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References from Genetic Susceptibility Versus Fibrosis Progression in North Indian Metabolic Dysfunction–Associated Steatotic Liver Disease: Distinct Roles of APOC3 and PNPLA3 in a Candidate Gene Study. Local targets link to admitted publications; unresolved targets remain external evidence.
The global epidemiology of nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH): a systematic review
10.1097/hep.0000000000000004 · 2023 · External reference
Epidemiology of metabolic dysfunction-associated steatotic liver disease
10.3350/cmh.2024.0431 · 2025 · External reference
A multisociety Delphi consensus statement on new fatty liver disease nomenclature
10.1097/hep.0000000000000520 · 2023 · External reference
Metabolic dysfunction-associated steatotic liver disease
10.1016/j.clinme.2025.100526 · 2025 · External reference
Metabolic dysfunction-associated steatotic liver disease in adults: a review
10.1001/jama.2025.19615 · 2026 · External reference
MASLD pharmacotherapy: current standards, emerging treatments, and practical guidance for Indian physicians
10.59556/japi.73.1058 · 2025 · External reference
Consensus guidelines for the diagnosis and management of metabolic dysfunction-associated steatotic liver disease in adult Asian Indians with type 2 diabetes
10.1016/j.dsx.2025.103209 · 2025 · External reference
Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD): mechanisms, clinical implications and therapeutic advances
10.1002/edm2.70132 · 2025 · External reference
A new definition for metabolic dysfunction-associated fatty liver disease: an international expert consensus statement
10.1016/j.jhep.2020.03.039 · 2020 · External reference
Defining and diagnosing obesity in India: a call for advocacy and action
10.1155/2023/4178121 · 2023 · External reference
Non-alcoholic fatty liver disease and metabolic syndrome-position paper of the Indian National Association for the Study of the Liver, Endocrine Society of India, Indian College of Cardiology and Indian Society of Gastroenterology
10.1016/j.jceh.2015.02.006 · 2015 · External reference
Indian National Association for Study of the Liver (INASL) guidance paper on nomenclature, diagnosis and treatment of nonalcoholic fatty liver disease (NAFLD)
10.1016/j.jceh.2022.11.014 · 2023 · External reference
Prevalence of non-alcoholic fatty liver disease in India: a systematic review and meta-analysis
10.1016/j.jceh.2021.11.010 · 2022 · External reference
Prevalence of metabolic dysfunction-associated steatotic liver disease: mapping across different Indian populations (MAP study)
10.1007/s13300-025-01748-1 · 2025 · External reference
Genome-wide association study of NAFLD using electronic health records
10.1002/hep4.1805 · 2022 · External reference
A comprehensive evaluation of candidate genetic polymorphisms in a large histologically characterized MASLD cohort using a novel framework
10.1097/hc9.0000000000000728 · 2025 · External reference
Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease
10.1038/ng.257 · 2008 · External reference
Meta-analysis of the influence of I148M variant of patatin-like phospholipase domain containing 3 gene (PNPLA3) on the susceptibility and histological severity of nonalcoholic fatty liver disease
10.1002/hep.24283 · 2011 · External reference
Impact of PNPLA3 I148M on clinical outcomes in patients with MASLD
10.1111/liv.16133 · 2025 · External reference
Exome-wide association study identifies a TM6SF2 variant that confers susceptibility to nonalcoholic fatty liver disease
10.1038/ng.2901 · 2014 · External reference
Association of TM6SF2 gene polymorphism with susceptibility to metabolic dysfunction-associated steatotic liver disease (MASLD) in north coastal Andhra Pradesh population
2025 · External reference
TM6SF2: a novel genetic player in nonalcoholic fatty liver and cardiovascular disease
10.1002/hep4.1822 · 2022 · External reference
