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References from PDE2A is involved in negative emotional behaviors via the cAMP-PKA signaling pathway in the SPS&S model. Local targets link to admitted publications; unresolved targets remain external evidence.
Molecular pathways underlying sympathetic autonomic overshooting leading to fear and traumatic memories: looking for alternative therapeutic options for post-traumatic stress disorder
2023 · External reference
Differentiating PTSD from anxiety and depression: lessons from the ICD-11 PTSD diagnostic criteria
10.1002/da.22881 · 2019 · External reference
Common data elements in the assessment of military-related PTSD research applied in the Consortium to Alleviate PTSD
10.1093/milmed/usy226 · 2019 · External reference
Trauma and posttraumatic stress disorder in the community: the 1996 Detroit Area Survey of Trauma
10.1001/archpsyc.55.7.626 · 1998 · External reference
Reduced phosphodiesterase-2 activity in the amygdala results in anxiolytic-like effects on behavior in mice
10.1177/0269881119832753 · 2019 · External reference
Cyclic AMP-specific PDE4 phosphodiesterases as critical components of cyclic AMP signaling
10.1074/jbc.r200029200 · 2003 · External reference
Effects of single-prolonged stress on neurons and their afferent inputs in the amygdala
10.1016/j.neuroscience.2007.12.028 · 2008 · External reference
Defects in AMPAR trafficking and microglia activation underlie socio-cognitive deficits associated to decreased expression of phosphodiesterase 2 a
10.1016/j.nbd.2023.106393 · 2024 · External reference
PKA-GluA1 coupling via AKAP5 controls AMPA receptor phosphorylation and cell-surface targeting during bidirectional homeostatic plasticity
10.1016/j.neuron.2014.09.024 · 2014 · External reference
Protective effects of phosphodiesterase 2 inhibitor on depression- and anxiety-like behaviors: involvement of antioxidant and anti-apoptotic mechanisms
10.1016/j.bbr.2014.03.042 · 2014 · External reference
Haploinsufficiency of PDE2A causes in mice increased exploratory behavior associated with upregulation of neural nitric oxide synthase in the striatum
10.1016/j.nbd.2024.106781 · 2025 · External reference
Post-traumatic stress disorder: a psychiatric disorder requiring urgent attention
10.1515/mr-2022-0012 · 2022 · External reference
Functional neuroimaging of anxiety: a meta-analysis of emotional processing in PTSD, social anxiety disorder, and specific phobia
10.1176/appi.ajp.2007.07030504 · 2007 · External reference
Phosphodiesterases PDE2A and PDE10A both change mRNA expression in the human brain with age, but only PDE2A changes in a region-specific manner with psychiatric disease
10.1016/j.cellsig.2020.109592 · 2020 · External reference
Inhibition of PDE2A, but not PDE9A, modulates presynaptic short-term plasticity measured by paired-pulse facilitation in the CA1 region of the hippocampus
10.1002/syn.21840 · 2015 · External reference
cAMP-PKA cascade: an outdated topic for depression?
2022 · External reference
Functional connectivity of amygdala subnuclei in PTSD: a narrative review
10.1038/s41380-023-02291-w · 2023 · External reference
Sensing the invisible: differential sensitivity of visual cortex and amygdala to traumatic context
10.1016/s1053-8119(03)00141-1 · 2003 · External reference
Fear memory regulation by the cAMP signaling pathway as an index of reexperiencing symptoms in posttraumatic stress disorder
10.1038/s41380-024-02453-4 · 2024 · External reference
Neuroimaging findings in post-traumatic stress disorder. Systematic review
2002 · External reference
Psychological therapies for post-traumatic stress disorder in children and adolescents
2025 · External reference
Curculigoside rescues hippocampal synaptic deficits elicited by PTSD through activating cAMP-PKA signaling
10.1002/ptr.7658 · 2023 · External reference
Malnutrition exacerbating neuropsychiatric symptoms on the Alzheimer’s continuum is relevant to the cAMP signaling pathway: human and mouse studies
10.1002/alz.14506 · 2025 · External reference
BDNF-induced local translation of GluA1 is regulated by HNRNP A2/B1
10.1126/sciadv.abd2163 · 2020 · External reference
Tong-Qiao-Huo-Xue decoction promotes synaptic remodeling via cAMP/PKA/CREB pathway in vascular dementia rats
2024 · External reference
Acrylamide exposure promotes the progression of depression-like behavior in mice with CUMS via GSDMD-mediated pyroptosis
10.1016/j.ecoenv.2024.117443 · 2025 · External reference
(2R,6R)-hydroxynorketamine alleviates PTSD-like endophenotypes by regulating the PI3K/AKT signaling pathway in rats
10.1016/j.pbb.2024.173891 · 2024 · External reference
Mechanisms of stress in the brain
