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References from An integrated prediction model using machine learning and dynamics simulation for the selection of transdermal penetration enhancers. Local targets link to admitted publications; unresolved targets remain external evidence.
Effects of concentrations on the transdermal permeation enhancing mechanisms of borneol: a coarse-grained molecular dynamics simulation on mixed-bilayer membranes
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Molecular perspective of efficiency and safety problems of chemical enhancers: bottlenecks and recent advances
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Mechanisms of the drug penetration enhancer propylene glycol interacting with skin lipid membranes
10.1021/acs.jpcb.3c06784 · 2024 · External reference
Fluorescent penetration enhancers reveal complex interactions among the enhancer, drug, solvent, and skin
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The effect of penetration enhancers on drug delivery through skin: a QSAR study
10.1016/j.jconrel.2004.06.010 · 2004 · External reference
Removal efficacy and cytotoxicity of a calcium hydroxide paste using N-2-methyl-pyrrolidone as a vehicle
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Predicting skin permeability
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Hydrogen bonding part 46: a review of the correlation and prediction of transport properties by an LFER method: physicochemical properties, brain penetration and skin permeability
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Dermal permeation data and models for the prioritization and screening-level exposure assessment of organic chemicals
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HuskinDB, a database for skin permeation of xenobiotics
10.1038/s41597-020-00764-z · 2020 · External reference
CPE-DB: an open database of chemical penetration enhancers
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Validated models for predicting skin penetration from different vehicles
10.1016/j.ejps.2010.08.014 · 2010 · External reference
Modelling the effect of mixture components on permeation through skin
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Computer simulation of skin permeability of hydrophobic and hydrophilic chemicals – influence of follicular pathway
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Predicting skin permeability using HuskinDB
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Machine learning for skin permeability prediction: random forest and XG boost regression
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Artificial intelligence for skin permeability prediction: deep learning
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Transdermal drug delivery systems powered by artificial intelligence
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Predictive modeling of skin permeability for molecules: investigating FDA-approved drug permeability with various AI algorithms
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Skin permeability prediction with MD simulation sampling spatial and alchemical reaction coordinates
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Effects and action mode of oleic acid and Azone on release and penetration process of levothyroxine sodium patches
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Penetration enhancement of menthol on quercetin through skin: insights from atomistic simulation
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Preparation and in vitro and in vivo evaluation of a testosterone film forming gel for the treatment of hypoactive sexual desire disorder in women
10.1208/s12249-021-02201-9 · 2022 · External reference
The enhancing effect and promoting mechanisms of the stereoisomeric monoterpene alcohol esters as enhancers for drugs with different physicochemical properties
2022 · External reference
Borneol-mediated vardenafil hydrochloride patch for pediatric pulmonary arterial hypertension: preparation, characterization and in vivo study
10.1016/j.ijpharm.2020.119864 · 2020 · External reference
Role of sodium l-cysteine alginate conjugate and isopropyl myristate to enhance the permeation enhancing activity of BCS class III drug from TDDS; optimization by central composite design and in vivo pharmacokinetics study
10.1080/03639045.2020.1791167 · 2020 · External reference
Transdermal delivery of the free base of 3-fluoroamphetamine: in vitro skin permeation and irritation potential
10.1208/s12249-020-01649-5 · 2020 · External reference
Effective therapeutic delivery and bioavailability enhancement of pioglitazone using drug in adhesive transdermal patch
