Research graph
References from Protocolised analgosedation in mechanically ventilated adult patients: A scoping review. Local targets link to admitted publications; unresolved targets remain external evidence.
Clinical practice guidelines for the prevention and Management of Pain, agitation/sedation, delirium, immobility, and sleep disruption in adult patients in the ICU
10.1097/ccm.0000000000003299 · 2018 · External reference
Evolving targets for sedation during mechanical ventilation
2020 · External reference
Sedation and analgesia in the mechanically ventilated patient
10.1164/rccm.201102-0273ci · 2012 · External reference
What are the perceptions of intensive care staff about their sedation practices when caring for a mechanically ventilated patient?: a systematic mixed-methods review
2022 · External reference
Sedation in the intensive care unit
2008 · External reference
Lorazepam is an independent risk factor for transitioning to delirium in intensive care unit patients
10.1097/00000542-200601000-00005 · 2006 · External reference
A narrative review on antimicrobial dosing in adult critically ill patients on extracorporeal membrane oxygenation
10.1186/s13054-024-05101-z · 2024 · External reference
Pharmacokinetic changes in patients receiving extracorporeal membrane oxygenation
10.1016/j.jcrc.2012.02.013 · 2012 · External reference
Antimicrobial exposures in critically ill patients receiving extracorporeal membrane oxygenation
10.1164/rccm.202207-1393oc · 2023 · External reference
Medicating patients during extracorporeal membrane oxygenation: the evidence is building
10.1186/s13054-017-1644-y · 2017 · External reference
The association of sleep quality, delirium, and sedation status with daily participation in physical therapy in the ICU
10.1186/s13054-016-1433-z · 2016 · External reference
Early deep sedation is associated with decreased in-hospital and two-year follow-up survival
10.1186/s13054-015-0929-2 · 2015 · External reference
A focused update to the clinical practice guidelines for the prevention and Management of Pain, anxiety, agitation/sedation, delirium, immobility, and sleep disruption in adult patients in the ICU
10.1097/ccm.0000000000006574 · 2025 · External reference
2021 KSCCM clinical practice guidelines for pain, agitation, delirium, immobility, and sleep disturbance in the intensive care unit
10.4266/acc.2022.00094 · 2022 · External reference
Daily interruption of sedative infusions in critically ill patients undergoing mechanical ventilation
10.1056/nejm200005183422002 · 2000 · External reference
Practice patterns and outcomes associated with early sedation depth in mechanically ventilated patients: a systematic review and Meta-analysis*
10.1097/ccm.0000000000002885 · 2018 · External reference
Inconsistent relationship between depth of sedation and intensive care outcome: systematic review and meta-analysis
10.1136/thoraxjnl-2020-216098 · 2021 · External reference
Effect of a nursing-implemented sedation protocol on the duration of mechanical ventilation
10.1097/00003246-199912000-00001 · 1999 · External reference
The Richmond agitation–sedation scale: validity and reliability in adult intensive care unit patients
10.1164/rccm.2107138 · 2002 · External reference
Accuracy of critical care pain observation tool and Behavioral pain scale to assess pain in critically ill conscious and unconscious patients: prospective, observational study
10.1186/s40560-016-0192-x · 2016 · External reference
Scoping reviews
2024 · External reference
PRISMA extension for scoping reviews (PRISMA-ScR): checklist and explanation
10.7326/m18-0850 · 2018 · External reference
Protocol-directed sedation versus non-protocol-directed sedation in mechanically ventilated intensive care adults and children
2018 · External reference
Validation of the theoretical domains framework for use in behaviour change and implementation research
10.1186/1748-5908-7-37 · 2012 · External reference
The qualitative content analysis process
10.1111/j.1365-2648.2007.04569.x · 2008 · External reference
The mixed methods appraisal tool (MMAT) version 2018 for information professionals and researchers
2018 · External reference
Sedation depth and long-term mortality in mechanically ventilated critically ill adults: a prospective longitudinal multicentre cohort study
10.1007/s00134-013-2830-2 · 2013 · External reference
Dexmedetomidine vs midazolam or propofol for sedation during prolonged mechanical ventilation: two randomized controlled trials
10.1001/jama.2012.304 · 2012 · External reference
Effect of sedation with dexmedetomidine vs lorazepam on acute brain dysfunction in mechanically ventilated patients: the MENDS randomized controlled trial
10.1001/jama.298.22.2644 · 2007 · External reference
Dexmedetomidine vs midazolam for sedation of critically ill PatientsA randomized trial
10.1001/jama.2009.56 · 2009 · External reference
Outcome of delirium in critically ill patients: systematic review and meta-analysis
10.1136/bmj.h2538 · 2015 · External reference
Long-term cognitive impairment after critical illness
10.1056/nejmoa1301372 · 2013 · External reference
Dexmedetomidine- or clonidine-based sedation compared with propofol in critically ill patients: the A2B randomized clinical trial
10.1001/jama.2025.7200 · 2025 · External reference
Efficacy and safety of a paired sedation and ventilator weaning protocol for mechanically ventilated patients in intensive care (awakening and breathing controlled trial): a randomised controlled trial
