Research graph
References from A Mir338-CDK8-mitochondrial axis governs lineage-specific osteogenesis and defines Runx2 pleiotropy in cranial sutures. Local targets link to admitted publications; unresolved targets remain external evidence.
The many bits of positional information
10.1242/dev.176065 · 2021 · External reference
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10.1016/j.cell.2024.05.053 · 2024 · External reference
Cranial Suture Mesenchymal Stem Cells: Insights and advances
10.3390/biom11081129 · 2021 · External reference
The suture provides a niche for mesenchymal stem cells of craniofacial bones
10.1038/ncb3139 · 2015 · External reference
The intertwined evolution and development of sutures and cranial morphology
10.3389/fcell.2021.653579 · 2021 · External reference
Dchs1-Fat4 regulation of osteogenic differentiation in mouse
10.1242/dev.176776 · 2019 · External reference
FGFR3 mutation causes abnormal membranous ossification in achondroplasia
10.1093/hmg/ddu004 · 2014 · External reference
Wnt/β-catenin signaling in craniomaxillofacial osteocytes
10.1007/s11914-023-00775-w · 2023 · External reference
Cranial suture lineage and contributions to repair of the mouse skull
10.1242/dev.202116 · 2024 · External reference
Skeletal stem and progenitor cells maintain cranial suture patency and prevent craniosynostosis
10.1038/s41467-021-24801-6 · 2021 · External reference
The balance of WNT and FGF signaling influences mesenchymal stem cell fate during skeletal development
10.1126/scisignal.2000727 · 2010 · External reference
Runx2 regulates cranial suture closure by inducing hedgehog, Fgf, Wnt and Pthlh signaling pathway gene expressions in suture mesenchymal cells
10.1093/hmg/ddy386 · 2019 · External reference
Mutations of ephrin-B1 (EFNB1), a marker of tissue boundary formation, cause craniofrontonasal syndrome
10.1073/pnas.0402819101 · 2004 · External reference
Cbfa1, a candidate gene for cleidocranial dysplasia syndrome, is essential for osteoblast differentiation and bone development
10.1016/s0092-8674(00)80259-7 · 1997 · External reference
Genetic analysis of Runx2 function during intramembranous ossification
10.1242/dev.128793 · 2015 · External reference
Runx2 function in cells of neural crest origin during intramembranous ossification
10.1016/j.bbrc.2019.01.059 · 2019 · External reference
Circulating miR-338 cluster activities on osteoblast differentiation: potential diagnostic and therapeutic targets for postmenopausal osteoporosis
10.7150/thno.34493 · 2019 · External reference
Inhibition of miR338 rescues cleidocranial dysplasia in Runx2 mutant mice partially via the Hif1a-Vegfa axis
10.1038/s12276-022-00914-w · 2023 · External reference
Comprehensive integration of single-cell data
10.1016/j.cell.2019.05.031 · 2019 · External reference
Fast, sensitive and accurate integration of single-cell data with Harmony
10.1038/s41592-019-0619-0 · 2019 · External reference
Single-cell expression profiling reveals dynamic flux of cardiac stromal, vascular and immune cells in health and injury
10.7554/elife.43882 · 2019 · External reference
Near-optimal probabilistic RNA-seq quantification
10.1038/nbt.3519 · 2016 · External reference
Differential analysis of RNA-seq incorporating quantification uncertainty
10.1038/nmeth.4324 · 2017 · External reference
Fast gapped-read alignment with Bowtie 2
10.1038/nmeth.1923 · 2012 · External reference
miRBase: microRNA sequences and annotation
10.1002/0471250953.bi1209s29 · 2010 · External reference
Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2
10.1186/s13059-014-0550-8 · 2014 · External reference
Meta- and orthogonal integration of influenza “OMICs” data defines a role for UBR4 in virus budding
10.1016/j.chom.2015.11.002 · 2015 · External reference
Harnessing a feasible and versatile ex vivo calvarial suture 2-D culture system to study suture biology
10.3389/fphys.2022.823661 · 2022 · External reference
MethPrimer: designing primers for methylation PCRs
10.1093/bioinformatics/18.11.1427 · 2002 · External reference
MicroRNAs can generate thresholds in target gene expression
