References

Cardiac arrhythmias: the quest for a cure: a historical perspective

2004 · External reference

Drug-induced prolongation of the QT interval

10.1056/nejmra032426 · 2004 · External reference

The Cardiac Arrhythmia Suppression Trial

10.1056/nejm198912213212510 · 1989 · External reference

Small molecule and peptide therapies for chronic heart failure: a patent review (2011-2014)

10.1517/13543776.2015.1061997 · 2015 · External reference

Contemporary drug development in heart failure: call for hemodynamically neutral therapies

10.1161/circheartfailure.115.002271 · 2015 · External reference

A perspective on antiarrhythmic drug therapy to treat atrial fibrillation: there remains an unmet need

10.1016/j.ahj.2005.06.014 · 2006 · External reference

Mechanisms of atrial fibrillation

2003 · External reference

Arrhythmias in heart failure: current concepts of mechanisms and therapy

10.1111/j.1540-8167.2000.tb00746.x · 2000 · External reference

Mechanisms and management of proarrhythmia

10.1016/s0002-9149(98)00472-x · 1998 · External reference

The Cardiac Arrhythmia Suppression Trial (CAST)

10.1056/nejm198908103210608 · 1989 · External reference

Sudden cardiac death, genes, and arrhythmogenesis : consideration of new population and mechanistic approaches from a National Heart, Lung, and Blood Institute workshop, part I

10.1161/01.cir.103.19.2361 · 2001 · External reference

Genetic screening and risk assessment in hypertrophic cardiomyopathy

10.1016/j.jacc.2004.09.032 · 2004 · External reference

Genetic and biophysical basis of sudden unexplained nocturnal death syndrome (SUNDS), a disease allelic to Brugada syndrome

10.1093/hmg/11.3.337 · 2002 · External reference

Molecular and cellular mechanisms of cardiac arrhythmias

10.1016/s0092-8674(01)00243-4 · 2001 · External reference

Metabolic abnormalities of the heart in type II diabetes

10.1177/1479164115580936 · 2015 · External reference

Myocardial blood flow and oxygen consumption in patients with Friedreich’s ataxia prior to the onset of cardiomyopathy

10.1097/01.mca.0000236289.02178.60 · 2007 · External reference

High density lipoprotein cholesterol: an evolving target of therapy in the management of cardiovascular disease

10.2147/vhrm.s1940 · 2008 · External reference

Lifetime risk for development of atrial fibrillation: the Framingham Heart Study

10.1161/01.cir.0000140263.20897.42 · 2004 · External reference

Molecular basis of arrhythmias

10.1161/circulationaha.104.494476 · 2005 · External reference

Can the flow of medicines be improved? Fundamental pharmacokinetic and pharmacological principles toward improving phase II survival

10.1016/j.drudis.2011.12.020 · 2012 · External reference

A new initiative on precision medicine

10.1056/nejmp1500523 · 2015 · External reference

Opportunities for the cardiovascular community in the precision medicine initiative

10.1161/circulationaha.115.019475 · 2016 · External reference

The future of cardiovascular therapeutics

10.1161/circulationaha.116.023555 · 2016 · External reference

Assessment of diastolic function with Doppler tissue imaging to predict genotype in preclinical hypertrophic cardiomyopathy

10.1161/01.cir.0000019070.70491.6d · 2002 · External reference

Mechanisms and models in heart failure: a combinatorial approach

10.1161/01.cir.100.9.999 · 1999 · External reference

Angiotensin-neprilysin inhibition versus enalapril in heart failure

10.1056/nejmoa1409077 · 2014 · External reference

Molecular physiology of cardiac repolarization

10.1152/physrev.00002.2005 · 2005 · External reference

10.1016/j.bcp.2009.03.014

10.1016/j.bcp.2009.03.014 · 2009 · External reference

How were new medicines discovered?

10.1038/nrd3480 · 2011 · External reference

The discovery of first-in-class drugs: origins and evolution

10.1038/nrd4336 · 2014 · External reference

Validating therapeutic targets through human genetics

10.1038/nrd4051 · 2013 · External reference

Cardiac ion channels

10.1146/annurev.physiol.64.083101.145105 · 2002 · External reference

Mouse models of long QT syndrome

10.1113/jphysiol.2006.118745 · 2007 · External reference

Targeted point mutagenesis of mouse Kcnq1: phenotypic analysis of mice with point mutations that cause Romano-Ward syndrome in humans

10.1016/j.ygeno.2004.06.007 · 2004 · External reference

Plasma HDL cholesterol and risk of myocardial infarction: a mendelian randomisation study

10.1016/s0140-6736(12)60312-2 · 2012 · External reference

Do glia have heart? Expression and functional role for ether-a-go-go currents in hippocampal astrocytes

