Research graph
References from Postoperative glioblastoma management: from relapse mechanisms and clinical interventions to emerging drug delivery strategies. Local targets link to admitted publications; unresolved targets remain external evidence.
Comprehensive multi-omics approach reveals critical genes and immunometabolic networks in glioblastoma
10.1097/js9.0000000000002634 · 2025 · External reference
Brain immunology and immunotherapy in brain tumours
10.1038/s41568-019-0224-7 · 2020 · External reference
Glioblastoma multiforme (GBM): an overview of current therapies and mechanisms of resistance
10.1016/j.phrs.2021.105780 · 2021 · External reference
Advancing glioblastoma therapy: learning from the past and innovations for the future
10.1016/j.canlet.2025.217601 · 2025 · External reference
EANO guidelines on the diagnosis and treatment of diffuse gliomas of adulthood
10.1038/s41571-020-00447-z · 2021 · External reference
Targeting the glioblastoma resection margin with locoregional nanotechnologies
10.1038/s41571-025-01020-2 · 2025 · External reference
Supramarginal resection of glioblastoma: a review[J]
10.1016/j.nec.2024.08.007 · 2024 · External reference
Glioblastoma in adults: a society for neuro-oncology (SNO) and European Society of Neuro-oncology (EANO) consensus review on current management and future directions
10.1093/neuonc/noaa106 · 2020 · External reference
Intratumoral heterogeneity: pathways to treatment resistance and relapse in human glioblastoma
10.1093/annonc/mdx169 · 2017 · External reference
Recurrence pattern analysis of primary glioblastoma
10.1016/j.wneu.2017.04.053 · 2017 · External reference
Targeting therapeutic nanoparticles to the glioblastoma resection margin by harnessing postoperative blood-brain barrier disruption
10.1126/scitranslmed.adv8761 · 2026 · External reference
The dynamics of tumor-infiltrating myeloid cell activation and the cytokine expression profile in a glioma resection site during the post-surgical period in mice
10.3390/brainsci12070893 · 2022 · External reference
Interrogation of the microenvironmental landscape in brain tumors reveals disease-specific alterations of immune cells
10.1016/j.cell.2020.05.007 · 2020 · External reference
Single-cell transcriptomic analysis of glioblastoma reveals pericytes contributing to the blood-brain-tumor barrier and tumor progression
2024 · External reference
CRISPR/Cas9-induced knockout reveals the role of ABCB1 in the response to temozolomide, carmustine and lomustine in glioblastoma multiforme
10.1016/j.phrs.2022.106510 · 2022 · External reference
Single-cell dissection of the human blood-brain barrier and glioma blood-tumor barrier
10.1016/j.neuron.2024.07.026 · 2024 · External reference
Tailoring glioblastoma treatment based on longitudinal analysis of post-surgical tumor microenvironment
10.1186/s13046-024-03231-4 · 2024 · External reference
Construction of a whole-brain panorama for glioma vasculature reveals tumor heterogeneity and blood-brain barrier disruption
10.1126/sciadv.adw8330 · 2025 · External reference
Dual-responsive nanoparticle system for enhanced blood-brain barrier crossing and glioblastoma penetration
10.1016/j.biomaterials.2025.123730 · 2026 · External reference
Reprogramming systemic and local immune function to empower immunotherapy against glioblastoma
10.1038/s41467-023-35957-8 · 2023 · External reference
A phase 3 trial of local chemotherapy with biodegradable carmustine (BCNU) wafers (Gliadel wafers) in patients with primary malignant glioma
10.1093/neuonc/5.2.79 · 2003 · External reference
Biomarkers and smart intracranial devices for the diagnosis, treatment, and monitoring of high-grade gliomas: a review of the literature and future prospects
2019 · External reference
