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References from Mulberry fruit anthocyanin extract modulates insomnia-related behavioral and neurochemical alterations via the gut–brain axis: A multi-omics and network pharmacology study. Local targets link to admitted publications; unresolved targets remain external evidence.
Epidemiology of insomnia, depression, and anxiety
10.1093/sleep/28.11.1457 · 2005 · External reference
Neurocognitive consequences of sleep deprivation
10.1055/s-2005-867080 · 2005 · External reference
Functional neuroimaging and behavioral correlates of capacity decline in visual short-term memory after sleep deprivation
10.1073/pnas.0610712104 · 2007 · External reference
Sleep deprivation amplifies reactivity of brain reward networks, biasing the appraisal of positive emotional experiences
10.1523/jneurosci.3220-10.2011 · 2011 · External reference
Sleep function, with particular reference to sleep deprivation
1985 · External reference
Sleep benefits subsequent hippocampal functioning
10.1038/nn.2253 · 2009 · External reference
Age-related impairments of memory and fast sleep spindles are mediated by deterioration of cortico-thalamic white matter pathways
2012 · External reference
The digestibility of mulberry fruit polysaccharides and its impact on lipolysis under simulated saliva, gastric and intestinal conditions
10.1016/j.foodhyd.2016.02.033 · 2016 · External reference
Chemical properties in fruits of mulberry species from the Xinjiang province of China
10.1016/j.foodchem.2014.11.083 · 2015 · External reference
Neuroprotective effect of prenylated arylbenzofuran and flavonoids from Morus alba fruits on glutamate-induced oxidative injury in HT22 hippocampal cells
10.1089/jmf.2014.3196 · 2015 · External reference
In vitro and in vivo antioxidant activity of flavonoid extracted from mulberry fruit (Morus alba L.)
10.4103/0973-1296.177910 · 2016 · External reference
Anti-inflammatory and antiobesity effects of mulberry leaf and fruit extract on high fat diet-induced obesity
10.1177/1535370213498982 · 2013 · External reference
Neuroprotective effects of the cyanidin-3-O-β-d-glucopyranoside isolated from mulberry fruit against cerebral ischemia
10.1016/j.neulet.2005.08.053 · 2006 · External reference
Mulberry fruit protects dopaminergic neurons in toxin-induced Parkinson‘s disease models
10.1017/s0007114510000218 · 2010 · External reference
Mulberry fruit extract protects against memory impairment and hippocampal damage in animal model of vascular dementia
10.1155/2012/263520 · 2012 · External reference
Ultrasonic-assisted enzymatic extraction and identification of anthocyanin components from mulberry wine residues
10.1016/j.foodchem.2020.126714 · 2020 · External reference
Flavonoid-rich mulberry leaf extract modulates lipid metabolism, antioxidant capacity, and gut microbiota in high-fat diet-induced obesity: potential roles of FGF21 and SOCS2
2024 · External reference
Co-pigmentation mechanism and thermal reaction kinetics of mulberry anthocyanins with different phenolic acids
10.3390/foods11233806 · 2022 · External reference
Sedative and hypnotic effects of Schisandrin B through increasing GABA/Glu ratio and upregulating the expression of GABAA in mice and rats
10.1016/j.biopha.2018.04.017 · 2018 · External reference
Molecular mechanisms of glutamate receptor-mediated excitotoxic neuronal cell death
10.1385/mn:24:1-3:107 · 2001 · External reference
On the relationship between GABA+ and glutamate across the brain
10.1016/j.neuroimage.2022.119273 · 2022 · External reference
Embracing diversity in the 5-HT neuronal system
10.1038/s41583-019-0151-3 · 2019 · External reference
Neuroanatomy and neurochemistry of sleep
10.1007/s00018-007-6530-3 · 2007 · External reference
An important link between the gut microbiota and the circadian rhythm: imply for treatments of circadian rhythm sleep disorder
10.1007/s10068-021-01015-6 · 2022 · External reference
