Research graph
References from Immune memory engineering in mRNA therapeutics. Local targets link to admitted publications; unresolved targets remain external evidence.
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10.1038/nri3084 · 2011 · External reference
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10.3390/pharmaceutics12111068 · 2020 · External reference
Anti-PEG antibodies boosted in humans by SARS-CoV-2 lipid nanoparticle mRNA vaccine
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PEG shedding-rate-dependent blood clearance of PEGylated lipid nanoparticles in mice: faster PEG shedding attenuates anti-PEG IgM production
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Tissue resident memory T cells in the respiratory tract
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The developmental pathway for CD103+ CD8+ tissue-resident memory T cells of skin
10.1038/ni.2744 · 2013 · External reference
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The mRNA-LNP platform's lipid nanoparticle component used in preclinical vaccine studies is highly inflammatory
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10.1016/j.celrep.2012.05.010 · 2012 · External reference
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Germinal centers
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Intratumoral Tcf1+ PD-1+ CD8+ T cells with stem-like properties promote tumor control in response to vaccination and checkpoint blockade immunotherapy
10.1016/j.immuni.2018.12.021 · 2019 · External reference
Stem-like CD8 T cells mediate response of adoptive cell immunotherapy against human cancer
10.1126/science.abb9847 · 2020 · External reference
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10.1016/j.coi.2017.06.008 · 2017 · External reference
Personalized RNA mutanome vaccines mobilize poly-specific therapeutic immunity against cancer
10.1038/nature23003 · 2017 · External reference
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10.1038/s41551-021-00786-x · 2021 · External reference
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10.1002/advs.202508907 · ExternalCitation · doi-reference
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10.1002/mco2.714 · ExternalCitation · doi-reference
The signal peptide
10.1007/bf01868635 · ExternalCitation · doi-reference
Signatures of trained immunity following mRNA vaccination: differences between mRNA-1273 and BNT162b2
10.1007/s10875-025-01977-w · ExternalCitation · doi-reference
B cell responses: cell interaction dynamics and decisions
10.1016/j.cell.2019.03.016 · ExternalCitation · doi-reference
Adaptive immunity to SARS-CoV-2 and COVID-19
10.1016/j.cell.2021.01.007 · ExternalCitation · doi-reference
Clonal replacement sustains long-lived germinal centers primed by respiratory viruses
10.1016/j.cell.2022.11.031 · ExternalCitation · doi-reference
A theory of germinal center B cell selection, division, and exit
10.1016/j.celrep.2012.05.010 · ExternalCitation · doi-reference
The follicular dendritic cell: at the germinal center of autoimmunity?
10.1016/j.celrep.2024.113869 · ExternalCitation · doi-reference
Glutaminolysis and fumarate accumulation integrate immunometabolic and epigenetic programs in trained immunity
10.1016/j.cmet.2016.10.008 · ExternalCitation · doi-reference
Clonal and cellular dynamics in germinal centers
10.1016/j.coi.2014.02.010 · ExternalCitation · doi-reference
Germinal center enhancement by extended antigen availability
10.1016/j.coi.2017.06.008 · ExternalCitation · doi-reference
Antigen presentation by dendritic cells for B cell activation
10.1016/j.coi.2019.04.003 · ExternalCitation · doi-reference
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10.1016/j.coi.2021.07.013 · ExternalCitation · doi-reference
PEG shedding-rate-dependent blood clearance of PEGylated lipid nanoparticles in mice: faster PEG shedding attenuates anti-PEG IgM production
10.1016/j.ijpharm.2020.119792 · ExternalCitation · doi-reference
From vaccines to memory and back
10.1016/j.immuni.2010.10.008 · ExternalCitation · doi-reference
Histo-cytometry: a method for highly multiplex quantitative tissue imaging analysis applied to dendritic cell subset microanatomy in lymph nodes
10.1016/j.immuni.2012.07.011 · ExternalCitation · doi-reference
T follicular helper cell differentiation, function, and roles in disease
10.1016/j.immuni.2014.10.004 · ExternalCitation · doi-reference
Tissue-resident memory T cells
10.1016/j.immuni.2014.12.007 · ExternalCitation · doi-reference
CD4+ T cell help confers a cytotoxic T cell effector program including coinhibitory receptor downregulation and increased tissue invasiveness
10.1016/j.immuni.2017.10.009 · ExternalCitation · doi-reference
Intratumoral Tcf1+ PD-1+ CD8+ T cells with stem-like properties promote tumor control in response to vaccination and checkpoint blockade immunotherapy
10.1016/j.immuni.2018.12.021 · ExternalCitation · doi-reference
Innate immune mechanisms of mRNA vaccines
10.1016/j.immuni.2022.10.014 · ExternalCitation · doi-reference
Immunological memory to vaccines
10.1016/j.immuni.2026.02.019 · ExternalCitation · doi-reference
