Research graph
References from HuaTanJiangQi formula regulates Nrf2-mediated CYP2J2/EETs/NF-κB axis to alleviate glucocorticoid resistance in COPD. Local targets link to admitted publications; unresolved targets remain external evidence.
Global, regional, and national prevalence of, and risk factors for, chronic obstructive pulmonary disease (COPD) in 2019: a systematic review and modelling analysis
10.1016/s2213-2600(21)00511-7 · 2022 · External reference
Global initiative for chronic obstructive lung disease 2023 Report: GOLD executive summary
10.1183/13993003.00239-2023 · 2023 · External reference
Glucocorticoid receptor signaling represses the antioxidant response by inhibiting histone acetylation mediated by the transcriptional activator NRF2
10.1074/jbc.m116.773960 · 2017 · External reference
Role of HDAC2 in the pathophysiology of COPD
10.1146/annurev.physiol.010908.163257 · 2009 · External reference
Corticosteroid resistance in patients with asthma and chronic obstructive pulmonary disease
10.1016/j.jaci.2012.12.1564 · 2013 · External reference
Inflammatory mechanisms in patients with chronic obstructive pulmonary disease
10.1016/j.jaci.2016.05.011 · 2016 · External reference
Oxidative stress in chronic obstructive pulmonary disease
10.3390/antiox11050965 · 2022 · External reference
Glucocorticoid resistance in inflammatory diseases
10.1016/s0140-6736(09)60326-3 · 2009 · External reference
Nuclear factor-kappaB: a pivotal transcription factor in chronic inflammatory diseases
10.1056/nejm199704103361506 · 1997 · External reference
Airway inflammation in COPD: progress to precision medicine
10.1183/13993003.00651-2019 · 2019 · External reference
Incorporation of phosphorylated tyrosine into proteins: in vitro translation and study of phosphorylated IκB-α and its interaction with NF-κB
10.1021/jacs.7b05168 · 2017 · External reference
The involvement of soluble epoxide hydrolase in the development of cardiovascular diseases through epoxyeicosatrienoic acids
2024 · External reference
Glucocorticoid insensitivity in severe asthma: underlying molecular mechanisms, challenges, and emerging therapies
2025 · External reference
Up-down regulation of HO-1 and iNOS gene expressions by ethyl pyruvate via recruiting p300 to Nrf2 and depriving it from p65
10.1016/j.freeradbiomed.2013.07.028 · 2013 · External reference
Nrf2 suppresses macrophage inflammatory response by blocking proinflammatory cytokine transcription
10.1038/ncomms11624 · 2016 · External reference
The glucocorticoid receptor inhibits NRF2-Mediated expression of SLC7A11
10.1016/j.freeradbiomed.2025.09.008 · 2025 · External reference
Oxidative stress promotes corticosteroid insensitivity in asthma and COPD
10.3390/antiox10091335 · 2021 · External reference
Identification and characterization of chemical constituents in HuaTanJiangQi capsules by UPLC-QTOF-MS method
10.1093/jaoacint/qsab004 · 2021 · External reference
Inhibition of spleen tyrosine kinase restores glucocorticoid sensitivity to improve steroid-resistant asthma
2022 · External reference
The glucocorticoid receptor: isoforms, functions, and contribution to glucocorticoid sensitivity
10.1210/endrev/bnae008 · 2024 · External reference
Pathological and pharmacological functions of the metabolites of polyunsaturated fatty acids mediated by cyclooxygenases, lipoxygenases, and cytochrome P450s in cancers
10.1016/j.pharmthera.2024.108612 · 2024 · External reference
NF-κB-dependent GR cistrome redistribution recruits GR to inflammatory genes but correlates with lesser glucocorticoid-mediated repression
10.1016/j.isci.2025.114206 · 2025 · External reference
Glucocorticoid and cytokine crosstalk: feedback, feedforward, and co-regulatory interactions determine repression or resistance
10.1074/jbc.r117.777318 · 2017 · External reference
Anti-inflammatory properties of cytochrome P450 epoxygenase-derived eicosanoids
10.1126/science.285.5431.1276 · 1999 · External reference
NF-κB signaling
10.1002/wsbm.30 · 2009 · External reference
The association between polyunsaturated fatty acids and chronic obstructive pulmonary disease: a meta-analysis
10.1039/d3fo04675c · 2024 · External reference
Activation of NF-κB in B cell receptor signaling through Bruton's tyrosine kinase-dependent phosphorylation of IκB-α
10.1007/s00109-019-01777-x · 2019 · External reference
A phase III study of triple therapy with budesonide/glycopyrrolate/formoterol fumarate metered dose inhaler 320/18/9.6 μg and 160/18/9.6 μg using co-suspension delivery technology in moderate-to-very severe COPD: the ETHOS study protocol
10.1016/j.rmed.2019.08.010 · 2019 · External reference
Antiinflammatory action of glucocorticoids--new mechanisms for old drugs
10.1056/nejmra050541 · 2005 · External reference
Global initiative for chronic obstructive lung disease (GOLD) 20th anniversary: a brief history of time
10.1183/13993003.00671-2017 · 2017 · External reference
CYP450 epoxygenase metabolites, epoxyeicosatrienoic acids, as novel anti-inflammatory mediators
10.3390/molecules27123873 · 2022 · External reference
Action of epoxyeicosatrienoic acids on cellular function
10.1152/ajpcell.00402.2006 · 2007 · External reference
Towards the elimination of chronic obstructive pulmonary disease: a lancet commission
10.1016/s0140-6736(22)01273-9 · 2022 · External reference
Molecular basis of the Keap1-Nrf2 system
10.1016/j.freeradbiomed.2015.06.006 · 2015 · External reference
Paricalcitol ameliorates diabetic nephropathy by promoting EETs and M2 macrophage polarization and inhibiting inflammation by regulating VDR/CYP2J2 axis
10.1096/fj.202401489r · 2024 · External reference
Dissecting molecular cross-talk between Nrf2 and NF-κB response pathways
10.1042/bst20150014 · 2015 · External reference
Triple regulation of oxidative-acetylation cycling pathways in COPD glucocorticoid resistance by HuaTanJiangQi capsules
10.1007/s13205-025-04249-x · 2025 · External reference
Huatanjiangqi capsule upregulating NRF2 and MRP1 expression in chronic obstructive pulmonary disease in rats
10.1007/s11094-018-1771-z · 2018 · External reference
14,15-epoxyeicosatrienoic acid suppresses cigarette smoke extract-induced apoptosis in lung epithelial cells by inhibiting endoplasmic reticulum stress
10.1159/000430113 · 2015 · External reference
NLRX1 knockout aggravates lipopolysaccharide (LPS)-induced heart injury and attenuates the anti-LPS cardioprotective effect of CYP2J2/11,12-EET by enhancing activation of NF-κB and NLRP3 inflammasome
10.1016/j.ejphar.2020.173276 · 2020 · External reference
Effect of allyl isothiocyanate on oxidative stress in COPD via the AhR/CYP1A1 and Nrf2/NQO1 pathways and the underlying mechanism
10.1016/j.phymed.2023.154774 · 2023 · External reference
Effects of allyl isothiocyanate on the expression, function, and its mechanism of ABCA1 and ABCG1 in pulmonary of COPD rats
2021 · External reference
