Research graph
References from Integrative multiomics and machine learning identify uridine as a candidate modulator of MMP7-mediated immune cell infiltration in pulmonary fibrosis. Local targets link to admitted publications; unresolved targets remain external evidence.
Idiopathic pulmonary fibrosis
10.1016/s0140-6736(17)30866-8 · 2017 · External reference
The therapy of idiopathic pulmonary fibrosis: what is next?
10.1183/16000617.0021-2019 · 2019 · External reference
Baseline characteristics and survival of patients of idiopathic pulmonary fibrosis: a longitudinal analysis of the Swedish IPF Registry
10.1186/s12931-021-01634-x · 2021 · External reference
Idiopathic pulmonary fibrosis: state of the art for 2023
10.1183/13993003.00957-2022 · 2023 · External reference
Current and future treatment landscape for idiopathic pulmonary fibrosis
10.1007/s40265-023-01950-0 · 2023 · External reference
Immune cells crosstalk pathways, and metabolic alterations in Idiopathic pulmonary fibrosis
10.1016/j.intimp.2024.112269 · 2024 · External reference
Potential role of senescent macrophages in radiation-induced pulmonary fibrosis
10.1038/s41419-021-03811-8 · 2021 · External reference
Loss of IGFBP2 mediates alveolar type 2 cell senescence and promotes lung fibrosis
2023 · External reference
YAP1 inhibits the senescence of alveolar epithelial cells by targeting Prdx3 to alleviate pulmonary fibrosis
10.1038/s12276-024-01277-0 · 2024 · External reference
ROS-mediated lysosomal membrane permeabilization and autophagy inhibition regulate bleomycin-induced cellular senescence
10.1080/15548627.2024.2353548 · 2024 · External reference
SIRT3/6: an amazing challenge and opportunity in the fight against fibrosis and aging
10.1007/s00018-023-05093-z · 2024 · External reference
Monocytes and macrophages: emerging mechanisms and novel therapeutic targets in pulmonary fibrosis
10.1152/ajpcell.00302.2023 · 2023 · External reference
PAD4 deficiency improves bleomycin-induced neutrophil extracellular traps and fibrosis in mouse lung
10.1165/rcmb.2019-0433oc · 2020 · External reference
T cells in idiopathic pulmonary fibrosis: crucial but controversial
10.1038/s41420-023-01344-x · 2023 · External reference
Regulation of immune cells in lung fibrosis: the reign of regnase-1?
10.1183/13993003.04029-2020 · 2021 · External reference
Comparison of pirfenidone and nintedanib
10.1016/j.chest.2023.11.035 · 2024 · External reference
Salvage of ribose from uridine or RNA supports glycolysis in nutrient-limited conditions
10.1038/s42255-023-00774-2 · 2023 · External reference
Uridine-derived ribose fuels glucose-restricted pancreatic cancer
10.1038/s41586-023-06073-w · 2023 · External reference
Cross-species metabolomic analysis identifies uridine as a potent regeneration promoting factor
10.1038/s41421-021-00361-3 · 2022 · External reference
Uridine alleviates sepsis-induced acute lung injury by inhibiting ferroptosis of macrophage
10.3390/ijms24065093 · 2023 · External reference
Uridine as a protector against hypoxia-induced lung injury
10.1038/s41598-019-45979-2 · 2019 · External reference
Progressive pulmonary fibrosis is caused by elevated mechanical tension on alveolar stem cells
10.1016/j.cell.2019.11.027 · 2020 · External reference
WGCNA: an R package for weighted correlation network analysis
10.1186/1471-2105-9-559 · 2008 · External reference
Large-scale comparative analysis of canine and human osteosarcomas uncovers conserved clinically relevant tumor microenvironment subtypes
10.1158/1078-0432.ccr-24-1854 · 2024 · External reference
Prognostic value of CDKN2A in head and neck squamous cell carcinoma via pathomics and machine learning
2024 · External reference
Clinical and demographic predictors of heart failure outcomes: a machine learning perspective
10.36922/ejmo.6583 · 2025 · External reference
Robust enumeration of cell subsets from tissue expression profiles
10.1038/nmeth.3337 · 2015 · External reference
Integrated analysis of multimodal single-cell data
10.1016/j.cell.2021.04.048 · 2021 · External reference
scTenifoldKnk: an efficient virtual knockout tool for gene function predictions via single-cell gene regulatory network perturbation
10.1016/j.patter.2022.100434 · 2022 · External reference
An official American thoracic society workshop report: features and measurements of experimental acute lung injury in animals
10.1165/rcmb.2009-0210st · 2011 · External reference
Simple method of estimating severity of pulmonary fibrosis on a numerical scale