10.1016/s0140-6736(08)60105-1 · 2008 · External reference
Influence of clinicians’ values and perceptions on use of clinical practice guidelines for sedation and neuromuscular blockade in patients receiving mechanical ventilation
10.4037/ajcc2000.9.6.412 · 2000 · External reference
Introduction of sedative, analgesic, and neuromuscular blocking agent guidelines in a medical intensive care unit: physician and nurse adherence
10.1097/00003246-200003000-00018 · 2000 · External reference
Response to a nursing-driven protocol for sedation and analgesia in a burn-trauma ICU
10.1097/bcr.0b013e3181921f7e · 2009 · External reference
Development, implementation, and evaluation of an institutional daily awakening and spontaneous breathing trial protocol: a quality improvement project
10.1177/0885066612444255 · 2013 · External reference
Clinician perspectives on protocols designed to minimize sedation
10.1016/j.jcrc.2014.10.021 · 2015 · External reference
Daily interruption of sedation in patients receiving mechanical ventilation
10.4037/ajcc2011415 · 2011 · External reference
What stops us from following sedation recommendations in intensive care units? A multicentric qualitative study
10.1016/j.jcrc.2013.11.004 · 2014 · External reference
Adherence to all steps of a pain management protocol in intensive care patients after cardiac surgery is hard to achieve
10.1155/2017/7187232 · 2017 · External reference
The effect of an algorithm-based sedation guideline on the duration of mechanical ventilation in an Australian intensive care unit
10.1007/s00134-006-0309-0 · 2006 · External reference
Adoption of a sedation scoring system and sedation guideline in an intensive care unit
10.1111/j.1365-2648.2006.03798.x · 2006 · External reference
A prospective evaluation of empiric versus protocol-based sedation and analgesia
10.1592/phco.20.7.662.35172 · 2000 · External reference
Daily sedation interruption in mechanically ventilated critically ill patients cared for with a sedation protocol: a randomized controlled trial
10.1001/jama.2012.13872 · 2012 · External reference
The use of clustering algorithms in critical care research to unravel patient heterogeneity
10.1007/s00134-019-05631-z · 2019 · External reference
A quality improvement project to increase adherence to a pain, agitation, and delirium protocol in the intensive care unit
10.1097/dcc.0000000000000353 · 2019 · External reference
Critical care nurses’ knowledge of, adherence to, and barriers toward institution-specific ventilator bundle
10.1016/j.ajic.2018.02.004 · 2018 · External reference
Perceived barriers to the use of sedation protocols and daily sedation interruption: a multidisciplinary survey
10.1016/j.jcrc.2008.03.037 · 2009 · External reference
Knowledge, attitudes, and practices of ICU nurses regarding daily sedation interruption: a cross-sectional study
2026 · External reference
Interprofessional implementation of a pain/sedation guideline on a trauma intensive care unit
10.1097/jtn.0000000000000205 · 2016 · External reference
Staff perceptions on the use of a sedation protocol in the intensive care setting
10.1016/s1036-7314(04)80020-1 · 2004 · External reference
Facilitators and barriers to optimizing sedation practices in critically ill adult patients: a qualitative study
10.1016/j.iccn.2026.104351 · 2026 · External reference
Prognostic factors and outcomes of unplanned extubation
10.1038/s41598-017-08867-1 · 2017 · External reference
Self-extubation in critically ill patients: from the French OUTCOMEREA network
10.1186/s13054-025-05472-x · 2025 · External reference
Identifying barriers to delivering the awakening and breathing coordination, delirium, and early exercise/mobility bundle to minimize adverse outcomes for mechanically ventilated patients
10.1016/j.chest.2017.03.054 · 2017 · External reference
Feasibility and impact of the implementation of a clinical scale-based sedation-analgesia protocol in severe burn patients undergoing mechanical ventilation. A before-after bi-center study
10.1016/j.burns.2020.02.009 · 2020 · External reference
Impact of oversedation prevention in ventilated critically ill patients: a randomized trial—the AWARE study
10.1186/s13613-018-0425-3 · 2018 · External reference
Daily sedative interruption versus intermittent sedation in mechanically ventilated critically ill patients: a randomized trial
10.1186/2110-5820-4-14 · 2014 · External reference
Pre- and post-intervention study to assess the impact of a sedation protocol in critically ill surgical patients
10.1016/j.jss.2013.03.065 · 2013 · External reference
A protocol of no sedation for critically ill patients receiving mechanical ventilation: a randomised trial
10.1016/s0140-6736(09)62072-9 · 2010 · External reference
Strategies for the prevention and treatment of iatrogenic withdrawal from opioids and benzodiazepines in critically ill neonates, children and adults: a systematic review of clinical studies
10.1007/s40265-020-01338-4 · 2020 · External reference
A randomized trial of daily awakening in critically ill patients managed with a sedation protocol: a pilot trial*
10.1097/ccm.0b013e31817bff85 · 2008 · External reference
Pain, agitation, and delirium guidelines: interprofessional perspectives to translate the evidence
10.1097/dcc.0000000000000239 · 2017 · External reference
Analgesia-first sedation in critically ill adults: a U.S. pilot, randomized controlled trial
10.1016/j.jcrc.2019.06.008 · 2019 · External reference
