Research graph
References from Intrinsically disordered regions of Src and Abl kinases contribute to membrane binding. Local targets link to admitted publications; unresolved targets remain external evidence.
Regulation of membrane protein structure and function by their lipid nano-environment
10.1038/s41580-022-00524-4 · 2023 · External reference
Membrane Protein Structure, Function, and Dynamics: a Perspective from Experiments and Theory
10.1007/s00232-015-9802-0 · 2015 · External reference
A regulatory role of membrane by direct modulation of the catalytic kinase domain
10.1080/21541248.2020.1788886 · 2021 · External reference
Structural basis of Focal Adhesion Kinase activation on lipid membranes
10.15252/embj.2020104743 · 2020 · External reference
Structural and mechanistic insights into mechanoactivation of focal adhesion kinase
10.1073/pnas.1820567116 · 2019 · External reference
Mechanical force can enhance c-Src kinase activity by impairing autoinhibition
10.1016/j.bpj.2022.01.028 · 2022 · External reference
Amino-terminal basic residues of Src mediate membrane binding through electrostatic interaction with acidic phospholipids
10.1073/pnas.91.25.12253 · 1994 · External reference
Structural Thermodynamics of myr-Src(2–19) Binding to Phospholipid Membranes
10.1016/j.bpj.2015.06.051 · 2015 · External reference
Myristoyl’s dual role in allosterically regulating and localizing Abl kinase
10.7554/elife.85216.sa2 · 2023 · External reference
Association of Human Immunodeficiency Virus Nef Protein with Actin is Myristoylation Dependent and Influences its Subcellular Localization
10.1111/j.1432-1033.1997.00843.x · 1997 · External reference
HIV-1 Nef membrane association depends on charge, curvature, composition and sequence
10.1038/nchembio.268 · 2010 · External reference
Role of myristoylation and N-terminal basic residues in membrane association of the human immunodeficiency virus type 1 Nef protein
10.1099/vir.0.81200-0 · 2006 · External reference
Integrin adhesion and force coupling are independently regulated by localized PtdIns(4,5)2 synthesis
10.1038/emboj.2011.332 · 2011 · External reference
Spatial and temporal regulation of focal adhesion kinase activity in living cells
10.1128/mcb.01324-07 · 2008 · External reference
Phosphatidylinositol 4,5-bisphosphate triggers activation of focal adhesion kinase by inducing clustering and conformational changes
10.1073/pnas.1317022111 · 2014 · External reference
PI(4,5)P2: signaling the plasma membrane
10.1042/bcj20220445 · 2022 · External reference
A computational model for the electrostatic sequestration of PI(4,5)P2 by membrane-adsorbed basic peptides
10.1016/s0006-3495(04)74260-5 · 2004 · External reference
Multivalent Cation-Bridged PI(4,5)P2 Clusters Form at Very Low Concentrations
10.1016/j.bpj.2018.04.048 · 2018 · External reference
Src activation and translocation from focal adhesions to membrane ruffles contribute to formation of new adhesion sites
10.1007/s00018-008-8424-4 · 2009 · External reference
The Abl and Arg non-receptor tyrosine kinases regulate different zones of stress fiber, focal adhesion, and contractile network localization in spreading fibroblasts
10.1002/cm.20479 · 2010 · External reference
UCSF Chimera–a visualization system for exploratory research and analysis
10.1002/jcc.20084 · 2004 · External reference
CHARMM-GUI: A web-based graphical user interface for CHARMM
10.1002/jcc.20945 · 2008 · External reference
CHARMM-GUI Input Generator for NAMD, GROMACS, AMBER, OpenMM, and CHARMM/OpenMM Simulations Using the CHARMM36 Additive Force Field
10.1021/acs.jctc.5b00935 · 2016 · External reference
The focusing positions of polypeptides in immobilized pH gradients can be predicted from their amino acid sequences
10.1002/elps.11501401163 · 1993 · External reference
Reference points for comparisons of two-dimensional maps of proteins from different human cell types defined in a pH scale where isoelectric points correlate with polypeptide compositions
10.1002/elps.1150150171 · 1994 · External reference
10.1385/1-59259-890-0:571
10.1385/1-59259-890-0:571 · External reference
Prediction of amphipathic in-plane membrane anchors in monotopic proteins using a SVM classifier
10.1186/1471-2105-7-255 · 2006 · External reference
PI(4,5)P2 Clustering and Its Impact on Biological Functions
10.1146/annurev-biochem-070920-094827 · 2021 · External reference
Mechanism of Focal Adhesion Kinase Mechanosensing
10.1371/journal.pcbi.1004593 · 2015 · External reference
Allosteric regulation of focal adhesion kinase by PIP2 and ATP
10.1016/j.bpj.2014.11.3454 · 2015 · External reference
GROMACS: fast, flexible, and free
10.1002/jcc.20291 · 2005 · External reference
