Research graph
References from Methanolic extract of Lippia graveolens (Mexican oregano) protects against iron- and lead-induced genomic damage without evidence of toxicity in CD-1 mice. Local targets link to admitted publications; unresolved targets remain external evidence.
Effects of plant extracts on antioxidant status and oxidant-induced stress in Caco-2 cells
10.1017/s0007114507250469 · 2007 · External reference
Intraperitoneal route of drug administration: should it be used in experimental animal studies?
10.1007/s11095-019-2745-x · 2020 · External reference
Genotoxic and antigenotoxic medicinal plant extracts and their main phytochemicals: a review
10.3389/fphar.2024.1448731 · 2024 · External reference
Galangin activates Nrf2 signaling and attenuates oxidative damage, inflammation, and apoptosis in a rat model of cyclophosphamide-induced hepatotoxicity
10.3390/biom9080346 · 2019 · External reference
Antigenotoxicity of extracts and metabolites of Lippia spp.: phytochemical basis, experimental evidence, and molecular mechanisms of genomic protection
10.1080/15376516.2026.2698040 · 2026 · External reference
Protective effects of chlorogenic acid in 3-nitropropionic acid induced toxicity and genotoxicity
10.1016/j.fct.2017.04.048 · 2017 · External reference
Raw data of the effects of chlorogenic acid in 3-nitropropionic acid induced toxicity and genotoxicity
10.1016/j.dib.2017.07.004 · 2017 · External reference
Genotoxic effects of atmospheric PAH and heavy metals: interaction and mechanistic evidence – a narrative review
2026 · External reference
Assessment of genotoxic damage induced by exposure to binary mixtures of polycyclic aromatic hydrocarbons and three heavy metals in male mice
10.1080/15376516.2024.2365434 · 2024 · External reference
Cytotoxic, anti-inflammatory, and α-glucosidase inhibitory effects of flavonoids from L. graveolens (Mexican oregano)
10.1007/s00044-020-02569-6 · 2020 · External reference
Adverse outcome pathways: a conceptual framework to support ecotoxicology research and risk assessment
10.1002/etc.34 · 2010 · External reference
Using the comet and micronucleus assays for genotoxicity studies: a review
10.1016/j.biopha.2015.04.004 · 2015 · External reference
Synergistic interactions of polyphenols and their effect on antiradical potential
2017 · External reference
Natural products in drug discovery: advances and opportunities
10.1038/s41573-020-00114-z · 2021 · External reference
The antioxidant, cytotoxic, and antigenotoxic effects of galangin, puerarin, and ursolic acid in mammalian cells
10.1080/01480545.2016.1209680 · 2017 · External reference
Mexican oregano (L. graveolens Kunth) as source of bioactive compounds: a review
10.3390/molecules26175156 · 2021 · External reference
Synergy and antagonism in natural product extracts: when 1 + 1 does not equal 2
10.1039/c9np00011a · 2019 · External reference
Protective role of chlorogenic acid on DNA damage caused by ochratoxin A exposure
10.24215/15142590e049 · 2020 · External reference
Genotoxic, mutagenic, and DNA-protective properties of South American plant extracts: mechanisms and bioactive compounds
10.1016/j.jep.2025.121040 · 2026 · External reference
Comprehensive investigation of the antioxidant and pro-oxidant effects of phenolic compounds: a double-edged sword in the context of oxidative stress
10.1021/acs.jpcb.8b03500 · 2018 · External reference
Phytochemicals involved in mitigating silent toxicity induced by heavy metals
10.3390/foods13070978 · 2024 · External reference
Phytochemicals in drug discovery—A confluence of tradition and innovation
10.3390/ijms25168792 · 2024 · External reference
The comet assay for DNA damage and repair: principles, applications and limitations
10.1385/mb:26:3:249 · 2004 · External reference
Measuring oxidative damage to DNA and its repair with the comet assay
10.1016/j.bbagen.2013.04.022 · 2014 · External reference
Plant phenolics: bioavailability as a key determinant of their potential health-promoting applications
