism remodeling
10.1161/circheartfailure.114.001180 · 2015 · External reference
Drug-induced mitochondrial dysfunction and cardiotoxicity
10.1152/ajpheart.00554.2015 · 2015 · External reference
Alpha-1-adrenergic receptors: targets for agonist drugs to treat heart failure
10.1016/j.yjmcc.2010.11.014 · 2011 · External reference
Alpha-1-adrenergic receptors in heart failure: the adaptive arm of the cardiac response to chronic catecholamine stimulation
10.1097/fjc.0000000000000032 · 2014 · External reference
Involvement of mitogen-activated protein kinases in adriamycin-induced cardiomyopathy
10.1152/ajpheart.01054.2004 · 2005 · External reference
Mitochondrial membrane potential regulates matrix configuration and cytochrome c release during apoptosis
10.1038/sj.cdd.4401231 · 2003 · External reference
The CO/HO system reverses inhibition of mitochondrial biogenesis and prevents murine doxorubicin cardiomyopathy
2007 · External reference
Altered function and structure of the heart in dogs with chronic elevation in plasma norepinephrine
10.1161/01.cir.84.5.2091 · 1991 · External reference
The a1A/C- and a1B-adrenergic receptors are required for physiological cardiac hypertrophy in the double-knockout mouse
10.1172/jci200316100 · 2003 · External reference
Cloning of the rat alpha 1C-adrenergic receptor from cardiac myocytes. alpha 1C, alpha 1B, and alpha 1D mRNAs are present in cardiac myocytes but not in cardiac fibroblasts
10.1161/01.res.75.4.796 · 1994 · External reference
PKC-epsilon regulation of extracellular signal-regulated kinase: a potential role in phenylephrine-induced cardiocyte growth
10.1152/ajpheart.00475.2003 · 2004 · External reference
The three alpha1-adrenoceptor subtypes show different spatio-temporal mechanisms of internalization and ERK1/2 phosphorylation
10.1016/j.bbamcr.2013.06.013 · 2013 · External reference
MURC/Cavin-4 facilitates recruitment of ERK to caveolae and concentric cardiac hypertrophy induced by alpha1-adrenergic receptors
10.1073/pnas.1315359111 · 2014 · External reference
Nuclear alpha1-adrenergic receptors signal activated ERK localization to caveolae in adult cardiac myocytes
10.1161/circresaha.108.176024 · 2008 · External reference
Nonpegylated liposomal doxorubicin (MyocetTM) combination (R-COMP) chemotherapy in elderly patients with diffuse large B-cell lymphoma (DLBCL): results from the phase II EUR018 trial
10.1093/annonc/mdp544 · 2010 · External reference
CHOP is the standard regimen in patients > or = 70 years of age with intermediate-grade and high-grade non-Hodgkin's lymphoma: results of a randomized study of the European Organization for Research and Treatment of Cancer Lymphoma Cooperative Study Group
10.1200/jco.1998.16.1.27 · 1998 · External reference
Left ventricular dysfunction predicted by early troponin I release after high-dose chemotherapy
10.1016/s0735-1097(00)00748-8 · 2000 · External reference
Early detection of anthracycline cardiotoxicity and improvement with heart failure therapy
10.1161/circulationaha.114.013777 · 2015 · External reference
Mitochondria in cardiac hypertrophy and heart failure
10.1016/j.yjmcc.2012.09.002 · 2013 · External reference
{alpha}1-Adrenergic receptor subtypes in nonfailing and failing human myocardium
10.1161/circheartfailure.108.846212 · 2009 · External reference
Alpha-1 adrenergic receptors in the nonfailing and failing human heart
10.1016/s0022-3565(25)13255-2 · 1988 · External reference
The use of midodrine in patients with advanced heart failure
10.1111/j.1751-7133.2008.00042.x · 2009 · External reference
Long-term alpha1B-adrenergic receptor activation shortens lifespan, while alpha1A-adrenergic receptor stimulation prolongs lifespan in association with decreased cancer incidence
10.1007/s11357-014-9675-7 · 2014 · External reference
Long-term alpha1A-adrenergic receptor stimulation improves synaptic plasticity, cognitive function, mood, and longevity
10.1124/mol.111.073734 · 2011 · External reference
