Research graph
References from Exercise to enhance antipsychotic effectiveness and mitigate metabolic harm: systematic review and meta-analysis. Local targets link to admitted publications; unresolved targets remain external evidence.
The effects of physical exercises to mental state and quality of life in patients with schizophrenia
10.1111/j.1365-2850.2008.01317.x · 2008 · External reference
Effects of physical exercise on metabolic syndrome in psychotic disorders: a systematic review with meta-analysis of randomized controlled trials
10.1192/j.eurpsy.2025.10064 · 2025 · External reference
The impact of aerobic exercise training on cardiopulmonary functioning in individuals with schizophrenia
10.1016/j.schres.2016.03.009 · 2016 · External reference
Physical activity as a critical component of first-line treatment for elevated blood pressure or cholesterol: who, what, and how?: a scientific statement from the American Heart Association
10.1161/hyp.0000000000000196 · 2021 · External reference
Adjusting for publication bias in JASP and R: selection models, PET-PEESE, and robust Bayesian meta-analysis
2022 · External reference
Soccer practice as an add-on treatment in the management of individuals with a diagnosis of schizophrenia
10.2147/ndt.s44066 · 2013 · External reference
Effects of exercise on mental and physical health parameters of persons with schizophrenia
10.1080/01612840590959551 · 2005 · External reference
Drug–drug interactions involving antipsychotics and antihypertensives
10.1080/17425255.2022.2086121 · 2022 · External reference
Positive impact of prescribed physical activity on symptoms of schizophrenia: randomized clinical trial
10.24869/psyd.2017.459 · 2017 · External reference
Cardiovascular and cerebrovascular risk factors and events associated with second-generation antipsychotic compared to antidepressant use in a non-elderly adult sample: results from a claims-based inception cohort study
10.1002/wps.20187 · 2015 · External reference
Mortality in people with schizophrenia: a systematic review and meta-analysis of relative risk and aggravating or attenuating factors
10.1002/wps.20994 · 2022 · External reference
What is the minimum clinically important change in negative symptoms of schizophrenia? PANSS based post-hoc analyses of a phase III clinical trial
2022 · External reference
CCRT and aerobic exercise: a randomised controlled study of processing speed, cognitive flexibility, and serum BDNF expression in schizophrenia
10.1038/s41537-022-00297-x · 2022 · External reference
Metabolic and cardiovascular adverse effects associated with antipsychotic drugs
10.1038/nrendo.2011.156 · 2012 · External reference
Analysing data and undertaking meta-analyses
2019 · External reference
Assessing the evidence for health benefits of low-level weight loss: a systematic review
10.1038/s41366-024-01664-7 · 2025 · External reference
Exercise4Psychosis: a randomised control trial assessing the effect of moderate-to-vigorous exercise on inflammatory biomarkers and negative symptom profiles in men with first-episode psychosis
10.1016/j.bbi.2024.06.017 · 2024 · External reference
10.1016/j.neubiorev.2021.01.005
10.1016/j.neubiorev.2021.01.005 · 2021 · External reference
Lifestyle intervention based on exercise and behavioural counselling and its effect on physical and psychological health in outpatients with schizophrenia spectrum disorders. An exploratory, pragmatic randomized clinical trial
10.1016/j.schres.2023.09.036 · 2023 · External reference
Motivating factors and barriers towards exercise in severe mental illness: a systematic review and meta-analysis
10.1017/s0033291716001732 · 2016 · External reference
A meta-review of “lifestyle psychiatry”: the role of exercise, smoking, diet and sleep in the prevention and treatment of mental disorders
10.1002/wps.20773 · 2020 · External reference
Designing a feasible exercise intervention in first-episode psychosis: exercise quality, engagement and effect
10.1016/j.psychres.2020.112840 · 2020 · External reference
Systematic review of early cardiometabolic outcomes of the first treated episode of psychosis
10.1001/archgenpsychiatry.2011.2 · 2011 · External reference
Negative symptoms of schizophrenia: new developments and unanswered research questions
10.1016/s2215-0366(18)30050-6 · 2018 · External reference
Token reinforcement therapeutic approach is more effective than exercise for controlling negative symptoms of schizophrenic patients: a randomized controlled trial
2012 · External reference
Exercise as a treatment for schizophrenia: a review
10.64719/pb.4584 · 2019 · External reference
International trends in antipsychotic use: a study in 16 countries, 2005–2014
10.1016/j.euroneuro.2017.07.001 · 2017 · External reference
Association between percent body fat reduction and changes of the metabolic score for insulin resistance in overweight/obese people with metabolic dysfunction-associated steatotic liver disease
10.2147/dmso.s486841 · 2024 · External reference
Pathophysiological mechanisms of increased cardiometabolic risk in people with schizophrenia and other severe mental illnesses
