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References from Mitochondria-associated endoplasmic reticulum membranes facilitate gastric epithelial injury in hypoxia-induced gastric mucosal lesions. Local targets link to admitted publications; unresolved targets remain external evidence.
Hypoxia: an alarm signal during intestinal inflammation
10.1038/nrgastro.2010.39 · 2010 · External reference
Mitochondrial dysfunction induced by HIF-1α under hypoxia contributes to the development of gastric mucosal lesions
10.1002/ctm2.1653 · 2024 · External reference
Systematic and comprehensive insights into HIF-1 stabilization under normoxic conditions: implications for cellular adaptation and therapeutic strategies in cancer
10.1186/s11658-024-00682-7 · 2025 · External reference
Intestinal HIF-1α deletion exacerbates alcoholic liver disease by inducing intestinal dysbiosis and barrier dysfunction
10.1016/j.jhep.2018.05.021 · 2018 · External reference
Oral administration of Robinia pseudoacacia L. flower exosome-like nanoparticles attenuates gastric and small intestinal mucosal ferroptosis caused by hypoxia through inhibiting HIF-1α- and HIF-2α-mediated lipid peroxidation
10.1186/s12951-024-02663-6 · 2024 · External reference
Cellular adaptation to hypoxia through hypoxia inducible factors and beyond
10.1038/s41580-020-0227-y · 2020 · External reference
Mitochondria-associated endoplasmic reticulum membranes in human health and diseases
2020 · External reference
Intermittent hypoxia-induced cardiomyocyte death is mediated by HIF-1 dependent MAM disruption
10.3390/antiox11081462 · 2022 · External reference
ER-mitochondria contact sites in neurodegeneration: genetic screening approaches to investigate novel disease mechanisms
10.1038/s41418-020-00705-8 · 2021 · External reference
FUNDC1-dependent mitochondria-associated endoplasmic reticulum membranes are involved in angiogenesis and neoangiogenesis
10.1038/s41467-021-22771-3 · 2021 · External reference
FUNDC1 regulates mitochondrial dynamics at the ER-mitochondrial contact site under hypoxic conditions
10.15252/embj.201593102 · 2016 · External reference
Binding of FUN14 domain containing 1 with inositol 1,4,5-trisphosphate receptor in mitochondria-associated endoplasmic reticulum membranes maintains mitochondrial dynamics and function in hearts in vivo
10.1161/circulationaha.117.030235 · 2017 · External reference
NINJ1 regulates plasma membrane fragility under mechanical strain
10.1038/s41586-025-09222-5 · 2025 · External reference
Inhibiting membrane rupture with NINJ1 antibodies limits tissue injury
10.1038/s41586-023-06191-5 · 2023 · External reference
NINJ1 is activated by cell swelling to regulate plasma membrane permeabilization during regulated necrosis
10.1038/s41419-023-06284-z · 2023 · External reference
Mitochondrial dysfunction by FADDosome promotes gastric mucosal injury in portal hypertensive gastropathy
10.7150/ijbs.90835 · 2024 · External reference
The gastrointestinal symptom rating scale has a good test-retest reliability in well-trained athletes with and without previously self-identified gastrointestinal complaints
10.1007/s40279-024-02122-0 · 2025 · External reference
Hyperglycemia-driven inhibition of AMP-activated protein kinase α2 induces diabetic cardiomyopathy by promoting mitochondria-associated endoplasmic reticulum membranes in vivo
10.1161/circulationaha.118.033552 · 2019 · External reference
HIF-1α pathway: role, regulation and intervention for cancer therapy
10.1016/j.apsb.2015.05.007 · 2015 · External reference
Mitochondrial electron transport chain: oxidative phosphorylation, oxidant production, and methods of measurement
10.1016/j.redox.2020.101674 · 2020 · External reference
N4-acetylcytidine drives glycolysis addiction in gastric cancer via NAT10/SEPT9/HIF-1α positive feedback loop
2023 · External reference
HIF-1 mediates metabolic responses to intratumoral hypoxia and oncogenic mutations
10.1172/jci67230 · 2013 · External reference
m6A-regulated tumor glycolysis: new advances in epigenetics and metabolism
10.1186/s12943-023-01841-8 · 2023 · External reference
HIF-1α-induced expression of m6A reader YTHDF1 drives hypoxia-induced autophagy and malignancy of hepatocellular carcinoma by promoting ATG2A and ATG14 translation
10.1038/s41392-020-00453-8 · 2021 · External reference
HIF-1α-induced expression of the m6A reader YTHDF1 inhibits the ferroptosis of nucleus pulposus cells by promoting SLC7A11 translation
10.1111/acel.14210 · 2024 · External reference
PUMA mediates ER stress-induced apoptosis in portal hypertensive gastropathy
10.1038/cddis.2014.95 · 2014 · External reference
Impaired oxygen-sensitive regulation of mitochondrial biogenesis within the von Hippel-Lindau syndrome
10.1038/s42255-022-00593-x · 2022 · External reference
Warburg effect revisited: an epigenetic link between glycolysis and gastric carcinogenesis
10.1038/onc.2009.332 · 2010 · External reference