10.1038/ng.905 · 2011 · External reference
The multiMiR R package and database: integration of microRNA–target interactions along with their disease and drug associations
10.1093/nar/gku631 · 2014 · External reference
MicroRNA-155 inhibits the osteogenic differentiation of mesenchymal stem cells induced by BMP9 via downregulation of BMP signaling pathway
2018 · External reference
miR-106b-5p and miR-17-5p suppress osteogenic differentiation by targeting Smad5 and inhibit bone formation
10.1016/j.yexcr.2016.07.010 · 2016 · External reference
miR-221-3p and miR-222-3p downregulation promoted osteogenic differentiation of bone marrow mesenchyme stem cells through IGF-1/ERK pathway under high glucose condition
10.1016/j.diabres.2020.108121 · 2020 · External reference
Overexpression of miR-182 inhibits ossification of ligamentum flavum cells by targeting NAMPT
10.1016/j.yexcr.2018.03.008 · 2018 · External reference
Exosomes derived from mesenchymal stromal cells promote bone regeneration by delivering miR-182–5p-inhibitor
10.1016/j.phrs.2023.106798 · 2023 · External reference
Ortho-silicic acid enhances osteogenesis of osteoblasts through the upregulation of miR-130b which directly targets PTEN
10.1016/j.lfs.2020.118680 · 2021 · External reference
Effects of miR-335-5p in modulating osteogenic differentiation by specifically downregulating Wnt antagonist DKK1
10.1002/jbmr.377 · 2011 · External reference
MiR-503 promotes bone formation in distraction osteogenesis through suppressing Smurf1 expression
10.1038/s41598-017-00466-4 · 2017 · External reference
MicroRNA-322 (miR-322) and its target protein Tob2 modulate osterix (Osx) mRNA stability
10.1074/jbc.m112.432104 · 2013 · External reference
Functions of osteocalcin in bone, pancreas, testis, and muscle
10.3390/ijms21207513 · 2020 · External reference
Runx2, an inducer of osteoblast and chondrocyte differentiation
10.1007/s00418-018-1640-6 · 2018 · External reference
Dynamics and cellular localization of Bmp2, Bmp4, and noggin transcription in the postnatal mouse skeleton
10.1002/jbmr.2313 · 2015 · External reference
Regulation and function of SOX9 during cartilage development and regeneration
10.1016/j.semcancer.2020.04.008 · 2020 · External reference
Overview of MMP-13 as a promising target for the treatment of osteoarthritis
10.3390/ijms22041742 · 2021 · External reference
Mice lacking the matrilin family of extracellular matrix proteins develop mild skeletal abnormalities and are susceptible to age-associated osteoarthritis
10.3390/ijms21020666 · 2020 · External reference
Morphology of the development of the sagittal suture of mice
10.1007/s004290050127 · 1998 · External reference
Cranial suture regeneration mitigates skull and neurocognitive defects in craniosynostosis
10.1016/j.cell.2020.11.037 · 2021 · External reference
Embryonic requirements for Tcf12 in the development of the mouse coronal suture
10.1242/dev.199575 · 2022 · External reference
Single-cell analysis identifies a key role for Hhip in murine coronal suture development
10.1038/s41467-021-27402-5 · 2021 · External reference
Pax3 and hippo signaling coordinate melanocyte gene expression in neural crest
10.1016/j.celrep.2014.10.061 · 2014 · External reference
PAX transcription factors in neural crest development
10.1016/j.semcdb.2015.09.015 · 2015 · External reference
The developing mouse coronal suture at single-cell resolution
10.1038/s41467-021-24917-9 · 2021 · External reference
Conditional disruption of miR17-92 cluster in collagen type I-producing osteoblasts results in reduced periosteal bone formation and bone anabolic response to exercise
10.1152/physiolgenomics.00107.2014 · 2015 · External reference
microRNA function in craniofacial bone formation
2022 · External reference
Differential activation of canonical Wnt signaling determines cranial sutures fate: a novel mechanism for sagittal suture craniosynostosis
10.1016/j.ydbio.2010.06.009 · 2010 · External reference
Cranial suture biology. Current topics in developmental biology
2005 · External reference