10.3390/pharmaceutics11070359 · 2019 · External reference
Effect of permeation enhancers on in vitro release and transdermal delivery of lamotrigine from Eudragit(®)RS100 polymer matrix-type drug in adhesive patches
10.1007/s40204-019-0114-9 · 2019 · External reference
Development and in vitro evaluation of pressure sensitive adhesive patch for the transdermal delivery of galantamine: effect of penetration enhancers and crystallization inhibition
10.1016/j.ejpb.2019.04.008 · 2019 · External reference
Effects of solvents and penetration enhancers on transdermal delivery of thymoquinone: permeability and skin deposition study
10.1080/10717544.2018.1523256 · 2018 · External reference
Effect of the dispersion states of Azone in Hydroalcoholic gels on its transdermal permeation enhancement efficacy
10.1016/j.xphs.2018.02.020 · 2018 · External reference
Mechanistic insights of the enhancement effect of sorbitan monooleate on olanzapine transdermal patch both in release and percutaneous absorption processes
10.1016/j.ejps.2017.07.006 · 2017 · External reference
Transdermal delivery of dimethyl fumarate for Alzheimer's disease: effect of penetration enhancers
10.1016/j.ijpharm.2017.07.031 · 2017 · External reference
Effect of borneol on the transdermal permeation of drugs with differing lipophilicity and molecular organization of stratum corneum lipids
10.3109/03639045.2015.1107095 · 2016 · External reference
Nano-transfersomal formulations for transdermal delivery of asenapine maleate: in vitro and in vivo performance evaluations
10.3109/08982104.2015.1098659 · 2016 · External reference
Transdermal permeation of drugs with differing lipophilicity: effect of penetration enhancer camphor
10.1016/j.ijpharm.2016.05.004 · 2016 · External reference
The application of anethole, menthone, and eugenol in transdermal penetration of valsartan: enhancement and mechanistic investigation
10.3109/13880209.2015.1100639 · 2016 · External reference
Effect of menthone and related compounds on skin permeation of drugs with different lipophilicity and molecular organization of stratum corneum lipids
2016 · External reference
Transdermal delivery of diltiazem HCl from matrix film: effect of penetration enhancers and study of antihypertensive activity in rabbit model
10.1016/j.jare.2015.09.001 · 2016 · External reference
Novel perspectives in the tuberculosis treatment: administration of isoniazid through the skin
10.1016/j.ijpharm.2015.08.067 · 2015 · External reference
Development and in-vivo evaluation of ondansetron gels for transdermal delivery
10.3109/03639045.2014.925916 · 2015 · External reference
The influence of the acyl chain on the transdermal penetration-enhancing effect of synthetic phytoceramides
10.1159/000365730 · 2015 · External reference
Skin deposition and permeation of finasteride in vitro: effects of propylene glycol, ethanol and sodium lauryl sulfate
10.3109/10837450.2014.954727 · 2015 · External reference
Enhancement of ketorolac tromethamine permeability through rat skin using penetration enhancers: an ex-vivo study
10.4103/2230-973x.160850 · 2015 · External reference
Rapid pain relief using transdermal film forming polymeric solution of ketorolac
10.3109/10837450.2011.627867 · 2013 · External reference
Structure activity relationships in alkylammonium C12-gemini surfactants used as dermal permeation enhancers
10.1208/s12248-013-9518-y · 2013 · External reference
Formulation, in vitro, and in vivo evaluation of matrix-type transdermal patches containing olanzapine
10.3109/10837450.2011.609993 · 2013 · External reference
Optimization and characterization of chitosan films for transdermal delivery of ondansetron
10.3390/molecules18055455 · 2013 · External reference
L-Carvyl esters as penetration enhancers for the transdermal delivery of 5-fluorouracil
10.1208/s12249-013-9952-2 · 2013 · External reference
In vitro percutaneous absorption enhancement of granisetron by chemical penetration enhancers
10.3109/03639045.2012.665924 · 2013 · External reference
Effect of unsaturated menthol analogues on the in vitro penetration of 5-fluorouracil through rat skin
10.1016/j.ijpharm.2013.01.015 · 2013 · External reference
Amino acid derivatives as transdermal permeation enhancers
10.1016/j.jconrel.2012.11.003 · 2013 · External reference
Development of a reservoir-type transdermal delivery system containing eucalyptus oil for tetramethylpyrazine
10.3109/10717544.2012.742938 · 2013 · External reference
Investigation of formulation factors affecting in vitro and in vivo characteristics of a galantamine transdermal system
10.1016/j.ijpharm.2012.06.057 · 2012 · External reference