Regulation of glycolysis by the hypoxia-inducible factor (HIF): implications for cellular physiology
10.1113/jp280572 · 2021 · External reference
HIF1α-regulated glycolysis promotes activation-induced cell death and IFN-γ induction in hypoxic T cells
10.1038/s41467-024-53593-8 · 2024 · External reference
Blocking the HIF-1α/glycolysis axis inhibits allergic airway inflammation by reducing ILC2 metabolism and function
10.1111/all.16361 · 2025 · External reference
ESM1 enhances fatty acid synthesis and vascular mimicry in ovarian cancer by utilizing the PKM2-dependent Warburg effect within the hypoxic tumor microenvironment
10.1186/s12943-024-02009-8 · 2024 · External reference
Deregulation of lactate permeability using a small-molecule transporter (Lactrans-1) disturbs intracellular pH and triggers cancer cell death
10.1016/j.bcp.2024.116469 · 2024 · External reference
Extracellular acidification induces ROS- and mPTP-mediated death in HEK293 cells
10.1016/j.redox.2017.12.018 · 2018 · External reference
ROS as signalling molecules: mechanisms that generate specificity in ROS homeostasis
10.1038/nrm2256 · 2007 · External reference
NINJ1 mediates plasma membrane rupture during lytic cell death
10.1038/s41586-021-03218-7 · 2021 · External reference
Structural basis of NINJ1-mediated plasma membrane rupture in cell death
10.1038/s41586-023-05991-z · 2023 · External reference
NINJ1 mediates inflammatory cell death, PANoptosis, and lethality during infection conditions and heat stress
10.1038/s41467-024-45466-x · 2024 · External reference
Identification of an IRF–ZBP1–caspase-8–NINJ1 axis in driving PANoptosis and pathology during alcohol-associated liver disease
10.1073/pnas.2525296122 · 2025 · External reference
How NINJ1 mediates plasma membrane rupture and why NINJ2 cannot
10.1016/j.cell.2024.11.021 · 2025 · External reference
NINJ1 mediates plasma membrane rupture by cutting and releasing membrane disks
10.1016/j.cell.2024.03.008 · 2024 · External reference
Autoinhibition of dimeric NINJ1 prevents plasma membrane rupture
10.1038/s41586-024-08273-4 · 2025 · External reference
Rings of death: how NINJ1 executes plasma membrane rupture
10.1016/j.cell.2024.12.030 · 2025 · External reference
Mitochondria-associated membranes (MAMs): molecular organization, cellular functions, and their role in health and disease
10.1002/2211-5463.70121 · 2026 · External reference
VDR regulates mitochondrial function as a protective mechanism against renal tubular cell injury in diabetic rats
10.1016/j.redox.2024.103062 · 2024 · External reference
Targeting mitochondria-associated membranes as a potential therapy against endothelial injury induced by hypoxia
10.1002/jcb.29220 · 2019 · External reference
Diallyl trisulfide from garlic regulates RAB18 phase separation to inhibit lipophagy and induce cuproptosis in hepatic stellate cells for antifibrotic effects
2025 · External reference
Mitochondrial DNA and the STING pathway are required for hepatic stellate cell activation
10.1097/hep.0000000000000388 · 2023 · External reference
Chronic enrichment of hepatic endoplasmic reticulum-mitochondria contact leads to mitochondrial dysfunction in obesity
10.1038/nm.3735 · 2014 · External reference
Deficient endoplasmic reticulum-mitochondrial phosphatidylserine transfer causes liver disease
10.1016/j.cell.2019.04.010 · 2019 · External reference
Mic19 depletion impairs endoplasmic reticulum-mitochondrial contacts and mitochondrial lipid metabolism and triggers liver disease
10.1038/s41467-023-44057-6 · 2024 · External reference
A new perspective on liver diseases: focusing on the mitochondria-associated endoplasmic reticulum membranes
10.1016/j.phrs.2024.107409 · 2024 · External reference
FUNDC1 interacts with GPx4 to govern hepatic ferroptosis and fibrotic injury through a mitophagy-dependent manner
10.1016/j.jare.2023.02.012 · 2024 · External reference
Mitochondria-meditated pathways of organ failure upon inflammation
10.1016/j.redox.2017.05.017 · 2017 · External reference
NINJ1: bridging lytic cell death and inflammation therapy
10.1038/s41419-024-07203-6 · 2024 · External reference
Peptide-based targeted covalent inhibitors
10.1021/acsami.5c18100 · 2025 · External reference
Structural insights into the recognition of phosphorylated FUNDC1 by LC3B in mitophagy, Protein
2017 · External reference
The role and mechanism of METTL3 in cancer: emerging insights into m6A methylation and therapeutic potential
10.1186/s40001-025-03351-3 · 2025 · External reference
1,4,9-Triazaspiro[5.5]undecan-2-one derivatives as potent and selective METTL3 inhibitors
10.1021/acs.jmedchem.1c00773 · 2021 · External reference
A small molecule inhibitor of RNA-binding protein IGF2BP3 shows anti-leukemic activity
10.3324/haematol.2025.288221 · 2025 · External reference
Ultra-pH-sensitive nanoplatform for precise tumor therapy
10.1016/j.biomaterials.2024.122858 · 2025 · External reference
