Research graph
References from Neuroprotective effects of Isodon ramosissimus (Hook.f.) Codd (Lamiaceae) aqueous extract against scopolamine-induced Alzheimer-like phenotype. Local targets link to admitted publications; unresolved targets remain external evidence.
Ambroxol confers neuroprotection against scopolamine-induced Alzheimer’s-like pathology by modulating oxidative stress, neuroinflammation, and cognitive deficits via Nrf-2/JNK/GSK-3β signaling pathways
10.3389/fnagi.2025.1607289 · 2025 · External reference
Cholinesterase inhibitors from plants and their potential in alzheimer's treatment: systematic review
10.3390/brainsci15020215 · 2025 · External reference
TeMacTM ameliorates memory impairment and cholinergic dysfunction in rats induced by scopolamine
10.1007/s11011-024-01521-6 · 2025 · External reference
Ameliorative effect of vanillin on scopolamine-induced dementia-like cognitive impairment in a mouse model
10.3389/fnins.2022.1005972 · 2022 · External reference
Narrative review on essential oils and brain aging: aromatherapy for cognitive health
10.4103/agingadv.agingadv-d-25-00022 · 2026 · External reference
The hydrophilic and lipophilic contribution to total antioxidant activity
10.1016/s0308-8146(00)00324-1 · 2001 · External reference
Progesterone–estrogen interactions in synaptic plasticity and neuroprotection
10.1016/j.neuroscience.2012.10.051 · 2013 · External reference
The ferric reducing ability of plasma (FRAP) as a measure of “antioxidant power”: the FRAP assay
10.1006/abio.1996.0292 · 1996 · External reference
Antioxidant determinations by the use of a stable free radical
10.1038/1811199a0 · 1958 · External reference
The Redox properties of polyphenols and their role in ROS generation for biomedical applications
2025 · External reference
Nanomaterials in alzheimer's disease treatment and EnvironmentalImpression
2025 · External reference
Estimation of total flavonoid content in propolis by two complementary colometric methods
2020 · External reference
Unresolved reference
1988 · External reference
Assessing rodent hippocampal involvement in the novel object recognition task. A review
10.1016/j.bbr.2014.08.002 · 2015 · External reference
Memory: organization and control
10.1146/annurev-psych-010416-044131 · 2017 · External reference
A new and rapid colorimetric determination of acetylcholinesterase activity
10.1016/0006-2952(61)90145-9 · 1961 · External reference
Stigmasterol attenuates inflammatory response of microglia via NF-κB and NLRP3 signaling by AMPK activation
2022 · External reference
The dual role of amyloid beta-peptide in oxidative stress and inflammation: unveiling their connections in alzheimer's disease etiopathology
10.3390/antiox13101208 · 2024 · External reference
Unresolved reference
2024 · External reference
Effects of plant-derived dietary antioxidants on Alzheimer's disease: focus on ferroptosis
2025 · External reference
Neuroinflammation in Alzheimer disease
10.1038/s41577-024-01104-7 · 2025 · External reference
Biological determinants of blood-based biomarker levels in Alzheimer's disease: role of nutrition, inflammation, and metabolic factors
10.3389/fnagi.2025.1614962 · 2025 · External reference
Memory loss in Alzheimer's disease
10.31887/dcns.2013.15.4/hjahn · 2013 · External reference
Functional diversification of kaurene synthase-like genes in Isodon rubescens
10.1104/pp.17.00202 · 2017 · External reference
Kalanchoe crenata haw. (Crassulacea) decreases Hippocampal Neuron loss and improves memory and executive function in aged rats: implications for anti-inflammatory and antioxidant mechanisms
10.1002/brb3.70261 · 2025 · External reference
Ziziphus jujuba (Rhamnaceae) alleviates working memory impairment and restores neurochemical alterations in the prefrontal Cortex of D-Galactose-Treated rats. Evid. Based. Complement
2021 · External reference
Matricaria chamomilla L. leaf and flower extracts improved scopolamine-induced amnesia via regulation of cholinergic dysfunction and brain antioxidant status: an in-vivo and in-silico study
10.1016/j.jep.2025.120141 · 2025 · External reference
Antioxidative effects of Chrysoeriol via activation of the Nrf2 signaling pathway and modulation of mitochondrial function
2021 · External reference
Neuroinflammation, its role in alzheimer's disease and therapeutic strategies
10.14283/jpad.2023.109 · 2023 · External reference
Alzheimer disease
10.1038/s41572-021-00269-y · 2021 · External reference
Antioxidative properties of phenolic compounds and their effect on oxidative stress induced by severe physical exercise
10.1186/s12576-022-00845-1 · 2022 · External reference
Synaptic plasticity-enhancing and cognitive-improving effects of standardized ethanol extract of Perilla frutescens var. acuta in a scopolamine-induced mouse model
10.3390/ijms26209925 · 2025 · External reference
Improving vulnerable Calbindin1- neurons in the ventral hippocampus rescues tau-induced impairment of episodic memory
10.1186/s40035-025-00473-w · 2025 · External reference
Neurobehavioral effects of dietary soy phytoestrogens
10.1016/s0892-0362(01)00197-0 · 2002 · External reference
Impaired hippocampal circuit function underlying memory encoding and consolidation precede robust Aβ deposition in a mouse model of alzheimer's disease
2025 · External reference