Gut microbiota changes and their relationship with inflammation in patients with acute and chronic insomnia
10.2147/nss.s271927 · 2020 · External reference
Gut microbiome composition and its association with sleep in major psychiatric disorders
10.1159/000530386 · 2023 · External reference
Short chain fatty acids: microbial metabolites for gut-brain axis signalling
2022 · External reference
Uncovering the anti-atherosclerotic effect of isoquercitrin via microbiome metabolic modulation and network pharmacology
10.1021/acs.jafc.5c09903 · 2025 · External reference
Consumption of butylated starch alleviates the chronic restraint stress-induced neurobehavioral and gut barrier deficits through reshaping the gut microbiota
10.3389/fimmu.2021.755481 · 2021 · External reference
CD4+ lymphoid tissue-inducer cells promote innate immunity in the gut
10.1016/j.immuni.2010.12.009 · 2011 · External reference
Indigenous bacteria from the gut microbiota regulate host serotonin biosynthesis
10.1016/j.cell.2015.02.047 · 2015 · External reference
Microbiota-derived short-chain fatty acids promote Th1 cell IL-10 production to maintain intestinal homeostasis
10.1038/s41467-018-05901-2 · 2018 · External reference
Altered metabolism during the dark period in Drosophila short sleep mutants
10.1021/acs.jproteome.4c00106 · 2024 · External reference
Metabolomics in sleep, insomnia and sleep apnea
10.3390/ijms21197244 · 2020 · External reference
Integrative metabolomics and transcriptomics analysis of hippocampus reveals taurine metabolism and sphingolipid metabolism dysregulation associated with sleep deprivation-induced memory impairment
10.1016/j.brainresbull.2025.111397 · 2025 · External reference
The dopaminergic system modulates the electrophysiological activity of the suprachiasmatic nucleus dependent on the circadian cycle
10.1007/s11064-023-03988-8 · 2023 · External reference
Porphyromonas gingivalis lipopolysaccharide induces cognitive dysfunction, mediated by neuronal inflammation via activation of the TLR4 signaling pathway in C57BL/6 mice
10.1186/s12974-017-1052-x · 2018 · External reference
PI3K/Akt and HIF-1 signaling pathway in hypoxia-ischemia
2018 · External reference
PI3K/Akt signaling transduction pathway, erythropoiesis and glycolysis in hypoxia
2019 · External reference
Disrupted sleep without sleep curtailment induces sleepiness and cognitive dysfunction via the tumor necrosis factor-α pathway
10.1186/1742-2094-9-91 · 2012 · External reference
Interleukin-17 impairs salivary tight junction integrity in Sjögren‘s syndrome
10.1177/0022034516634647 · 2016 · External reference
The role of AGE-RAGE signalling as a modulator of gut permeability in diabetes
10.3390/ijms23031766 · 2022 · External reference
Dietary advanced glycation end products modify gut microbial composition and partially increase colon permeability in rats
10.1002/mnfr.201700118 · 2017 · External reference
Serotonin signalling in the gut—functions, dysfunctions and therapeutic targets
10.1038/nrgastro.2013.105 · 2013 · External reference
Improvement in constipation and diarrhea is associated with improved abdominal pain in patients with functional bowel disorders
2022 · External reference
Cloning of a serotonin transporter affected by antidepressants
10.1126/science.1948036 · 1991 · External reference
Role of 5-HT2A receptor antagonists in the treatment of insomnia
10.2147/nss.s6849 · 2010 · External reference
Rapid modulation of spine morphology by the 5-HT2A serotonin receptor through kalirin-7 signaling
10.1073/pnas.0905884106 · 2009 · External reference
Prostaglandin-mediated inhibition of serotonin signaling controls the affective component of inflammatory pain
10.1172/jci90678 · 2017 · External reference
Cyclooxygenase-2 (COX-2)-dependent mechanisms mediate sleep responses to microbial and thermal stimuli
10.1016/j.bbi.2024.08.014 · 2024 · External reference
Alzheimer‘s disease, sleep disordered breathing, and microglia: puzzling out a common link
10.3390/cells10112907 · 2021 · External reference
