Research graph
References from Pharmacological interventions for acute major depression and bipolar depression with mixed features: A systematic review and dose-related network meta-analysis across different age groups. Local targets link to admitted publications; unresolved targets remain external evidence.
Unresolved reference
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Unresolved reference
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Unresolved reference
2022 · External reference
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A double-blind, randomized, placebo-controlled study of aspirin and N-acetylcysteine as adjunctive treatments for bipolar depression
10.4088/jcp.18m12200 · 2018 · External reference
Intra-episode hypomanic symptoms during major depression and their correlates
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Effects of asenapine in bipolar I patients meeting proxy criteria for moderate-to-severe mixed major depressive episodes: a post hoc analysis
10.4088/jcp.13m08827 · 2015 · External reference
A randomized, double-blind, placebo-controlled trial of quetiapine in patients with bipolar disorder, mixed or depressed phase, and alcohol dependence
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10.1097/jcp.0000000000001314 · 2021 · External reference
Intravenous trazodone for the treatment of psychomotor agitation and associated symptoms in major depressive disorder patients experiencing a depressive episode with mixed features
10.1097/yic.0000000000000580 · 2025 · External reference
Treatment of mixed features in bipolar disorder: an updated view
10.1007/s11920-020-1137-6 · 2020 · External reference
Effect of lurasidone on sexual function in major depressive disorder patients with subthreshold hypomanic symptoms (mixed features): results from a placebo-controlled trial
10.4088/jcp.18m12132 · 2018 · External reference
Efficacy of 42 pharmacologic cotreatment strategies added to antipsychotic monotherapy in schizophrenia: systematic overview and quality appraisal of the meta-analytic evidence
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Mixed depression: toward a conceptual framework
10.25259/fh_97_2025 · 2026 · External reference
Efficacy and safety of lurasidone in children and adolescents with bipolar I depression: a double-blind, placebo-controlled study
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A prospective study of the impact of subthreshold mixed states on the 24-month clinical outcomes of bipolar I disorder or schizoaffective disorder
10.1016/j.jad.2009.10.027 · 2010 · External reference
Lumateperone for the treatment of major depressive disorder with mixed features or bipolar depression with mixed features: a randomized placebo-controlled trial
10.1097/jcp.0000000000001964 · 2025 · External reference
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10.1016/j.euroneuro.2019.09.118 · 2019 · External reference
Atypical antipsychotics in the treatment of acute bipolar depression with mixed features: a systematic review and exploratory meta-analysis of placebo-controlled clinical trials
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10.1016/j.jad.2018.02.085 · 2018 · External reference
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10.1111/bdi.12612 · 2018 · External reference
Atypical depression and emotion dysregulation: clinical and psychopathological features
10.1016/j.jad.2025.02.034 · 2025 · External reference
Efficacy and safety of pharmacological interventions for the maintenance of bipolar disorder: a systematic review and dose-related network meta-analysis across different age groups
2026 · External reference
Efficacy, acceptability, and related outcomes of pharmacological interventions for acute bipolar mania: a systematic review and dose-related network meta-analysis across different age groups
2026 · External reference
Efficacy, acceptability, and related outcomes of pharmacological interventions for acute bipolar depression: a systematic review and dose-related network meta-analysis across different age groups
2026 · External reference
Prevalence and outcomes of real-world bipolar depression patients underrepresented in guideline RCTs
10.1016/j.jad.2026.122363 · 2026 · External reference
Correlates of treatment-emergent mania associated with antidepressant treatment in bipolar depression
10.1176/appi.ajp.2008.08030322 · 2009 · External reference
The efficacy and safety of pharmacological treatment for major depressive episode with mixed features specifier: a systematic review and meta-analysis
10.1017/s0033291725101955 · 2025 · External reference
Mixed depression: a farewell to differential diagnosis?
10.4088/jcp.14com09578 · 2015 · External reference
Adjunctive antidepressant use and symptomatic recovery among bipolar depressed patients with concomitant manic symptoms: findings from the STEP-BD
10.1176/appi.ajp.2007.05122032 · 2007 · External reference
Manic symptoms during depressive episodes in 1,380 patients with bipolar disorder: findings from the STEP-BD
10.1176/appi.ajp.2008.08050746 · 2009 · External reference
Remission and recovery associated with lurasidone in the treatment of major depressive disorder with subthreshold hypomanic symptoms (mixed features): post-hoc analysis of a randomized, placebo-controlled study with longer-term extension
10.1017/s1092852917000025 · 2017 · External reference
Major depressive disorder with mixed features and treatment response to lurasidone: a symptom network model
10.1016/j.jad.2020.08.048 · 2020 · External reference
Mixed features in depressive and bipolar disorders: an updated systematic review
2025 · External reference
A rating scale for depression
10.1136/jnnp.23.1.56 · 1960 · External reference
The potential utility of aripiprazole augmentation for major depressive disorder with mixed features specifier: a retrospective study
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Quantifying heterogeneity in a meta-analysis
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Consistency and inconsistency in network meta-analysis: concepts and models for multi-arm studies
10.1002/jrsm.1044 · 2012 · External reference
Unresolved reference
2022 · External reference
Early symptom change and prediction of subsequent remission with olanzapine augmentation in divalproex-resistant bipolar mixed episodes
10.1016/j.jpsychires.2010.05.016 · 2011 · External reference
Prevalence and clinical significance of subsyndromal manic symptoms, including irritability and psychomotor agitation, during bipolar major depressive episodes
10.1016/j.jad.2011.12.046 · 2012 · External reference
The CANMAT and ISBD guidelines for the treatment of bipolar disorder: summary and a 2023 update of evidence
10.1176/appi.focus.20230009 · 2023 · External reference
Correlates of metabolic abnormalities in bipolar I disorder at initiation of acute phase treatment
10.4306/pi.2009.6.2.78 · 2009 · External reference
DSM-5 criteria for depression with mixed features: a farewell to mixed depression
10.1111/acps.12140 · 2014 · External reference
Mixed features of depression: why DSM-5 is wrong (and so was DSM-IV)
10.1192/bjp.bp.112.124404 · 2013 · External reference
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10.1177/07067437241245384 · 2024 · External reference
Quantifying publication bias in meta-analysis
10.1111/biom.12817 · 2018 · External reference
Are manic symptoms that ‘dip’ into depression the essence of mixed features?