10.1016/s2215-0366(15)00115-7 · 2015 · External reference
Minimum clinically important difference in the positive and negative syndrome scale with data from the Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE)
10.4088/jcp.11m07162 · 2012 · External reference
Measuring inconsistency in meta-analyses
10.1136/bmj.327.7414.557 · 2003 · External reference
Quantifying heterogeneity in a meta-analysis
10.1002/sim.1186 · 2002 · External reference
The prevention of diabetes and cardiovascular disease in people with schizophrenia
10.1111/acps.12443 · 2015 · External reference
Incongruent changes in heart rate variability and body weight after discontinuing aerobic exercise in patients with schizophrenia
10.1016/j.ijpsycho.2016.08.011 · 2016 · External reference
Effects of exercise training with traditional dancing on functional capacity and quality of life in patients with schizophrenia: a randomized controlled study
10.1177/0269215514564085 · 2015 · External reference
Aerobic exercise as a tool to improve hippocampal plasticity and function in humans: practical implications for mental health treatment
10.3389/fnhum.2016.00373 · 2016 · External reference
Effect of aerobic exercise as adjunct therapy on the improvement of negative symptoms and cognitive impairment in patients with schizophrenia: a randomized, case-control clinical trial
10.3928/02793695-20211014-03 · 2022 · External reference
Increase of circulating BDNF levels and its relation to improvement of physical fitness following 12 weeks of combined exercise in chronic patients with schizophrenia: a pilot study
10.1016/j.psychres.2014.09.020 · 2014 · External reference
Effects of exercise on positive symptoms, negative symptoms, and depression in patients with schizophrenia: a systematic review and meta-analysis
10.3390/ijerph20043719 · 2023 · External reference
Enhancement of aerobic fitness improves social functioning in individuals with schizophrenia
10.1007/s00406-020-01220-0 · 2021 · External reference
Investigating the effect of exercise on clinical symptoms, cognitive performance, and quality of life in schizophrenia patients treated with clozapine
2024 · External reference
Effects of mild-intensity physical exercise on neurocognition in inpatients with schizophrenia: a pilot randomized controlled trial
10.1111/ppc.12896 · 2022 · External reference
Metabolic syndrome and hypertension: regular exercise as part of lifestyle management
10.1007/s11906-014-0492-2 · 2014 · External reference
Excess early mortality in schizophrenia
10.1146/annurev-clinpsy-032813-153657 · 2014 · External reference
Antipsychotic drugs versus placebo for relapse prevention in schizophrenia: a systematic review and meta-analysis
10.1016/s0140-6736(12)60239-6 · 2012 · External reference
Sixty years of placebo-controlled antipsychotic drug trials in acute schizophrenia: systematic review, Bayesian meta-analysis, and meta-regression of efficacy predictors
10.1176/appi.ajp.2017.16121358 · 2017 · External reference
The effect of a physical activity program on subjective well-being, happiness and problem-solving skills in patients with schizophrenia: a randomized controlled trial
10.1007/s10597-024-01366-4 · 2024 · External reference
Feasibility and effects of a group-based resistance and aerobic exercise program for individuals with severe schizophrenia: a multidisciplinary approach
10.1016/j.mhpa.2008.11.001 · 2009 · External reference
Resistance training in patients with schizophrenia: concept and proof of principle trial
10.1016/j.jpsychires.2019.09.015 · 2020 · External reference
PICO, PICOS and SPIDER: a comparison study of specificity and sensitivity in three search tools for qualitative systematic reviews
10.1186/s12913-014-0579-0 · 2014 · External reference
Exercise training complementary to specialised early intervention in patients with first-episode psychosis: a feasibility randomised trial
10.1186/s40814-021-00900-5 · 2021 · External reference
Lipoprotein ratios: physiological significance and clinical usefulness in cardiovascular prevention
2009 · External reference
Second-generation antipsychotics and metabolic syndrome: a role for mitochondria
2023 · External reference
Second-generation (atypical) antipsychotics and metabolic effects: a comprehensive literature review
10.2165/00023210-200519001-00001 · 2005 · External reference
Effects of exercise intervention on psychotic symptoms: a meta-analysis and hypothetical model of neurobiological mechanisms
10.1016/j.pnpbp.2023.110771 · 2023 · External reference
Lower- and higher-level social cognitive factors across individuals with schizophrenia spectrum disorders and healthy controls: relationship with neurocognition and functional outcome
10.1093/schbul/sby114 · 2019 · External reference
Linking metabolic disorders and immune system phenomena in schizophrenia: the role of adipose tissue and inflammation
10.3390/biomedicines13092308 · 2025 · External reference