10.1038/nn.4086 · 2015 · External reference
Subthreshold posttraumatic stress disorder in the world health organization world mental health surveys
10.1016/j.biopsych.2014.03.028 · 2015 · External reference
Mechanisms of fear extinction
10.1038/sj.mp.4001939 · 2007 · External reference
The potential role of the HCN1 ion channel and BDNF-mTOR signaling pathways and synaptic transmission in the alleviation of PTSD
2020 · External reference
International meta-analysis of PTSD genome-wide association studies identifies sex- and ancestry-specific genetic risk loci
10.1038/s41467-019-12576-w · 2019 · External reference
Influence of anhedonic symptom severity on reward circuit connectivity in PTSD
10.1016/j.bbr.2021.113258 · 2021 · External reference
Neurofunctional correlates of posttraumatic stress disorder: a PET symptom provocation study
10.1007/s004060200014 · 2002 · External reference
Biological studies of post-traumatic stress disorder
10.1038/nrn3339 · 2012 · External reference
Differential manifestations of anhedonia in people with social anhedonia and subsyndromal depression
10.1016/j.ajp.2024.104188 · 2024 · External reference
Post-traumatic stress disorder: clinical and translational neuroscience from cells to circuits
10.1038/s41582-022-00635-8 · 2022 · External reference
Phosphodiesterase inhibitors as potential cognition enhancing agents
10.2174/156802610790411009 · 2010 · External reference
Greater avoidance behavior in individuals with posttraumatic stress disorder symptoms
10.1080/10253890.2017.1309523 · 2017 · External reference
Chronic phosphodiesterase type 2 inhibition improves memory in the APPswe/PS1dE9 mouse model of Alzheimer’s disease
10.1016/j.neuropharm.2012.06.048 · 2013 · External reference
Understanding emotions: origins and roles of the amygdala
10.3390/biom11060823 · 2021 · External reference
Emotional regulation of pain: the role of noradrenaline in the amygdala
10.1007/s11427-014-4638-x · 2014 · External reference
Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles
10.1073/pnas.0506580102 · 2005 · External reference
Functional, synaptoproteomic and structural adaptations underlying sex-dependent traumatic stress susceptibility/resilience in the hippocampus
10.1016/j.phrs.2025.108072 · 2026 · External reference
ConsensusClusterPlus: a class discovery tool with confidence assessments and item tracking
2010 · External reference
Positive emotion dysregulation in posttraumatic stress disorder
10.1016/j.janxdis.2022.102534 · 2022 · External reference
Modulating NLRP3 inflammasome activity and enhancing cortical synaptic plasticity: nanoparticulate hydrogen’s role in relief of post-traumatic anxiety-like behaviors in rats
10.1007/s12035-025-05524-x · 2025 · External reference
An explainable predictive machine learning model reveals ARRB2 as a key gene in post-traumatic stress disorder: a GEO database study
10.1016/j.jpsychires.2025.12.037 · 2026 · External reference
Single-prolonged stress induces apoptosis by activating cytochrome C/caspase-9 pathway in a rat model of post-traumatic stress disorder
10.1007/s10571-010-9550-8 · 2011 · External reference
Construction of novel 10 signatures in diabetic retinopathy construction of model based on WGCNA: mechanism of action of RPL3 and MRPL16 protein
10.1016/j.ijbiomac.2024.138235 · 2025 · External reference
Phosphodiesterase-2 inhibitor reverses corticosterone-induced neurotoxicity and related behavioural changes via cGMP/PKG dependent pathway
10.1017/s146114571200065x · 2013 · External reference
Protective effects of phosphodiesterase 2 inhibitor against Aβ(1-42) induced neuronal toxicity
10.1016/j.neuropharm.2022.109128 · 2022 · External reference
Characterization of 2 novel phosphodiesterase 2 inhibitors Hcyb1 and PF-05180999 on depression- and anxiety-like behavior
10.1093/ijnp/pyad020 · 2023 · External reference
Activation of protein kinase A in the amygdala modulates anxiety-like behaviors in social defeat exposed mice
10.1186/s13041-015-0181-3 · 2016 · External reference
clusterProfiler: an R package for comparing biological themes among gene clusters
10.1089/omi.2011.0118 · 2012 · External reference
Stress-induced bystander signaling as a possible factor contributing to neuronal excitability and seizure generation/epileptogenesis
10.1016/j.mehy.2016.03.008 · 2016 · External reference
Effect of ketamine on mood dysfunction and spatial cognition deficits in PTSD mouse models via HCN1-BDNF signaling
10.1016/j.jad.2021.02.058 · 2021 · External reference
Phosphodiesterase 2 inhibitor Hcyb1 reverses corticosterone-induced neurotoxicity and depression-like behavior
10.1007/s00213-019-05401-1 · 2020 · External reference