10.1016/j.jad.2015.12.009 · 2016 · External reference
Anxiety disorders in children and adolescents with bipolar disorder: a neglected comorbidity
10.1177/070674370104600902 · 2001 · External reference
Diagnosing and treating major depressive episodes that lie along the mood disorders spectrum: focus on depression with mixed features
10.1017/s1092852921000262 · 2021 · External reference
Is obesity changing the phenotype of bipolar disorder from predominately euphoric toward mixed presentations?
10.1111/bdi.12717 · 2018 · External reference
A 3-week, randomized, placebo-controlled trial of asenapine in the treatment of acute mania in bipolar mania and mixed states
10.1111/j.1399-5618.2009.00748.x · 2009 · External reference
Asenapine versus olanzapine in acute mania: a double-blind extension study
10.1111/j.1399-5618.2009.00749.x · 2009 · External reference
Asenapine in the treatment of acute mania in bipolar I disorder: a randomized, double-blind, placebo-controlled trial
10.1016/j.jad.2009.12.028 · 2010 · External reference
The prevalence and illness characteristics of DSM-5-defined “mixed feature specifier” in adults with major depressive disorder and bipolar disorder: results from the International Mood Disorders Collaborative Project
10.1016/j.jad.2014.09.026 · 2015 · External reference
Original research lurasidone in the treatment of bipolar depression
10.4088/jcp.14m09410 · 2015 · External reference
Major depressive disorder with subthreshold hypomanic (mixed) features: a real-world assessment of treatment patterns and economic burden
10.1016/j.jad.2016.12.033 · 2017 · External reference
Cariprazine efficacy in bipolar I depression with and without concurrent manic symptoms: post hoc analysis of 3 randomized, placebo-controlled studies
10.1017/s1092852919001287 · 2020 · External reference
The effectiveness of ketamine on anxiety, irritability, and agitation: implications for treating mixed features in adults with major depressive or bipolar disorder
10.1111/bdi.12941 · 2020 · External reference
Bipolar disorders
10.1016/s0140-6736(20)31544-0 · 2020 · External reference
Cariprazine efficacy in bipolar I depression with and without concurrent manic symptoms: post hoc analysis of 3 randomized, placebo-controlled studies
10.1017/s1092852919001287 · 2020 · External reference
The clinical characterization of the adult patient with bipolar disorder aimed at personalization of management
10.1002/wps.20997 · 2022 · External reference
The efficacy of lumateperone in patients with bipolar depression with mixed features
10.4088/jcp.22m14739 · 2023 · External reference
Adjunctive antipsychotics in major depressive disorder: a systematic review and network meta-analysis
10.1001/jamapsychiatry.2026.0658 · 2026 · External reference
Prevalence and outcomes of rapid cycling bipolar disorder: mixed method systematic meta-review
10.1016/j.jpsychires.2023.06.021 · 2023 · External reference
A new depression scale designed to be sensitive to change
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Efficacy of second generation antipsychotics in treating acute mixed episodes in bipolar disorder: a meta-analysis of placebo-controlled trials
10.1016/j.jad.2013.04.032 · 2013 · External reference
Celecoxib as an adjunct in the treatment of depressive or mixed episodes of bipolar disorder: a double-blind, randomized, placebo-controlled study
10.1002/hup.912 · 2008 · External reference
CINeMA: an approach for assessing confidence in the results of a network meta-analysis
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Retrospective analysis of psychomotor agitation, hypomanic symptoms, and suicidal ideation in unipolar depression
10.1002/da.20191 · 2006 · External reference
Switch to mania after acute antidepressant treatment for bipolar depression: a systematic review and network meta-analysis of randomised controlled trials
10.1016/j.eclinm.2025.103413 · 2025 · External reference
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2021 · External reference
A 6 week randomized double-blind placebo-controlled trial of ziprasidone for the acute depressive mixed state
10.1371/journal.pone.0034757 · 2012 · External reference
ICD-11 mixed episode: nothing new despite the evidence
10.1111/bdi.12783 · 2019 · External reference
Bipolar disorder treatment guidelines and their limits in every day clinical practice
2011 · External reference
Phenomenological subtypes of severe bipolar mixed states: a factor analytic study
10.1016/j.comppsych.2014.01.012 · 2014 · External reference
Mixed features in patients with a major depressive episode: the BRIDGE-II-MIX study
10.4088/jcp.14m09092 · 2015 · External reference
Irritability in a mixed sample of patients with unipolar and bipolar II depression predicts responsiveness to lamotrigine
2018 · External reference
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10.1136/bmj.d549 · 2011 · External reference
Ranking treatments in frequentist network meta-analysis works without resampling methods
10.1186/s12874-015-0060-8 · 2015 · External reference
Frequency of manic symptoms during a depressive episode and unipolar ‘depressive mixed state’ as bipolar spectrum
