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References from Process development for high-purity recombinant hyaluronate lyase preparation, its specific HA degradation profile and chemosensitizing potential in lung cancer combined chemotherapy. Local targets link to admitted publications; unresolved targets remain external evidence.
Targeting Notch signaling as a novel therapy for retinoblastoma
10.18632/oncotarget.12142 · 2016 · External reference
Extracellular matrices and cancer-associated fibroblasts: targets for cancer diagnosis and therapy?
10.3390/cancers13143466 · 2021 · External reference
A new staining technique for proteins in polyacrylamide gels using Coomassie Brilliant Blue G250
10.1016/0003-2697(77)90197-x · 1977 · External reference
Combined application of hyaluronidase and collagenase for late-onset edema in periocular area after hyaluronic acid volume repositioning: a six-case retrospective review
10.7759/cureus.74297 · 2024 · External reference
An efficient method for FITC labelling of proteins using tandem affinity purification
10.1042/bsr20181764 · 2018 · External reference
Hyaluronan: a modulator of the tumor microenvironment
10.1016/j.canlet.2016.02.031 · 2016 · External reference
Phosphorylation of IGFBP-3 by casein kinase 2 blocks its interaction with hyaluronan, enabling HA-CD44 signaling leading to increased NSCLC cell survival and cisplatin resistance
10.3390/cells12030405 · 2023 · External reference
The matrix in cancer
10.1038/s41568-020-00329-7 · 2021 · External reference
Flip the chip: trapping a low number of cancer and immune cells for spheroid formation of homogeneous size
10.1039/d5lc00210a · 2025 · External reference
Effect of spheroidal age on sorafenib diffusivity and toxicity in a 3D HepG2 spheroid model
10.1038/s41598-019-41273-3 · 2019 · External reference
Suppression of MUC1-overexpressing tumors by a novel MUC1/CD3 bispecific antibody
10.3390/antib12030047 · 2023 · External reference
Targeted optimization of single-chain variable fragment (scFv) expression in E. coli using a design-of-experiment approach
10.1016/j.ijbiomac.2025.147881 · 2025 · External reference
Ketoprofen-based polymer-drug nanoparticles provide anti-inflammatory properties to HA/Collagen Hydrogels
10.3390/jfb14030160 · 2023 · External reference
Isoenzyme-specific differences in the degradation of hyaluronic acid by mammalian-type hyaluronidases
10.1007/s10719-007-9058-8 · 2008 · External reference
Hyaluronan impairs vascular function and drug delivery in a mouse model of pancreatic cancer
10.1136/gutjnl-2012-302529 · 2013 · External reference
Structures of vertebrate hyaluronidases and their unique enzymatic mechanism of hydrolysis
10.1002/prot.20592 · 2005 · External reference
A multicentre, double-blind, randomised, non-inferiority trial of a novel single-injection intra-articular HMDA-cross-linked hyaluronate gel for knee osteoarthritis
10.3390/jcm14124384 · 2025 · External reference
Transient receptor potential vanilloid 1: a potential therapeutic target for the treatment of osteoarthritis and rheumatoid arthritis
10.1111/cpr.13569 · 2024 · External reference
Activin-A, growth differentiation factor-11 and transforming Growth Factor-β as predictive biomarkers for platinum chemotherapy in advanced non-small cell lung cancer
2022 · External reference
ENHANZE® drug delivery technology: a novel approach to subcutaneous administration using recombinant human hyaluronidase PH20
10.1080/10717544.2018.1551442 · 2019 · External reference
Expression in CHO cells and pharmacokinetics and brain uptake in the Rhesus monkey of an IgG-iduronate-2-sulfatase fusion protein
10.1002/bit.23118 · 2011 · External reference
Cepharanthine enhances MHC-I antigen presentation and anti-tumor immunity in melanoma via autophagy inhibition
10.3390/cells14161231 · 2025 · External reference
Sulfenamide derivatives can improve transporter-mediated cellular uptake of metformin and induce cytotoxicity in human breast adenocarcinoma cell lines
10.1016/j.bioorg.2019.03.036 · 2019 · External reference
Transwell® invasion assays
2011 · External reference
Hyaluronic acid degradation by Purpureocillium lilacinum: biochemical and transcriptomic insights
10.1007/s00253-026-13790-5 · 2026 · External reference
Epitope affinity chromatography and biophysical studies of monoclonal antibodies and recombinant antibody fragments
10.1093/chromsci/40.6.343 · 2002 · External reference
Substitution of acidic residues near the catalytic Glu131 leads to human HYAL1 activity at neutral pH via charge-charge interactions
10.1371/journal.pone.0308370 · 2024 · External reference
Positive ion MALDI-TOF mass spectra are more suitable than negative ion spectra to characterize sulphated glycosaminoglycan oligosaccharides
10.1016/j.ijms.2011.11.003 · 2012 · External reference
Active expression of human hyaluronidase PH20 and characterization of its hydrolysis pattern
10.3389/fbioe.2022.885888 · 2022 · External reference
Integrative modeling of FOXO-mediated autophagy in NSCLC: linking cGAS–STING signaling to IL-6 dynamics
10.3389/fonc.2025.1689137 · 2025 · External reference
Breaching the castle walls: hyaluronan depletion as a therapeutic approach to cancer therapy
10.3389/fonc.2015.00192 · 2015 · External reference
Subcutaneous injection performance in yucatan miniature pigs with and without human hyaluronidase and auto-injector tolerability in humans
10.1208/s12249-020-01880-0 · 2021 · External reference
optimization of the purification process for lactiplantibacillus plantarum lipoteichoic acid with anti-biofilm properties against dental pathogens
10.4014/jmb.2506.06045 · 2025 · External reference
Structure of a group A streptococcal phage-encoded virulence factor reveals a catalytically active triple-stranded β-helix
10.1073/pnas.0504782102 · 2005 · External reference
WDR90 is a centriolar microtubule wall protein important for centriole architecture integrity
10.7554/elife.57205 · 2020 · External reference
Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries
2021 · External reference
Different effects of albumin and hydroxyethyl starch on low molecular-weight solute permeation through sodium hyaluronic acid solution
10.3390/polym13040514 · 2021 · External reference
The Rab25-ADAMTS5 axis as a previously undescribed mechanism for sensing tumor microenvironment complexity
10.1111/febs.70147 · 2025 · External reference
Rapid quantification of cellular proliferation and migration using ImageJ
10.2144/btn-2018-0132 · 2019 · External reference
Deciphering drug resistance: investigating the emerging role of hyaluronan metabolism and signaling and tumor extracellular matrix in cancer chemotherapy
10.3390/ijms25147607 · 2024 · External reference
Regulation of CAF by α-mangostin promotes the penetration of nanomedicine and inhibits the metastasis of breast tumor
10.1021/acs.molpharmaceut.5c01357 · 2026 · External reference
Oncolytic viruses: advanced strategies in cancer therapy
10.1038/s41392-025-02343-3 · 2026 · External reference
The human GLUD2 glutamate dehydrogenase: localization and functional aspects
10.1016/j.neuint.2009.03.001 · 2009 · External reference
Novel mycoplasma nucleomodulin MbovP475 decreased cell viability by regulating expression of CRYAB and MCF2L2
10.1080/21505594.2022.2117762 · 2022 · External reference
New insights into the important roles of phase seperation in the targeted therapy of lung cancer
10.1186/s13578-023-01101-8 · 2023 · External reference