Iodine-131-labeled antitenascin monoclonal antibody 81C6 treatment of patients with recurrent malignant gliomas: phase I trial results
10.1200/jco.1998.16.6.2202 · 1998 · External reference
Multifunctional hybrid hydrogel system enhanced the therapeutic efficacy of treatments for postoperative glioma
10.1021/acsami.2c05147 · 2022 · External reference
Stimulation of tumoricidal immunity via bacteriotherapy inhibits glioblastoma relapse
10.1038/s41467-024-48606-5 · 2024 · External reference
Neural stem cell-delivered oncolytic virus via intracerebroventricular administration enhances glioblastoma therapy and immune modulation
10.1136/jitc-2025-012934 · 2025 · External reference
Postoperative injection of a triptolide-preloaded hydrogel prevents the recurrence of glioblastoma by dual-pathway activation of ferroptosis
10.1002/smll.202406036 · 2024 · External reference
Developing implantable scaffolds to enhance neural stem cell therapy for post-operative glioblastoma
10.1016/j.ymthe.2020.02.008 · 2020 · External reference
Biodegradable nanofibrous scaffolds enhance standard of care for glioblastoma via localized targeted therapy
10.1016/j.jconrel.2025.114225 · 2025 · External reference
Glioblastoma cell adhesion properties through bacterial cellulose nanocrystals in polycaprolactone/gelatin electrospun nanofibers
10.1016/j.carbpol.2019.115820 · 2020 · External reference
3D-printed implants loaded with acriflavine for glioblastoma treatment
10.1016/j.ijpharm.2024.124710 · 2024 · External reference
Implantable microneedle-mediated eradication of postoperative tumor foci mitigates glioblastoma relapse
10.1002/adma.202409857 · 2024 · External reference
Self-oxygenating PROTAC microneedle for spatiotemporally-confined protein degradation and enhanced glioblastoma therapy
10.1002/adma.202411869 · 2025 · External reference
Silk microneedle patch capable of on-demand multidrug delivery to the brain for glioblastoma treatment
2022 · External reference
Spatiotemporal tracking of gold nanorods after intranasal administration for brain targeting
10.1016/j.jconrel.2023.04.022 · 2023 · External reference
A microfluidics-based scalable approach to generate extracellular vesicles with enhanced therapeutic microRNA loading for intranasal delivery to mouse glioblastomas
10.1021/acsnano.1c07587 · 2021 · External reference
Multiplexed epigenetic memory editing using CRISPRoff sensitizes glioblastoma to chemotherapy
10.1093/neuonc/noaf055 · 2025 · External reference
Hyaluronan decorated layer-by-layer assembled lipid nanoparticles for miR-181a delivery in glioblastoma treatment
10.1016/j.biomaterials.2023.122341 · 2023 · External reference
CD47 knock-out using CRISPRI-Cas9 RNA lipid nanocarriers results in reduced mesenchymal glioblastoma growth in vivo
2025 · External reference
Bio-polymeric transferrin-targeted temozolomide nanoparticles in gel for synergistic post-surgical GBM therapy
10.1039/d2nr00171c · 2022 · External reference
Inorganic and hybrid nanomaterials for NIR-II fluorescence imaging-guided therapy of glioblastoma and perspectives
10.7150/thno.112204 · 2025 · External reference
TREM2 mediates MHCII-associated CD4+ T-cell response against gliomas
10.1093/neuonc/noad214 · 2024 · External reference
Dual avβ8 integrin and PD-1 blockade overcomes TGFβ-mediated B-cell suppression to enhance anti-tumor immunity
10.1093/neuonc/noaf106 · 2025 · External reference
Emerging extracellular vesicle-based carriers for glioblastoma diagnosis and therapy
10.1039/d3nr01667f · 2023 · External reference
Glioblastoma at the crossroads: current understanding and future therapeutic horizons
10.1038/s41392-025-02299-4 · 2025 · External reference
Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma
10.1056/nejmoa043330 · 2005 · External reference
Effect of tumor-treating fields plus maintenance temozolomide vs maintenance temozolomide alone on survival in patients with glioblastoma: a randomized clinical trial