10.1523/jneurosci.20-10-03915.2000 · 2000 · External reference

Low penetrance in the long-QT syndrome: clinical impact

10.1161/01.cir.99.4.529 · 1999 · External reference

Electrical remodeling and arrhythmias in long-QT syndrome: lessons from genetic models in mice

10.1080/17431380410032643 · 2004 · External reference

Clinical and genetic variables associated with acute arousal and nonarousal-related cardiac events among subjects with long QT syndrome

10.1016/s0002-9149(99)90772-5 · 2000 · External reference

Genotype-phenotype correlation in the long-QT syndrome: gene-specific triggers for life-threatening arrhythmias

10.1161/01.cir.103.1.89 · 2001 · External reference

Nanoscale visualization of functional adhesion/excitability nodes at the intercalated disc

10.1038/ncomms10342 · 2016 · External reference

Ion channels: function unravelled by dysfunction

10.1038/ncb1104-1039 · 2004 · External reference

Role of the cytosolic chaperones Hsp70 and Hsp90 in maturation of the cardiac potassium channel HERG

10.1161/01.res.0000079028.31393.15 · 2003 · External reference

Ankyrin-B mutation causes type 4 long-QT cardiac arrhythmia and sudden cardiac death

10.1038/nature01335 · 2003 · External reference

A cardiac arrhythmia syndrome caused by loss of ankyrin-B function

10.1073/pnas.0402546101 · 2004 · External reference

Mutant caveolin-3 induces persistent late sodium current and is associated with long-QT syndrome

10.1161/circulationaha.106.635268 · 2006 · External reference

N-linked glycosylation sites determine HERG channel surface membrane expression

10.1111/j.1469-7793.1999.041ad.x · 1999 · External reference

Novel mechanism associated with an inherited cardiac arrhythmia: defective protein trafficking by the mutant HERG (G601S) potassium channel

10.1161/01.cir.99.17.2290 · 1999 · External reference

Cytometry of raft and caveola membrane microdomains: from flow and imaging techniques to high throughput screening assays

10.1002/cyto.a.20572 · 2008 · External reference

Drug-sensitized zebrafish screen identifies multiple genes, including GINS3, as regulators of myocardial repolarization

10.1161/circulationaha.108.821082 · 2009 · External reference

Mechanisms of atrial remodeling and clinical relevance

2005 · External reference

Molecular mechanisms of remodeling in human atrial fibrillation

10.1016/s0008-6363(02)00222-5 · 2002 · External reference

Electrical heterogeneity within the ventricular wall

10.1007/s003950170002 · 2001 · External reference

Architectural plan for the heart: early patterning and delineation of the chambers and the nodes

10.1016/j.tcm.2004.09.002 · 2004 · External reference

Progressive familial heart block type I. Clinical and pathological observations

1991 · External reference

Gene for progressive familial heart block type I maps to chromosome 19q13

10.1161/01.cir.91.6.1633 · 1995 · External reference

Reentry as a cause of ventricular tachycardia in patients with chronic ischemic heart disease: electrophysiologic and anatomic correlation

10.1161/01.cir.77.3.589 · 1988 · External reference

Functional nitric oxide synthase mislocalization in cardiomyopathy

10.1016/j.yjmcc.2003.09.020 · 2004 · External reference

Histological substrate of atrial biopsies in patients with lone atrial fibrillation

10.1161/01.cir.96.4.1180 · 1997 · External reference

Role of inflammation in initiation and perpetuation of atrial fibrillation: a systematic review of the published data

10.1016/j.jacc.2007.06.054 · 2007 · External reference

Role of TGF-beta on cardiac structural and electrical remodeling

10.2147/vhrm.s3985 · 2008 · External reference

Regulatory mechanisms of atrial fibrotic remodeling in atrial fibrillation

10.1007/s00018-008-7408-8 · 2008 · External reference

A novel locus for dilated cardiomyopathy, diffuse myocardial fibrosis, and sudden death on chromosome 10q25-26

10.1016/j.jacc.2006.01.079 · 2006 · External reference

Fibrosis and hypertensive heart disease

10.1097/00001573-200007000-00010 · 2000 · External reference

Origins and fates of cardiovascular progenitor cells

10.1016/j.cell.2008.02.002 · 2008 · External reference

Cardiac myocyte cell cycle control in development, disease, and regeneration

10.1152/physrev.00032.2006 · 2007 · External reference

Animal models for arrhythmias

10.1016/j.cardiores.2005.06.012 · 2005 · External reference

Pharmacogenomics: challenges and opportunities

10.7326/0003-4819-145-10-200611210-00007 · 2006 · External reference

Efficacy of chronic amiodarone therapy in patients with variant angina pectoris and inhibition of ergonovine coronary constriction

10.1016/0002-8703(82)90526-9 · 1982 · External reference

Mechanism of block and identification of the verapamil binding domain to HERG potassium channels

