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References from Material basis, herbal contribution, and potential quality markers of Kanggan Granules against influenza revealed by UPLC-HRMS, network pharmacology, and experimental validation. Local targets link to admitted publications; unresolved targets remain external evidence.
Dryopteris crassirhizoma Nakai.: a review of its botany, traditional use, phytochemistry, pharmacological activity, toxicology and pharmacokinetics
10.1016/j.jep.2024.118109 · 2024 · External reference
How to manage antivirals in critically ill patients with influenza?
10.1016/j.cmi.2025.04.002 · 2025 · External reference
Influenza and viral pneumonia
2024 · External reference
Anti-influenza A (H1N1) virus effect of gallic acid through inhibition of virulent protein production and association with autophagy
10.1002/fsn3.3852 · 2024 · External reference
Dynamic changes of lymphocyte counts in adult patients with severe pandemic H1N1 influenza A
10.1016/j.jiph.2019.05.017 · 2019 · External reference
Unresolved reference
2025 · External reference
Antiviral activity of chlorogenic acid against influenza A (H1N1/H3N2) virus and its inhibition of neuraminidase
2017 · External reference
Influenza virus and SARS-CoV-2: pathogenesis and host responses in the respiratory tract
10.1038/s41579-021-00542-7 · 2021 · External reference
Dynamic natural killer cell and T cell responses to influenza infection
10.3389/fcimb.2020.00425 · 2020 · External reference
Mechanistic insights from inflammasome structures
10.1038/s41577-024-00995-w · 2024 · External reference
Kanggan granules ameliorates dexamethasone-induced immunosuppression in mice
2019 · External reference
Oligonol a low molecular weight polyphenol of lychee fruit extract inhibits proliferation of influenza virus by blocking reactive oxygen species-dependent ERK phosphorylation
10.1016/j.phymed.2010.03.016 · 2010 · External reference
Rhei radix et rhizoma in Xuanbai-Chengqi decoction strengthens the intestinal barrier function and promotes lung barrier repair in preventing severe viral pneumonia induced by influenza A virus
2024 · External reference
Global trends of seasonal influenza-associated mortality in 2001-2018: a longitudinal epidemiological study
10.1016/j.jinf.2023.06.011 · 2023 · External reference
Antimicrobial acylphloroglucinol meroterpenoids and acylphloroglucinols from Dryopteris crassirhizoma
2022 · External reference
Antiviral resistance in influenza viruses - implications for management and pandemic response
10.1056/nejmp068030 · 2006 · External reference
Evaluating the antiviral efficacy and specificity of chlorogenic acid and related herbal extracts against SARS-CoV-2 variants via spike protein binding intervention
10.1016/j.jtcme.2024.11.009 · 2025 · External reference
Artemisia extracts suppress H1N1 influenza A virus infection by targeting viral HA/NA proteins and modulating the TLR4/MyD88/NF-κB signaling axis
10.3390/ph19020275 · 2026 · External reference
Small molecule-constrained paratope mimetic bicyclic peptides as potent inhibitors of group 1 and 2 influenza A virus hemagglutinins
10.1073/pnas.2537533123 · 2026 · External reference
Cytokine storm
10.1038/s41572-025-00677-4 · 2026 · External reference
Deciphering the immunomodulatory mechanisms of Bojungikki-tang via systematic transcriptomic and immune cell interaction network analysis
10.1016/j.biopha.2025.118129 · 2025 · External reference
Wars and pandemics: AMR accelerators of the 21st century?
