Research graph
References from Prunella vulgaris L. ameliorates goiter in Wistar rats is associated with changes in Rap1GAP/CREB3L1/PI3K-AKT signaling pathway. Local targets link to admitted publications; unresolved targets remain external evidence.
Indications for the Surgical Management of Benign Goiter in Adults
2018 · External reference
Rhodiolin inhibits the PI3K/AKT/mTOR signaling pathway via the glycolytic enzyme GPI in human papillary thyroid cancer
10.1016/j.phymed.2024.155804 · 2024 · External reference
The EANM guideline on radioiodine therapy of benign thyroid disease
10.1007/s00259-023-06274-5 · 2023 · External reference
Role of the small GTPase Rap1 for integrin activity regulation in endothelial cells and angiogenesis
10.1182/blood-2008-02-138438 · 2009 · External reference
RUNX2 and the PI3K/AKT axis reciprocal activation as a driving force for tumor progression
10.1186/s12943-015-0404-3 · 2015 · External reference
CREB3L1-mediated functional and structural adaptation of the secretory pathway in hormone-stimulated thyroid cells
10.1242/jcs.211102 · 2017 · External reference
CREB3L1-mediated functional and structural adaptation of the secretory pathway in hormone-stimulated thyroid cells
10.1242/jcs.211102 · 2017 · External reference
Development and validation of a liquid chromatography-tandem mass spectrometry method for simultaneous quantification of eight Xiakucao Oral liquid-related compounds in rat plasma and its application in pharmacokinetic study
10.1002/bmc.5902 · 2024 · External reference
The Role of Rosmarinic Acid in Cancer Prevention and Therapy: Mechanisms of Antioxidant and Anticancer Activity
10.3390/antiox13111313 · 2024 · External reference
Efficacy and Safety of Long-Term Universal Salt Iodization on Thyroid Disorders: Epidemiological Evidence from 31 Provinces of Mainland China
10.1089/thy.2019.0067 · 2020 · External reference
Iodine Deficiency and Iodine Prophylaxis: An Overview and Update
10.3390/nu15041004 · 2023 · External reference
Iodine Deficiency and Iodine Prophylaxis: An Overview and Update
10.3390/nu15041004 · 2023 · External reference
Loss of Rap1GAP in papillary thyroid cancer
10.1210/jc.2008-1042 · 2009 · External reference
Loss of Rap1GAP in papillary thyroid cancer
10.1210/jc.2008-1042 · 2009 · External reference
Integrated Bioinformatics Analysis of Master Regulators in Anaplastic Thyroid Carcinoma
10.1155/2019/9734576 · 2019 · External reference
The differences of regulatory networks between papillary and anaplastic thyroid carcinoma: an integrative transcriptomics study
10.1080/15384047.2020.1803009 · 2020 · External reference
CREB3L1 promotes tumor growth and metastasis of anaplastic thyroid carcinoma by remodeling the tumor microenvironment
10.1186/s12943-022-01658-x · 2022 · External reference
CREB3L1 promotes tumor growth and metastasis of anaplastic thyroid carcinoma by remodeling the tumor microenvironment
10.1186/s12943-022-01658-x · 2022 · External reference
Targeting PKM2 signaling cascade with salvianic acid A normalizes tumor blood vessels to facilitate chemotherapeutic drug delivery
10.1016/j.apsb.2024.02.003 · 2024 · External reference
Prunella vulgaris L. attenuates experimental autoimmune thyroiditis by inducing indoleamine 2,3-dioxygenase 1 expression and regulatory T cell expansion
10.1016/j.biopha.2020.110288 · 2020 · External reference
MicroRNA-146b promotes PI3K/AKT pathway hyperactivation and thyroid cancer progression by targeting PTEN
10.1038/s41388-017-0088-9 · 2018 · External reference
Thyroid hormone suppressive therapy of sporadic nontoxic goiter
10.1089/thy.1992.2.263 · 1992 · External reference
Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries
2021 · External reference
Effect of iodine intake on thyroid diseases in China
10.1056/nejmoa054022 · 2006 · External reference
Emerging therapeutic role of Prunella vulgaris in thyroid disease
2022 · External reference
Down-regulation of Rap1GAP via promoter hypermethylation promotes melanoma cell proliferation, survival, and migration
10.1158/0008-5472.can-08-2399 · 2009 · External reference
Downregulation of Rap1GAP through epigenetic silencing and loss of heterozygosity promotes invasion and progression of thyroid tumors
10.1158/0008-5472.can-09-2812 · 2010 · External reference
Downregulation of Rap1GAP through epigenetic silencing and loss of heterozygosity promotes invasion and progression of thyroid tumors
10.1158/0008-5472.can-09-2812 · 2010 · External reference
Therapeutic effect and mechanism of aqueous extract of Prunella vulgaris L. on experimental autoimmune thyroiditis
2020 · External reference
Unresolved reference
External reference
Effects of aqueous extract of Prunella vulgaris L. on 5-HT and Th17 in rats with autoimmune thyroiditis
2022 · External reference
Characterization of chemical components and antioxidant activities in different parts of Prunella vulgaris L. by UPLC-Q-TOF-MS/MS combined with UPLC
2023 · External reference
