Research graph
References from Cannabis use and subsequent onset of manic symptoms and bipolar disorder: A systematic review and meta-analysis. Local targets link to admitted publications; unresolved targets remain external evidence.
Evidence-based atlas of risk and protective factors for psychotic disorders: an umbrella review to inform personalized prognosis and prevention
2026 · External reference
Convergence of cannabis and psychosis on the dopamine system
10.1001/jamapsychiatry.2025.0432 · 2025 · External reference
Future directions for understanding adolescent bipolar spectrum disorders: a reward hypersensitivity perspective
10.1080/15374416.2019.1567347 · 2019 · External reference
Days out of role due to common physical and mental conditions: results from the WHO World Mental Health surveys
10.1038/mp.2010.101 · 2011 · External reference
EQUATOR: reporting guidelines for health research
10.1016/s0140-6736(08)60505-x · 2008 · External reference
The impact of schizophrenia genetic load and heavy cannabis use on the risk of psychotic disorder in the EU-GEI case-control and UK Biobank studies
10.1017/s0033291724002058 · 2024 · External reference
Aggressive behavior in children and adolescents with bipolar spectrum disorder: a systematic review of the prevalence, associated factors, and treatment
10.1016/j.jaacop.2024.02.009 · 2025 · External reference
Risk factors for new-onset bipolar disorder in a community cohort: a five-year follow up study
10.1016/j.psychres.2021.114109 · 2021 · External reference
Cannabis use in children and adolescents with first episode psychosis: influence on psychopathology and short-term outcome (CAFEPS study)
10.1016/j.schres.2009.04.005 · 2009 · External reference
Cannabis use and first manic episode
10.1016/j.jad.2014.04.038 · 2014 · External reference
Adolescent cannabis use and onset of bipolar disorder: gaining causal clarity by viewing the evidence through the Bradford Hill lens
10.1017/s1092852925100345 · 2025 · External reference
Further human evidence for striatal dopamine release induced by administration of ∆9-tetrahydrocannabinol (THC): selectivity to limbic striatum
10.1007/s00213-015-3915-0 · 2015 · External reference
Associations of cannabis use, tobacco use, and incident anxiety, mood, and psychotic disorders: a systematic review and meta-analysis
10.1017/s0033291724002587 · 2024 · External reference
The relationship between cannabis use, schizophrenia, and bipolar disorder: a genetically informed study
10.1016/s2215-0366(23)00143-8 · 2023 · External reference
Cell type specific cannabinoid CB1 receptor distribution across the human and non-human primate cortex
10.1038/s41598-022-13724-x · 2022 · External reference
Quality of life and risk of psychiatric disorders among regular users of alcohol, nicotine, and cannabis: an analysis of the National Epidemiological Survey on Alcohol and Related Conditions (NESARC)
10.1016/j.jpsychires.2015.05.004 · 2015 · External reference
Public health and international drug policy
10.1016/s0140-6736(16)00619-x · 2016 · External reference
A systematic review of the molecular and cellular alterations induced by cannabis that may serve as risk factors for bipolar disorder
10.1093/ijnp/pyae002 · 2024 · External reference
Is early exposure to cannabis associated with bipolar disorder? Results from a Finnish birth cohort study
10.1111/add.15881 · 2022 · External reference
Dysfunction and dysconnection in cortical-striatal networks during sustained attention: genetic risk for schizophrenia or bipolar disorder and its impact on brain network function
2014 · External reference
An International Society of Bipolar Disorders task force report: precursors and prodromes of bipolar disorder
10.1111/bdi.12831 · 2019 · External reference
The association between cannabis use and mood disorders: a longitudinal study
10.1016/j.jad.2014.10.006 · 2015 · External reference
The Mantel-Haenszel procedure revisited: models and generalizations
10.1371/journal.pone.0058327 · 2013 · External reference
Lower-Risk Cannabis Use Guidelines (LRCUG) for reducing health harms from non-medical cannabis use: a comprehensive evidence and recommendations update
10.1016/j.drugpo.2021.103381 · 2022 · External reference