10.3390/antiox9121263 · 2020 · External reference
Kinetics of the in vivo genotoxic and radioprotective effects of methyl gallate and epigallocatechin gallate
10.1002/em.22563 · 2023 · External reference
Protocol recommended by the CSGMT/JEMS.MMS for the short-term mouse peripheral blood micronucleus test
10.1093/mutage/10.3.153 · 1995 · External reference
Prooxidant activity of polyphenols, flavonoids, anthocyanins and carotenoids: updated review of mechanisms and catalyzing metals
10.1002/ptr.5643 · 2016 · External reference
The value of plants used in traditional medicine for drug discovery
2001 · External reference
Toxicity of lead: a review with recent updates
10.2478/v10102-012-0009-2 · 2012 · External reference
Flower extracts from ornamental plants as sources of sunscreen ingredients: determination by in vitro methods of photoprotective efficacy, antigenotoxicity and safety
10.3390/molecules27175525 · 2022 · External reference
Iron-induced damage in cardiomyopathy: Oxidative-dependent and independent mechanisms
10.1155/2015/230182 · 2015 · External reference
L. graveolens photochemopreventive effect against UVB radiation-induced skin carcinogenesis
10.1016/j.jphotobiol.2016.12.014 · 2017 · External reference
Pharmacological evaluation of the anxiolytic-like effects of Lippia graveolens and bioactive compounds
10.1080/13880209.2017.1310908 · 2017 · External reference
Antioxidants: a comprehensive review
10.1007/s00204-025-03997-2 · 2025 · External reference
The micronucleus test—Most widely used in vivo genotoxicity test
10.1186/s41021-016-0044-x · 2016 · External reference
In vivo rodent erythrocyte micronucleus assay. II. Some aspects of protocol design including repeated treatments, integration with toxicity testing, and automated scoring
10.1002/(sici)1098-2280(2000)35:3<234::aid-em10>3.0.co;2-l · 2000 · External reference
In vivo rodent erythrocyte micronucleus assay
10.1016/0165-1161(94)90039-6 · 1994 · External reference
Best practice in the chemical characterisation of extracts used in pharmacological and toxicological research—The ConPhyMP guidelines
10.3389/fphar.2022.953205 · 2022 · External reference
Genotoxic effects of lead and their impact on the expression of DNA repair genes
10.3390/ijerph19074307 · 2022 · External reference
Protective effects of acerola juice on genotoxicity induced by iron in vivo
10.1590/1678-4685-gmb-2015-0157 · 2016 · External reference
Comet and micronucleus assays for analyzing DNA damage and genome integrity
10.1016/bs.mie.2019.05.015 · 2019 · External reference
Characterization of a strain-specific CD-1 reference genome reveals potential inter- and intra-strain functional variability
10.1186/s12864-023-09523-x · 2023 · External reference
Selection and characterization of botanical natural products for research studies: a NaPDI center recommended approach
10.1039/c8np00065d · 2019 · External reference
Iron chelation by chlorogenic acid as a natural antioxidant
10.1271/bbb.62.22 · 1998 · External reference
Protective role of terpenes and polyphenols from three species of oregano (L. graveolens, Lippia palmeri and Hedeoma patens) on the suppression of lipopolysaccharide-induced inflammation in RAW 264.7 macrophage cells
10.1016/j.jep.2016.04.051 · 2016 · External reference
Caffeic acid improves cell viability and protects against DNA damage: involvement of reactive oxygen species and extracellular signal-regulated kinase
10.1590/1414-431x20143729 · 2015 · External reference
Las Verbenaceae empleadas como recurso herbolario en México: una revisión etnobotánica-médica
2017 · External reference
A new approach to practical acute toxicity testing
10.1007/bf01234480 · 1983 · External reference
In vitro genotoxicity assessment of caffeic, cinnamic and ferulic acids
10.4238/vol10-2gmr1278 · 2011 · External reference
Immunomodulatory activity of ethanol extract of Annona reticulata L. leaf in cultured immune cells and in Swiss albino mice