The MBOAT7-TMC4 variant rs641738 increases risk of nonalcoholic fatty liver disease in individuals of European descent
10.1053/j.gastro.2016.01.032 · 2016 · External reference
MBOAT7 in liver and extrahepatic diseases
10.1111/liv.15706 · 2023 · External reference
A protein-truncating HSD17B13 variant and protection from chronic liver disease
10.1056/nejmoa1712191 · 2018 · External reference
Inhibition of HSD17B13 protects against liver fibrosis by inhibition of pyrimidine catabolism in nonalcoholic steatohepatitis
10.1073/pnas.2217543120 · 2023 · External reference
Genome-wide association analysis identifies variants associated with nonalcoholic fatty liver disease that have distinct effects on metabolic traits
10.1371/journal.pgen.1001324 · 2011 · External reference
A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity
10.1126/science.1141634 · 2007 · External reference
Genome-wide scan revealed that polymorphisms in the PNPLA3, SAMM50, and PARVB genes are associated with development and progression of nonalcoholic fatty liver disease in Japan
10.1007/s00439-013-1294-3 · 2013 · External reference
Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes
10.1038/ng1732 · 2006 · External reference
Association of apolipoprotein C-III gene polymorphisms (rs2854116 and rs2854117) with susceptibility to metabolic dysfunction-associated steatotic liver disease (MASLD) in a Turkish population
10.3390/medicina61081479 · 2025 · External reference
The missing diversity in human genetic studies
10.1016/j.cell.2019.02.048 · 2019 · External reference
Next generation disparities in human genomics: concerns and remedies
10.1016/j.tig.2009.09.012 · 2009 · External reference
IndiGenomes: a comprehensive resource of genetic variants from over 1000 Indian genomes
2021 · External reference
Regional differences in genetic susceptibility to non-alcoholic liver disease in two distinct Indian ethnicities
10.4254/wjh.v9.i26.1101 · 2017 · External reference
SREBP-2 1784 G/C genotype is associated with non-alcoholic fatty liver disease in north Indians
10.1155/2011/950102 · 2011 · External reference
Association of peroxisome proliferator activated receptor-γ gene with non-alcoholic fatty liver disease in Asian Indians residing in North India
10.1016/j.gene.2012.09.067 · 2013 · External reference
Association of GCKR and MBOAT7 genetic polymorphisms with non-alcoholic fatty liver disease
10.5114/ceh.2024.136326 · 2024 · External reference
Nonalcoholic fatty liver disease risk and histologic severity are associated with genetic polymorphisms in children
10.1002/hep.32570 · 2023 · External reference
I148M variant of PNPLA3-gene is not associated with metabolic syndrome in patients with NAFLD in the Indian ethnicity
10.1016/j.humgen.2022.201073 · 2022 · External reference
Study of family clustering and PNPLA3 gene polymorphism in pediatric non alcoholic fatty liver disease
10.1007/s13312-018-1297-1 · 2018 · External reference
17-Beta-Hydroxysteroid dehydrogenase 13 loss of function does not confer protection to nonalcoholic fatty liver disease in Indian population
10.1016/j.jceh.2024.101371 · 2024 · External reference
PNPLA3 rs738409 and risk of fibrosis in NAFLD: exploring mediation pathways through intermediate histological features
10.1002/hep.32491 · 2022 · External reference
Combined effects of PNPLA3, TM6SF2 and HSD17B13 variants on severity of biopsy-proven non-alcoholic fatty liver disease
10.1007/s12072-021-10200-y · 2021 · External reference
Relevance of PNPLA3, TM6SF2, HSD17B13, and GCKR variants to MASLD severity in an Egyptian population
10.3390/genes15040455 · 2024 · External reference
Review article: the role of HSD17B13 on global epidemiology, natural history, pathogenesis and treatment of NAFLD
10.1111/apt.17292 · 2023 · External reference
Single nucleotide polymorphism of genes associated with metabolic fatty liver disease
10.1155/2022/9282557 · 2022 · External reference