Terpenes: effect of lipophilicity in enhancing transdermal delivery of alfuzosin hydrochloride
10.4103/2231-4040.104712 · 2012 · External reference
Influence of formulation variables in transdermal drug delivery system containing zolmitriptan
10.1016/j.ijpharm.2011.08.002 · 2011 · External reference
Role of novel terpenes in transcutaneous permeation of valsartan: effectiveness and mechanism of action
10.3109/03639045.2010.532219 · 2011 · External reference
Influence of chemical permeation enhancers on transdermal permeation of alfuzosin: an investigation using response surface modeling
10.3109/03639045.2010.522192 · 2011 · External reference
Effect of permeation enhancers on the iontophoretic transport of metoprolol tartrate and the drug retention in skin
10.3109/10717544.2010.509361 · 2011 · External reference
In vitro enhancement of lactate esters on the percutaneous penetration of drugs with different lipophilicity
10.1208/s12249-010-9449-1 · 2010 · External reference
Transdermal patches for site-specific delivery of anastrozole: in vitro and local tissue disposition evaluation
10.1016/j.ijpharm.2010.02.021 · 2010 · External reference
Development of the loratadine gel for enhanced transdermal delivery
10.1080/03639040802680289 · 2009 · External reference
Effect of chemical enhancers on percutaneous absorption of daphnetin in isopropyl myristate vehicle across rat skin in vitro
10.1080/10717540902836715 · 2009 · External reference
Delivery of a classical antihypertensive agent through the skin by chemical enhancers and iontophoresis
10.1111/j.1600-0846.2009.00350.x · 2009 · External reference
Mechanism of in vitro percutaneous absorption enhancement of carvedilol by penetration enhancers
10.1080/10837450802309646 · 2008 · External reference
Matrix-type transdermal patches of verapamil hydrochloride: in vitro permeation studies through excised rat skin and pharmacodynamic evaluation in rats
10.1080/10837450802088851 · 2008 · External reference
Preparation and evaluation of diltiazem hydrochloride diffusion-controlled transdermal delivery system
10.1208/s12249-008-9062-8 · 2008 · External reference
Transdermal delivery of valsartan: I. Effect of various terpenes
10.1080/03639040701833740 · 2008 · External reference
Effect of permeation enhancers and organic acids on the skin permeation of indapamide
10.1016/j.ijpharm.2007.08.020 · 2008 · External reference
The effect of clove oil on the transdermal delivery of ibuprofen in the rabbit by in vitro and in vivo methods
10.1080/03639040701399346 · 2007 · External reference
The effect of terpene concentrations on the skin penetration of diclofenac sodium
10.1016/j.ijpharm.2006.10.041 · 2007 · External reference
Effects of pressure sensitive adhesives and chemical permeation enhancers on the permeability of fentanyl through excised rat skin
2006 · External reference
The effect of pH and organic ester penetration enhancers on skin permeation kinetics of terbutaline sulfate from pseudolatex-type transdermal delivery systems through mouse and human cadaver skins
10.1208/pt060225 · 2005 · External reference
Feasibility of transdermal delivery of fluoxetine
10.1208/pt060222 · 2005 · External reference
Effects of ionization and penetration enhancers on the transdermal delivery of 5-fluorouracil through excised human stratum corneum
10.1016/j.ijpharm.2005.04.004 · 2005 · External reference
Formulation and in vitro evaluation of transdermal patches of melatonin
10.1081/ddc-120028716 · 2004 · External reference
Transdermal delivery of zidovudine: effect of terpenes and their mechanism of action
10.1016/j.jconrel.2003.11.022 · 2004 · External reference
Formulation of an HPMC gel drug reservoir system with ethanol-water as a solvent system and limonene as a penetration enhancer for enhancing in vitro transdermal delivery of nicorandil
10.1159/000081117 · 2004 · External reference
Effects of adhesives and permeation enhancers on the skin permeation of captopril
10.1081/ddc-100107679 · 2001 · External reference
Comparison of the effect of fatty alcohols on the permeation of melatonin between porcine and human skin
10.1016/s0168-3659(01)00439-4 · 2001 · External reference
Transdermal absorption of bupranolol in rabbit skin in vitro and in vivo
10.1248/bpb.24.588 · 2001 · External reference
Capsaicin and nonivamide as novel skin permeation enhancers for indomethacin
10.1016/s0928-0987(00)00118-4 · 2001 · External reference
Effect of fatty acids on the permeation of melatonin across rat and pig skin in-vitro and on the transepidermal water loss in rats in-vivo
10.1211/0022357991773140 · 1999 · External reference
