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References from Effect of once-daily ICS/LAMA/LABA triple therapy versus ICS/LABA on respiratory symptoms (E-RS: Asthma): Analysis of the phase IIIA CAPTAIN trial. Local targets link to admitted publications; unresolved targets remain external evidence.
Unresolved reference
2025 · External reference
Determinants and impact of suboptimal asthma control in Europe: the international cross-sectional and longitudinal assessment on asthma control (LIASON) study
10.1186/s12931-016-0374-z · 2016 · External reference
Asthma control is associated with economic outcomes, work productivity and health-related quality of life in patients with asthma
2020 · External reference
Asthma exacerbations are associated with a decline in lung function: a longitudinal population-based study
10.1136/thorax-2021-217032 · 2023 · External reference
Management of severe asthma: a European Respiratory Society/American Thoracic Society guideline
10.1183/13993003.00588-2019 · 2020 · External reference
Unresolved reference
2020 · External reference
Unresolved reference
2024 · External reference
Unresolved reference
2024 · External reference
Efficacy and safety of once-daily single-inhaler triple therapy (FF/UMEC/VI) versus FF/VI in patients with inadequately controlled asthma (CAPTAIN): a double-blind, randomised, phase 3A trial
10.1016/s2213-2600(20)30389-1 · 2021 · External reference
International variation in severe exacerbation rates in patients with severe asthma
10.1016/j.chest.2024.02.029 · 2024 · External reference
The frequency of asthma exacerbations and healthcare utilization in patients with asthma from the UK and USA
10.1186/s12890-017-0409-3 · 2017 · External reference
Association between pulmonary function and asthma symptoms
10.1016/j.jaip.2019.04.019 · 2019 · External reference
Relationships between symptoms and lung function in asthma and/or chronic obstructive pulmonary disease in a real-life setting: the NOVEL observational longiTudinal studY
10.1177/17534666241254212 · 2024 · External reference
Effect of montelukast, a once-daily leukotriene receptor antagonist, on peak expiratory flow variability
10.1016/s0149-2918(02)85133-5 · 2002 · External reference
Measuring respiratory symptoms in moderate/severe asthma: evaluation of a respiratory symptom tool, the E-RS®: COPD in asthma populations
10.1186/s41687-021-00338-6 · 2021 · External reference
Measuring respiratory symptoms of COPD: performance of the EXACT- Respiratory Symptoms Tool (E-RS) in three clinical trials
10.1186/s12931-014-0124-z · 2014 · External reference
Reliability, validity and responsiveness of E-RS:COPD in patients with spirometric asthma-COPD overlap
10.1186/s12931-019-1070-6 · 2019 · External reference
Development and validation of a questionnaire to measure asthma control
10.1034/j.1399-3003.1999.14d29.x · 1999 · External reference
Unresolved reference
2017 · External reference
Executive summary: Japanese guidelines for adult asthma (JGL) 2021
10.1016/j.alit.2023.02.006 · 2023 · External reference
Association of dose of inhaled corticosteroids and frequency of adverse events
10.1164/rccm.202402-0368oc · 2025 · External reference
Association of stepping up to high-dose inhaled corticosteroids and risk of future asthma exacerbations: data from the United States
10.1016/j.jaip.2025.10.005 · 2026 · External reference
Triple therapy in uncontrolled asthma: a network meta-analysis of phase III studies
10.1183/13993003.04233-2020 · 2021 · External reference
Triple vs dual inhaler therapy and asthma outcomes in moderate to severe asthma: a systematic review and meta-analysis
10.1001/jama.2021.7872 · 2021 · External reference
Consensus of an American College of Allergy, Asthma, and Immunology, American Academy of Allergy, Asthma, and Immunology, and American Thoracic Society workgroup on definition of clinical remission in asthma on treatment
10.1016/j.anai.2023.08.609 · 2023 · External reference
An expert consensus framework for asthma remission as a treatment goal
10.1016/j.jaci.2019.12.006 · 2020 · External reference
The inflammatory profile of exacerbations in patients with severe refractory eosinophilic asthma receiving mepolizumab (the MEX study): a prospective observational study
10.1016/s2213-2600(21)00004-7 · 2021 · External reference
Analysis of airway inflammation demonstrates a mechanism for T2-biologic failure in asthma
10.1016/j.jaci.2025.05.031 · 2025 · External reference
Role and impact of chronic cough in individuals with asthma from the general population