Cannabis use and mania symptoms: a systematic review and meta-analysis
10.1016/j.jad.2014.09.016 · 2015 · External reference
Risks for the transition from major depressive disorder to bipolar disorder in the National Epidemiologic Survey on alcohol and related conditions
10.4088/jcp.11m06912 · 2012 · External reference
Treatment development and feasibility study of family-focused treatment for adolescents with bipolar disorder and comorbid substance use disorders
10.1097/01.pra.0000450325.21791.7e · 2014 · External reference
The reward circuit: linking primate anatomy and human imaging
10.1038/npp.2009.129 · 2010 · External reference
Assessing the public health impacts of legalizing recreational cannabis use: the US experience
10.1002/wps.20735 · 2020 · External reference
Public health implications of legalising the production and sale of cannabis for medicinal and recreational use
10.1016/s0140-6736(19)31789-1 · 2019 · External reference
Prevalence and correlates of DSM-5 cannabis use disorder, 2012-2013: findings from the National Epidemiologic Survey on alcohol and related conditions-III
10.1176/appi.ajp.2015.15070907 · 2016 · External reference
Self-reported sleep and circadian characteristics predict alcohol and cannabis use: a longitudinal analysis of the National Consortium on alcohol and neurodevelopment in adolescence study
10.1111/acer.14808 · 2022 · External reference
Cannabis use and expression of mania in the general population
10.1016/j.jad.2006.05.002 · 2006 · External reference
Unresolved reference
2024 · External reference
Prevalence of schizophrenia spectrum and bipolar disorder among patients with cannabis induced psychosis: a systematic review and meta-analysis
10.1186/s12888-025-07382-2 · 2026 · External reference
Cannabis use disorder and subsequent risk of psychotic and nonpsychotic unipolar depression and bipolar disorder
10.1001/jamapsychiatry.2023.1256 · 2023 · External reference
Early exposure to cannabis and bipolar disorder incidence: findings from a 22-year birth cohort study in Brazil
10.1111/acps.13670 · 2024 · External reference
Multiple functions of endocannabinoid signaling in the brain
10.1146/annurev-neuro-062111-150420 · 2012 · External reference
Associations between cannabis use, cannabis use disorder, and mood disorders: longitudinal, genetic, and neurocognitive evidence
10.1007/s00213-021-06001-8 · 2022 · External reference
Potential for prediction of psychosis and bipolar disorder in Child and Adolescent Mental Health Services: a longitudinal register study of all people born in Finland in 1987
10.1002/wps.21009 · 2022 · External reference
Unresolved reference
2009 · External reference
Cannabis use and its relationship with bipolar disorder: a systematic review and meta-analysis
10.4103/ipj.ipj_43_23 · 2023 · External reference
Predicting bipolar disorder on the basis of phenomenology: implications for prevention and early intervention
10.1111/bdi.12133 · 2014 · External reference
Cannabis use and depression: a longitudinal study of a national cohort of Swedish conscripts
10.1186/1471-244x-12-112 · 2012 · External reference
Meta-analysis of the association between the level of cannabis use and risk of psychosis
10.1093/schbul/sbw003 · 2016 · External reference
Cannabis use and hypomania in young people: a prospective analysis
10.1093/schbul/sbx158 · 2018 · External reference
Prefrontal function and activation in bipolar disorder and schizophrenia
10.1176/appi.ajp.2007.07020365 · 2008 · External reference
Co-morbid cannabis use disorder and chronotype are associated with mood symptom onset in people with bipolar disorder
10.1016/j.jpsychires.2024.11.007 · 2024 · External reference
Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement
10.1136/bmj.b2535 · 2009 · External reference
Cannabis use and risk of psychotic or affective mental health outcomes: a systematic review
10.1016/s0140-6736(07)61162-3 · 2007 · External reference
National trends in the outpatient diagnosis and treatment of bipolar disorder in youth
10.1001/archpsyc.64.9.1032 · 2007 · External reference
Mental health
2017 · External reference
Precursors of self-reported subclinical hypomania in adolescence: a longitudinal general population study