Oridonin ameliorates caspase-9-mediated brain neuronal apoptosis in mouse with ischemic stroke by inhibiting RIPK3-mediated mitophagy
2022 · External reference
Structure and cytotoxicity of diterpenoids from Isodon eriocalyx
10.1021/np1004328 · 2010 · External reference
Dementia prevention, intervention, and care: 2024 report of the Lancet standing Commission
10.1016/s0140-6736(24)01296-0 · 2024 · External reference
Dementia prevention, intervention, and care: 2020 report of the Lancet Commission
10.1016/s0140-6736(20)30367-6 · 2020 · External reference
Novel object recognition Test for the investigation of learning and memory in mice
2017 · External reference
Neuroprotective effects of aqueous extract of Pterocarpus mildbraedii Harms. on some biochemical markers in Alzheimer's disease using an AlCl3-induced rat model: integrated ADMET, network pharmacology, molecular docking, and in vivo experimental validati
10.1016/j.jep.2026.121962 · 2026 · External reference
Tat-Beclin-1 ameliorates memory by improving neuronal cytoarchitecture and mitigating mitochondrial dysfunction in scopolamine-induced amnesic Male mice
10.1021/acsptsci.4c00283 · 2024 · External reference
The role of superoxide anion in the autoxidation of epinephrine and a simple assay for superoxide dismutase
10.1016/s0021-9258(19)45228-9 · 1972 · External reference
Isodon ramosissimus (Hook.f.)
2000 · External reference
Anti-cholinesterase activity of crude drugs selected from the ingredients of incense sticks and heartwood of chamaecyparis obtusa
2018 · External reference
Natural products in neurodegenerative diseases: recent advances and future outlook
10.3389/fphar.2025.1529194 · 2025 · External reference
A simple practice guide for dose conversion between animals and human
10.4103/0976-0105.177703 · 2016 · External reference
Alzheimer's disease puzzle: delving into pathogenesis hypotheses
2024 · External reference
Quercetin mitigates memory deficits in scopolamine mice model via protection against neuroinflammation and neurodegeneration
10.1016/j.lfs.2022.120326 · 2022 · External reference
The ameliorating effects of stigmasterol on scopolamine-induced memory impairments in mice
10.1016/j.ejphar.2011.11.050 · 2012 · External reference
Alzheimer's disease: treatment strategies and their limitations
10.3390/ijms232213954 · 2022 · External reference
Roles of oxidative stress in synaptic dysfunction and neuronal cell death in alzheimer's disease
10.3390/antiox12081628 · 2023 · External reference
Global trends in Alzheimer's disease and other dementias: a comprehensive analysis of incidence, socio-demographic variations, and future projections
10.1371/journal.pone.0338018 · 2025 · External reference
Identification of stigmasterol derived AChE inhibitors for Alzheimer's disease using high throughput virtual screening and molecular dynamics simulations
10.1038/s41598-025-20527-3 · 2025 · External reference
Advancements in the treatment of Alzheimer's disease: a comprehensive review
10.1590/1980-5764-dn-2024-0204 · 2025 · External reference
Hippocampus and its involvement in Alzheimer's disease: a review
10.1007/s13205-022-03123-4 · 2022 · External reference
Neuroprotective effects of astaxanthin in a scopolamine-induced rat model of Alzheimer's disease through antioxidant/anti-inflammatory pathways and opioid/benzodiazepine receptors: attenuation of Nrf2, NF-κB, and interconnected pathways
10.3389/fphar.2025.1589751 · 2025 · External reference
The potential neuroprotective effect of Cyperus esculentus L. extract in scopolamine-induced cognitive impairment in rats: extensive biological and metabolomics approaches
10.3390/molecules27207118 · 2022 · External reference
Antioxidant activity and mechanism of the abietane-type diterpene ferruginol
10.1080/14786419.2014.997233 · 2015 · External reference
The hippocampus is necessary for the consolidation of a task that does not require the hippocampus for initial learning
10.1002/hipo.23101 · 2019 · External reference
Chrysoeriol promotes functional neurological recovery in a rat model of cerebral ischemia
10.4103/pm.pm_329_21 · 2021 · External reference
Neuroprotective potential of Oroxylum indicum seeds in antioxidant activity, enzyme inhibition and cognitive improvement for alzheimer's disease
10.2174/0115734080365174250527061145 · 2025 · External reference
Isolation and characterization of phytoconstituents from Lepidium meyenii roots, antioxidant activity and molecular docking analysis for alzheimer's disease
2025 · External reference
Challenges and future prospects: a benefaction of phytoconstituents on molecular targets pertaining to Alzheimer's disease
10.5530/ijpi.14.1.15 · 2023 · External reference
Hippocampal-prefrontal interactions in cognition, behavior and psychiatric disease
10.3389/fnsys.2015.00190 · 2016 · External reference
Bauhinia coccinea extract prevents memory loss induced by scopolamine through activation of antiapoptotic and antioxidant pathways in mice
10.1038/s41598-025-88152-8 · 2025 · External reference
Neuroprotective potential of phytocompounds in the treatment of dementia: the State of knowledge from the scopolamine-induced animal model of alzheimer's disease
10.3390/cimb47080635 · 2025 · External reference
Alleviative effect of scopolamine-induced memory deficit via enhancing antioxidant and cholinergic function in rats by pinostrobin from Boesenbergia rotunda (L.)