10.1016/j.jaip.2019.02.021 · 2019 · External reference
Tiotropium attenuates refractory cough and capsaicin cough reflex sensitivity in patients with asthma
10.1016/j.jaip.2018.01.016 · 2018 · External reference
Tiotropium for refractory cough in asthma via cough reflex sensitivity: a randomized, parallel, open-label trial
10.1016/j.anai.2023.03.032 · 2023 · External reference
The efficacy and safety of fluticasone furoate/umeclidinium/vilanterol (FF/UMEC/VI) on cough symptoms in adult patients with asthma, a randomized double-blind, placebo-controlled, parallel group study: Chronic Cough in Asthma (COCOA) study
10.1080/02770903.2025.2455416 · 2025 · External reference
Effect of bronchoconstriction on airway remodeling in asthma
10.1056/nejmoa1014350 · 2011 · External reference
Tiotropium attenuates IL-13-induced goblet cell metaplasia of human airway epithelial cells
10.1136/thoraxjnl-2014-205731 · 2015 · External reference
The mode of action of anticholinergics in asthma
10.1183/13993003.01247-2017 · 2018 · External reference
The impact of long-acting muscarinic antagonists on mucus hypersecretion and cough in chronic obstructive pulmonary disease: a systematic review
10.1183/16000617.0196-2021 · 2022 · External reference
Corticosteroid and long-acting ß-agonist therapy reduces epithelial goblet cell metaplasia
10.1111/cea.13015 · 2017 · External reference
A comparative study of the effects of an inhaled corticosteroid, budesonide, and a beta 2-agonist, terbutaline, on airway inflammation in newly diagnosed asthma: a randomized, double-blind, parallel-group controlled trial
10.1016/s0091-6749(06)80008-4 · 1992 · External reference
Acquired cilia dysfunction in chronic rhinosinusitis
10.2500/ajra.2012.26.3716 · 2012 · External reference
Gastroesophageal reflux disease is a risk factor for sputum production in the general population: the Nagahama study
10.1186/s12931-020-01601-y · 2021 · External reference
Bronchiectasis
10.1038/s41572-018-0042-3 · 2018 · External reference
Effects of regular treatment with combination of salmeterol/fluticasone propionate and salmeterol alone in cough variant asthma
10.3109/02770903.2014.975358 · 2015 · External reference
Effects of inhaled corticosteroids on cough threshold in patients with bronchial asthma
10.1006/pupt.2000.0264 · 2001 · External reference
Managing chronic cough due to asthma and NAEB in adults and adolescents: CHEST guideline and expert panel report
10.1016/j.chest.2019.12.021 · 2020 · External reference
Real-world evidence: patient views on asthma in respiratory specialist clinics in America
10.1016/j.anai.2020.12.015 · 2021 · External reference
Long-term use of short-acting beta(2)-agonists in patients with adult-onset asthma
10.1016/j.jaip.2022.03.027 · 2022 · External reference
Systemic adverse effects from inhaled corticosteroid use in asthma: a systematic review
2020 · External reference
Effect of stepping up to high-dose inhaled corticosteroids in patients with asthma: UK database study
10.1016/j.jaip.2022.10.040 · 2023 · External reference
Efficacy and safety of benralizumab for patients with severe asthma uncontrolled with high-dosage inhaled corticosteroids and long-acting beta(2)-agonists (SIROCCO): a randomised, multicentre, placebo-controlled phase 3 trial
10.1016/s0140-6736(16)31324-1 · 2016 · External reference
Effects of benralizumab on airway eosinophils in asthmatic patients with sputum eosinophilia
10.1016/j.jaci.2013.05.020 · 2013 · External reference
Reslizumab for inadequately controlled asthma with elevated blood eosinophil counts: results from two multicentre, parallel, double-blind, randomised, placebo-controlled, phase 3 trials
10.1016/s2213-2600(15)00042-9 · 2015 · External reference
Mepolizumab treatment in patients with severe eosinophilic asthma
10.1056/nejmoa1403290 · 2014 · External reference
Mepolizumab for prednisone-dependent asthma with sputum eosinophilia
10.1056/nejmoa0805435 · 2009 · External reference
Predictors of enhanced response with benralizumab for patients with severe asthma: pooled analysis of the SIROCCO and CALIMA studies
10.1016/s2213-2600(17)30344-2 · 2018 · External reference
Severe eosinophilic asthma treated with mepolizumab stratified by baseline eosinophil thresholds: a secondary analysis of the DREAM and MENSA studies
10.1016/s2213-2600(16)30031-5 · 2016 · External reference
Asthma Control Test: reliability, validity, and responsiveness in patients not previously followed by asthma specialists
10.1016/j.jaci.2006.01.011 · 2006 · External reference