Research graph
References from Nanocarrier-based intranasal drug delivery: A transformative strategy for brain-targeted epilepsy therapy. Local targets link to admitted publications; unresolved targets remain external evidence.
The epidemiology of epilepsy
10.1159/000503831 · 2020 · External reference
No prevention or cure of epilepsy as yet
10.1016/j.neuropharm.2019.107762 · 2020 · External reference
Pharmacogenomics in epilepsy
10.1016/j.neulet.2017.01.014 · 2018 · External reference
Memory in children with epilepsy: a systematic review
10.1016/j.seizure.2014.10.002 · 2015 · External reference
Drug development for refractory epilepsy: the past 25 years and beyond
10.1016/j.seizure.2016.11.022 · 2017 · External reference
Epilepsy-associated genes
10.1016/j.seizure.2016.11.030 · 2017 · External reference
Establishing an adult epilepsy Diet Center: experience, efficacy and challenges
10.1016/j.yebeh.2016.02.038 · 2016 · External reference
Computational analysis in epilepsy neuroimaging: a survey of features and methods
10.1016/j.nicl.2016.02.013 · 2016 · External reference
Interactions between hormones and epilepsy
10.1016/j.seizure.2015.02.012 · 2015 · External reference
A pharmacological basis of herbal medicines for epilepsy
10.1016/j.yebeh.2015.05.012 · 2015 · External reference
Epilepsy-associated stigma from the perspective of people with epilepsy and the community in Italy
10.1016/j.yebeh.2019.06.026 · 2019 · External reference
The economic impact of epilepsy: a systematic review
10.1186/s12883-015-0494-y · 2015 · External reference
Epilepsy coexisting with depression
10.1016/j.pharep.2016.06.011 · 2016 · External reference
Nose-to-brain delivery of lipid-based nanosystems for epileptic seizures and anxiety crisis
10.1016/j.jconrel.2018.12.049 · 2019 · External reference
Direct nose-to-brain delivery of lamotrigine following intranasal administration to mice
10.1016/j.ijpharm.2015.05.021 · 2015 · External reference
Direct nose to brain drug delivery via integrated nerve pathways bypassing the blood–brain barrier: an excellent platform for brain targeting
10.1517/17425247.2013.790887 · 2013 · External reference
Intranasal delivery of biotechnology-based therapeutics
10.1016/j.drudis.2022.103371 · 2022 · External reference
Development of antiepileptic drugs throughout history: from serendipity to artificial intelligence
10.3390/biomedicines11061632 · 2023 · External reference
The pharmacological treatment of epilepsy: recent advances and future perspectives
10.1186/s42494-021-00055-z · 2021 · External reference
New trends and Most promising therapeutic strategies for epilepsy treatment
10.3389/fneur.2021.753753 · 2021 · External reference
New GABA-Targeting therapies for the treatment of seizures and epilepsy: II. Treatments in clinical development
10.1007/s40263-023-01025-4 · 2023 · External reference
GABA and its receptors in epilepsy
10.1007/978-1-4757-6376-8_7 · 2004 · External reference
Mechanism of anti-seizure medications and emerging trends in epilepsy treatment
2023 · External reference
Probing protein aggregation through spectroscopic insights and multimodal approaches: a comprehensive review for counteracting neurodegenerative disorders
10.1016/j.heliyon.2024.e27949 · 2024 · External reference
Development of phenytoin intranasal microemulsion for treatment of epilepsy
10.1007/s40005-015-0190-3 · 2015 · External reference
In Silico molecular screening of bioactive natural compounds of Rosemary essential oil and extracts for Pharmacological potentials against rhinoviruses
2024 · External reference
Ion channels and epilepsy
10.2174/1381612054021006 · 2005 · External reference
A comprehensive overview of the current status and advancements in various treatment strategies against epilepsy
10.1021/acsptsci.4c00494 · 2024 · External reference
A review of non-invasive drug delivery through respiratory routes
10.3390/pharmaceutics14091974 · 2022 · External reference
Formulation and In-vivo pharmacokinetic consideration of intranasal microemulsion and mucoadhesive microemulsion of rivastigmine for brain targeting
10.1007/s11095-017-2279-z · 2018 · External reference
Oil-in-water nanoemulsion with reversible charge prepared by the phase inversion composition method
10.1016/j.molliq.2021.116174 · 2021 · External reference
Formulation and characterization of amisulpride microemulsions for brain targeting via intranasal route-pharmacodynamic evaluation in Rat model
10.5530/jyp.2020.12s.42 · 2020 · External reference
Microemulsion-Based media in nose-to-brain drug delivery
10.3390/pharmaceutics13020201 · 2021 · External reference
How to characterize a nasal product. The state of the art of in vitro and ex vivo specific methods
10.1016/j.ijpharm.2019.02.026 · 2019 · External reference
Microemulsion as a promising carrier for nose to brain delivery: Journey since last decade
10.1007/s40005-021-00528-w · 2021 · External reference
Nasal drug delivery System and devices: an overview on health effects
