Research graph
References from A systemic-absorption-blocked (SEAL) nanoplatform for mRNA-based local immunotherapy. Local targets link to admitted publications; unresolved targets remain external evidence.
mRNA-based cancer therapeutics
10.1038/s41568-023-00586-2 · 2023 · External reference
Targeting cancer with mRNA–lipid nanoparticles: key considerations and future prospects
10.1038/s41571-023-00811-9 · 2023 · External reference
Non-liver mRNA Delivery
10.1021/acs.accounts.1c00601 · 2022 · External reference
Placenta-tropic VEGF mRNA lipid nanoparticles ameliorate murine pre-eclampsia
10.1038/s41586-024-08291-2 · 2025 · External reference
Tuning lipid nanoparticles for RNA delivery to extrahepatic organs
10.1002/adma.202401445 · 2024 · External reference
Intravesical delivery of KDM6A-mRNA via mucoadhesive nanoparticles inhibits the metastasis of bladder cancer
10.1073/pnas.2112696119 · 2022 · External reference
Ionizable lipid nanoparticles for therapeutic base editing of congenital brain disease
10.1021/acsnano.3c02268 · 2023 · External reference
Optimized inhaled LNP formulation for enhanced treatment of idiopathic pulmonary fibrosis via mRNA-mediated antibody therapy
10.1038/s41467-024-51056-8 · 2024 · External reference
Intratumoral delivery of lipid nanoparticle-formulated mRNA encoding IL-21, IL-7, and 4-1BBL induces systemic anti-tumor immunity
10.1038/s41467-024-54877-9 · 2024 · External reference
The molecular biology of peritoneal metastatic disease
10.15252/emmm.202215914 · 2023 · External reference
Primary and metastatic peritoneal surface malignancies
10.1038/s41572-021-00326-6 · 2021 · External reference
I.P.-injected cationic liposomes are retained and accumulate in peritoneally disseminated tumors
10.1016/j.jconrel.2021.12.004 · 2022 · External reference
Clinically translatable cytokine delivery platform for eradication of intraperitoneal tumors
10.1126/sciadv.abm1032 · 2022 · External reference
The journey of nanoparticles in the abdominal cavity: exploring their in vivo fate and impact factors
10.1016/j.jconrel.2024.10.011 · 2024 · External reference
Local delivery of cell surface-targeted immunocytokines programs systemic antitumor immunity
10.1038/s41590-024-01925-7 · 2024 · External reference
Local delivery of mRNA-encoded cytokines promotes antitumor immunity and tumor eradication across multiple preclinical tumor models
10.1126/scitranslmed.abc7804 · 2021 · External reference
Intratumor adoptive transfer of IL-12 mRNA transiently engineered antitumor CD8(+) T cells
10.1016/j.ccell.2019.10.006 · 2019 · External reference
Intratumoral injection of IL-12-encoding mRNA targeted to CSFR1 and PD-L1 exerts potent anti-tumor effects without substantial systemic exposure
10.1016/j.omtn.2023.07.020 · 2023 · External reference
Local delivery of IL-12 mRNA and indoximod prodrug potentiates antitumor immunity by increasing T cell effector function
10.1016/j.jconrel.2025.113970 · 2025 · External reference
A modular mRNA platform for programmable induction of tumour-specific immunogenic cell death
10.1038/s41565-025-02045-5 · 2025 · External reference
SARS-CoV-2 vaccination can elicit a CD8 T-cell dominant hepatitis
10.1016/j.jhep.2022.03.040 · 2022 · External reference
Expression kinetics of nucleoside-modified mRNA delivered in lipid nanoparticles to mice by various routes
10.1016/j.jconrel.2015.08.007 · 2015 · External reference
Ionizable lipid nanoparticles deliver mRNA to pancreatic beta cells via macrophage-mediated gene transfer
10.1126/sciadv.ade1444 · 2023 · External reference
Blood-brain-barrier-crossing lipid nanoparticles for mRNA delivery to the central nervous system
10.1038/s41563-024-02114-5 · 2025 · External reference
Tissue-specific mRNA delivery and prime editing with peptide-ionizable lipid nanoparticles
10.1038/s41563-025-02320-9 · 2025 · External reference
Selective organ targeting (SORT) nanoparticles for tissue-specific mRNA delivery and CRISPR-Cas gene editing
10.1038/s41565-020-0669-6 · 2020 · External reference