Postnatal calvarial skeletal stem cells expressing PRX1 reside exclusively in the calvarial sutures and are required for bone regeneration
10.1016/j.stemcr.2017.03.002 · 2017 · External reference
Cranial neural crest cells contribution to craniofacial bone development and regeneration
10.1007/s11914-023-00804-8 · 2023 · External reference
Understanding paraxial mesoderm development and sclerotome specification for skeletal repair
10.1038/s12276-020-0482-1 · 2020 · External reference
Integrated transcriptome and network analysis reveals spatiotemporal dynamics of calvarial suturogenesis
10.1016/j.celrep.2020.107871 · 2020 · External reference
The role of mitochondria in osteogenic, adipogenic and chondrogenic differentiation of mesenchymal stem cells
10.1007/s13238-017-0385-7 · 2017 · External reference
Mechanisms of mitochondrial respiratory adaptation
10.1038/s41580-022-00506-6 · 2022 · External reference
The multifaceted roles of mitochondria in osteoblasts: from energy production to mitochondrial-derived vesicle secretion
10.1093/jbmr/zjae088 · 2024 · External reference
Mitochondrial fragmentation and donut formation enhance mitochondrial secretion to promote osteogenesis
10.1016/j.cmet.2023.01.003 · 2023 · External reference
SIRT3/SOD2 maintains osteoblast differentiation and bone formation by regulating mitochondrial stress
10.1038/cdd.2017.144 · 2018 · External reference
RUNX2 co‐operates with EGR1 to regulate osteogenic differentiation through Htra1 enhancers
10.1002/jcp.29704 · 2020 · External reference
BMP2-dependent gene regulatory network analysis reveals Klf4 as a novel transcription factor of osteoblast differentiation
10.1038/s41419-021-03480-7 · 2021 · External reference
Accessory subunits are integral for assembly and function of human mitochondrial complex I
10.1038/nature19754 · 2016 · External reference
Mitochondrial complex I
10.1146/annurev-biochem-070511-103700 · 2013 · External reference
Optimization of differential filtration-based mitochondrial isolation for mitochondrial transplant to cerebral organoids
10.1186/s13287-023-03436-y · 2023 · External reference
Cdk8/CDK19 promotes mitochondrial fission through Drp1 phosphorylation and can phenotypically suppress pink1 deficiency in Drosophila
10.1038/s41467-024-47623-8 · 2024 · External reference
Assessing the mechanism and therapeutic potential of modulators of the human Mediator complex-associated protein kinases
10.7554/elife.20722 · 2016 · External reference
Mitochondrial regulation of stem cells in bone homeostasis
10.1016/j.molmed.2019.04.008 · 2020 · External reference
Active mitochondria support osteogenic differentiation by stimulating β-catenin acetylation
10.1074/jbc.ra118.004102 · 2018 · External reference
Mitochondria in mesenchymal stem cell biology and cell therapy: from cellular differentiation to mitochondrial transfer
10.1016/j.semcdb.2016.02.011 · 2016 · External reference
Mutations involving the transcription factor CBFA1 cause cleidocranial dysplasia
10.1016/s0092-8674(00)80260-3 · 1997 · External reference
An Evolutionary conserved signaling network between mouse and human underlies the differential osteoskeletal potential of frontal and parietal calvarial bones
10.3389/fphys.2021.747091 · 2021 · External reference
Biomaterials-based approaches to mandibular tissue engineering: where we were, where we are, where we are going
10.1093/rb/rbaf024 · 2025 · External reference
Biomimetic tissue‐engineered bone substitutes for maxillofacial and craniofacial repair: the potential of cell sheet technologies
10.1002/adhm.201700919 · 2018 · External reference
Use of human dental pulp and endothelial cell seeded tyrosine-derived polycarbonate scaffolds for robust in vivo alveolar jaw bone regeneration
10.3389/fbioe.2020.00796 · 2020 · External reference
Glutamine: a novel player in maintaining skeletal strength and body fitness in obese mice
10.1016/j.clnu.2025.09.018 · 2025 · External reference
Exercise for optimizing bone health after hormone-induced increases in bone stiffness
10.3389/fendo.2023.1219454 · 2023 · External reference