Percutaneous penetration enhancement activity of aromatic S, S-dimethyliminosulfuranes
10.1016/s0378-5173(99)00194-5 · 1999 · External reference
Percutaneous absorption of captopril from hydrophilic cellulose derivatives through excised rabbit skin and human skin
10.3109/03639049809085604 · 1998 · External reference
Effect of various enhancers on transdermal penetration of indomethacin and urea, and relationship between penetration parameters and enhancement factors
10.1002/jps.2600840418 · 1995 · External reference
In vitro effect of penetration enhancers on sodium nonivamide acetate in rat skin
10.1248/bpb.18.1790 · 1995 · External reference
Enhancing effect of pyrrolidone derivatives on transdermal penetration of 5-fluorouracil, triamcinolone acetonide, indomethacin, and flurbiprofen
10.1002/jps.2600800606 · 1991 · External reference
Effect of penetration enhancers on transdermal delivery of propofol
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Efficacy and mechanism of methyl salicylate in the enhancement of skin delivery of herbal medicines
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Investigation of muscone as transdermal penetration enhancer: enhancing activity and molecular mechanisms
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Controlled release of testosterone by polymer-polymer interaction enriched organogel as a novel transdermal drug delivery system: effect of limonene/PG and carbon-chain length on drug permeability
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Novel mono, di and tri- fatty acid esters bearing secondary amino acid ester head group as transdermal permeation enhancers
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Effects of various vehicles and fatty acids on the skin permeation of lornoxicam
10.1007/s40005-012-0035-2 · 2012 · External reference
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10.1016/0168-3659(96)01351-x · 1996 · External reference
Differences in penetration-enhancing effect of Azone through excised rabbit, rat, hairless mouse, guinea pig and human skins
10.1016/0378-5173(95)04319-5 · 1996 · External reference
Effect of penetration enhancers on flurbiprofen permeation through rat skin
10.1016/0378-5173(95)04137-0 · 1995 · External reference
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Investigation of iminosulfuranes as novel transdermal penetration enhancers: enhancement activity and cytotoxicity
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Influence of drug lipophilicity on terpenes as transdermal penetration enhancers
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Synthesis and evaluation of N-acetylprolinate esters - novel skin penetration enhancers
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Synthesis and in vitro transdermal penetration enhancing activity of lactam N-acetic acid esters
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N-(4-Bromobenzoyl)-S,S-dimethyliminosulfurane, a potent dermal penetration enhancer
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Enhancing effect of terpenes on the in vitro percutaneous absorption of diclofenac sodium
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In vitro evaluation of a series of Azone analogs as dermal penetration enhancers: IV. Amines
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Investigation of enhancer structure activity relationships in congeners of 2-(1-nonyl)-1, 3-dioxolane
10.3109/10717549509031359 · 1995 · External reference
In vitro evaluation of a series of azone analogs as dermal penetration enhancers: III. Acyclic amides
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Skin permeation enhancement in aqueous solution: correlation with equilibrium enhancer concentration and octanol/water partition coefficient
10.1016/j.xphs.2018.08.014 · 2019 · External reference
A widely applicable set of descriptors
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Electroporation-enhanced transdermal drug delivery: effects of logP, pKa, solubility and penetration time
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Electrorepulsion versus electroosmosis: effect of pH on the lontophoretic flux of 5-fluorouracil
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pH-responsive transdermal release from poly(vinyl alcohol)-coated liposomes and transethosomes: investigating the role of coating in delayed drug delivery
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Effect of pH on niacinamide skin permeation
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Permeation enhancers in transdermal drug delivery: benefits and limitations
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