Impact of genotyping (PTPN2, rs2542151) and (MBOAT7, rs641738) in prediction of fibrosis in metabolic dysfunction- associated steatotic liver disease’ patients
10.3389/fendo.2025.1615162 · 2025 · External reference
Polymorphism's MBOAT7 as risk and MTARC1 as protection for liver fibrosis in MASLD
10.3390/ijms26136406 · 2025 · External reference
Contribution of Rs780094 and Rs1260326 polymorphisms in GCKR gene to non-alcoholic fatty liver disease: a meta-analysis involving 26,552 participants
10.2174/1871530320999201126202706 · 2021 · External reference
Fat mass and obesity-associated (FTO) and leptin receptor (LEPR) gene polymorphisms in Egyptian obese subjects
10.1080/13813455.2019.1573841 · 2021 · External reference
Genetic risk of MASLD in mongolians: role of PNPLA3 and FTO SNPs
10.3390/cimb47080605 · 2025 · External reference
Type 2 diabetes-associated genetic variants of FTO, LEPR, PPARg, and TCF7L2 in gestational diabetes in a Brazilian population
10.1590/2359-3997000000258 · 2017 · External reference
The spatial transcriptional activity of hepatic TCF7L2 regulates zonated metabolic pathways that contribute to liver fibrosis
10.1038/s41467-025-58714-5 · 2025 · External reference
Tcf7l2 in hepatocytes regulates de novo lipogenesis in diet-induced non-alcoholic fatty liver disease in mice
10.1007/s00125-023-05878-8 · 2023 · External reference
Vitamin E modulates hepatic extracellular adenosine signaling to attenuate metabolic dysfunction-associated steatotic liver disease (MASLD)
10.3390/ijms27020614 · 2026 · External reference
The impact of variants in four genes: MC4R, FTO, PPARG and PPARGC1A in overweight and obesity in a large sample of the Brazilian population
10.1007/s10528-021-10079-2 · 2021 · External reference
Association between APOC3 polymorphisms and non-alcoholic fatty liver disease risk: a meta-analysis
10.4314/ahs.v20i4.34 · 2020 · External reference
APOC3 rs2070666 is associated with the hepatic steatosis independently of PNPLA3 rs738409 in Chinese Han patients with nonalcoholic fatty liver diseases
10.1007/s10620-016-4120-7 · 2016 · External reference
Genetic polymorphisms of PNPLA3 and SAMM50 are associated with nonalcoholic fatty liver disease in a Korean population
10.5009/gnl17306 · 2018 · External reference
PNPLA3 gene in liver diseases
10.1016/j.jhep.2016.03.011 · 2016 · External reference
The effect of PNPLA3 on fibrosis progression and development of hepatocellular carcinoma: a meta-analysis
10.1038/ajg.2013.476 · 2014 · External reference
A multi-ethnic study of a PNPLA3 gene variant and its association with disease severity in non-alcoholic fatty liver disease
10.1007/s00439-012-1141-y · 2012 · External reference
Prevalence and risk factors of significant fibrosis in patients with nonalcoholic fatty liver without steatohepatitis
2019 · External reference
Evidence of NAFLD progression from steatosis to fibrosing-steatohepatitis using paired biopsies: implications for prognosis and clinical management
10.1016/j.jhep.2014.11.034 · 2015 · External reference
SAMM50 affects mitochondrial morphology through the association of Drp1 in mammalian cells
10.1002/1873-3468.12170 · 2016 · External reference
The bigger picture of FTO: the first GWAS-identified obesity gene
10.1038/nrendo.2013.227 · 2014 · External reference
Genetic variants in FTO associated with metabolic syndrome: a meta- and gene-based analysis
10.1007/s11033-011-1377-y · 2012 · External reference
From NASH to HCC: current concepts and future challenges
10.1038/s41575-019-0145-7 · 2019 · External reference
The South Asian genome
10.1371/journal.pone.0102645 · 2014 · External reference
Genome-wide association study in individuals of South Asian ancestry identifies six new type 2 diabetes susceptibility loci
10.1038/ng.921 · 2011 · External reference
APOC3 inhibition with volanesorsen reduces hepatic steatosis in patients with severe hypertriglyceridemia
10.1016/j.jacl.2023.04.007 · 2023 · External reference