10.1001/jama.2017.18718 · 2017 · External reference
The 2021 WHO classification of tumors of the central nervous system: a summary
10.1093/neuonc/noab106 · 2021 · External reference
MGMT gene silencing and benefit from temozolomide in glioblastoma
10.1056/nejmoa043331 · 2005 · External reference
Bevacizumab alone and in combination with irinotecan in recurrent glioblastoma
10.1200/jco.2008.19.8721 · 2009 · External reference
Lomustine and bevacizumab in progressive glioblastoma
10.1056/nejmoa1707358 · 2017 · External reference
RAGE inhibitors as alternatives to dexamethasone for managing cerebral edema following brain tumor surgery
10.1007/s13311-022-01207-w · 2022 · External reference
Surgical resection of glioblastomas induces pleiotrophin-mediated self-renewal of glioblastoma stem cells in recurrent tumors
10.1093/neuonc/noab302 · 2022 · External reference
Shared inflammatory glial cell signature after stab wound injury, revealed by spatial, temporal, and cell-type-specific profiling of the murine cerebral cortex
10.1038/s41467-024-46625-w · 2024 · External reference
Surgical debulking promotes recruitment of macrophages and triggers glioblastoma phagocytosis in combination with CD47 blocking immunotherapy
10.18632/oncotarget.14553 · 2017 · External reference
Mesoscale recovery of microglial and neuronal dynamics after craniotomy across wide cortex in transgenic mice
2026 · External reference
Limited recurrence distance of glioblastoma under modern radiotherapy era
10.1186/s12885-021-08467-3 · 2021 · External reference
Brain invasion along perivascular spaces by glioma cells: relationship with blood-brain barrier
10.3390/cancers12010018 · 2019 · External reference
Precancerous cells initiate glioblastoma evolution and contribute to intratumoral heterogeneity
10.1158/2159-8290.cd-24-0234 · 2025 · External reference
Glioblastoma evolution and heterogeneity from a 3D whole-tumor perspective
10.1016/j.cell.2023.12.013 · 2024 · External reference
Cancer stem cell hypothesis 2.0 in glioblastoma: where are we now and where are we going?
10.1093/neuonc/noae011 · 2024 · External reference
Characterisation of the tumour microenvironment in primary and recurrent glioblastomas
10.1111/nan.13012 · 2024 · External reference
CD103+ regulatory T cells underlie resistance to radio-immunotherapy and impair CD8+ T cell activation in glioblastoma
2023 · External reference
Single-cell transcriptomics reveals immunosuppressive microenvironment and highlights tumor-promoting macrophage cells in glioblastoma
10.1371/journal.pone.0312764 · 2025 · External reference
Localized treatment of glioblastoma: a review of clinical strategies and advances in drug delivery systems
10.1080/17435889.2025.2550239 · 2025 · External reference
IGFBP5 is an ROR1 ligand promoting glioblastoma invasion via ROR1/HER2-CREB signaling axis
10.1038/s41467-023-37306-1 · 2023 · External reference
Local therapeutic platform prevents postsurgical GBM recurrence by diminishing GICs and reshaping immunosuppressive microenvironment
10.1038/s41467-025-67415-y · 2025 · External reference
The invasion phenotypes of glioblastoma depend on plastic and reprogrammable cell states
10.1038/s41467-025-61999-1 · 2025 · External reference
Mechanisms regulating glioma invasion
10.1016/j.canlet.2015.03.015 · 2015 · External reference
Recent development of contrast agents for magnetic resonance and multimodal imaging of glioblastoma
10.1186/s12951-022-01479-6 · 2022 · External reference
Preoperative PET imaging and fluorescence-guided surgery of human glioblastoma using dual-labeled antibody targeting ET(A) receptors in a preclinical mouse model: a theranostic approach
10.7150/thno.98163 · 2024 · External reference