10.1371/journal.pone.0253507 · 2021 · External reference
Diagnosis and treatment of bipolar disorder: a review
10.1001/jama.2023.18588 · 2023 · External reference
Cannabis and tobacco use in bipolar disorder: associations with early onset, psychotic symptoms, and relapse risk (2015–2019)
10.1016/j.jad.2025.04.026 · 2025 · External reference
Systematic review and meta-analysis: medical and recreational cannabis legalization and cannabis use among youth in the United States
10.1016/j.jaac.2024.02.016 · 2024 · External reference
Longitudinal changes in the antecedent and early manifest course of bipolar disorder-a narrative review of prospective studies
10.1177/0004867417700730 · 2017 · External reference
Common and specific patterns of functional and structural brain alterations in schizophrenia and bipolar disorder: a multimodal voxel-based meta-analysis
10.1503/jpn.210111 · 2022 · External reference
Comorbidity and coaggregation of major depressive disorder and bipolar disorder and cannabis use disorder in a controlled family study
10.1001/jamapsychiatry.2022.1338 · 2022 · External reference
Interaction between environmental and familial affective risk impacts psychosis admixture in states of affective dysregulation
10.1017/s0033291718002635 · 2019 · External reference
Prospective progression from high-prevalence disorders to bipolar disorder: exploring characteristics of pre-illness stages
10.1016/j.jad.2015.04.025 · 2015 · External reference
Pre-onset risk characteristics for mania among young people at clinical high risk for psychosis
10.1016/j.schres.2017.04.036 · 2018 · External reference
Environmental risk factors for schizophrenia and bipolar disorder from childhood to diagnosis: a Swedish nested case-control study
10.1017/s0033291724000266 · 2024 · External reference
Cannabis use in early adulthood is prospectively associated with prescriptions of antipsychotics, mood stabilizers, and antidepressants
10.1111/acps.13104 · 2020 · External reference
Demographic and clinical characteristics, including subsyndromal symptoms across bipolar-spectrum disorders in adolescents
10.1089/cap.2019.0138 · 2020 · External reference
Occurrence of psychosis and bipolar disorder in individuals with attention-deficit/hyperactivity disorder treated with stimulants: a systematic review and meta-analysis
10.1001/jamapsychiatry.2025.2311 · 2025 · External reference
Development and validation of a prognostic model and risk calculator for the estimation of bipolar-spectrum disorder risk in hospitalised adolescents with non-psychotic/non-bipolar mental disorders
10.1038/s41380-025-03244-1 · 2026 · External reference
Early intervention for people at high risk of developing bipolar disorder: a systematic review of clinical trials
10.1016/s2215-0366(20)30188-7 · 2021 · External reference
Molecular mechanism and cannabinoid pharmacology
10.1007/164_2019_298 · 2020 · External reference
Predicting diagnostic conversion from major depressive disorder to bipolar disorder: an EHR based study from Colombia
2023 · External reference
Meta-analysis of observational studies in epidemiology: a proposal for reporting. Meta-analysis Of Observational Studies in Epidemiology (MOOSE) group
10.1001/jama.283.15.2008 · 2000 · External reference
Unresolved reference
2025 · External reference
Risk factors predicting onset and persistence of subthreshold expression of bipolar psychopathology among youth from the community
10.1111/j.1600-0447.2010.01539.x · 2010 · External reference
Using Mendelian randomization analysis to better understand the relationship between mental health and substance use: a systematic review
10.1017/s003329172100180x · 2021 · External reference
Unresolved reference
External reference
Does cannabis use predict the first incidence of mood and anxiety disorders in the adult population?
10.1111/j.1360-0443.2007.01875.x · 2007 · External reference
Bipolar disorders
10.1038/nrdp.2018.8 · 2018 · External reference
Cannabis use and cannabis use disorders and their relationship to mental disorders: a 10-year prospective-longitudinal community study in adolescents
10.1016/j.drugalcdep.2006.12.013 · 2007 · External reference