10.1136/jcp.41.4.467 · 1988 · External reference
Identification of immune biomarkers associated with basement membranes in idiopathic pulmonary fibrosis and their pan-cancer analysis
10.3389/fgene.2023.1114601 · 2023 · External reference
Targeting matrix metalloproteinase-1, matrix metalloproteinase-7, and serine protease inhibitor E1: implications in preserving lung vascular endothelial integrity and immune modulation in COVID-19
10.1016/j.ijbiomac.2025.141602 · 2025 · External reference
Identification of diagnostic gene biomarkers related to immune infiltration in patients with idiopathic pulmonary fibrosis based on bioinformatics strategies
10.3389/fmed.2022.959010 · 2022 · External reference
Expression and role of connexin-based gap junctions in pulmonary inflammatory diseases
10.1016/j.pharmthera.2016.04.004 · 2016 · External reference
21st century tools for nanotoxicology: transcriptomic biomarker panel and precision‐cut lung slice organ mimic system for the assessment of nanomaterial‐induced lung fibrosis
10.1002/smll.202000272 · 2020 · External reference
Enhanced carbonic anhydrase expression with calcification and fibrosis in bronchial cartilage during COPD
10.1016/j.acthis.2021.151834 · 2022 · External reference
Carbonic anhydrase and soluble adenylate cyclase regulation of cystic fibrosis cellular phenotypes
10.1152/ajplung.00022.2021 · 2022 · External reference
Cathepsin K aggravates pulmonary fibrosis through promoting fibroblast glutamine metabolism and collagen synthesis
2025 · External reference
Tunneling CARs: increasing CAR T-Cell tumor infiltration through the overexpression of MMP-7 and osteopontin-b
10.1158/2326-6066.cir-25-0149 · 2025 · External reference
The co‐location of CD14+APOE+ cells and MMP7+ tumour cells contributed to worse immunotherapy response in non‐small cell lung cancer
10.1002/ctm2.70009 · 2024 · External reference
Homeostatic control of uridine and the role of uridine phosphorylase: a biological and clinical update
10.1016/s0925-4439(02)00076-5 · 2002 · External reference
Enhanced uridine bioavailability following administration of a triacetyluridine-rich nutritional supplement
10.1371/journal.pone.0014709 · 2011 · External reference
Therapeutic potential of aronia melanocarpa in the prevention of bleomycin-induced lung fibrosis in rats
10.36922/ejmo025170148 · 2025 · External reference
Uridine supplementation exerts anti-inflammatory and anti-fibrotic effects in an animal model of pulmonary fibrosis
10.1186/s12931-015-0264-9 · 2015 · External reference
Emerging role of immune cells as drivers of pulmonary fibrosis
10.1016/j.pharmthera.2023.108562 · 2023 · External reference
The role of inflammation in the pathogenesis of idiopathic pulmonary fibrosis
10.1089/ars.2007.1897 · 2008 · External reference
Aberrant intermediate alveolar epithelial cells promote pathogenic activation of lung fibroblasts in preclinical fibrosis models
10.1038/s41467-025-63735-1 · 2025 · External reference
Alveolar epithelial type II cells as drivers of lung fibrosis in idiopathic pulmonary fibrosis
10.3390/ijms21072269 · 2020 · External reference
MMP1 and MMP7 as potential peripheral blood biomarkers in idiopathic pulmonary fibrosis
10.1371/journal.pmed.0050093 · 2008 · External reference
MMP-7 is a predictive biomarker of disease progression in patients with idiopathic pulmonary fibrosis
10.1183/23120541.00074-2016 · 2017 · External reference
Pre‐treatment MMP7 Predicts progressive idiopathic pulmonary fibrosis in antifibrotic treated patients
10.1111/resp.14894 · 2025 · External reference
Macrophage migration inhibitory factor (MIF): a multifaceted cytokine regulated by genetic and physiological strategies
10.1016/j.pharmthera.2021.108024 · 2022 · External reference
Midkine (MDK) in cancer and drug resistance: from inflammation to therapy
10.1007/s12672-025-02941-1 · 2025 · External reference
The importance of estimating the therapeutic index in the development of matrix metalloproteinase inhibitors
10.1016/j.cardiores.2005.11.032 · 2006 · External reference
Uridine as a hub in cancer metabolism and RNA biology
10.1038/s12276-025-01402-7 · 2025 · External reference
Uridine and its role in metabolic diseases, tumors, and neurodegenerative diseases
2024 · External reference
Matrix metalloproteinase-7 is a urinary biomarker and pathogenic mediator of kidney fibrosis
10.1681/asn.2016030354 · 2017 · External reference
Mapping spatially resolved transcriptomes in human and mouse pulmonary fibrosis
10.1038/s41588-024-01819-2 · 2024 · External reference