The mRNA-LNP platform's lipid nanoparticle component used in preclinical vaccine studies is highly inflammatory
10.1016/j.isci.2021.103479 · ExternalCitation · doi-reference
Optimized lipid nanoparticles (LNPs) for organ-selective nucleic acids delivery in vivo
10.1016/j.isci.2024.109804 · ExternalCitation · doi-reference
Present yourself! By MHC class I and MHC class II molecules
10.1016/j.it.2016.08.010 · ExternalCitation · doi-reference
Antigen presentation to B cells
10.1016/j.it.2016.10.003 · ExternalCitation · doi-reference
Machine learning-driven optimization of mRNA-lipid nanoparticle vaccine quality with XGBoost/Bayesian method and ensemble model approaches
10.1016/j.jpha.2024.100996 · ExternalCitation · doi-reference
Optimization of lipid nanoparticles for intramuscular administration of mRNA vaccines
10.1016/j.omtn.2019.01.013 · ExternalCitation · doi-reference
mRNA-LNP vaccines tuned for systemic immunization induce strong antitumor immunity by engaging splenic immune cells
10.1016/j.ymthe.2022.07.007 · ExternalCitation · doi-reference
CircRNA: unlocking new frontiers in therapeutic and vaccine development
10.1016/j.ymthe.2025.10.038 · ExternalCitation · doi-reference
STING agonist-derived LNP-mRNA vaccine enhances protective immunity against SARS-CoV-2
10.1021/acs.nanolett.2c04883 · ExternalCitation · doi-reference
Anti-PEG antibodies boosted in humans by SARS-CoV-2 lipid nanoparticle mRNA vaccine
10.1021/acsnano.2c04543 · ExternalCitation · doi-reference
Iterative design of ionizable lipids for intramuscular mRNA delivery
10.1021/jacs.2c10670 · ExternalCitation · doi-reference
Fluorinated ionizable lipids for efficient spleen-targeted mRNA delivery in cancer immunotherapy
10.1021/jacs.5c13982 · ExternalCitation · doi-reference
Memory CD8+ T cell differentiation: initial antigen encounter triggers a developmental program in naive cells
10.1038/87720 · ExternalCitation · doi-reference
Incorporation of pseudouridine into mRNA yields superior nonimmunogenic vector with increased translational capacity and biological stability
10.1038/mt.2008.200 · ExternalCitation · doi-reference
Adaptive immune features of natural killer cells
10.1038/nature07665 · ExternalCitation · doi-reference
Systemic RNA delivery to dendritic cells exploits antiviral defence for cancer immunotherapy
10.1038/nature18300 · ExternalCitation · doi-reference
Personalized RNA mutanome vaccines mobilize poly-specific therapeutic immunity against cancer
10.1038/nature23003 · ExternalCitation · doi-reference
The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors
10.1038/ni.1863 · ExternalCitation · doi-reference
Immunological mechanisms of vaccination
10.1038/ni.2039 · ExternalCitation · doi-reference
The developmental pathway for CD103+ CD8+ tissue-resident memory T cells of skin
10.1038/ni.2744 · ExternalCitation · doi-reference
Molecular regulation of effector and memory T cell differentiation
10.1038/ni.3031 · ExternalCitation · doi-reference
A human memory T cell subset with stem cell–like properties
10.1038/nm.2446 · ExternalCitation · doi-reference
T memory stem cells in health and disease
10.1038/nm.4241 · ExternalCitation · doi-reference
Engineering synthetic vaccines using cues from natural immunity
10.1038/nmat3775 · ExternalCitation · doi-reference
mRNA vaccines—a new era in vaccinology
10.1038/nrd.2017.243 · ExternalCitation · doi-reference
mRNA-based therapeutics—developing a new class of drugs
10.1038/nrd4278 · ExternalCitation · doi-reference
Immunological memory: lessons from the past and a look to the future
10.1038/nri.2016.13 · ExternalCitation · doi-reference
A guide to immunometabolism for immunologists
10.1038/nri.2016.70 · ExternalCitation · doi-reference
The who, how and where of antigen presentation to B cells
10.1038/nri2454 · ExternalCitation · doi-reference
Towards a systems understanding of MHC class I and MHC class II antigen presentation
10.1038/nri3084 · ExternalCitation · doi-reference
Transcriptional control of effector and memory CD8+ T cell differentiation
10.1038/nri3307 · ExternalCitation · doi-reference
The integration of T cell migration, differentiation and function
10.1038/nri3442 · ExternalCitation · doi-reference
Regulation of type I interferon responses
10.1038/nri3581 · ExternalCitation · doi-reference
Follicular dendritic cells: dynamic antigen libraries
10.1038/nri3689 · ExternalCitation · doi-reference
The generation of antibody-secreting plasma cells
10.1038/nri3795 · ExternalCitation · doi-reference
A brief history of T cell help to B cells
10.1038/nri3803 · ExternalCitation · doi-reference
The ins and outs of MHC class II-mediated antigen processing and presentation
10.1038/nri3818 · ExternalCitation · doi-reference
Molecular and cellular insights into T cell exhaustion
10.1038/nri3862 · ExternalCitation · doi-reference
Immunogenicity of lipid nanoparticles and its impact on the efficacy of mRNA vaccines and therapeutics
10.1038/s12276-023-01086-x · ExternalCitation · doi-reference
Tissue resident memory T cells in the respiratory tract
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