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References from Jiao-tai-wan alleviates cognitive impairment induced by sleep deprivation through IL33-associated lipid metabolism and PTP1B/SYK/AKT signaling pathway. Local targets link to admitted publications; unresolved targets remain external evidence.
Anti-depressive effects of Jiao-Tai-Wan on CORT-induced depression in mice by inhibiting inflammation and microglia activation
10.1016/j.jep.2021.114717 · 2022 · External reference
Sleep Loss Promotes Astrocytic Phagocytosis and Microglial Activation in Mouse Cerebral Cortex
10.1523/jneurosci.3981-16.2017 · 2017 · External reference
PTP1B inhibition promotes microglial phagocytosis in Alzheimer’s disease models by enhancing SYK signaling
10.1073/pnas.2521944123 · 2026 · External reference
White matter alterations in heart-kidney imbalance insomnia and Jiao-Tai-Wan treatment: A diffusion-tensor imaging study
10.1007/s11682-022-00653-6 · 2022 · External reference
Simultaneous determination of six coptis alkaloids in urine and feces by LC–MS/MS and its application to excretion kinetics and the compatibility mechanism of Jiao‐Tai‐Wan in insomniac rats
10.1002/bmc.4248 · 2018 · External reference
Neuronal protein-tyrosine phosphatase 1B hinders sensory-motor functional recovery and causes affective disorders in two different focal ischemic stroke models
2020 · External reference
Microglia dynamics in sleep/wake states and in response to sleep loss
10.1016/j.neuint.2020.104944 · 2021 · External reference
Evaluation of Sleep Habits and Disturbances Among US Adults, 2017-2020
10.1001/jamanetworkopen.2022.40788 · 2022 · External reference
SYK coordinates neuroprotective microglial responses in neurodegenerative disease
10.1016/j.cell.2022.09.030 · 2022 · External reference
IL-33 ameliorates alzheimer’s disease-like pathology and cognitive decline
10.1073/pnas.1604032113 · 2016 · External reference
Overexpression of forebrain PTP1B leads to synaptic and cognitive impairments in obesity
10.1016/j.bbi.2024.02.008 · 2024 · External reference
Sleep Deficiency: Epidemiology and Effects
10.1016/j.jsmc.2024.07.001 · 2024 · External reference
Microglial pattern recognition via IL-33 promotes synaptic refinement in developing corticothalamic circuits in mice
10.1084/jem.20220605 · 2023 · External reference
Disruption of the IL-33-ST2-AKT signaling axis impairs neurodevelopment by inhibiting microglial metabolic adaptation and phagocytic function
10.1016/j.immuni.2021.12.001 · 2022 · External reference
Effect of Jiaotai Pill on intestinal damage in partially sleep deprived rats
10.1007/s11655-017-2969-8 · 2017 · External reference
Single-cell transcriptomics and cell-specific proteomics reveals molecular signatures of sleep. Commun
2022 · External reference
Exploring macrophage and nerve interaction in endometriosis-associated pain: the inductive role of IL-33
10.1007/s00011-025-02010-x · 2025 · External reference
Akkermansia muciniphila supplementation prevents cognitive impairment in sleep-deprived mice by modulating microglial engulfment of synapses
10.1080/19490976.2023.2252764 · 2023 · External reference
IL-33 alleviates postoperative cognitive impairment by inhibiting hippocampal inflammation and upregulating excitatory synaptic number in aged mice
10.3390/brainsci12091244 · 2022 · External reference
IL-33/ST2 axis promotes remodeling of the extracellular matrix and drives protective microglial responses in the mouse model of perioperative neurocognitive disorders
10.1016/j.intimp.2022.109479 · 2023 · External reference
Sleep deprivation and its association with diseases- a review
10.1016/j.sleep.2020.07.048 · 2021 · External reference
Elucidating the mechanism of the first chinese herbal formula shuangxia decoction to alleviate insomnia using multi-omics technologies
10.1016/j.phymed.2025.156454 · 2025 · External reference