10.1161/01.res.84.9.989 · 1999 · External reference

Efficacy of amiodarone during long-term treatment of potentially dangerous ventricular arrhythmias in patients with chronic stable ischemic heart disease

10.1016/0002-8703(84)90310-7 · 1984 · External reference

Strategy for identifying repurposed drugs for the treatment of cerebral cavernous malformation

10.1161/circulationaha.114.010403 · 2015 · External reference

Large-scale prediction and testing of drug activity on side-effect targets

10.1038/nature11159 · 2012 · External reference

Zebrafish as tools for drug discovery

10.1038/nrd4627 · 2015 · External reference

Genetic screening in C. elegans identifies rho-GTPase activating protein 6 as novel HERG regulator

10.1016/j.yjmcc.2008.10.015 · 2009 · External reference

Zebrafish: a new model on the pharmaceutical catwalk

10.1002/bies.10326 · 2003 · External reference

Animal models of human disease: zebrafish swim into view

10.1038/nrg2091 · 2007 · External reference

In vivo drug discovery in the zebrafish

10.1038/nrd1606 · 2005 · External reference

Zebrafish-based small molecule discovery

10.1016/j.chembiol.2003.10.003 · 2003 · External reference

High-throughput assay for small molecules that modulate zebrafish embryonic heart rate

10.1038/nchembio732 · 2005 · External reference

Drugs that induce repolarization abnormalities cause bradycardia in zebrafish

10.1161/01.cir.0000061912.88753.87 · 2003 · External reference

Genomics. Zebrafish—the canonical vertebrate

10.1126/science.1066652 · 2001 · External reference

Effective targeted gene “knockdown” in zebrafish

10.1038/79951 · 2000 · External reference

Targeted gene inactivation in zebrafish using engineered zinc-finger nucleases

10.1038/nbt1398 · 2008 · External reference

The zebrafish: heritable disorders in transparent embryos

10.1172/jci118608 · 1996 · External reference

Rapid behavior-based identification of neuroactive small molecules in the zebrafish

10.1038/nchembio.307 · 2010 · External reference

AML1-ETO reprograms hematopoietic cell fate by downregulating scl expression

10.1242/dev.008904 · 2008 · External reference

Chemical suppression of a genetic mutation in a zebrafish model of aortic coarctation

10.1038/nbt963 · 2004 · External reference

Systematic approaches to toxicology in the zebrafish

10.1146/annurev-pharmtox-010611-134751 · 2012 · External reference

Structure-activity relationship study of bone morphogenetic protein (BMP) signaling inhibitors

10.1016/j.bmcl.2008.06.052 · 2008 · External reference

In vivo recording of adult zebrafish electrocardiogram and assessment of drug-induced QT prolongation

10.1152/ajpheart.00960.2005 · 2006 · External reference

In vivo natriuretic peptide reporter assay identifies chemical modifiers of hypertrophic cardiomyopathy signalling

10.1093/cvr/cvr350 · 2012 · External reference

High-resolution cardiovascular function confirms functional orthology of myocardial contractility pathways in zebrafish

10.1152/physiolgenomics.00206.2009 · 2010 · External reference

Refining detection of drug-induced proarrhythmia: QT interval and TRIaD

10.1016/j.hrthm.2005.03.023 · 2005 · External reference

Homozygous SCN5A mutation in long-QT syndrome with functional two-to-one atrioventricular block

10.1161/hh1401.095087 · 2001 · External reference

NOS1AP is a genetic modifier of the long-QT syndrome

10.1161/circulationaha.109.879643 · 2009 · External reference

Novel chemical suppressors of long QT syndrome identified by an in vivo functional screen

10.1161/circulationaha.110.003731 · 2011 · External reference

Identification of a new modulator of the intercalated disc in a zebrafish model of arrhythmogenic cardiomyopathy

10.1126/scitranslmed.3008008 · 2014 · External reference

Central role for GSK3beta in the pathogenesis of arrhythmogenic cardiomyopathy

10.1172/jci.insight.85923 · 2016 · External reference

Dorsomorphin inhibits BMP signals required for embryogenesis and iron metabolism

10.1038/nchembio.2007.54 · 2008 · External reference

BMP type I receptor inhibition reduces heterotopic [corrected] ossification

10.1038/nm.1888 · 2008 · External reference

Visnagin protects against doxorubicin-induced cardiomyopathy through modulation of mitochondrial malate dehydrogenase

10.1126/scitranslmed.3010189 · 2014 · External reference

Lipid metabolism in zebrafish

10.1016/s0091-679x(04)76006-9 · 2004 · External reference

What guides early embryonic blood vessel formation?

10.1002/(sici)1097-0177(199905)215:1<2::aid-dvdy2>3.0.co;2-u · 1999 · External reference

From zebrafish to human: modular medical models

10.1146/annurev.genom.3.031402.131506 · 2002 · External reference