Irdye800cw labeled upar-targeting peptide for fluorescence-guided glioblastoma surgery: preclinical studies in orthotopic xenografts
10.7150/thno.49787 · 2021 · External reference
First-in-human study of pet and optical dual-modality image-guided surgery in glioblastoma using (68)Ga-IRDye800CW-BBN
10.7150/thno.25599 · 2018 · External reference
Residual tumor cells are unique cellular targets in glioblastoma
10.1002/ana.22036 · 2010 · External reference
Surgical results of tumor resection using tractography-integrated navigation-guided fence-post catheter techniques and motor-evoked potentials for preservation of motor function in patients with glioblastomas near the pyramidal tracts
10.1007/s10143-014-0593-z · 2015 · External reference
Integrative multi-omics analysis reveal novel therapeutic targets for glioblastoma
10.1097/js9.0000000000002941 · 2025 · External reference
The somatic genomic landscape of glioblastoma
10.1016/j.cell.2013.09.034 · 2013 · External reference
Integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR, and NF1
10.1016/j.ccr.2009.12.020 · 2010 · External reference
EPHA2 mediates PDGFA activity and functions together with PDGFRA as prognostic marker and therapeutic target in glioblastoma
10.1038/s41392-021-00855-2 · 2022 · External reference
Endothelial-secreted endocan activates PDGFRA and regulates vascularity and spatial phenotype in glioblastoma
10.1038/s41467-024-55487-1 · 2025 · External reference
Cancer cell heterogeneity and plasticity: a paradigm shift in glioblastoma
10.1093/neuonc/noab269 · 2022 · External reference
Integrated single-cell transcriptomic analyses reveal that GPNMB-high macrophages promote PN-MES transition and impede T cell activation in GBM
10.1016/j.ebiom.2022.104239 · 2022 · External reference
Integrative analysis identifies an immune-relevant epigenetic signature for prognostication of non-G-CIMP glioblastomas
10.1080/2162402x.2021.1902071 · 2021 · External reference
Genome-wide methylation profiling identifies an essential role of reactive oxygen species in pediatric glioblastoma multiforme and validates a methylome specific for H3 histone family 3A with absence of G-CIMP/isocitrate dehydrogenase 1 mutation
10.1093/neuonc/nou113 · 2014 · External reference
Role of N6-methyladenosine methylation in glioma: recent insights and future directions
10.1186/s11658-023-00514-0 · 2023 · External reference
m6A modification in rna: biogenesis, functions and roles in gliomas
10.1186/s13046-020-01706-8 · 2020 · External reference
O-GlcNAcylation stabilized WTAP promotes GBM malignant progression in an N6-methyladenosine-dependent manner
10.1093/neuonc/noae268 · 2025 · External reference
Metabolic regulation of the glioblastoma stem cell epitranscriptome by malate dehydrogenase 2
10.1016/j.cmet.2024.09.014 · 2024 · External reference
Hypoxia-induced neuronal activity in glioma patients polarizes microglia by potentiating RNA m6A demethylation
10.1158/1078-0432.ccr-23-0430 · 2024 · External reference
Glioblastoma cortical organoids recapitulate cell-state heterogeneity and intercellular transfer
10.1158/2159-8290.cd-23-1336 · 2025 · External reference
The development and potent antitumor efficacy of CD44/CD133 dual-targeting IL7Rα-armored CAR-T cells against glioblastoma
10.1016/j.canlet.2025.217541 · 2025 · External reference
The rational development of CD133-targeting immunotherapies for glioblastoma
10.1016/j.stem.2020.04.008 · 2020 · External reference
Reprogramming transcription factors Oct4 and Sox2 induce a BRD-dependent immunosuppressive transcriptome in GBM-propagating cells
10.1158/0008-5472.can-20-2489 · 2021 · External reference
Reconstructing and reprogramming the tumor-propagating potential of glioblastoma stem-like cells
10.1016/j.cell.2014.02.030 · 2014 · External reference
HIF1α/ATF3 partake in PGK1 k191/k192 succinylation by modulating p4ha1/succinate signaling in glioblastoma
