References

Changing trends in asthma prevalence among children

10.1542/peds.2015-2354 · 2016 · External reference

The national cost of asthma among school-aged children in the United States

10.1016/j.anai.2017.07.002 · 2017 · External reference

Seasonal risk factors for asthma exacerbations among inner-city children

10.1016/j.jaci.2014.12.1942 · 2015 · External reference

Association of elevated plasminogen activator inhibitor 1 levels with diminished lung function in patients with asthma

10.1016/j.anai.2010.12.021 · 2011 · External reference

Soy isoflavones reduce asthma exacerbation in asthmatic patients with high PAI-1-producing genotypes

10.1016/j.jaci.2019.01.020 · 2019 · External reference

Association of a PAI-1 gene polymorphism and early life infections with asthma risk, exacerbations, and reduced lung function

10.1371/journal.pone.0157848 · 2016 · External reference

Production of plasminogen activator inhibitor-1 by human mast cells and its possible role in asthma

10.4049/jimmunol.165.6.3154 · 2000 · External reference

PAI-1 gain-of-function genotype, factors increasing PAI-1 levels, and airway obstruction: the GALA II cohort

10.1111/cea.12958 · 2017 · External reference

Promoter (4G/5G) plasminogen activator inhibitor-1 genotype and plasminogen activator inhibitor-1 levels in blacks, Hispanics, and non-Hispanic whites: the Insulin Resistance Atherosclerosis Study

10.1161/01.cir.0000066908.82782.3a · 2003 · External reference

Binding of upstream stimulatory factor 1 to the E-box regulates the 4G/5G polymorphism-dependent plasminogen activator inhibitor 1 expression in mast cells

10.1016/j.jaci.2007.11.015 · 2008 · External reference

Upstream stimulating factors: highly versatile stress-responsive transcription factors

10.1111/j.1600-0749.2005.00262.x · 2005 · External reference

Cross-talk between human mast cells and bronchial epithelial cells in plasminogen activator inhibitor-1 production via transforming growth factor-beta1

10.1165/rcmb.2013-0399oc · 2015 · External reference

Effects of an anti-TSLP antibody on allergen-induced asthmatic responses

10.1056/nejmoa1402895 · 2014 · External reference

Mast cell–derived plasminogen activator inhibitor type 1 promotes airway inflammation and remodeling in a murine model of asthma

10.1016/j.jaci.2018.01.040 · 2018 · External reference

Intra-airway administration of small interfering RNA targeting plasminogen activator inhibitor-1 attenuates allergic asthma in mice

10.1152/ajplung.00115.2011 · 2011 · External reference

Airway remodeling in asthma

10.1172/jci8124 · 1999 · External reference

Eosinophil-associated TGF-β1 mRNA expression and airways fibrosis in bronchial asthma

10.1165/ajrcmb.17.3.2733 · 1997 · External reference

Bleomycin-induced pulmonary fibrosis in transgenic mice that either lack or overexpress the murine plasminogen activator inhibitor-1 gene

10.1172/jci118396 · 1996 · External reference

Bleomycin-induced pulmonary fibrosis in fibrinogen-null mice

10.1172/jci10531 · 2000 · External reference

PAI-1 promotes extracellular matrix deposition in the airways of a murine asthma model

10.1016/s0006-291x(02)00577-6 · 2002 · External reference

A plasminogen activator inhibitor-1 inhibitor reduces airway remodeling in a murine model of chronic asthma

10.1165/rcmb.2011-0369oc · 2012 · External reference

Suppression of plasminogen activator inhibitor-1 by RNA interference attenuates pulmonary fibrosis

10.1136/thx.2009.119974 · 2010 · External reference

Plasminogen activator inhibitor-1 in sputum and nasal lavage fluids increases in asthmatic patients during common colds

10.1016/j.jaci.2013.11.009 · 2014 · External reference

Transcriptome networks identify mechanisms of viral and nonviral asthma exacerbations in children

10.1038/s41590-019-0347-8 · 2019 · External reference

Mepolizumab for urban children with exacerbation-prone eosinophilic asthma in the USA (MUPPITS-2): a randomised, double-blind, placebo-controlled, parallel-group trial

10.1016/s0140-6736(22)01198-9 · 2022 · External reference

Genetic contributions to epigenetic-defined endotypes of allergic phenotypes in children

10.1016/j.ajhg.2025.05.006 · 2025 · External reference

Comprehensive survey of common genetic variation at the plasminogen activator inhibitor-1 locus and relations to circulating plasminogen activator inhibitor-1 levels

10.1161/circulationaha.105.547836 · 2005 · External reference

WGCNA: an R package for weighted correlation network analysis

10.1186/1471-2105-9-559 · 2008 · External reference

The STRING database in 2025: protein networks with directionality of regulation

10.1093/nar/gkae1113 · 2025 · External reference

Gene Ontology: tool for the unification of biology. The Gene Ontology Consortium

10.1038/75556 · 2000 · External reference

Toward understanding the origin and evolution of cellular organisms

10.1002/pro.3715 · 2019 · External reference

KEGG: biological systems database as a model of the real world

10.1093/nar/gkae909 · 2025 · External reference

KEGG: Kyoto encyclopedia of genes and genomes

10.1093/nar/28.1.27 · 2000 · External reference

Inflammatory pathways in residual asthma exacerbations among mepolizumab-treated urban children: a secondary analysis of a randomized clinical trial

10.1001/jamapediatrics.2025.2044 · 2025 · External reference

Plasminogen activator inhibitor 1 (PAI-1) level and lung function over 30 years: the CARDIA study

10.1016/j.jaci.2017.12.359 · 2018 · External reference

Elevated circulating PAI-1 levels are related to lung function decline, systemic inflammation, and small airway obstruction in chronic obstructive pulmonary disease

10.2147/copd.s107409 · 2016 · External reference

Sample collection for laboratory-based study of the nasal airway and sinuses: a research compendium

10.1002/alr.22510 · 2020 · External reference