Research graph
References from LIF and let die: Generation, mechanistical and structural characterization of bispecific antibodies triggering leukemia inhibitory factor (LIF) receptor activation independent of the cytokine LIF. Local targets link to admitted publications; unresolved targets remain external evidence.
Recent insights into targeting the IL-6 cytokine family in inflammatory diseases and cancer
10.1038/s41577-018-0066-7 · 2018 · External reference
Historical overview of the interleukin-6 family cytokine
2020 · External reference
Exploring the landscape of synthetic IL ‐6‐type cytokines
10.1111/febs.16909 · 2024 · External reference
Leukemia inhibitory factor (LIF)
10.1016/j.cytogfr.2015.07.001 · 2015 · External reference
Leukemia inhibitory factor, a double-edged sword with therapeutic implications in human diseases
10.1016/j.ymthe.2022.12.016 · 2023 · External reference
Leukemia Inhibitory Factor: An Important Cytokine in Pathologies and Cancer
10.3390/biom12020217 · 2022 · External reference
Molecular cloning and expression of cDNA encoding a murine myeloid leukaemia inhibitory factor (LIF)
10.1002/j.1460-2075.1987.tb02742.x · 1987 · External reference
Leukemia Inhibitory Factor Can Substitute for Nidatory Estrogen and Is Essential to Inducing a Receptive Uterus for Implantation But Is Not Essential for Subsequent Embryogenesis1
10.1210/endo.141.12.7855 · 2000 · External reference
Blastocyst implantation depends on maternal expression of leukaemia inhibitory factor
10.1038/359076a0 · 1992 · External reference
Dysregulation of EGF Family of Growth Factors and COX-2 in the Uterus during the Preattachment and Attachment Reactions of the Blastocyst with the Luminal Epithelium Correlates with Implantation Failure in LIF- Deficient Mice
10.1210/mend.14.8.0498 · 2000 · External reference
Myeloid leukaemia inhibitory factor maintains the developmental potential of embryonic stem cells
10.1038/336684a0 · 1988 · External reference
Cytokines affecting survival and differentiation of an astrocyte progenitor cell line
10.1016/0165-3806(93)90132-t · 1993 · External reference
Ciliary neurotrophic factor and leukemia inhibitory factor promote the generation, maturation and survival of oligodendrocytes in vitro
10.1242/dev.120.1.143 · 1994 · External reference
Astrocyte‐specific activation of TNFR2 promotes oligodendrocyte maturation by secretion of leukemia inhibitory factor
10.1002/glia.22605 · 2014 · External reference
The role of the leukemia inhibitory factor receptor in neuroprotective signaling
10.1016/j.pharmthera.2017.08.008 · 2018 · External reference
Tumor-associated leukemia inhibitory factor and IL-6 skew monocyte differentiation into tumor-associated macrophage-like cells
10.1182/blood-2007-02-072587 · 2007 · External reference
Leukemia inhibitory factor (LIF) modulates the development of dendritic cells in a dual manner
10.1080/08923973.2019.1619761 · 2019 · External reference
Treg versus Th17 lymphocyte lineages are cross-regulated by LIF versus IL-6
10.4161/cc.8.9.8348 · 2009 · External reference
Emerging Perspectives on Leukemia Inhibitory Factor and its Receptor in Cancer
10.3389/fonc.2021.693724 · 2021 · External reference
The Pleiotropic role, functions and targeted therapies of LIF/LIFR axis in cancer: Old spectacles with new insights
10.1016/j.bbcan.2022.188737 · 2022 · External reference
Targeting LIF/LIFR signaling in cancer
10.1016/j.gendis.2021.04.003 · 2022 · External reference
Convergent Mechanisms for Recognition of Divergent Cytokines by the Shared Signaling Receptor gp130
10.1016/s1097-2765(03)00365-4 · 2003 · External reference
An unusual cytokine:Ig-domain interaction revealed in the crystal structure of leukemia inhibitory factor (LIF) in complex with the LIF receptor
10.1073/pnas.0705577104 · 2007 · External reference
Structural Organization of a Full-Length gp130/LIF-R Cytokine Receptor Transmembrane Complex
10.1016/j.molcel.2008.08.011 · 2008 · External reference
Antibody display technologies: selecting the cream of the crop
10.1515/hsz-2020-0377 · 2022 · External reference
Targeting the major pro-inflammatory interleukin-6-type cytokine receptor gp130 by antagonistic single domain antibodies
10.3389/fimmu.2025.1613004 · 2025 · External reference
Efficient generation of stable bispecific IgG1 by controlled Fab-arm exchange
10.1073/pnas.1220145110 · 2013 · External reference
Beyond bispecificity: Controlled Fab arm exchange for the generation of antibodies with multiple specificities
10.1080/19420862.2021.2018960 · 2022 · External reference
A Generic Approach for Miniaturized Unbiased High-Throughput Screens of Bispecific Antibodies and Biparatopic Antibody–Drug Conjugates
10.3390/ijms25042097 · 2024 · External reference