10.1093/neuonc/noae040 · 2024 · External reference
Hypoxia-driven protease legumain promotes immunosuppression in glioblastoma
2023 · External reference
Hypoxia-induced complement component 3 promotes aggressive tumor growth in the glioblastoma microenvironment
10.1172/jci.insight.179854 · 2024 · External reference
Hypoxia-induced TGFBI maintains glioma stem cells by stabilizing EPHA2
10.7150/thno.95141 · 2024 · External reference
STAT3 blockade inhibits radiation-induced malignant progression in glioma
10.1158/0008-5472.can-14-3331 · 2015 · External reference
Temozolomide promotes glioblastoma stemness expression through senescence-associated reprogramming via HIF1α/HIF2α regulation
10.1038/s41419-025-07617-w · 2025 · External reference
Glioma stem cells remodel immunotolerant microenvironment in GBM and are associated with therapeutic advancements
10.3233/cbm-230486 · 2024 · External reference
NOTCH -induced MDSC recruitment after oHSV virotherapy in CNS cancer models modulates antitumor immunotherapy
10.1158/1078-0432.ccr-21-2347 · 2022 · External reference
β2-microglobulin maintains glioblastoma stem cells and induces M2-like polarization of tumor-associated macrophages
10.1158/0008-5472.can-22-0507 · 2022 · External reference
IL-13Rα2/TGF-β bispecific CAR-T cells counter TGF-β-mediated immune suppression and potentiate anti-tumor responses in glioblastoma
10.1093/neuonc/noae126 · 2024 · External reference
Multi-scale signaling and tumor evolution in high-grade gliomas
10.1016/j.ccell.2024.06.004 · 2024 · External reference
Aberrant STAT3 signaling by Interleukin-4 in malignant glioma cells: involvement of IL-13Rα2
10.1158/0008-5472.can-04-3592 · 2005 · External reference
CSF-1R inhibition alters macrophage polarization and blocks glioma progression
10.1038/nm.3337 · 2013 · External reference
Antigen presentation by tumor-associated macrophages drives T cells from a progenitor exhaustion state to terminal exhaustion
10.1016/j.immuni.2024.11.026 · 2025 · External reference
Endothelial cells induce cancer stem cell features in differentiated glioblastoma cells via bFGF
10.1186/s12943-015-0420-3 · 2015 · External reference
Intracavitary VEGF, bFGF, IL-8, IL-12 levels in primary and recurrent malignant glioma
10.1023/a:1023367223575 · 2003 · External reference
Cancer cell autophagy, reprogrammed macrophages, and remodeled vasculature in glioblastoma triggers tumor immunity
10.1016/j.ccell.2022.08.014 · 2022 · External reference
Fibrotic response to anti-CSF-1R therapy potentiates glioblastoma recurrence
10.1016/j.ccell.2024.08.012 · 2024 · External reference
Reactive astrocytes potentiate tumor aggressiveness in a murine glioma resection and recurrence model
10.1093/neuonc/now117 · 2016 · External reference
Modulation of the blood-brain barrier permeability by patient-derived glioblastoma stem cell secretome
10.1038/s41598-025-21272-3 · 2025 · External reference
Altered abundance of barrier-related proteins in brain microvascular endothelial cells of the GL261 mouse model of glioblastoma
10.1021/acs.molpharmaceut.5c00609 · 2025 · External reference
Cells of the blood-brain barrier: an overview of the neurovascular unit in health and disease
10.1007/978-1-0716-2289-6_1 · 2022 · External reference
Fixed-point cleaved bioinspired nanosystem via promoting LAT1-mediated BBB penetration for spatiotemporal therapy in TMZ resistant glioblastoma
10.1016/j.cej.2025.164470 · 2025 · External reference
Temozolomide competes for P-glycoprotein and contributes to chemoresistance in glioblastoma cells
10.1016/j.canlet.2015.07.013 · 2015 · External reference
Surface functionalized albumin nanoparticles of palbociclib with amplified brain delivery for treating brain glioblastoma
10.1038/s41598-025-13721-w · 2025 · External reference