10.1021/acs.estlett.3c00020 · 2023 · External reference
A herbal mixture formula of OCD20015-V009 prophylactic administration to enhance interferon-mediated antiviral activity against influenza A virus
10.3389/fphar.2021.764297 · 2021 · External reference
Global burden of influenza-associated lower respiratory tract infections and hospitalizations among adults: a systematic review and meta-analysis
10.1371/journal.pmed.1003550 · 2021 · External reference
Effect of Kanggan granules (children's formula) on immune function and inflammatory factors in children with ordinary hand-foot-mouth disease
2021 · External reference
Material-herbology: an effective and safe strategy to eradicate lethal viral-bacterial pneumonia
10.1016/j.matt.2021.07.001 · 2021 · External reference
A comprehensive review on pharmacokinetic mechanism of herb-herb/drug interactions in Chinese herbal formula
10.1016/j.pharmthera.2024.108728 · 2024 · External reference
Traditional uses, botany, phytochemistry, and pharmacology of Lonicerae japonicae flos and Lonicerae flos: a systematic comparative review
10.1016/j.jep.2023.117278 · 2024 · External reference
Efficacy observation of Kanggan granules combined with oseltamivir phosphate granules in the treatment of influenza B in children
2024 · External reference
A small molecule compound targeting hemagglutinin inhibits influenza A virus and exhibits broad-spectrum antiviral activity
10.1038/s41401-024-01331-7 · 2024 · External reference
Effect of Haoqin qingdan tang on influenza A virus through the Janus kinase/signal transducer and activator of transcription (JAK/STAT) pathway
10.1016/j.phymed.2024.155680 · 2024 · External reference
A truncated pre-F protein mRNA vaccine elicits an enhanced immune response and protection against respiratory syncytial virus
10.1038/s41467-025-56302-1 · 2025 · External reference
Experimental observation on the anti-influenza A virus effect of Kanggan granules
2010 · External reference
The cytokine storm of severe influenza and development of immunomodulatory therapy
10.1038/cmi.2015.74 · 2015 · External reference
Elucidation of Cortex Dictamni hepatotoxicity mechanism by integrated serum pharmacochemistry and metabolomics
10.1016/j.phymed.2025.157631 · 2026 · External reference
Clinical effect of Kanggan granules versus Lianhua Qingwen granules in treating mild influenza
2025 · External reference
Metabolomics and serum pharmacochemistry combined with network pharmacology uncover the potential effective ingredients and mechanisms of yin-chen-si-ni decoction treating ANIT-induced cholestatic liver injury
10.1016/j.jep.2024.118713 · 2024 · External reference
Computational screen and experimental validation of anti-influenza effects of quercetin and chlorogenic acid from traditional Chinese medicine
2016 · External reference
Chlorogenic acid reduces inflammation by inhibiting the elevated expression of KAT2A to ameliorate lipopolysaccharide-induced acute lung injury
10.1111/bph.16069 · 2023 · External reference
A review of the ethnopharmacology, phytochemistry, pharmacology, pharmacokinetics and quality control of Paeonia lactiflora Pall
10.1016/j.jep.2024.118616 · 2024 · External reference
Innate immune responses to influenza virus infections in the upper respiratory tract
10.3390/v13102090 · 2021 · External reference
Effect of structural differences in naringenin, prenylated naringenin, and their derivatives on the anti-influenza virus activity and cellular uptake of their flavanones
10.3390/ph15121480 · 2022 · External reference
Dose translation between laboratory animals and human in preclinical and clinical phases of drug development
10.1002/ddr.21461 · 2018 · External reference
A simple practice guide for dose conversion between animals and human
10.4103/0976-0105.177703 · 2016 · External reference
Influenza
10.1038/s41572-018-0006-7 · 2018 · External reference
Huopu Xialing decoction mitigates influenza A-induced pulmonary injury by inhibiting METTL3-Nlrp3(m6A) mediated NLRP3 inflammasome activation
10.1016/j.jep.2025.120577 · 2026 · External reference
Erratum: the evolution of seasonal influenza viruses
10.1038/nrmicro.2017.146 · 2018 · External reference
Hemagglutinin consensus-based prophylactic approaches to overcome influenza virus diversity
2019 · External reference
Editorial: cytokine-mediated organ dysfunction and tissue damage induced by viruses
10.3389/fimmu.2020.00002 · 2020 · External reference
3,4-Dicaffeoylquinic acid, a major constituent of brazilian propolis, increases TRAIL expression and extends the lifetimes of mice infected with the influenza A virus. Evid. -Based Complement
2012 · External reference
Cytokine storms in infectious diseases
10.1007/s00281-017-0640-2 · 2017 · External reference
Influenza
10.1016/s0140-6736(22)00982-5 · 2022 · External reference
Isoliquiritigenin inhibits virus replication and virus-mediated inflammation via NRF2 signaling
10.1016/j.phymed.2023.154786 · 2023 · External reference
Luteolin ameliorates LPS-induced acute liver injury by inhibiting TXNIP-NLRP3 inflammasome in mice
10.1016/j.phymed.2021.153586 · 2021 · External reference
Single-dose suraxavir marboxil for acute uncomplicated influenza in adults and adolescents: a multicenter, randomized, double-blind, placebo-controlled phase 3 trial
10.1038/s41591-024-03419-3 · 2025 · External reference
Mechanism of action of Daqinjiao decoction in treating cerebral small vessel disease explored using network pharmacology and molecular docking technology
10.1016/j.phymed.2022.154538 · 2023 · External reference
Automated interpretation of influenza hemagglutination inhibition (HAI) assays: is plate tilting necessary?