10.3892/br.2024.1818 · 2024 · External reference
The extract of Sclerocarya birrea, Nauclea latifolia, and Piper longum mixture ameliorates diabetes-associated cognitive dysfunction
10.1007/s11011-023-01291-7 · 2023 · External reference
Neuroavailable peptides from hempseed protein hydrolysates reduce hippocampal inflammation and glial activation in a scopolamine-induced Alzheimer's disease
10.1016/j.biopha.2025.118438 · 2025 · External reference
Oxidative stress in brain function
10.3390/antiox14030297 · 2025 · External reference
Analysis of nitrite and nitrate in biological fluids by assays based on the griess reaction: appraisal of the griess reaction in the L-arginine/nitric oxide area of research
10.1016/j.jchromb.2006.07.054 · 2007 · External reference
Global diseases deserve global solutions: alzheimer's disease
10.3390/neurolint17060092 · 2025 · External reference
The State of the art on acetylcholinesterase inhibitors in the treatment of alzheimer's disease
10.1177/11795735211029113 · 2021 · External reference
Phenol antioxidant quantity and quality in foods: fruits
10.1021/jf0009293 · 2001 · External reference
Morris water maze: procedures for assessing spatial and related forms of learning and memory
10.1038/nprot.2006.116 · 2006 · External reference
The effects of nitric oxide in Alzheimer's disease
10.4103/2045-9912.385939 · 2023 · External reference
Natural bioactive compounds form herbal medicine in Alzheimer's disease: from the perspective of GSK-3β
2025 · External reference
Oridonin attenuates Aβ1–42-induced neuroinflammation and inhibits NF-κB pathway
2014 · External reference
Chemical constituents from Isodon sculponeatus
10.1007/s10600-013-0479-2 · 2013 · External reference
The thiobarbituric acid reagent as a test for the oxidation of
1949 · External reference
Animal models of Alzheimer's disease: preclinical insights and challenges
2023 · External reference
Scopolamine-Induced memory impairment in mice: neuroprotective effects of Carissa edulis (Forssk.) Valh (Apocynaceae) aqueous extract
10.1155/2020/6372059 · 2020 · External reference
Multifaceted role of nitric oxide in vascular dementia
10.4103/mgr.medgasres-d-24-00158 · 2025 · External reference
[Chemical constituents of Rabdosia japonica var. glaucocalyx and their anti-complementary activity]. Zhongguo Zhong Yao Za Zhi Zhongguo Zhongyao Zazhi China J
2013 · External reference
Stigmasterol- an Acetylcholinesterase Inhibitor from Phormidium retzii with relevance to Alzheimer's disease Therapy
2023 · External reference
Diterpenoids from Isodon excisoides
10.3184/030823409x396391 · 2009 · External reference
Neuroprotective effect of Corosolic acid against cerebral ischemia-reperfusion injury in experimental rats
10.5650/jos.ess22130 · 2022 · External reference
An extract from shrimp processing By-Products protects SH-SY5Y cells from neurotoxicity induced by Aβ25-35
10.3390/md15030083 · 2017 · External reference
Oridonin ameliorates traumatic brain injury-induced neurological damage by improving mitochondrial function and antioxidant capacity and suppressing neuroinflammation through the Nrf2 pathway
10.1089/neu.2021.0466 · 2022 · External reference
