Research graph
References from IL-15 drives antigen-independent increase in granzyme K+B+ CD8 T cells enriched in rheumatoid arthritis joints. Local targets link to admitted publications; unresolved targets remain external evidence.
The HLA-DRB1 shared epitope alleles are primarily a risk factor for anti-cyclic citrullinated peptide antibodies and are not an independent risk factor for development of rheumatoid arthritis
10.1002/art.21739 · 2006 · External reference
Characterization of effector memory CD8+ T cells in the synovial fluid of rheumatoid arthritis
10.1007/s10875-012-9674-3 · 2012 · External reference
CD8+ T cell profiles in patients with rheumatoid arthritis and their relationship to disease activity
10.1002/art.38941 · 2015 · External reference
Preferential accumulation of activated Th1 cells not only in rheumatoid arthritis but also in osteoarthritis joints
10.3899/jrheum.101355 · 2011 · External reference
Arthritis flares mediated by tissue-resident memory T cells in the joint
10.1016/j.celrep.2021.109902 · 2021 · External reference
Defining inflammatory cell states in rheumatoid arthritis joint synovial tissues by integrating single-cell transcriptomics and mass cytometry
10.1038/s41590-019-0378-1 · 2019 · External reference
Granzyme K+ CD8 T cells form a core population in inflamed human tissue
10.1126/scitranslmed.abo0686 · 2022 · External reference
Granzyme K activates the entire complement cascade
10.1038/s41586-025-08713-9 · 2025 · External reference
Induction of bystander T cell proliferation by viruses and type I interferon in vivo
10.1126/science.272.5270.1947 · 1996 · External reference
Significance of bystander T cell activation in microbial infection
10.1038/s41590-021-00985-3 · 2022 · External reference
Specificity of T cells in synovial fluid: high frequencies of CD8(+) T cells that are specific for certain viral epitopes
10.1186/ar80 · 2000 · External reference
Epitope specificity of clonally expanded populations of CD8+ T cells found within the joints of patients with inflammatory arthritis
10.1002/1529-0131(200109)44:9<2038::aid-art353>3.0.co;2-1 · 2001 · External reference
T cell response to Epstein-Barr virus transactivators in chronic rheumatoid arthritis
10.1084/jem.184.5.1791 · 1996 · External reference
Clonal associations between lymphocyte subsets and functional states in rheumatoid arthritis synovium
10.1038/s41467-024-49186-0 · 2024 · External reference
Deconstruction of rheumatoid arthritis synovium defines inflammatory subtypes
10.1038/s41586-023-06708-y · 2023 · External reference
TCR signaling via NFATc1 constrains IL-15-induced bystander activation of human memory CD8+ T cells
2025 · External reference
The role of interleukin-15 in T-cell migration and activation in rheumatoid arthritis
10.1038/nm0296-175 · 1996 · External reference
Human granzyme K is a feature of innate T cells in blood, tissues, and tumors, responding to cytokines rather than TCR stimulation
10.4049/jimmunol.2300083 · 2023 · External reference
GZMKhigh CD8+ T effector memory cells are associated with CD15high neutrophil abundance in non-metastatic colorectal tumors and predict poor clinical outcome
10.1038/s41467-022-34467-3 · 2022 · External reference
Single-cell immune profiling reveals functional diversity of T cells in tuberculous pleural effusion
10.1084/jem.20211777 · 2022 · External reference
Characteristics and functions of an atypical inflammation-associated GZMK+GZMB+CD8+ T subset in people living with HIV-1
10.1016/j.molimm.2024.07.003 · 2024 · External reference
Comprehensive profiling of an aging immune system reveals clonal GZMK+ CD8+ T cells as conserved hallmark of inflammaging
10.1016/j.immuni.2020.11.005 · 2021 · External reference
GZMK+CD8+ T cells: multifaceted roles beyond cytotoxicity
10.1016/j.it.2025.06.003 · 2025 · External reference
Single-cell profiling reveals pathogenic role and differentiation trajectory of granzyme K+CD8+ T cells in primary Sjögren’s syndrome
10.1172/jci.insight.167490 · 2023 · External reference
How important are T cells in chronic rheumatoid synovitis?
10.1002/art.1780330602 · 1990 · External reference
Infection history determines the differentiation state of human CD8+ T cells
10.1128/jvi.03478-14 · 2015 · External reference
Granzyme K+CD8+ T cells interact with fibroblasts to promote neutrophilic inflammation in nasal polyps
10.1038/s41467-024-54685-1 · 2024 · External reference
Innate-like cytotoxic function of bystander-activated CD8+ T cells is associated with liver injury in acute hepatitis A
10.1016/j.immuni.2017.11.025 · 2018 · External reference
Contribution of herpesvirus specific CD8 T cells to anti-viral T cell response in humans
10.1371/journal.ppat.1001051 · 2010 · External reference
IL-15 enhances CCR5-mediated migration of memory CD8+ T cells by upregulating CCR5 expression in the absence of TCR stimulation
10.1016/j.celrep.2021.109438 · 2021 · External reference