Olezarsen in patients with hypertriglyceridemia at high cardiovascular risk: rationale and design of the Essence–TIMI 73b trial
10.1016/j.ahj.2025.02.022 · 2025 · External reference
Metabolic dysfunction-associated steatotic liver disease in adults: a review
10.1001/jama.2025.19615 · ExternalCitation · doi-reference
SAMM50 affects mitochondrial morphology through the association of Drp1 in mammalian cells
10.1002/1873-3468.12170 · ExternalCitation · doi-reference
Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD): mechanisms, clinical implications and therapeutic advances
10.1002/edm2.70132 · ExternalCitation · doi-reference
Meta-analysis of the influence of I148M variant of patatin-like phospholipase domain containing 3 gene (PNPLA3) on the susceptibility and histological severity of nonalcoholic fatty liver disease
10.1002/hep.24283 · ExternalCitation · doi-reference
PNPLA3 rs738409 and risk of fibrosis in NAFLD: exploring mediation pathways through intermediate histological features
10.1002/hep.32491 · ExternalCitation · doi-reference
Nonalcoholic fatty liver disease risk and histologic severity are associated with genetic polymorphisms in children
10.1002/hep.32570 · ExternalCitation · doi-reference
Genome-wide association study of NAFLD using electronic health records
10.1002/hep4.1805 · ExternalCitation · doi-reference
TM6SF2: a novel genetic player in nonalcoholic fatty liver and cardiovascular disease
10.1002/hep4.1822 · ExternalCitation · doi-reference
Tcf7l2 in hepatocytes regulates de novo lipogenesis in diet-induced non-alcoholic fatty liver disease in mice
10.1007/s00125-023-05878-8 · ExternalCitation · doi-reference
A multi-ethnic study of a PNPLA3 gene variant and its association with disease severity in non-alcoholic fatty liver disease
10.1007/s00439-012-1141-y · ExternalCitation · doi-reference
Genome-wide scan revealed that polymorphisms in the PNPLA3, SAMM50, and PARVB genes are associated with development and progression of nonalcoholic fatty liver disease in Japan
10.1007/s00439-013-1294-3 · ExternalCitation · doi-reference
The impact of variants in four genes: MC4R, FTO, PPARG and PPARGC1A in overweight and obesity in a large sample of the Brazilian population
10.1007/s10528-021-10079-2 · ExternalCitation · doi-reference
APOC3 rs2070666 is associated with the hepatic steatosis independently of PNPLA3 rs738409 in Chinese Han patients with nonalcoholic fatty liver diseases
10.1007/s10620-016-4120-7 · ExternalCitation · doi-reference
Genetic variants in FTO associated with metabolic syndrome: a meta- and gene-based analysis
10.1007/s11033-011-1377-y · ExternalCitation · doi-reference
Combined effects of PNPLA3, TM6SF2 and HSD17B13 variants on severity of biopsy-proven non-alcoholic fatty liver disease
10.1007/s12072-021-10200-y · ExternalCitation · doi-reference
Prevalence of metabolic dysfunction-associated steatotic liver disease: mapping across different Indian populations (MAP study)
10.1007/s13300-025-01748-1 · ExternalCitation · doi-reference
Study of family clustering and PNPLA3 gene polymorphism in pediatric non alcoholic fatty liver disease
10.1007/s13312-018-1297-1 · ExternalCitation · doi-reference
Olezarsen in patients with hypertriglyceridemia at high cardiovascular risk: rationale and design of the Essence–TIMI 73b trial
10.1016/j.ahj.2025.02.022 · ExternalCitation · doi-reference
The missing diversity in human genetic studies
10.1016/j.cell.2019.02.048 · ExternalCitation · doi-reference
Metabolic dysfunction-associated steatotic liver disease
10.1016/j.clinme.2025.100526 · ExternalCitation · doi-reference
Consensus guidelines for the diagnosis and management of metabolic dysfunction-associated steatotic liver disease in adult Asian Indians with type 2 diabetes
10.1016/j.dsx.2025.103209 · ExternalCitation · doi-reference
Association of peroxisome proliferator activated receptor-γ gene with non-alcoholic fatty liver disease in Asian Indians residing in North India
