Research graph
References from Terminal-overhang-restricted CRISPR logic nanodevice for precision cancer therapy. Local targets link to admitted publications; unresolved targets remain external evidence.
The European Society for Medical Oncology (ESMO) precision medicine glossary
10.1093/annonc/mdx707 · 2018 · External reference
Molecular tumour boards — current and future considerations for precision oncology
10.1038/s41571-023-00824-4 · 2023 · External reference
Immunostimulation with chemotherapy in the era of immune checkpoint inhibitors
10.1038/s41571-020-0413-z · 2020 · External reference
Progress and challenges towards targeted delivery of cancer therapeutics
10.1038/s41467-018-03705-y · 2018 · External reference
Relative dose intensity of chemotherapy and survival in patients with advanced stage solid tumor cancer: a systematic review and meta-analysis
10.1002/onco.13822 · 2021 · External reference
Magnetic field-activated sensing of mRNA in living cells
10.1021/jacs.7b06022 · 2017 · External reference
A targeted, self-delivered, and photocontrolled molecular beacon for mRNA detection in living cells
10.1021/ja406252w · 2013 · External reference
Fluorescence activation imaging of cytochrome c released from mitochondria using aptameric nanosensor
10.1021/ja511988w · 2015 · External reference
DNA aptamer-based activatable probes for photoacoustic imaging in living mice
10.1021/jacs.7b07913 · 2017 · External reference
DNA nanodevices map enzymatic activity in organelles
10.1038/s41565-019-0365-6 · 2019 · External reference
Upconversion luminescence-activated DNA nanodevice for ATP sensing in living cells
10.1021/jacs.7b11161 · 2018 · External reference
Spatial confinement of a dual activatable DNAzyme sensor in the cavity of a DNA nanocage for logic-gated molecular imaging
10.1002/anie.202424684 · 2025 · External reference
Multiplexed and portable nucleic acid detection platform with Cas13, Cas12a, and Csm6
10.1126/science.aaq0179 · 2018 · External reference
A CRISPR-Cas autocatalysis-driven feedback amplification network for supersensitive DNA diagnostics
10.1126/sciadv.abc7802 · 2021 · External reference
Functionally diverse type V CRISPR-Cas systems
10.1126/science.aav7271 · 2019 · External reference
RNA-triggered cell killing with CRISPR–Cas12a2
10.1038/s41586-026-10466-y · 2026 · External reference
A field-deployable CRISPR-based biosensing platform for monitoring marine ecosystems
10.1038/s41893-025-01752-0 · 2026 · External reference
Activation mechanism and integrated one-pot assay of chiral-like cRNA-enhanced CRISPR/Cas12a systems
2026 · External reference
MicroRNA-responsive release of Cas9/sgRNA from DNA nanoflower for cytosolic protein delivery and enhanced genome editing
10.1016/j.biomaterials.2020.120221 · 2020 · External reference
Genotype-specific precision tumor therapy using mitochondrial DNA mutation-induced drug release system
2023 · External reference
Antibody therapy of cancer
10.1038/nrc3236 · 2012 · External reference
Current and future perspectives of liquid biopsies in genomics-driven oncology
10.1038/s41576-018-0071-5 · 2018 · External reference
Protocell arrays for simultaneous detection of diverse analytes
10.1038/s41467-021-25989-3 · 2021 · External reference
Early detection of cancer
10.1126/science.aay9040 · 2022 · External reference
Towards precision medicine
10.1038/nrg.2016.86 · 2016 · External reference
Detection and localization of surgically resectable cancers with a multi-analyte blood test
10.1126/science.aar3247 · 2018 · External reference
Integrated dual-biomarker detection: transforming proteins and nucleic acids into ssDNA for enhanced disease diagnosis
10.1016/j.cej.2024.157910 · 2024 · External reference
Human AP endonuclease 1 (APE1): from mechanistic insights to druggable target in cancer
10.1016/j.ctrv.2009.12.006 · 2010 · External reference
NAPTUNE: nucleic acids and protein biomarkers testing via ultra-sensitive nucleases escalation
2025 · External reference