Flavonoid-rich mulberry leaf extract modulate lipid metabolism, antioxidant capacity, and gut microbiota in high-fat diet-induced obesity: potential roles of FGF21 and SOCS2
2024 · External reference
Lipid-droplet-accumulating microglia represent a dysfunctional and proinflammatory state in the aging brain
10.1038/s41593-019-0566-1 · 2020 · External reference
Epidemiology of Insomnia: Prevalence, Course, Risk Factors, and Public Health Burden
10.1016/j.jsmc.2022.03.003 · 2022 · External reference
Microglial Remodeling of the Extracellular Matrix Promotes Synapse Plasticity
10.1016/j.cell.2020.05.050 · 2020 · External reference
Protein tyrosine phosphatase 1B (PTP1B) as a potential therapeutic target for neurological disorders
10.1016/j.biopha.2022.113709 · 2022 · External reference
Circadian Rhythms of Perineuronal Net Composition
10.1523/eneuro.0034-19.2020 · 2020 · External reference
Perineuronal nets affect memory and learning after synapse withdrawal
10.1038/s41398-022-02226-z · 2022 · External reference
The therapeutic potential of butyrate and lauric acid in modulating glial and neuronal activity in alzheimer’s disease
10.3390/nu17142286 · 2025 · External reference
Jiao-tai-wan inhibits inflammation of the gut-brain-axis and attenuates cognitive impairment in insomnic rats
10.1016/j.jep.2019.112478 · 2020 · External reference
Exploring the mechanism by which Zexie Tang regulates Alzheimer’s disease: Insights from multi-omics analysis
10.1016/j.phymed.2025.156453 · 2025 · External reference
Integrated screening of effective anti-insomnia fractions of zhi-zi-hou-Po decoction via drosophila melanogaster and network pharmacology analysis of the underlying pharmacodynamic material and mechanism
10.1021/acsomega.1c00445 · 2021 · External reference
TREM2 drives microglia response to amyloid-β via SYK-dependent and -independent pathways
10.1016/j.cell.2022.09.033 · 2022 · External reference
α-linolenic acid mitigates microglia-mediated neuroinflammation of schizophrenia in mice by suppressing the NF-κB/NLRP3 pathway via binding GPR120-β-arrestin 2
2024 · External reference
Jiao-Tai-Wan Improves Cognitive Dysfunctions through Cholinergic Pathway in Scopolamine-Treated Mice
2018 · External reference
Reducing microglial lipid load enhances β amyloid phagocytosis in an Alzheimer’s disease mouse model
2025 · External reference
Chronic sleep fragmentation shares similar pathogenesis with neurodegenerative diseases: Endosome-autophagosome-lysosome pathway dysfunction and microglia-mediated neuroinflammation
10.1111/cns.13218 · 2020 · External reference
IL-33 induces thymic involution-associated naive T cell aging and impairs host control of severe infection
10.1038/s41467-022-34660-4 · 2022 · External reference
Sleep deprivation induces anxiety-like behaviors through IL-6 driven astrocyte-GABAergic neuron crosstalk in the PAG-ACC circuit
10.1186/s12974-026-03879-z · 2026 · External reference
Interleukin-33 ameliorates perioperative neurocognitive disorders by modulating microglial state
10.1016/j.neuropharm.2024.109982 · 2024 · External reference
The food and medicine homologous chinese medicine from leguminosae species: a comprehensive review on bioactive constituents with neuroprotective effects on nervous system
2025 · External reference
Jiao-tai-wan for insomnia symptoms caused by the disharmony of the heart and kidney: a study protocol for a randomized, double-blind, placebo-controlled trial
10.1186/s13063-020-04299-x · 2020 · External reference
Global analysis the potential medicinal substances of shuangxia decoction and the process In vivo via mass spectrometry technology
2021 · External reference
Intestinal dysbiosis mediates cognitive impairment via the intestine and brain NLRP3 inflammasome activation in chronic sleep deprivation
10.1016/j.bbi.2022.11.013 · 2023 · External reference
The effects of jiao-tai-wan on sleep, inflammation and insulin resistance in obesity-resistant rats with chronic partial sleep deprivation
10.1186/s12906-017-1648-9 · 2017 · External reference
