Research graph
References from Sedation trajectories and circadian rhythm disruption in critically ill adults: an observational cohort study with external validation using MIMIC-IV and eICU-CRD. Local targets link to admitted publications; unresolved targets remain external evidence.
Mechanisms linking circadian clocks, sleep, and neurodegeneration
10.1126/science.aah4968 · 2016 · External reference
Altered circadian rhythmicity in patients in the ICU
10.1378/chest.12-2405 · 2013 · External reference
Circadian rhythm disruption in critically ill patients
10.1111/apha.13962 · 2023 · External reference
Sleep in the intensive care unit
10.1164/rccm.201411-2099ci · 2015 · External reference
Temporal disorganization of circadian rhythmicity and sleep-wake regulation in mechanically ventilated patients receiving continuous intravenous sedation
10.5665/sleep.1998 · 2012 · External reference
Causes, consequences, and treatments of sleep and circadian disruption in the ICU: an official American thoracic society research statement
10.1164/rccm.202301-0184st · 2023 · External reference
Low-dose nocturnal dexmedetomidine prevents ICU delirium. A randomized, placebo-controlled trial
10.1164/rccm.201710-1995oc · 2018 · External reference
Dexmedetomidine promotes biomimetic non-rapid eye movement stage 3 sleep in humans: a pilot study
10.1016/j.clinph.2017.10.005 · 2018 · External reference
Clinical practice guidelines for the prevention and management of pain, agitation/sedation, delirium, immobility, and sleep disruption in adult patients in the ICU
10.1097/ccm.0000000000003299 · 2018 · External reference
Dexmedetomidine or propofol for sedation in mechanically ventilated adults with sepsis
10.1056/nejmoa2024922 · 2021 · External reference
Early sedation with dexmedetomidine in critically ill patients
10.1056/nejmoa1904710 · 2019 · External reference
Delirium
10.1038/s41572-020-00223-4 · 2020 · External reference
The strengthening the reporting of observational studies in epidemiology (STROBE) statement: guidelines for reporting observational studies
10.1016/s0140-6736(07)61602-x · 2007 · External reference
MIMIC-IV, a freely accessible electronic health record dataset
10.1038/s41597-022-01899-x · 2023 · External reference
The eICU collaborative research database, a freely available multi-center database for critical care research
10.1038/sdata.2018.178 · 2018 · External reference
Tslearn, a machine learning toolkit for time series data
2020 · External reference
Understanding the Lomb–Scargle periodogram
10.3847/1538-4365/aab766 · 2018 · External reference
A practical guide to wavelet analysis
1998 · External reference
Multiscale entropy analysis of complex physiologic time series
10.1103/physrevlett.89.068102 · 2002 · External reference
Cosinor-based rhythmometry
10.1186/1742-4682-11-16 · 2014 · External reference
Delirium in mechanically ventilated patients: validity and reliability of the confusion assessment method for the intensive care unit (CAM-ICU)
10.1001/jama.286.21.2703 · 2001 · External reference
Marginal structural models and causal inference in epidemiology
10.1097/00001648-200009000-00011 · 2000 · External reference
Unresolved reference
2015 · External reference
Neural oscillations demonstrate that general anesthesia and sedative states are neurophysiologically distinct from sleep
10.1016/j.conb.2017.04.011 · 2017 · External reference
Dexmedetomidine accelerates photoentrainment and affects sleep structure through the activation of SCNVIP neurons
10.1038/s42003-024-07430-9 · 2024 · External reference
A comparison of propofol- and dexmedetomidine-induced electroencephalogram dynamics using spectral and coherence analysis
10.1097/aln.0000000000000419 · 2014 · External reference
Effects of general anesthesia on behavioral circadian rhythms and clock-gene expression in the suprachiasmatic nucleus in rats
10.1007/s00418-022-02113-0 · 2022 · External reference
A benzodiazepine used in the treatment of insomnia phase-shifts the mammalian circadian clock
10.1038/321167a0 · 1986 · External reference
Impaired circadian rhythm of melatonin secretion in sedated critically ill patients with severe sepsis
10.1097/00003246-200203000-00007 · 2002 · External reference
A systematic review and meta-analysis examining the impact of sleep disturbance on postoperative delirium
10.1097/ccm.0000000000003400 · 2018 · External reference
Sleep assessment in critically ill adults: a systematic review and meta-analysis
10.1016/j.jcrc.2022.154102 · 2022 · External reference
Temperature as a universal resetting cue for mammalian circadian oscillators
10.1126/science.1195262 · 2010 · External reference
Circadian rhythm disruption and sepsis in severe trauma patients
10.1097/shk.0000000000001241 · 2019 · External reference
Pilot study: an intensive care unit sleep promotion protocol
2019 · External reference
Nighttime dexmedetomidine for delirium prevention in non-mechanically ventilated patients after cardiac surgery (MINDDS): a single-centre, parallel-arm, randomised, placebo-controlled superiority trial
10.1016/j.eclinm.2022.101796 · 2023 · External reference
Delirium in elderly people
10.1016/s0140-6736(13)60688-1 · 2014 · External reference
Using big data to emulate a target trial when a randomized trial is not available
10.1093/aje/kwv254 · 2016 · External reference