UCSF ChimeraX : Tools for structure building and analysis
10.1002/pro.4792 · 2023 · External reference
(Cindy). JAK-STAT3 and somatic cell reprogramming
10.4161/jkst.24935 · 2013 · External reference
A Unique Loop Structure in Oncostatin M Determines Binding Affinity toward Oncostatin M Receptor and Leukemia Inhibitory Factor Receptor
10.1074/jbc.m112.387324 · 2012 · External reference
Structures of complete extracellular assemblies of type I and type II Oncostatin M receptor complexes
10.1038/s41467-024-54124-1 · 2024 · External reference
Biophysical and biochemical characterization of a VHH-based IgG-like bi- and trispecific antibody platform
10.1080/19420862.2020.1812210 · 2020 · External reference
SEEDbodies: fusion proteins based on strand-exchange engineered domain (SEED) CH3 heterodimers in an Fc analogue platform for asymmetric binders or immunofusions and bispecific antibodies
10.1093/protein/gzp094 · 2010 · External reference
Oncostatin M and leukemia inhibitory factor trigger overlapping and different signals through partially shared receptor complexes
10.1016/s0021-9258(17)37590-7 · 1994 · External reference
Leukemia inhibitory factor induces the 85-kDa cytosolic phospholipase A2 gene expression in cultured human bronchial epithelial cells
10.1016/s0167-4889(96)00122-x · 1997 · External reference
10.1016/j.csbj.2025.01.014 · 2025 · Admitted local publication
Emerging principles of cytokine pharmacology and therapeutics
10.1038/s41573-022-00557-6 · 2023 · External reference
Cytokines in clinical cancer immunotherapy
10.1038/s41416-018-0328-y · 2019 · External reference
Next-generation cytokines for cancer immunotherapy
10.1093/abt/tbab014 · 2021 · External reference
Engineering Strategies for Immunomodulatory Cytokine Therapies: Challenges and Clinical Progress
10.1002/adtp.202100035 · 2021 · External reference
Leukemia inhibitory factor: Recent advances and implications in biotechnology
10.1016/j.cytogfr.2019.11.005 · 2020 · External reference
Anti-drug antibodies
10.4081/dts.2012.e11 · 2012 · External reference
Tuning Cytokine Receptor Signaling by Re-orienting Dimer Geometry with Surrogate Ligands
10.1016/j.cell.2015.02.011 · 2015 · External reference
Topological control of cytokine receptor signaling induces differential effects in hematopoiesis
10.1126/science.aav7532 · 2019 · External reference
Generation and engineering of potent single domain antibody-based bispecific IL-18 mimetics resistant to IL-18BP decoy receptor inhibition
10.1080/19420862.2023.2236265 · 2023 · External reference
Nanobody Engineering: Toward Next Generation Immunotherapies and Immunoimaging of Cancer
10.3390/antib8010013 · 2019 · External reference
NKp46 ‐specific single domain antibodies enable facile engineering of various potent NK cell engager formats
10.1002/pro.4593 · 2023 · External reference
From discovery to the clinic: structural insights, engineering options, clinical, and ‘next wave’ applications of camelid-derived single-domain antibodies
10.1080/19420862.2025.2583210 · 2025 · External reference
Taming the beast: engineering strategies and biomedical potential of antibody-based cytokine mimetics
10.1080/14712598.2024.2322062 · 2024 · External reference
Taming interleukin‐12: Engineering of bispecific antibody‐based IL ‐12 mimetics with biased agonism capacities
10.1002/pro.70072 · 2025 · External reference
Multifunctional antibody-derived IL-12 mimetics: prospects of future clinical development
10.1080/13543784.2026.2613289 · 2026 · External reference
Antigen-directed single domain antibody-based TNFR1 agonists elicit preferential killing of HER2-overexpressing cancer cells
10.1016/j.isci.2026.115327 · 2026 · External reference
10.1080/19420862.2026.2726042 · 2026 · Admitted local publication
10.1007/978-1-4939-9853-1_10
10.1007/978-1-4939-9853-1_10 · External reference
cryoSPARC: algorithms for rapid unsupervised cryo-EM structure determination
10.1038/nmeth.4169 · 2017 · External reference
Accurate structure prediction of biomolecular interactions with AlphaFold 3
10.1038/s41586-024-07487-w · 2024 · External reference
Structural insights into the assembly of gp130 family cytokine signaling complexes
10.1126/sciadv.ade4395 · 2023 · External reference
UCSF ChimeraX : Structure visualization for researchers, educators, and developers
10.1002/pro.3943 · 2021 · External reference
A Pareto-Optimal Refinement Method for Protein Design Scaffolds
10.1371/journal.pone.0059004 · 2013 · External reference
Relaxation of backbone bond geometry improves protein energy landscape modeling
10.1002/pro.2389 · 2014 · External reference
Unresolved reference
External reference
Features and development of Coot
10.1107/s0907444910007493 · 2010 · External reference