Advances in brain-targeted delivery strategies and natural product-mediated enhancement of blood-brain barrier permeability
10.1186/s12951-025-03415-w · 2025 · External reference
P450 oxidoreductase regulates barrier maturation by mediating retinoic acid metabolism in a model of the human BBB
10.1016/j.stemcr.2022.07.010 · 2022 · External reference
The blood-brain barrier: bottleneck in brain drug development
10.1602/neurorx.2.1.3 · 2005 · External reference
The blood-brain barrier: structure, regulation, and drug delivery
10.1038/s41392-023-01481-w · 2023 · External reference
Enhancement of therapies for glioblastoma (gbm) using nanoparticle-based delivery systems
10.1208/s12249-021-01928-9 · 2021 · External reference
Key molecular alterations in endothelial cells in human glioblastoma uncovered through single-cell RNA sequencing
10.1172/jci.insight.150861 · 2021 · External reference
Angiogenic signaling pathways and anti-angiogenic therapy for cancer
10.1038/s41392-023-01460-1 · 2023 · External reference
Optical blood-brain-tumor barrier modulation expands therapeutic options for glioblastoma treatment
10.1038/s41467-023-40579-1 · 2023 · External reference
Microglia contributes to BAF-312 effects on blood-brain barrier stability
10.3390/biom12091174 · 2022 · External reference
Blood-brain barrier permeability increases with the differentiation of glioblastoma cells in vitro
10.1186/s12987-024-00590-0 · 2024 · External reference
The impact of P-glycoprotein and breast cancer resistance protein on the brain pharmacokinetics and pharmacodynamics of a panel of MEK inhibitors
10.1002/ijc.31052 · 2018 · External reference
Nanotherapeutic treatment of the invasive glioblastoma tumor microenvironment
10.1016/j.addr.2022.114415 · 2022 · External reference
Abbreviated course of radiation therapy in older patients with glioblastoma multiforme: a prospective randomized clinical trial
10.1200/jco.2004.06.082 · 2004 · External reference
NRG oncology/RTOG1205: a randomized phase II trial of concurrent bevacizumab and reirradiation versus bevacizumab alone as treatment for recurrent glioblastoma
10.1200/jco.22.00164 · 2023 · External reference
LncRNA-mediated TPI1 and PKM2 promote self-renewal and chemoresistance in GBM
2024 · External reference
Cellular senescence-associated gene IFI16 promotes HMOX1-dependent evasion of ferroptosis and radioresistance in glioblastoma
10.1038/s41467-025-56456-y · 2025 · External reference
Lactylation-driven USP4-mediated ANXA2 stabilization and activation promotes maintenance and radioresistance of glioblastoma stem cells
10.1038/s41418-025-01494-8 · 2025 · External reference
SDC1-dependent TGM2 determines radiosensitivity in glioblastoma by coordinating EPG5-mediated fusion of autophagosomes with lysosomes
10.1080/15548627.2022.2105562 · 2023 · External reference
Rbbp4 regulates the expression of the mre11-rad50-nbs1 (mrn) complex and promotes DNA double-strand break repair to mediate glioblastoma chemoradiotherapy resistance
10.1016/j.canlet.2023.216078 · 2023 · External reference
SP1 upregulation bolsters the radioresistance of glioblastoma cells by promoting double strand breaks repair
10.3390/ijms241310658 · 2023 · External reference
Aberrant ATM signaling and homology-directed DNA repair as a vulnerability of p53-mutant GBM to azd1390-mediated radiosensitization
10.1126/scitranslmed.adj5962 · 2024 · External reference
Radioresistance and transcriptional reprograming of invasive glioblastoma cells
10.1016/j.ijrobp.2021.09.017 · 2021 · External reference
Selective inhibition of parallel DNA damage response pathways optimizes radiosensitization of glioblastoma stem-like cells
10.1158/0008-5472.can-14-3790 · 2015 · External reference
Cancer stem cells and glioblastoma: time for innovative biomarkers of radio-resistance?
