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References from Maternal PM2.5 exposure induces preeclampsia-like phenotypes in mice through placental angiogenic dysfunction and lncRNA–RUNX1 dysregulation. Local targets link to admitted publications; unresolved targets remain external evidence.
Tracking placental development in health and disease
10.1038/s41574-020-0372-6 · 2020 · External reference
Animal models of preeclampsia: investigating pathophysiology and therapeutic targets
10.1016/j.ajog.2020.10.025 · 2022 · External reference
Human decidual RUNX1 promotes angiogenesis and trophoblast differentiation by regulating extracellular vesicle signaling
10.1210/endocr/bqaf133 · 2025 · External reference
Maternal exposure to fine particulate matter during pregnancy induces progressive senescence of hematopoietic stem cells under preferential impairment of the bone marrow microenvironment and aids development of myeloproliferative disease
10.1038/s41375-019-0665-8 · 2020 · External reference
Particulate matter and hypertensive disorders in pregnancy: systematic review and meta-analysis
10.1016/j.puhe.2021.08.013 · 2021 · External reference
The pathophysiological, genetic, and hormonal changes in preeclampsia: a systematic review of the molecular mechanisms
10.3390/ijms25084532 · 2024 · External reference
Inhibition of RUNX1 blocks the differentiation of lung fibroblasts to myofibroblasts
10.1002/jcp.30684 · 2022 · External reference
Red chemistry: principles and applications
2024 · External reference
Effect of PM2.5 exposure on gestational hypertension, fetal size in preeclampsia-like rats
10.1007/s11356-021-18233-4 · 2022 · External reference
Environmental exposure during pregnancy: influence on prenatal development and early life: a comprehensive review
10.1159/000514884 · 2021 · External reference
Effect of individual and combined ambient air pollutants exposure on the risk of preeclampsia: a retrospective cohort study in Tangshan, China
10.1186/s12889-026-27210-w · 2026 · External reference
Assessing the impact of data preprocessing on analyzing next generation sequencing data
10.3389/fbioe.2020.00817 · 2020 · External reference
Prenatal PM2.5 exposure impairs spatial learning and memory in male mice offspring: from transcriptional regulation to neuronal morphogenesis
10.1186/s12989-023-00520-2 · 2023 · External reference
Cellular senescence controls fibrosis in wound healing
10.18632/aging.100201 · 2010 · External reference
Environmental toxicant exposure and hypertensive disorders of pregnancy: recent findings
10.1007/s11906-018-0888-5 · 2018 · External reference
Runx1 regulates critical factors that control uterine angiogenesis and trophoblast differentiation during placental development
10.1093/pnasnexus/pgad215 · 2023 · External reference
Association of placental weight at birth with maternal whole blood concentration of heavy metals (cadmium, lead, mercury, selenium, and manganese): the Japan environment and Children's study (JECS)
10.1016/j.envint.2024.108725 · 2024 · External reference
Pathophysiology of pre-eclampsia-two theories of the development of the disease
10.3390/ijms25010307 · 2023 · External reference
Understanding the origin, activation and regulation of matrix-producing myofibroblasts for treatment of fibrotic disease
10.1002/path.4253 · 2013 · External reference
The placental epigenome as a molecular link between prenatal exposures and fetal health outcomes through the DOHaD hypothesis
10.1007/s40572-022-00354-8 · 2022 · External reference
Adverse pregnancy outcomes among mothers with hypertensive disorders in pregnancy: a meta-analysis of cohort studies
10.1016/j.preghy.2021.03.001 · 2021 · External reference
PM2.5 leads to adverse pregnancy outcomes by inducing trophoblast oxidative stress and mitochondrial apoptosis via KLF9/CYP1A1 transcriptional axis
10.7554/elife.85944 · 2023 · External reference
Effect of fine particulate matter (PM2.5) on rat placenta pathology and perinatal outcomes
10.12659/msm.897808 · 2016 · External reference
How do lncRNAs regulate transcription?