Lipid nanoparticles with fine-tuned composition show enhanced colon targeting as a platform for mRNA therapeutics
2025 · External reference
Targeting Dicer reprograms tumor-associated macrophages to promote anti-tumoral immunity in colorectal cancer liver metastasis
10.1186/s12951-025-03518-4 · 2025 · External reference
RNA-based modulation of macrophage-mediated efferocytosis potentiates antitumor immunity in colorectal cancer
10.1016/j.jconrel.2023.12.018 · 2024 · External reference
Multi-step screening of DNA/lipid nanoparticles and co-delivery with siRNA to enhance and prolong gene expression
10.1038/s41467-022-31993-y · 2022 · External reference
Mechanisms of metastatic colorectal cancer
10.1038/s41575-024-00934-z · 2024 · External reference
Deciphering the role of PEGylation on the lipid nanoparticle-mediated mRNA delivery to the liver
10.1021/acsnano.4c09399 · 2025 · External reference
Size-dependent translocation and lymphatic transportation of polymeric nanocarriers post intraperitoneal administration
10.1016/j.jconrel.2024.10.032 · 2024 · External reference
Transcytosis: crossing cellular barriers
10.1152/physrev.00001.2003 · 2003 · External reference
Intracellular transport and regulation of transcytosis across the blood-brain barrier
10.1007/s00018-018-2982-x · 2019 · External reference
Transepithelial transport of nanoparticles in oral drug delivery: from the perspective of surface and holistic property modulation
10.1016/j.apsb.2024.06.015 · 2024 · External reference
The endocytosis and intracellular fate of nanomedicines: implication for rational design
2013 · External reference
More than a delivery system: the evolving role of lipid-based nanoparticles
10.1039/d4nr04508d · 2025 · External reference
Localized Interleukin-12 for Cancer immunotherapy
10.3389/fimmu.2020.575597 · 2020 · External reference
Tertiary amine N-oxide zwitterionic lipids facilitate muscle-selective mRNA vaccine delivery for enhancing cDC1-mediated antitumor efficacy
10.1016/j.jconrel.2025.113892 · 2025 · External reference
Orthogonal design of experiments for engineering of lipid nanoparticles for mRNA delivery to the placenta
2024 · External reference
Phosphatidylserine lipid nanoparticles promote systemic RNA delivery to secondary lymphoid organs
10.1021/acs.nanolett.2c03234 · 2022 · External reference
Peritoneal retention of liposomes: effects of lipid composition, PEG coating and liposome charge
10.1016/j.jconrel.2010.08.026 · 2010 · External reference
Protein adsorption is required for stealth effect of poly(ethylene glycol)- and poly(phosphoester)-coated nanocarriers
10.1038/nnano.2015.330 · 2016 · External reference
Lipid nanoparticle composition directs systemic trafficking and tissue-specific T cell immunity after intramuscular injection
10.1038/s41551-026-01706-7 · 2026 · External reference
Therapeutic delivery to the peritoneal lymphatics: current understanding, potential treatment benefits and future prospects
10.1016/j.ijpharm.2019.118456 · 2019 · External reference
From sewer to saviour - targeting the lymphatic system to promote drug exposure and activity
10.1038/nrd4608 · 2015 · External reference
Pancreas-targeted lipid nanoparticles for relatively non-invasive interleukin-12 mRNA therapy in orthotopic pancreatic ductal adenocarcinoma
10.1016/j.jconrel.2025.113588 · 2025 · External reference
Simplified lipid nanoparticles for tissue- and cell-targeted mRNA delivery facilitate precision tumor therapy in a lung metastasis mouse model
10.1002/adma.202409812 · 2024 · External reference
Intraperitoneal carboplatin for ovarian Cancer - a phase 2/3 trial
10.1056/evidoa2200225 · 2023 · External reference
Ports and complications for intraperitoneal chemotherapy delivery
10.1111/j.1471-0528.2011.03179.x · 2012 · External reference
Combined intraperitoneal and systemic chemotherapy for peritoneal metastases: drug delivery concepts, pharmacokinetics, and clinical applications: a narrative review
10.3390/pharmaceutics18020179 · 2026 · External reference