10.1021/acs.chas.3c00069 · 2024 · External reference
Drug delivery to the brain via the nasal route of administration: exploration of key targets and major consideration factors
10.1007/s40005-022-00589-5 · 2023 · External reference
Quantitative analysis of drug delivery to the brain via nasal route
10.1016/j.jconrel.2014.06.053 · 2014 · External reference
Design and in vitro evaluation of intranasal diazepam for treating acute repetitive seizures: a technical note
10.1007/s12247-020-09519-0 · 2022 · External reference
Mechanism of intranasal drug delivery directly to the brain
10.1016/j.lfs.2017.12.025 · 2018 · External reference
Intranasal midazolam during presurgical epilepsy monitoring is well tolerated, delays seizure recurrence, and protects from generalized tonic–clonic seizures
10.1111/epi.13088 · 2015 · External reference
"Preanaesthetic sedation with intranasal midazolam atomizer versus oral midazolam in paediatric patients”-a randomized comparative study
10.5958/2394-4994.2016.00053.6 · 2016 · External reference
Intranasal nerve growth factor attenuating the seizure onset via p75R/Caspase pathway in the experimental epilepsy
10.1016/j.brainresbull.2017.07.006 · 2017 · External reference
Efficacy and tolerability of intranasal Midazolam Administration for antiseizure treatment in adults: a systematic review
10.1007/s12028-024-01971-x · 2024 · External reference
Safety and efficacy of midazolam nasal spray for the treatment of intermittent bouts of increased seizure activity in the epilepsy monitoring unit: a double‐blind, randomized, placebo‐controlled trial
10.1111/epi.16704 · 2020 · External reference
Optimization of nanostructured lipid carriers of lamotrigine for brain delivery: in vitro characterization and in vivo efficacy in epilepsy
10.1517/17425247.2014.945416 · 2015 · External reference
Intranasal tetrandrine temperature-sensitive in situ hydrogels for the treatment of microwave-induced brain injury
10.1016/j.ijpharm.2020.119384 · 2020 · External reference
Nanoparticle-mediated brain drug delivery: overcoming blood–brain barrier to treat neurodegenerative diseases
10.1016/j.jconrel.2016.05.044 · 2016 · External reference
Intranasal zolmitriptan-loaded bilosomes with extended nasal mucociliary transit time for direct nose to brain delivery
10.3390/pharmaceutics13111828 · 2021 · External reference
Mediterranean essential oils as precious matrix components and active ingredients of lipid nanoparticles
10.1016/j.ijpharm.2018.06.064 · 2018 · External reference
Crossing the blood–brain barrier: recent advances in drug delivery to the brain
10.1007/s40263-016-0405-9 · 2017 · External reference
Nose-to-brain delivery of perampanel formulated in a self-microemulsifying drug delivery system improves anticonvulsant and anxiolytic activity in mice
10.1016/j.ijpharm.2023.123145 · 2023 · External reference
Intranasal administration of mesenchymal stem cell-derived exosome alleviates hypoxic-ischemic brain injury
10.3390/pharmaceutics16040446 · 2024 · External reference
Zonisamide nanodiamonds for brain targeting: a comprehensive study utilising in silico, in vitro, in vivo, and molecular investigation for successful nose-to-brain delivery for epilepsy management
2025 · External reference
Benzodiazepines in the management of seizures and status epilepticus: a review of routes of delivery, pharmacokinetics, efficacy, and tolerability
10.1007/s40263-022-00940-2 · 2022 · External reference
Transport of drugs from the nasal cavity to the central nervous system
10.1016/s0928-0987(00)00087-7 · 2000 · External reference
Polymeric nanostructures for drug delivery applications based on pluronic copolymer systems
10.1166/jnn.2006.449 · 2006 · External reference
PLGA nanoparticles for nose to brain delivery of clonazepam: formulation, optimization by 32 factorial design, in vitro and in vivo evaluation
10.2174/18755704mta3lotgqw · 2021 · External reference
Intranasal brain-targeted clonazepam polymeric micelles for immediate control of status epilepticus: in vitro optimization, ex vivo determination of cytotoxicity, in vivo biodistribution and pharmacodynamics studies
10.1080/10717544.2016.1223216 · 2016 · External reference
Intranasal delivery of biologics to the central nervous system
10.1016/j.addr.2011.11.002 · 2012 · External reference
The design and development of high drug loading amorphous solid dispersion for hot-melt extrusion platform
10.1016/j.ijpharm.2020.119545 · 2020 · External reference
Controlled release and targeted drug delivery with poly (lactic-co-glycolic acid) nanoparticles: reviewing two decades of research
10.1007/s40005-022-00584-w · 2022 · External reference
Oxcarbazepine free or loaded PLGA nanoparticles as effective intranasal approach to control epileptic seizures in rodents
10.1016/j.ejpb.2018.11.002 · 2018 · External reference
Intranasal delivery to the central nervous system: mechanisms and experimental considerations
10.1002/jps.21924 · 2010 · External reference