10.1016/j.gene.2012.09.067 · ExternalCitation · doi-reference
I148M variant of PNPLA3-gene is not associated with metabolic syndrome in patients with NAFLD in the Indian ethnicity
10.1016/j.humgen.2022.201073 · ExternalCitation · doi-reference
APOC3 inhibition with volanesorsen reduces hepatic steatosis in patients with severe hypertriglyceridemia
10.1016/j.jacl.2023.04.007 · ExternalCitation · doi-reference
Non-alcoholic fatty liver disease and metabolic syndrome-position paper of the Indian National Association for the Study of the Liver, Endocrine Society of India, Indian College of Cardiology and Indian Society of Gastroenterology
10.1016/j.jceh.2015.02.006 · ExternalCitation · doi-reference
Prevalence of non-alcoholic fatty liver disease in India: a systematic review and meta-analysis
10.1016/j.jceh.2021.11.010 · ExternalCitation · doi-reference
Indian National Association for Study of the Liver (INASL) guidance paper on nomenclature, diagnosis and treatment of nonalcoholic fatty liver disease (NAFLD)
10.1016/j.jceh.2022.11.014 · ExternalCitation · doi-reference
17-Beta-Hydroxysteroid dehydrogenase 13 loss of function does not confer protection to nonalcoholic fatty liver disease in Indian population
10.1016/j.jceh.2024.101371 · ExternalCitation · doi-reference
Evidence of NAFLD progression from steatosis to fibrosing-steatohepatitis using paired biopsies: implications for prognosis and clinical management
10.1016/j.jhep.2014.11.034 · ExternalCitation · doi-reference
PNPLA3 gene in liver diseases
10.1016/j.jhep.2016.03.011 · ExternalCitation · doi-reference
A new definition for metabolic dysfunction-associated fatty liver disease: an international expert consensus statement
10.1016/j.jhep.2020.03.039 · ExternalCitation · doi-reference
Next generation disparities in human genomics: concerns and remedies
10.1016/j.tig.2009.09.012 · ExternalCitation · doi-reference
The effect of PNPLA3 on fibrosis progression and development of hepatocellular carcinoma: a meta-analysis
10.1038/ajg.2013.476 · ExternalCitation · doi-reference
Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease
10.1038/ng.257 · ExternalCitation · doi-reference
Exome-wide association study identifies a TM6SF2 variant that confers susceptibility to nonalcoholic fatty liver disease
10.1038/ng.2901 · ExternalCitation · doi-reference
Genome-wide association study in individuals of South Asian ancestry identifies six new type 2 diabetes susceptibility loci
10.1038/ng.921 · ExternalCitation · doi-reference
Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes
10.1038/ng1732 · ExternalCitation · doi-reference
The bigger picture of FTO: the first GWAS-identified obesity gene
10.1038/nrendo.2013.227 · ExternalCitation · doi-reference
The spatial transcriptional activity of hepatic TCF7L2 regulates zonated metabolic pathways that contribute to liver fibrosis
10.1038/s41467-025-58714-5 · ExternalCitation · doi-reference
From NASH to HCC: current concepts and future challenges
10.1038/s41575-019-0145-7 · ExternalCitation · doi-reference
The MBOAT7-TMC4 variant rs641738 increases risk of nonalcoholic fatty liver disease in individuals of European descent
10.1053/j.gastro.2016.01.032 · ExternalCitation · doi-reference
A protein-truncating HSD17B13 variant and protection from chronic liver disease
10.1056/nejmoa1712191 · ExternalCitation · doi-reference
Inhibition of HSD17B13 protects against liver fibrosis by inhibition of pyrimidine catabolism in nonalcoholic steatohepatitis
10.1073/pnas.2217543120 · ExternalCitation · doi-reference
Fat mass and obesity-associated (FTO) and leptin receptor (LEPR) gene polymorphisms in Egyptian obese subjects
10.1080/13813455.2019.1573841 · ExternalCitation · doi-reference
A comprehensive evaluation of candidate genetic polymorphisms in a large histologically characterized MASLD cohort using a novel framework
10.1097/hc9.0000000000000728 · ExternalCitation · doi-reference