10.1126/sciadv.aao2110 · 2017 · External reference
Effects of PM2.5 exposure on hematopoiesis and coupled immune disorder in adult male mice
2024 · External reference
Excess placental soluble fms-like tyrosine kinase 1 (sFlt1) may contribute to endothelial dysfunction, hypertension, and proteinuria in preeclampsia
10.1172/jci17189 · 2003 · External reference
Pre-eclampsia
10.1016/s0140-6736(15)00070-7 · 2016 · External reference
Role of endothelin in mediating soluble fms-like tyrosine kinase 1-induced hypertension in pregnant rats
10.1161/hypertensionaha.109.141473 · 2010 · External reference
Preeclampsia, a disease of the maternal endothelium: the role of antiangiogenic factors and implications for later cardiovascular disease
10.1161/circulationaha.109.853127 · 2011 · External reference
Understanding PPARγ and its agonists on trophoblast differentiation and invasion: potential therapeutic targets for gestational diabetes mellitus and preeclampsia
10.3390/nu15112459 · 2023 · External reference
Preeclampsia: pathophysiology, challenges, and perspectives
10.1161/circresaha.118.313276 · 2019 · External reference
Latest advances in understanding preeclampsia
10.1126/science.1111726 · 2005 · External reference
The pathological response of the vessels of the placental bed to hypertensive pregnancy
10.1002/path.1700930219 · 1967 · External reference
Polycyclic aromatic hydrocarbons (PAHs) exposure triggers inflammation and endothelial dysfunction in BALB/c mice: a pilot study
10.3390/toxics10090497 · 2022 · External reference
Targeting senescent cells in fibrosis: pathology, paradox, and practical considerations
10.1007/s11926-018-0712-x · 2018 · External reference
Prenatal exposure to PM2.5 and its specific components and risk of hypertensive disorders in pregnancy: a nationwide cohort study in China
10.1021/acs.est.2c01103 · 2022 · External reference
The two-stage placental model of preeclampsia: an update
10.1016/j.jri.2019.07.004 · 2019 · External reference
Roles of noncoding RNAs in preeclampsia
10.1186/s12958-021-00783-4 · 2021 · External reference
Association between particulate air pollution and hypertensive disorders in pregnancy: a retrospective cohort study
10.1371/journal.pmed.1004395 · 2024 · External reference
Full-length human placental sFlt-1-e15a isoform induces distinct maternal phenotypes of preeclampsia in mice
10.1371/journal.pone.0119547 · 2015 · External reference
Repression of vascular endothelial growth factor expression by the runt-related transcription factor 1 in acute myeloid leukemia
10.1158/0008-5472.can-10-0402 · 2011 · External reference
Soluble endoglin contributes to the pathogenesis of preeclampsia
10.1038/nm1429 · 2006 · External reference
The duration of pregnancy in ecologically-challenged area. The effects of environmental pollution with aromatic hydrocarbons on the angiogenesis and elements of the mesenchymal tissue of the human placenta
10.5603/gp.a2017.0035 · 2017 · External reference
Cellular senescence in acute and chronic wound repair
2022 · External reference
Targeting LOXL1-expressing hepatic stellate cell inhibits fibrogenesis and sinusoid angiogenesis via LOXL1/RUNX1/VEGFA axis during progression of liver fibrosis
10.1016/j.jcmgh.2025.101637 · 2026 · External reference
Gestational exposure to PM2.5 impairs vascularization of the placenta
10.1016/j.scitotenv.2019.02.101 · 2019 · External reference
Exposure to polycyclic aromatic hydrocarbons (PAHs) in outdoor air and respiratory health, inflammation and oxidative stress biomarkers: a panel study in healthy young adults
10.1016/j.scitotenv.2023.165582 · 2023 · External reference
Runt-related transcription factor 1 (RUNX1) promotes TGF-β-Induced renal tubular epithelial-to-mesenchymal transition (EMT) and renal fibrosis through the PI3K subunit p110δ
10.1016/j.ebiom.2018.04.023 · 2018 · External reference
Joint masking and self-supervised strategies for inferring small molecule-miRNA associations
10.1016/j.omtn.2023.102103 · 2024 · External reference
Maternal PM2.5 exposure and abnormal placental nutrient transport
10.1016/j.ecoenv.2020.111281 · 2021 · External reference