10.1371/journal.pone.0179939 · 2017 · External reference
Lung structural cells are altered by influenza virus leading to rapid immune protection following re-challenge
10.1038/s41467-025-62364-y · 2025 · External reference
How Chinese herbal medicine prevents epidemics: from ancient pestilences to COVID-19 pandemic
10.1142/s0192415x2150049x · 2021 · External reference
Molecular mechanism of Jianpiyifei II granules in the treatment of chronic obstructive pulmonary disease: network pharmacology analysis, molecular docking, and experimental assessment
10.1016/j.phymed.2023.155273 · 2024 · External reference
The NLRP3 inflammasome: activation and regulation
10.1016/j.tibs.2022.10.002 · 2023 · External reference
Discovery of multitarget-directed ligands against influenza A virus from compound Yizhihao through a predictive system for compound-protein interactions
10.3389/fcimb.2020.00016 · 2020 · External reference
Luteolin decreases the yield of influenza A virus in vitro by interfering with the coat protein I complex expression
10.1007/s11418-019-01287-7 · 2019 · External reference
Aqueous extract of Evodia lepta Merr. attenuates influenza virus infection via inhibition of the HSP90/NF-κB axis
10.1016/j.jep.2025.120337 · 2025 · External reference
Efficacy and safety of onradivir in adults with acute uncomplicated influenza A infection in China: a multicentre double-blind, randomised, placebo-controlled and oseltamivir-controlled, phase 3 trial
10.1016/s2213-2600(25)00046-3 · 2025 · External reference
Influenza A (H1N1) and COVID-19 pneumonias: an evaluation in the light of new hematologic indices
10.2147/jir.s545387 · 2025 · External reference
Anti-pandemic influenza A (H1N1) virus potential of catechin and gallic acid
10.1016/j.jcma.2017.11.007 · 2018 · External reference
Effect of paeoniflorin on acute lung injury induced by influenza A virus in mice
2021 · External reference
Phloroglucinol derivatives from Dryopteris crassirhizoma as potent xanthine oxidase inhibitors
10.3390/molecules26010122 · 2021 · External reference
Discovery of anti-flu substances and mechanism of shuang-huang-lian water extract based on serum pharmaco-chemistry and network pharmacology
10.1016/j.jep.2020.113660 · 2021 · External reference
Protective effects of diketopiperazines from Moslae Herba against influenza A virus-induced pulmonary inflammation via inhibition of viral replication and platelets aggregation
10.1016/j.jep.2018.01.005 · 2018 · External reference
Anti-influenza virus phytochemicals from Radix Paeoniae Alba and characterization of their neuraminidase inhibitory activities
10.1016/j.jep.2020.112671 · 2020 · External reference
Inhibitory effects and related molecular mechanisms of total flavonoids in Mosla chinensis Maxim against H1N1 influenza virus
10.1007/s00011-017-1109-4 · 2018 · External reference