Clinicopathological significance of human apurinic/apyrimidinic endonuclease 1 (APE1) expression in oestrogen-receptor-positive breast cancer
10.1007/s10549-013-2820-7 · 2014 · External reference
The splicing component ISY1 regulates APE1 in base excision repair
10.1016/j.dnarep.2019.102769 · 2020 · External reference
MicroRNAs in cancer
10.1146/annurev.med.59.053006.104707 · 2009 · External reference
Emerging role of microRNA-21 in cancer
10.3892/br.2016.747 · 2016 · External reference
The role of MicroRNAs in human cancer
10.1038/sigtrans.2015.4 · 2016 · External reference
Programmable RNA detection with CRISPR-Cas12a
10.1038/s41467-023-41006-1 · 2023 · External reference
Synergistic incorporation of two ssDNA activators enhances the trans-cleavage of CRISPR/Cas12a
10.1021/acs.analchem.3c00414 · 2023 · External reference
Modular CRISPR/Cas12a synergistic activation platform for detection and logic operations
10.1093/nar/gkae470 · 2024 · External reference
Asymmetric CRISPR enabling cascade signal amplification for nucleic acid detection by competitive crRNA
10.1038/s41467-023-43389-7 · 2023 · External reference
Switching the activity of Cas12a using guide RNA strand displacement circuits
10.1038/s41467-019-09953-w · 2019 · External reference
Plug-and-play fluorophores extend the spectral properties of spinach
10.1021/ja410819x · 2014 · External reference
DNA-guided CRISPR–Cas12 for cellular RNA targeting
10.1038/s41587-026-03129-w · 2026 · External reference
Cas9 senses CRISPR RNA abundance to regulate CRISPR spacer acquisition
10.1038/s41586-025-09577-9 · 2025 · External reference
Revisiting two decades of research focused on targeting APE1 for cancer therapy: the pros and cons
10.3390/cells12141895 · 2023 · External reference
Activation of NRF2 by APE1/REF1 is redox-dependent in Barrett’s related esophageal adenocarcinoma cells
10.1016/j.redox.2021.101970 · 2021 · External reference
miR-21 depletion in macrophages promotes tumoricidal polarization and enhances PD-1 immunotherapy
10.1038/s41388-018-0178-3 · 2018 · External reference
Photoactivated self-disassembly of multifunctional DNA nanoflower enables amplified autophagy suppression for low-dose photodynamic therapy
10.1002/smll.202104722 · 2021 · External reference
DNA nanosponge for adsorption and clearance of intracellular miR-21 and enhanced antitumor chemotherapy
10.1021/acsami.9b18282 · 2019 · External reference
Tumor-targeting cholesterol-decorated DNA nanoflowers for intracellular ratiometric aptasensing
2021 · External reference
Anti-miRs competitively inhibit microRNAs in argonaute complexes
10.1371/journal.pone.0100951 · 2014 · External reference
Structural basis for microRNA targeting
10.1126/science.1258040 · 2014 · External reference
Beyond the seed: structural basis for supplementary microRNA targeting by human Argonaute2
10.15252/embj.2018101153 · 2019 · External reference
Cytoplasmic localization and redox cysteine residue of APE1/Ref-1 are associated with its anti-inflammatory activity in cultured endothelial cells
10.1007/s10059-013-0195-6 · 2013 · External reference
Nitric oxide controls nuclear export of APE1/Ref-1 through S-nitrosation of cysteines 93 and 310
10.1093/nar/gkl1163 · 2007 · External reference
Molybdenum-bridged endo-exogenous antioxidant synergy reverses acute kidney injury via mitochondrial homeostasis reconstruction
2025 · External reference
Mitochondrial H2O2 release does not directly cause damage to chromosomal DNA
10.1038/s41467-024-47008-x · 2024 · External reference
Analysis of nuclear transport signals in the human apurinic/apyrimidinic endonuclease (APE1/Ref1)
10.1093/nar/gki641 · 2005 · External reference
Oxidative modification of miR-184 enables it to target Bcl-xL and Bcl-w
10.1016/j.molcel.2015.05.003 · 2015 · External reference
MicroRNA-21 regulates the proliferation and invasion in esophageal squamous cell carcinoma
10.1158/1078-0432.ccr-08-2545 · 2009 · External reference
MicroRNA-21 regulates expression of the PTEN tumor suppressor gene in human hepatocellular cancer
10.1053/j.gastro.2007.05.022 · 2007 · External reference