10.3390/biology12101295 · 2023 · External reference
Dynamic changes in glioma macrophage populations after radiotherapy reveal CSF-1R inhibition as a strategy to overcome resistance
10.1126/scitranslmed.aaw7843 · 2020 · External reference
Colony stimulating factor 1 receptor inhibition delays recurrence of glioblastoma after radiation by altering myeloid cell recruitment and polarization
10.1093/neuonc/nov272 · 2015 · External reference
Resistance of glioblastoma-initiating cells to radiation mediated by the tumor microenvironment can be abolished by inhibiting transforming growth factor-β
10.1158/0008-5472.can-12-0546 · 2012 · External reference
Suppression of ITPKB degradation by TRIM25 confers TMZ resistance in glioblastoma through ROS homeostasis
10.1038/s41392-024-01763-x · 2024 · External reference
Overcoming temozolomide resistance in glioma: recent advances and mechanistic insights
10.1186/s40478-025-02046-4 · 2025 · External reference
Mechanisms and therapeutic implications of hypermutation in gliomas
10.1038/s41586-020-2209-9 · 2020 · External reference
MSH6 mutations arise in glioblastomas during temozolomide therapy and mediate temozolomide resistance
10.1158/1078-0432.ccr-08-3012 · 2009 · External reference
Adaptive chromatin remodeling drives glioblastoma stem cell plasticity and drug tolerance
10.1016/j.stem.2016.11.003 · 2017 · External reference
An integrative model of cellular states, plasticity, and genetics for glioblastoma
10.1016/j.cell.2019.06.024 · 2019 · External reference
A single-cell atlas of glioblastoma evolution under therapy reveals cell-intrinsic and cell-extrinsic therapeutic targets
2022 · External reference
CCAAT/enhancer-binding protein delta mediates glioma stem-like cell enrichment and ATP-binding cassette transporter ABCA1 activation for temozolomide resistance in glioblastoma
10.1038/s41420-020-00399-4 · 2021 · External reference
Quiescent human glioblastoma cancer stem cells drive tumor initiation, expansion, and recurrence following chemotherapy
10.1016/j.devcel.2021.12.007 · 2022 · External reference
Doxorubicin-polyglycerol-nanodiamond conjugates disrupt STAT3/IL-6-mediated reciprocal activation loop between glioblastoma cells and astrocytes
10.1016/j.jconrel.2020.01.044 · 2020 · External reference
PI3Kγ inhibition suppresses microglia/TAM accumulation in glioblastoma microenvironment to promote exceptional temozolomide response
10.1073/pnas.2009290118 · 2021 · External reference
TGF-β1 modulates temozolomide resistance in glioblastoma via altered microRNA processing and elevated MGMT
10.1093/neuonc/noaa198 · 2021 · External reference
Nanoparticles for immobilization and delivery of temozolomide: functional design of carriers, advances, limitations and opportunities for glioblastoma co-therapy
10.1016/j.bioadv.2026.214829 · 2026 · External reference
Biomimetic hybrid PROTAC nanovesicles block multiple DNA repair pathways to overcome temozolomide resistance against orthotopic glioblastoma
10.1002/adma.202504253 · 2025 · External reference
Nano-codelivery of temozolomide and sipd-l1 to reprogram the drug-resistant and immunosuppressive microenvironment in orthotopic glioblastoma
10.1021/acsnano.1c09794 · 2022 · External reference
A local combination therapy to inhibit gbm recurrence
10.1016/j.jconrel.2019.08.012 · 2019 · External reference
Repurposing neurological drugs for brain cancer therapeutics: a systematic approach to identify charged molecules for affinity-based local drug delivery systems
10.1016/j.ijpharm.2025.125935 · 2025 · External reference
Spatial analysis of recurrent glioblastoma reveals perivascular niche organization
10.1172/jci.insight.179853 · 2024 · External reference