Adipose tissue dysfunction, inflammation, and insulin resistance: alternative pathways to cardiac remodelling in schizophrenia. A multimodal, case–control study
10.1038/s41398-021-01741-9 · 2021 · External reference
The PRISMA 2020 statement: an updated guideline for reporting systematic reviews
2021 · External reference
Twenty-four-hour ambulatory blood pressure monitoring
10.1177/2150132720940519 · 2020 · External reference
Negative symptoms have greater impact on functioning than positive symptoms in schizophrenia: analysis of CATIE data
10.1016/j.schres.2012.01.015 · 2012 · External reference
Systematic review and meta-analysis of exercise interventions for psychotic disorders: the impact of exercise intensity, mindfulness components, and other moderators on symptoms, functioning, and cardiometabolic health
10.1093/schbul/sbae015 · 2024 · External reference
Metabolic syndrome and obesity among users of second generation antipsychotics: a global challenge for modern psychopharmacology
10.1016/j.phrs.2015.07.022 · 2015 · External reference
Effects of high intensity interval training among overweight individuals with psychotic disorders: a randomized controlled trial
10.1016/j.schres.2018.12.021 · 2019 · External reference
Outdoor cycling improves clinical symptoms, cognition and objectively measured physical activity in patients with schizophrenia: a randomized controlled trial
10.1016/j.jpsychires.2019.10.015 · 2020 · External reference
Physical exercise for negative symptoms of schizophrenia: systematic review of randomized controlled trials and meta-analysis
10.1016/j.genhosppsych.2019.11.002 · 2020 · External reference
Comparative effects of 11 antipsychotics on weight gain and metabolic function in patients with acute schizophrenia: a dose-response meta-analysis
10.4088/jcp.22r14490 · 2023 · External reference
Effects of exercise therapy on cardiorespiratory fitness in patients with schizophrenia
10.1249/mss.0b013e318258e120 · 2012 · External reference
Exercise therapy improves mental and physical health in schizophrenia: a randomised controlled trial
10.1111/acps.12029 · 2013 · External reference
Exercise therapy, cardiorespiratory fitness and their effect on brain volumes: a randomised controlled trial in patients with schizophrenia and healthy controls
10.1016/j.euroneuro.2012.08.008 · 2013 · External reference
The impact of aerobic endurance training on cognitive performance in schizophrenic inpatients in a clinical routine setting
10.1007/s00406-024-01773-4 · 2025 · External reference
Effects of exercise on resilience, insight and functionality in patients with chronic schizophrenia in a psychiatric nursing home setting: a randomized controlled trial
10.1080/01612840.2020.1847221 · 2021 · External reference
Aerobic exercise and cognitive functioning in schizophrenia: a pilot randomized controlled trial
10.1016/j.psychres.2019.112638 · 2019 · External reference
Aerobic exercise and cognitive functioning in schizophrenia: results of a 1-year follow-up from a randomized controlled trial
10.1016/j.psychres.2020.112854 · 2020 · External reference
Antipsychotic dose, dopamine D2 receptor occupancy and extrapyramidal side-effects: a systematic review and dose-response meta-analysis
10.1038/s41380-023-02203-y · 2023 · External reference
The effect of exercise training on blood lipids: a systematic review and meta-analysis
10.1007/s40279-024-02115-z · 2025 · External reference
RoB 2: a revised tool for assessing risk of bias in randomised trials
10.1136/bmj.l4898 · 2019 · External reference
10.1016/j.eurpsy.2018.07.004
10.1016/j.eurpsy.2018.07.004 · 2018 · External reference
The effects of aerobic exercise on cognition in schizophrenia: a 3-month follow-up study
10.1016/j.psychres.2016.08.011 · 2016 · External reference
Hypertension and psychosis
10.1136/postgradmedj-2021-141386 · 2023 · External reference
The effectiveness of structured exercise programmes on psychological and physiological outcomes for patients with psychotic disorders: a systematic review and meta-analysis
10.1080/1612197x.2018.1519838 · 2020 · External reference
10.1016/s2215-0366(25)00170-1
10.1016/s2215-0366(25)00170-1 · External reference
As we were and as we should be, combined exercise training in adults with schizophrenia: CORTEX-SP study part I
10.1249/mss.0000000000003284 · 2024 · External reference
High intensity interval training exercise increases dopamine D2 levels and modulates brain dopamine signaling
10.3389/fpubh.2023.1257629 · 2023 · External reference
Risk of metabolic syndrome and its components in people with schizophrenia and related psychotic disorders, bipolar disorder and major depressive disorder: a systematic review and meta-analysis
10.1002/wps.20252 · 2015 · External reference
Measurement error of waist circumference: gaps in knowledge
10.1017/s1368980012002741 · 2013 · External reference
Effect of aerobic exercise on improving symptoms of individuals with schizophrenia: a single blinded randomized control study
2018 · External reference
Obesity as a risk factor for antipsychotic noncompliance
10.1016/s0920-9964(02)00498-x · 2004 · External reference