Research graph
References from N-terminal phosphatase of soluble epoxide hydrolase forms anandamide from anandamide phosphate. Local targets link to admitted publications; unresolved targets remain external evidence.
The N-terminal domain of mammalian soluble epoxide hydrolase is a phosphatase
10.1073/pnas.0437829100 · 2003 · External reference
The soluble epoxide hydrolase encoded by EPXH2 is a bifunctional enzyme with novel lipid phosphate phosphatase activity
10.1073/pnas.0437724100 · 2003 · External reference
Phosphatase activity of soluble epoxide hydrolase
10.1016/j.prostaglandins.2017.07.002 · 2017 · External reference
Soluble epoxide hydrolase: gene structure, expression and deletion
10.1016/j.gene.2013.05.008 · 2013 · External reference
Soluble epoxide hydrolase as a therapeutic target for pain, inflammatory and neurodegenerative diseases
10.1016/j.pharmthera.2017.06.006 · 2017 · External reference
Lipid sulfates and sulfonates are allosteric competitive inhibitors of the N-terminal phosphatase activity of the mammalian soluble epoxide hydrolase
10.1021/bi050842g · 2005 · External reference
Effects of human soluble epoxide hydrolase polymorphisms on isoprenoid phosphate hydrolysis
10.1016/j.bbrc.2005.12.180 · 2006 · External reference
Lysophosphatidic acids are new substrates for the phosphatase domain of soluble epoxide hydrolase
10.1194/jlr.m022319 · 2012 · External reference
Role of soluble epoxide hydrolase phosphatase activity in the metabolism of lysophosphatidic acids
10.1016/j.bbrc.2012.02.108 · 2012 · External reference
Contribution of hydrolase and phosphatase domains in soluble epoxide hydrolase to vascular endothelial growth factor expression and cell growth
10.1248/bpb.32.1962 · 2009 · External reference
N-terminal domain of soluble epoxide hydrolase negatively regulates the VEGF-mediated activation of endothelial nitric oxide synthase
10.1093/cvr/cvr267 · 2012 · External reference
Role of phosphatase activity of soluble epoxide hydrolase in regulating simvastatin-activated endothelial nitric oxide synthase
10.1038/srep13524 · 2015 · External reference
Opposite regulation of cholesterol levels by the phosphatase and hydrolase domains of soluble epoxide hydrolase
10.1074/jbc.m806315200 · 2008 · External reference
Alteration in plasma testosterone levels in male mice lacking soluble epoxide hydrolase
10.1152/ajpendo.00131.2009 · 2009 · External reference
The phosphatase activity of soluble epoxide hydrolase regulates ATP-binding cassette transporter-A1-dependent cholesterol efflux
10.1111/jcmm.14519 · 2019 · External reference
CRISPR/Cas9-mediated inactivation of the phosphatase activity of soluble epoxide hydrolase prevents obesity and cardiac ischemic injury
10.1016/j.jare.2022.03.004 · 2023 · External reference
Mice deficient in the phosphatase activity of sEH show decreased levels of the endocannabinoid 2-AG in the olfactory bulb and depressive-like behavior
10.1002/1873-3468.14984 · 2024 · External reference
N-Substituted amino acid inhibitors of the phosphatase domain of the soluble epoxide hydrolase
10.1016/j.bbrc.2019.05.088 · 2019 · External reference
Identification of aminobenzoic acids as selective inhibitors of the N-terminal phosphatase of soluble epoxide hydrolase
10.1093/bbb/zbad016 · 2023 · External reference
Soluble epoxide hydrolase maintains steady-state lipid turnover linked with autocrine signaling in peritoneal macrophages
10.1016/j.isci.2023.107465 · 2023 · External reference
Potent Efficacy of 3-Amino-4-hydroxy Benzoic Acid, a Small Molecule Having Anti-fibrotic Activity, in a Mouse Model of Non-alcoholic Steatohepatitis
10.1248/bpb.b23-00771 · 2024 · External reference
Soluble epoxide hydrolase as an anti-inflammatory target of the thrombolytic stroke drug SMTP-7
10.1074/jbc.m114.588087 · 2014 · External reference
Impact of SMTP Targeting Plasminogen and Soluble Epoxide Hydrolase on Thrombolysis, Inflammation, and Ischemic Stroke
10.3390/ijms22020954 · 2021 · External reference
Small-molecule modulators of the zymogen activation in the fibrinolytic and coagulation systems
10.1111/j.1742-4658.2010.07783.x · 2010 · External reference
SMTP-7, a novel small-molecule thrombolytic for ischemic stroke: a study in rodents and primates
10.1038/jcbfm.2013.191 · 2014 · External reference
Development of an HTS assay for EPHX2 phosphatase activity and screening of nontargeted libraries
10.1016/j.ab.2012.11.017 · 2013 · External reference
Structural refinement of inhibitors of urea-based soluble epoxide hydrolases
10.1016/s0006-2952(02)00952-8 · 2002 · External reference
HMG-CoA reductase inhibitors
10.1039/np9931000541 · 1993 · External reference
Recent Progress in
2025 · External reference
Biosynthesis and metabolism of endocannabinoids and their congeners from the monoacylglycerol and N-acyl-ethanolamine families
10.1016/j.bcp.2022.115261 · 2022 · External reference
Intradomain Allosteric Regulation of Soluble Epoxide Hydrolase by Its Substrates
10.3390/ijms252413496 · 2024 · External reference
A biosynthetic pathway for anandamide
10.1073/pnas.0601832103 · 2006 · External reference
Multiple pathways involved in the biosynthesis of anandamide
10.1016/j.neuropharm.2007.05.020 · 2008 · External reference
Alterations in Anandamide Synthesis and Degradation during Osteoarthritis Progression in an Animal Model
10.3390/ijms21197381 · 2020 · External reference
An anatomical and temporal portrait of physiological substrates for fatty acid amide hydrolase
10.1194/jlr.m012153 · 2011 · External reference
Fatty Acid-Derived N-acylethanolamines Dietary Supplementation Attenuates Neuroinflammation and Cognitive Impairment in LPS Murine Model
10.3390/nu14183879 · 2022 · External reference
Identification and structure-function analyses of an allosteric inhibitor of the tyrosine phosphatase PTPN22
10.1074/jbc.ra118.007129 · 2019 · External reference
Review of the Endocannabinoid System
2021 · External reference
Release of anandamide from blood cells
10.1515/cclm.2006.065 · 2006 · External reference
Activation of fibrinolysis by SMTP-7 and -8, novel staplabin analogs with a pseudosymmetric structure
10.7164/antibiotics.53.241 · 2000 · External reference
An extremely simple method for extraction of lysophospholipids and phospholipids from blood samples
10.1194/jlr.d001503 · 2010 · External reference