Rationally designed drug delivery systems for the local treatment of resected glioblastoma
10.1016/j.addr.2021.113951 · 2021 · External reference
Glioblastoma precision therapy: from the bench to the clinic
10.1016/j.canlet.2020.01.027 · 2020 · External reference
Preventing glioblastoma relapse by igniting innate immunity through mitochondrial stress in the surgical cavity
10.1002/adma.202511351 · 2026 · External reference
Pharmacokinetics of the carmustine implant
10.2165/00003088-200241060-00002 · 2002 · External reference
The delivery of BCNU to brain tumors
10.1016/s0168-3659(99)00098-x · 1999 · External reference
Limitations of Gliadel wafers and strategies for next-generation local delivery systems for glioblastoma
10.3390/cancers18060907 · 2026 · External reference
Gliadel wafer in initial surgery for malignant glioma: long-term follow-up of a multicenter controlled trial
10.1007/s00701-005-0707-z · 2006 · External reference
Gliadel wafer implantation combined with standard radiotherapy and concurrent followed by adjuvant temozolomide for treatment of newly diagnosed high-grade glioma: a systematic literature review
10.1186/s12957-016-0975-5 · 2016 · External reference
The effectiveness and cost-effectiveness of carmustine implants and temozolomide for the treatment of newly diagnosed high-grade glioma: a systematic review and economic evaluation
10.3310/hta11450 · 2007 · External reference
Intracranial microcapsule drug delivery device for the treatment of an experimental gliosarcoma model
10.1016/j.biomaterials.2010.12.020 · 2011 · External reference
Interstitial control-released polymer carrying a targeting small-molecule drug reduces PD-L1 and MGMT expression in recurrent high-grade gliomas with TMZ resistance
10.3390/cancers14041051 · 2022 · External reference
New approach in delivering chemotherapy: locoregional treatment for recurrent glioblastoma (rGBM)
2003 · External reference
Convection-enhanced delivery for the treatment of glioblastoma
10.1093/neuonc/nou354 · 2015 · External reference
Phase III randomized trial of CED of IL13-PE38QQR vs Gliadel wafers for recurrent glioblastoma
10.1093/neuonc/nop054 · 2010 · External reference
Convection-enhanced delivery of auristatin-conjugated layer-by-layer nanoparticles for glioblastoma treatment
10.1021/jacs.4c16898 · 2025 · External reference
Convection enhanced delivery of the oncolytic adenovirus Delta24-RGD in patients with recurrent GBM: a phase I clinical trial including correlative studies
10.1158/1078-0432.ccr-21-3324 · 2022 · External reference
Convection-enhanced delivery for brain malignancies: technical parameters, formulation strategies and clinical perspectives
10.1016/j.addr.2025.115657 · 2025 · External reference
A phase I study of convection-enhanced delivery (CED) of liposomal-irinotecan using real-time magnetic resonance imaging in patients with recurrent high-grade glioma
10.1007/s11060-024-04904-y · 2025 · External reference
Chronic convection-enhanced delivery of topotecan for patients with recurrent glioblastoma: a first-in-patient, single-Centre, single-arm, phase Ib trial
10.1016/s1470-2045(22)00599-x · 2022 · External reference
Flexible, sticky, and biodegradable wireless device for drug delivery to brain tumors
10.1038/s41467-019-13198-y · 2019 · External reference
Repeated blood-brain barrier opening with a nine-emitter implantable ultrasound device in combination with carboplatin in recurrent glioblastoma: a phase I/II clinical trial
10.1038/s41467-024-45818-7 · 2024 · External reference
Repeated blood-brain barrier opening with an implantable ultrasound device for delivery of albumin-bound paclitaxel in patients with recurrent glioblastoma: a phase I trial
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