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P. 290 early efficacy of trazodone for the treatment of depressive episodes with mixed features in patients with major depressive disorder
10.1016/j.euroneuro.2019.09.319 · 2019 · External reference
An open trial of iloperidone for mixed episodes in bipolar disorder
10.1097/jcp.0000000000000764 · 2017 · External reference
Lurasidone in children and adolescents with bipolar depression presenting with mixed (subsyndromal hypomanic) features: post hoc analysis of a randomized placebo-controlled trial
10.1089/cap.2020.0018 · 2020 · External reference
Sleep disturbance, irritability, and response to lurasidone treatment in children and adolescents with bipolar depression
10.2174/1570159x20666220927112625 · 2023 · External reference
Bipolar disorder
10.1016/s0140-6736(25)01140-7 · 2025 · External reference
Sub-threshold manic symptoms in recurrent major depressive disorder are a marker for poor outcome
10.1111/j.1600-0447.2008.01324.x · 2009 · External reference
Functional profile of a novel modulator of serotonin, dopamine, and glutamate neurotransmission
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Mixed features in bipolar disorder
10.1017/s1092852916000869 · 2017 · External reference
Lurasidone in post-menopausal females with major depressive disorder with mixed features: post-hoc analysis of a placebo-controlled trial
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A network meta-analysis of the dose–response effects of lurasidone on acute schizophrenia
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Mixed mood states: baffled, bewildered, befuddled and bemused
10.1111/bdi.12787 · 2019 · External reference
Guidelines for the recognition and management of mixed depression
10.1017/s1092852917000165 · 2017 · External reference
RoB 2: a revised tool for assessing risk of bias in randomised trials
2019 · External reference
Omega 3 fatty acids in bipolar disorder: a preliminary double-blind, placebo-controlled trial
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Lurasidone for the treatment of major depressive disorder with mixed features: a randomized, double-blind, placebo-controlled study
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Manic symptoms and impulsivity during bipolar depressive episodes
10.1111/j.1399-5618.2007.00357.x · 2007 · External reference
Lurasidone for major depressive disorder with mixed features and irritability: a post-hoc analysis
10.1017/s1092852917000232 · 2017 · External reference
Effects of asenapine on depressive symptoms in patients with bipolar I disorder experiencing acute manic or mixed episodes: a post hoc analysis of two 3-week clinical trials
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The complexity of “mixed” depression: a common clinical presentation
2011 · External reference
Unresolved reference
2023 · External reference
Efficacy of olanzapine and olanzapine-fluoxetine combination in the treatment of bipolar I depression
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Efficacy of olanzapine monotherapy in the treatment of bipolar depression with mixed features
10.1016/j.jad.2014.04.003 · 2014 · External reference
Characteristics of depressive and bipolar disorder patients with mixed features
10.1111/acps.12911 · 2018 · External reference
Lurasidone for major depressive disorder with mixed features and anxiety: a post-hoc analysis of a randomized, placebo-controlled study
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Mixed symptoms in major depressive and bipolar disorders: a systematic review
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Mixed states in bipolar and major depressive disorders: systematic review and quality appraisal of guidelines
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Evaluation of inconsistency in networks of interventions
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Treatment of depressive episodes with mixed features: a systematic review and meta-analysis
2025 · External reference
Lurasidone efficacy in mixed depressive states: a comparison of standard rating scales to the koukopoulos mixed depression rating scale
10.1097/jcp.0000000000001261 · 2020 · External reference
Olanzapine/fluoxetine combination for the treatment of mixed depression in bipolar I disorder: a post hoc analysis
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A randomized, double-blind, controlled clinical trial of omega-3 fatty acids and inositol as monotherapies and in combination for the treatment of pediatric bipolar spectrum disorder in children age 5–12
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The efficacy of pharmacological interventions in the treatment of major depressive disorder and bipolar depression with mixed features: a systematic review
10.1111/bdi.70049 · 2025 · External reference
Canadian Network for Mood and Anxiety Treatments (CANMAT) and International Society for Bipolar Disorders (ISBD) recommendations for the management of patients with bipolar disorder with mixed presentations
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Identifying the DSM-5 mixed features specifier in depressed patients: a comparison of measures
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