GROMACS: High performance molecular simulations through multi-level parallelism from laptops to supercomputers
10.1016/j.softx.2015.06.001 · 2015 · External reference
Optimization of the additive CHARMM all-atom protein force field targeting improved sampling of the backbone phi, psi and side-chain chi(1) and chi(2) dihedral angles
10.1021/ct300400x · 2012 · External reference
CHARMM36 all-atom additive protein force field: Validation based on comparison to NMR data
10.1002/jcc.23354 · 2013 · External reference
Update of the CHARMM all-atom additive force field for lipids: validation on six lipid types
10.1021/jp101759q · 2010 · External reference
Building Force Fields: An Automatic, Systematic, and Reproducible Approach
10.1021/jz500737m · 2014 · External reference
Simulations of lipid bilayers using the CHARMM36 force field with the TIP3P-FB and TIP4P-FB water models
10.7717/peerj.5472 · 2018 · External reference
Canonical sampling through velocity rescaling
10.1063/1.2408420 · 2007 · External reference
Molecular dynamics with coupling to an external bath
10.1063/1.448118 · 1984 · External reference
Polymorphic transitions in single crystals: A new molecular dynamics method
10.1063/1.328693 · 1981 · External reference
LINCS: A linear contraint solver for molecular simulations
10.1002/(sici)1096-987x(199709)18:12<1463::aid-jcc4>3.0.co;2-h · 1997 · External reference
Particle mesh Ewald: An Nlog(N) method for Ewald sums in large systems
10.1063/1.464397 · 1993 · External reference
gwham - A free weighted histogram analysis implementation including robust error and autocorrelation estimates
10.1021/ct100494z · 2010 · External reference
DSSP in GROMACS: Tool for Defining Secondary Structures of Proteins in Trajectories
10.1021/acs.jcim.3c01344 · 2024 · External reference
Computational analysis of local membrane properties
10.1007/s10822-013-9684-0 · 2013 · External reference
The PRIDE database at 20 years: 2025 update
10.1093/nar/gkae1011 · 2025 · External reference
Phosphatidylinositol 4,5-Bisphosphate (PI(4,5)P2)-dependent Oligomerization of Fibroblast Growth Factor 2 (FGF2) Triggers the Formation of a Lipidic Membrane Pore Implicated in Unconventional Secretion
10.1074/jbc.m112.381939 · 2012 · External reference
Performance of CHARMM36m with modified water model in simulating intrinsically disordered proteins: a case study
10.1007/s41048-020-00107-w · 2020 · External reference
How multisite phosphorylation impacts the conformations of intrinsically disordered proteins
10.1371/journal.pcbi.1008939 · 2021 · External reference
Novel Phosphotidylinositol 4,5-Bisphosphate Binding Sites on Focal Adhesion Kinase
10.1371/journal.pone.0132833 · 2015 · External reference
Mechanistic principles underlying regulation of the actin cytoskeleton by phosphoinositides
10.1073/pnas.1705032114 · 2017 · External reference
Cholesterol promotes clustering of PI(4,5)P2 driving unconventional secretion of FGF2
10.1083/jcb.202106123 · 2022 · External reference
Structural basis for the autoinhibition of c-Abl tyrosine kinase
10.1016/s0092-8674(03)00194-6 · 2003 · External reference
A myristoyl/phosphotyrosine switch regulates c-Abl
10.1016/s0092-8674(03)00191-0 · 2003 · External reference
A Dimerization Function in the Intrinsically Disordered N-Terminal Region of Src
10.1016/j.celrep.2018.09.035 · 2018 · External reference
Intramolecular dynamics within the N-Cap-SH3-SH2 regulatory unit of the c-Abl tyrosine kinase reveal targeting to the cellular membrane
10.1074/jbc.m113.500926 · 2013 · External reference
Tyrosine 416 Is Phosphorylated in the Closed, Repressed Conformation of c-Src
10.1371/journal.pone.0071035 · 2013 · External reference
Visualizing the mechanical activation of Src
10.1038/nature03469 · 2005 · External reference
An Abl-FBP17 mechanosensing system couples local plasma membrane curvature and stress fiber remodeling during mechanoadaptation
10.1038/s41467-019-13782-2 · 2019 · External reference
Abl and Canoe/Afadin mediate mechanotransduction at tricellular junctions
10.1126/science.aba5528 · 2020 · External reference
Binding of acylated peptides and fatty acids to phospholipid vesicles: pertinence to myristoylated proteins
10.1021/bi00090a020 · 1993 · External reference
Electrostatics and the membrane association of Src: theory and experiment
10.1021/bi972012b · 1998 · External reference
Regulation of F-actin-dependent processes by the Abl family of tyrosine kinases
10.1242/jcs.00622 · 2003 · External reference
Focal adhesion kinase-dependent focal adhesion recruitment of SH2 domains directs SRC into focal adhesions to regulate cell adhesion and migration
10.1038/srep18476 · 2015 · External reference