The global epidemiology of nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH): a systematic review
10.1097/hep.0000000000000004 · ExternalCitation · doi-reference
A multisociety Delphi consensus statement on new fatty liver disease nomenclature
10.1097/hep.0000000000000520 · ExternalCitation · doi-reference
Review article: the role of HSD17B13 on global epidemiology, natural history, pathogenesis and treatment of NAFLD
10.1111/apt.17292 · ExternalCitation · doi-reference
MBOAT7 in liver and extrahepatic diseases
10.1111/liv.15706 · ExternalCitation · doi-reference
Impact of PNPLA3 I148M on clinical outcomes in patients with MASLD
10.1111/liv.16133 · ExternalCitation · doi-reference
A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity
10.1126/science.1141634 · ExternalCitation · doi-reference
SREBP-2 1784 G/C genotype is associated with non-alcoholic fatty liver disease in north Indians
10.1155/2011/950102 · ExternalCitation · doi-reference
Single nucleotide polymorphism of genes associated with metabolic fatty liver disease
10.1155/2022/9282557 · ExternalCitation · doi-reference
Defining and diagnosing obesity in India: a call for advocacy and action
10.1155/2023/4178121 · ExternalCitation · doi-reference
Genome-wide association analysis identifies variants associated with nonalcoholic fatty liver disease that have distinct effects on metabolic traits
10.1371/journal.pgen.1001324 · ExternalCitation · doi-reference
The South Asian genome
10.1371/journal.pone.0102645 · ExternalCitation · doi-reference
Type 2 diabetes-associated genetic variants of FTO, LEPR, PPARg, and TCF7L2 in gestational diabetes in a Brazilian population
10.1590/2359-3997000000258 · ExternalCitation · doi-reference
Contribution of Rs780094 and Rs1260326 polymorphisms in GCKR gene to non-alcoholic fatty liver disease: a meta-analysis involving 26,552 participants
10.2174/1871530320999201126202706 · ExternalCitation · doi-reference
Epidemiology of metabolic dysfunction-associated steatotic liver disease
10.3350/cmh.2024.0431 · ExternalCitation · doi-reference
Impact of genotyping (PTPN2, rs2542151) and (MBOAT7, rs641738) in prediction of fibrosis in metabolic dysfunction- associated steatotic liver disease’ patients
10.3389/fendo.2025.1615162 · ExternalCitation · doi-reference
Genetic risk of MASLD in mongolians: role of PNPLA3 and FTO SNPs
10.3390/cimb47080605 · ExternalCitation · doi-reference
Relevance of PNPLA3, TM6SF2, HSD17B13, and GCKR variants to MASLD severity in an Egyptian population
10.3390/genes15040455 · ExternalCitation · doi-reference
Polymorphism's MBOAT7 as risk and MTARC1 as protection for liver fibrosis in MASLD
10.3390/ijms26136406 · ExternalCitation · doi-reference
Vitamin E modulates hepatic extracellular adenosine signaling to attenuate metabolic dysfunction-associated steatotic liver disease (MASLD)
10.3390/ijms27020614 · ExternalCitation · doi-reference
Association of apolipoprotein C-III gene polymorphisms (rs2854116 and rs2854117) with susceptibility to metabolic dysfunction-associated steatotic liver disease (MASLD) in a Turkish population
10.3390/medicina61081479 · ExternalCitation · doi-reference
Regional differences in genetic susceptibility to non-alcoholic liver disease in two distinct Indian ethnicities
10.4254/wjh.v9.i26.1101 · ExternalCitation · doi-reference
Association between APOC3 polymorphisms and non-alcoholic fatty liver disease risk: a meta-analysis
10.4314/ahs.v20i4.34 · ExternalCitation · doi-reference
Genetic polymorphisms of PNPLA3 and SAMM50 are associated with nonalcoholic fatty liver disease in a Korean population
10.5009/gnl17306 · ExternalCitation · doi-reference
Association of GCKR and MBOAT7 genetic polymorphisms with non-alcoholic fatty liver disease
10.5114/ceh.2024.136326 · ExternalCitation · doi-reference
MASLD pharmacotherapy: current standards, emerging treatments, and practical guidance for Indian physicians
10.59556/japi.73.1058 · ExternalCitation · doi-reference
