Contact and support
Need help, have a question, or want to contact the ResearchHub team?
© 2026 ResearchHub. Built for responsible scholarly connection.
Research graph
References from A lymph node-targeted nanoplatform reprograms metabolic and immune microenvironments via dual ACSL3/4 inhibition in lymphatic metastatic tumors. Local targets link to admitted publications; unresolved targets remain external evidence.
Advances in the treatment of hepatocellular carcinoma: an overview of the current and evolving therapeutic landscape for clinicians
2025 · External reference
Tumor-draining lymph nodes: at the crossroads of metastasis and immunity
10.1126/sciimmunol.abg3551 · 2021 · External reference
Metastatic hepatic carcinoma: mechanisms, emerging therapeutics, and future perspectives
10.1016/j.isci.2025.112902 · 2025 · External reference
Lymph node colonization induces tissue remodeling via immunosuppressive fibroblast-myeloid cell niches supporting metastatic tolerance
10.1016/j.ccell.2026.01.003 · 2026 · External reference
Dynamic CD8+ T cell responses to cancer immunotherapy in human regional lymph nodes are disrupted in metastatic lymph nodes
10.1016/j.cell.2023.02.021 · 2023 · External reference
Lymph nodes: the cradle for antitumor immunity
10.1126/scitranslmed.abe9219 · 2020 · External reference
Systemic immunity is required for effective Cancer immunotherapy
10.1016/j.cell.2016.12.022 · 2017 · External reference
Lymph node colonization induces tumor-immune tolerance to promote distant metastasis
10.1016/j.cell.2022.04.019 · 2022 · External reference
The metabolism of cancer cells during metastasis
10.1038/s41568-020-00320-2 · 2021 · External reference
Cancer cell metabolism and antitumour immunity
10.1038/s41577-024-01026-4 · 2024 · External reference
Single-cell omics in tumor lymph node metastasis: mechanisms and therapeutic implications
10.1186/s12943-026-02585-x · 2026 · External reference
Targeting metabolic-epigenetic-immune axis in cancer: molecular mechanisms and therapeutic implications
10.1038/s41392-025-02334-4 · 2026 · External reference
Lipids as mediators of cancer progression and metastasis
2024 · External reference
Tumor metastasis to lymph nodes requires YAP-dependent metabolic adaptation
10.1126/science.aav0173 · 2019 · External reference
Lymph protects metastasizing melanoma cells from ferroptosis
10.1038/s41586-020-2623-z · 2020 · External reference
Exogenous monounsaturated fatty acids promote a ferroptosis-resistant cell state
10.1016/j.chembiol.2018.11.016 · 2019 · External reference
Metastasis
10.1016/j.cell.2023.03.003 · 2023 · External reference
Emerging biological principles of metastasis
10.1016/j.cell.2016.11.037 · 2017 · External reference
A perspective on cancer cell metastasis
10.1126/science.1203543 · 2011 · External reference
Emerging strategies for treating metastasis
2021 · External reference
Mechanical signatures in cancer metastasis
2025 · External reference
ACSL4 and polyunsaturated lipids support metastatic extravasation and colonization
10.1016/j.cell.2024.10.047 · 2025 · External reference
ACSL4-mediated membrane phospholipid remodeling induces integrin β1 activation to facilitate triple-negative breast Cancer metastasis
10.1158/0008-5472.can-23-2491 · 2024 · External reference
Theoretical framework and emerging challenges of lipid metabolism in cancer
10.1016/j.semcancer.2024.12.002 · 2025 · External reference
Cancer cell plasticity during tumor progression, metastasis and response to therapy
2023 · External reference
Lipid metabolic reprogramming in tumor microenvironment: from mechanisms to therapeutics
10.1186/s13045-023-01498-2 · 2023 · External reference
The role of lipids in cancer progression and metastasis
10.1016/j.cmet.2022.09.023 · 2022 · External reference
Application of nano-delivery systems in lymph nodes for tumor immunotherapy
10.1007/s40820-023-01125-2 · 2023 · External reference
Material design for lymph node drug delivery
10.1038/s41578-019-0110-7 · 2019 · External reference
Monounsaturated fatty acids promote cancer radioresistance by inhibiting ferroptosis through ACSL3
2025 · External reference
The role of ferroptosis in ionizing radiation-induced cell death and tumor suppression
10.1038/s41422-019-0263-3 · 2020 · External reference
Carrier-free self-assembled nanomedicine based on celastrol and galactose for targeting therapy of hepatocellular carcinoma via inducing ferroptosis
