Research graph
References from Natural Asp-tRNA Synthetase Fragment Targets Myofibroblasts to Abrogate Tissue Fibrosis. Local targets link to admitted publications; unresolved targets remain external evidence.
Mechanisms of fibrosis: therapeutic translation for fibrotic disease
10.1038/nm.2807 · 2012 · External reference
Targeting metabolic dysregulation for fibrosis therapy
10.1038/s41573-019-0040-5 · 2020 · External reference
Fibrotic disease and the T(H)1/T(H)2 paradigm
10.1038/nri1412 · 2004 · External reference
Fibroblast and myofibroblast activation in normal tissue repair and fibrosis
10.1038/s41580-024-00716-0 · 2024 · External reference
Evasion of apoptosis by myofibroblasts: a hallmark of fibrotic diseases
10.1038/s41584-019-0324-5 · 2020 · External reference
Essential nontranslational functions of tRNA synthetases
10.1038/nchembio.1158 · 2013 · External reference
10.1002/emmm.201100626
10.1002/emmm.201100626 · External reference
Two distinct cytokines released from a human aminoacyl-tRNA synthetase
10.1126/science.284.5411.147 · 1999 · External reference
The role of tRNA synthetases in neurological and neuromuscular disorders
10.1002/1873-3468.12962 · 2018 · External reference
Serum-circulating His-tRNA synthetase inhibits organ-targeted immune responses Cell
10.1038/s41423-019-0331-0 · 2021 · External reference
10.1038/s12276-022-00765-5
10.1038/s12276-022-00765-5 · External reference
Glutamyl-prolyl-tRNA synthetase 1 coordinates early endosomal anti-inflammatory AKT signaling
10.1038/s41467-022-34226-4 · 2022 · External reference
Arginyl-tRNA synthetase in inflammation
10.1038/s41556-023-01090-3 · 2023 · External reference
A human histidyl-tRNA synthetase splice variant therapeutic targets NRP2 to resolve lung inflammation and fibrosis
10.1126/scitranslmed.adp4754 · 2025 · External reference
New functions of aminoacyl-tRNA synthetases beyond translation
10.1038/nrm2956 · 2010 · External reference
Architecture and metamorphosis
10.1007/128_2013_424 · 2014 · External reference
Human tRNA synthetase catalytic nulls with diverse functions
10.1126/science.1252943 · 2014 · External reference
Extracellular tyrosyl-tRNA synthetase cleaved by plasma proteinases and stored in platelet alpha-granules: Potential role in monocyte activation
10.1002/rth2.12429 · 2020 · External reference
Cleavage by granzyme B is strongly predictive of autoantigen status: implications for initiation of autoimmunity
10.1084/jem.190.6.815 · 1999 · External reference
10.1101/2024.09.09.612016
10.1101/2024.09.09.612016 · External reference
The dark proteome: translation from noncanonical open reading frames
10.1016/j.tcb.2021.10.010 · 2022 · External reference
Noncanonical microprotein regulation of immunity
10.1016/j.ymthe.2024.05.021 · 2024 · External reference
Macroevolutionary foundations of a recently evolved innate immune defense
10.1111/evo.14316 · 2021 · External reference
LTBPs in biology and medicine: LTBP diseases
10.1016/j.matbio.2017.11.014 · 2018 · External reference
Impact of structural modifications of IgG antibodies on effector functions
2023 · External reference
Disulfide by Design 2.0: a web-based tool for disulfide engineering in proteins
10.1186/1471-2105-14-346 · 2013 · External reference
Fc-fusion proteins and FcRn: structural insights for longer-lasting and more effective therapeutics
10.3109/07388551.2013.834293 · 2015 · External reference
SB-431542 is a potent and specific inhibitor of transforming growth factor-beta superfamily type I activin receptor-like kinase (ALK) receptors ALK4, ALK5, and ALK7
10.1124/mol.62.1.65 · 2002 · External reference
Inhibition of activin receptor-like kinase 5 attenuates bleomycin-induced pulmonary fibrosis
10.1016/j.yexmp.2006.12.003 · 2007 · External reference
Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles
10.1073/pnas.0506580102 · 2005 · External reference
PGC-1alpha-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes
10.1038/ng1180 · 2003 · External reference
Standardized quantification of pulmonary fibrosis in histological samples
10.2144/000112729 · 2008 · External reference
Guided construction of single cell reference for human and mouse lung
10.1038/s41467-023-40173-5 · 2023 · External reference
Antifibrotic role of vascular endothelial growth factor in pulmonary fibrosis
10.1172/jci.insight.92192 · 2017 · External reference
Potential of nintedanib in treatment of progressive fibrosing interstitial lung diseases
10.1183/13993003.00161-2019 · 2019 · External reference
Effect of pirfenidone on proliferation, TGF-beta-induced myofibroblast differentiation and fibrogenic activity of primary human lung fibroblasts
10.1016/j.ejps.2014.02.014 · 2014 · External reference
Antifibrotic therapy for idiopathic pulmonary fibrosis: time to treat
10.1186/s12931-019-1161-4 · 2019 · External reference
Resolution of organ fibrosis
10.1172/jci93563 · 2018 · External reference
Myofibroblast fate plasticity in tissue repair and fibrosis: Deactivation, apoptosis, senescence and reprogramming
10.1111/wrr.12952 · 2021 · External reference
10.1038/s41586-020-2938-9
10.1038/s41586-020-2938-9 · External reference
Homeostasis of peripheral CD4+ T cells: IL-2R alpha and IL-2 shape a population of regulatory cells that controls CD4+ T cell numbers
10.4049/jimmunol.169.9.4850 · 2002 · External reference
10.1007/s10238-022-00945-7
10.1007/s10238-022-00945-7 · External reference
The extracellular matrix as a key regulator of intracellular signalling networks
10.1111/bph.14195 · 2019 · External reference
DTASelect and Contrast: tools for assembling and comparing protein identifications from shotgun proteomics
10.1021/pr015504q · 2002 · External reference
Age and sex dimorphisms contribute to the severity of bleomycin-induced lung injury and fibrosis
10.1152/ajplung.00122.2011 · 2011 · External reference
A murine model of irreversible and reversible unilateral ureteric obstruction
2014 · External reference
Integrated analysis of multimodal single-cell data
10.1016/j.cell.2021.04.048 · 2021 · External reference
Scater: pre-processing, quality control, normalization and visualization of single-cell RNA-seq data in R
10.1093/bioinformatics/btw777 · 2017 · External reference
Fast, sensitive and accurate integration of single-cell data with Harmony
10.1038/s41592-019-0619-0 · 2019 · External reference
Robust decomposition of cell type mixtures in spatial transcriptomics
10.1038/s41587-021-00830-w · 2022 · External reference
Perturbation-response genes reveal signaling footprints in cancer gene expression
10.1038/s41467-017-02391-6 · 2018 · External reference
clusterProfiler 4.0: A universal enrichment tool for interpreting omics data
2021 · External reference