10.1016/j.jaim.2022.100554 · 2022 · External reference
Antimalarial activity of seed extracts of Schinus molle against Plasmodium berghei in mice
10.1177/2515690x20984287 · 2021 · External reference
Minimum information for reporting on the comet assay (MIRCA): recommendations for describing comet assay procedures and results
10.1038/s41596-020-0398-1 · 2020 · External reference
Oxidative stress: the role of antioxidant phytochemicals in the prevention and treatment of diseases
10.3390/ijms25063264 · 2024 · External reference
Association between lead exposure and DNA damage (genotoxicity): systematic review and meta-analysis
10.1007/s00204-022-03352-9 · 2022 · External reference
Unresolved reference
2003 · External reference
Unresolved reference
2011 · External reference
Natural products as sources of new drugs over the nearly four decades from 01/1981 to 09/2019
10.1021/acs.jnatprod.9b01285 · 2020 · External reference
Phytochemicals in the treatment of inflammation-associated diseases: the journey from preclinical trials to clinical practice
10.3389/fphar.2023.1177050 · 2023 · External reference
Unresolved reference
1997 · External reference
Unresolved reference
2016 · External reference
Unresolved reference
2016 · External reference
Caffeic acid protects against DNA damage, oxidative and inflammatory mediated toxicities, and upregulated caspases activation in the hepatorenal system of rats treated with aflatoxin B1
10.1016/j.toxicon.2021.12.021 · 2022 · External reference
Flavonoids: an overview
10.1017/jns.2016.41 · 2016 · External reference
A systematic review on ethnopharmacology, phytochemistry and pharmacological aspects of Thymus vulgaris Linn
10.1016/j.heliyon.2021.e07054 · 2021 · External reference
The ARRIVE guidelines 2.0: updated guidelines for reporting animal research
2020 · External reference
Unresolved reference
2001 · External reference
Phenolics and polyphenolics in foods, beverages and spices: antioxidant activity and health effects – a review
10.1016/j.jff.2015.06.018 · 2015 · External reference
Ginkgo biloba L. leaf extract protects HepG2 cells against paraquat-induced oxidative DNA damage
10.3390/plants8120556 · 2019 · External reference
A simple technique for quantitation of low levels of DNA damage in individual cells
10.1016/0014-4827(88)90265-0 · 1988 · External reference
Antigenotoxicity of galangin against N-methyl-N-nitrosourea
1998 · External reference
A review of the phytochemistry and antimicrobial properties of Origanum vulgare L. and subspecies
2021 · External reference
Non-random cell killing in cryopreservation: implications for performance of the battery of leukocyte tests (BLT). I. Toxic and immunotoxic effects
10.1016/0165-1161(91)90247-6 · 1991 · External reference
Fish bioaccumulation and biomarkers in environmental risk assessment: a review
10.1016/s1382-6689(02)00126-6 · 2003 · External reference
Genotoxicity and antigenotoxicity studies of traditional medicinal plants: how informative and accurate are the results?
2015 · External reference
Lead toxicity: a review with recent updates
10.1515/intox-2015-0009 · 2015 · External reference
The role of polyphenols in modern nutrition
10.1111/nbu.12278 · 2017 · External reference
Current understanding of modes of action of multicomponent bioactive phytochemicals: potential for nutraceuticals and antimicrobials
10.1146/annurev-food-052720-100326 · 2022 · External reference
The antioxidant and anti-inflammatory effects of flavonoids from propolis via Nrf2 and NF-κB pathways
10.3390/foods11162439 · 2022 · External reference
Guidance for the use and interpretation of assays for monitoring anti-genotoxicity
10.1016/j.lfs.2023.122341 · 2024 · External reference
The role of mitochondria in iron overload-induced damage
10.1186/s12967-024-05740-4 · 2024 · External reference
Hydroxyl radical generations form the physiologically relevant Fenton-like reactions
10.1016/j.freeradbiomed.2023.09.013 · 2023 · External reference