Intranasal administration of carbamazepine-loaded carboxymethyl chitosan nanoparticles for drug delivery to the brain
2018 · External reference
Study of valproic acid liposomes for delivery into the brain through an intranasal route
10.1016/j.heliyon.2022.e09030 · 2022 · External reference
Intranasal formulation and characterization of chitosan microsphere for improving in vitro mucoadhesion, residence time and absorption rate of pregabalin
10.22159/ijap.2023v15i1.46359 · 2023 · External reference
A simple method for synthesis of chitosan nanoparticles with ionic gelation and homogenization
10.3390/molecules28114328 · 2023 · External reference
The nasal approach to delivering treatment for brain diseases: an anatomic, physiologic, and delivery technology overview
10.4155/tde.14.41 · 2014 · External reference
Magnetic targeting of human olfactory Mucosa stem cells following intranasal administration: a novel approach to parkinson's disease treatment
10.1007/s12035-021-02392-z · 2021 · External reference
Intranasal formulation and characterization of chitosan microsphere for improving in vitro mucoadhesion, residence time and absorption rate of pregabalin
10.22159/ijap.2023v15i1.46359 · 2023 · External reference
Nose-to-brain delivery of chitosan coated Leciplex containing zopiclone for improved management of epilepsy: formulation, pharmacokinetics, and Pharmacodynamics
2025 · External reference
Lipid-Based Nano formulation approach to target brain for the management of tuberculosis through intranasal delivery: formulation development and evaluation
10.5530/ijper.54.2s.75 · 2020 · External reference
Comparison of oil-in-water emulsions prepared by ultrasound, high-pressure homogenization and high-speed homogenization
10.1016/j.ultsonch.2021.105885 · 2022 · External reference
Intranasal delivery of topiramate nanoemulsion: pharmacodynamic, pharmacokinetic and brain uptake studies
10.1016/j.ijpharm.2020.119486 · 2020 · External reference
Uniform-sized PLA nanoparticles: preparation by premix membrane emulsification
10.1016/j.ijpharm.2008.03.027 · 2008 · External reference
Correlating the impact of well-defined oligosaccharide structures on physical stability profiles of IgG1-Fc glycoforms
10.1016/j.xphs.2015.10.014 · 2016 · External reference
The challenges of treating epilepsy with 25 antiepileptic drugs
10.1016/j.phrs.2016.03.016 · 2016 · External reference
Coronary vascular and myocardial responses to carotid body stimulation in the dog
10.1152/ajplegacy.1975.229.3.754 · 1975 · External reference
Demonstration of direct nose-to-brain transport of unbound HIV-1 replication inhibitor DB213 via intranasal administration by pharmacokinetic modeling
10.1208/s12248-017-0179-0 · 2018 · External reference
Effect of lamotrigine on epilepsy‐induced cognitive impairment and hippocampal neuronal apoptosis in pentylenetetrazole‐kindled animal model
10.1002/syn.21945 · 2017 · External reference
Nose-to-brain delivery of levetiracetam after intranasal administration to mice
10.1016/j.ijpharm.2019.04.047 · 2019 · External reference
Zinc signaling and epilepsy
10.1016/j.pharmthera.2018.08.013 · 2019 · External reference
The gut microbiota as a biomarker in epilepsy
10.1016/j.nbd.2021.105598 · 2022 · External reference
Nose-to-brain drug delivery: challenges and progress towards brain targeting in the treatment of neurological disorders
2023 · External reference
Lipid-coated MCM-41 mesoporous silica nanoparticles loaded with berberine improved inhibition of acetylcholine esterase and amyloid formation
10.1021/acsbiomaterials.1c00514 · 2021 · External reference
Epidemiological profile of epilepsy in low income populations
10.1016/j.seizure.2018.02.002 · 2018 · External reference
Molecular mechanisms of topiramate and its clinical value in epilepsy
10.1016/j.seizure.2022.03.024 · 2022 · External reference
Inorganic clay nanocomposite system for improved cholinesterase inhibition and brain pharmacokinetics of donepezil
10.1080/03639045.2019.1698594 · 2020 · External reference
Cardiovascular disease risk, awareness, and treatment in people with epilepsy
10.1016/j.yebeh.2021.107878 · 2021 · External reference
From genetic testing to precision medicine in epilepsy
10.1007/s13311-020-00835-4 · 2020 · External reference
Neurosteroidal modulation of in vitro epileptiform activity is enhanced in pilocarpine-treated epileptic rats
10.1016/j.nbd.2015.03.020 · 2015 · External reference
Intranasal therapies for acute seizures
10.1016/j.yebeh.2015.04.027 · 2015 · External reference
Association of knowledge about epilepsy with mood and self-efficacy in Korean people with epilepsy
10.1016/j.yebeh.2015.08.027 · 2015 · External reference
Effect of sodium nitrate loading on electrolyte transport by the renal tubule
10.1152/ajplegacy.1975.229.3.746 · 1975 · External reference
Epilepsy in patients with autism: links, risks and treatment challenges
10.2147/ndt.s120509 · 2017 · External reference
A complex systems view on the current hypotheses of epilepsy pharmacoresistance
2022 · External reference