10.1016/j.ejmech.2024.116183 · 2024 · External reference
Engineered Akkermansia muciniphila vesicles for targeted pyroptosis and trained immunity to enhance immunotherapy in hepatocellular carcinoma
2026 · External reference
Understanding the diversity of membrane lipid composition
10.1038/nrm.2017.138 · 2018 · External reference
Biotin-dependent cell envelope remodelling is required for mycobacterium abscessus survival in lung infection
10.1038/s41564-022-01307-5 · 2023 · External reference
Epithelial-to-mesenchymal transition is dispensable for metastasis but induces chemoresistance in pancreatic cancer
10.1038/nature16064 · 2015 · External reference
PGE2 limits effector expansion of tumour-infiltrating stem-like CD8+ T cells
10.1038/s41586-024-07254-x · 2024 · External reference
PGE2 inhibits TIL expansion by disrupting IL-2 signalling and mitochondrial function
10.1038/s41586-024-07352-w · 2024 · External reference
Regulation of ferroptosis by lipid metabolism
10.1016/j.tcb.2023.05.003 · 2023 · External reference
Recommendations for robust and reproducible research on ferroptosis
10.1038/s41580-025-00843-2 · 2025 · External reference
Ferroptosis at the intersection of lipid metabolism and cellular signaling
10.1016/j.molcel.2022.03.022 · 2022 · External reference
Targeting ceramide transfer protein sensitizes AML to FLT3 inhibitors via a GRP78-ATF6-CHOP axis
10.1038/s41467-025-56520-7 · 2025 · External reference
The Vps13-like protein BLTP2 regulates phosphatidylethanolamine levels to maintain plasma membrane fluidity and breast cancer aggressiveness
10.1038/s41556-025-01672-3 · 2025 · External reference
Therapeutic efficacy of FASN inhibition in preclinical models of HCC
10.1002/hep.32359 · 2022 · External reference
Stearoyl coenzyme a desaturase-1: multitasker in cancer, metabolism, and ferroptosis
10.1016/j.trecan.2023.03.003 · 2023 · External reference
SLC7A11 is an unconventional H+ transporter in lysosomes
10.1016/j.cell.2025.04.004 · 2025 · External reference
The crosstalk between ferroptosis and anti-tumor immunity in the tumor microenvironment: molecular mechanisms and therapeutic controversy
10.1002/cac2.12487 · 2023 · External reference
Glycosphingolipid synthesis mediates immune evasion in KRAS-driven cancer
10.1038/s41586-024-07787-1 · 2024 · External reference
Lipids grease the chain of cancer progression
10.1016/j.trecan.2025.11.012 · 2026 · External reference
Safety, activity, and immune correlates of anti–PD-1 antibody in cancer
10.1056/nejmoa1200690 · 2012 · External reference
Regulation of PD-L1 through direct binding of cholesterol to CRAC motifs
2022 · External reference
Metabolic regulation of Tregs in cancer: opportunities for immunotherapy
10.1016/j.trecan.2017.06.005 · 2017 · External reference
Lipid accumulation and dendritic cell dysfunction in cancer
10.1038/nm.2172 · 2010 · External reference
Dendritic cell metabolism and function in tumors
10.1016/j.it.2019.06.004 · 2019 · External reference
Increased lipid metabolism impairs NK cell function and mediates adaptation to the lymphoma environment
10.1182/blood.2020005602 · 2020 · External reference
Lipid accumulation impairs natural killer cell cytotoxicity and tumor control in the postoperative period
10.1186/s12885-019-6045-y · 2019 · External reference
Tumor microenvironment Onmyoji: cytokines with dual protumor and antitumor roles
10.34133/cancomm.0008 · 2026 · External reference
New insights into the correlations between circulating tumor cells and target organ metastasis
10.1038/s41392-023-01725-9 · 2023 · External reference
Effects of radiotherapy in normal tissue
10.1056/nejmra2506017 · 2026 · External reference
Radiation as an immune modulator: mechanisms and implications for combination with immunotherapy
10.1038/s41568-025-00903-x · 2026 · External reference
Polarization of tumor-associated macrophages by TLR7/8 conjugated radiosensitive peptide hydrogel for overcoming tumor radioresistance
2022 · External reference
Metabolic programming and immune suppression in the tumor microenvironment
10.1016/j.ccell.2023.01.009 · 2023 · External reference
Tumor metastasis: molecular insights and evolving paradigms
10.1016/j.cell.2011.09.024 · 2011 · External reference
Emerging therapies in cancer metabolism
10.1016/j.cmet.2023.07.006 · 2023 · External reference