Research graph
References from Shema Zhichuan Liquid alleviates airway inflammation in Allergic Asthma by regulating autophagy pathways through DNA methylation. Local targets link to admitted publications; unresolved targets remain external evidence.
The ability of resveratrol to attenuate ovalbumin-mediated allergic asthma is associated with changes in microbiota involving the gut-lung axis, enhanced barrier function and decreased inflammation in the lungs
10.3389/fimmu.2022.805770 · 2022 · External reference
Autophagy in asthma and chronic obstructive pulmonary disease
10.1042/cs20210900 · 2022 · External reference
Macrophages: Sentinels, warriors, and healers
10.1093/hmg/ddaf087 · 2025 · External reference
Macrophages orchestrate airway inflammation, remodeling, and resolution in asthma
10.3390/ijms241310451 · 2023 · External reference
Advances and recent developments in asthma in 2020
10.1111/all.14607 · 2020 · External reference
The activation of mTOR signalling modulates DNA methylation by enhancing DNMT1 translation in hepatocellular carcinoma
10.1186/s12967-023-04103-9 · 2023 · External reference
SUMO1-modified DNA methyltransferase 1 induces DNA hypermethylation of VWC2 in the development of colorectal cancer
10.4149/neo_2022_220817n841 · 2022 · External reference
Protein phosphatase 1 regulatory subunit 15 a (PPP1R15A) promoted the progression of gastric cancer by activating cell autophagy under energy stress
10.1186/s13046-025-03320-y · 2025 · External reference
The epigenetic state of IL-4-polarized macrophages enables inflammatory cistromic expansion and extended synergistic response to TLR ligands
10.1016/j.immuni.2022.10.004 · 2022 · External reference
An autophagy modulator peptide prevents lung function decrease and corrects established inflammation in murine models of airway allergy
10.3390/cells10092468 · 2021 · External reference
The direct and indirect role of IgE on airway epithelium in asthma
10.1111/all.16459 · 2025 · External reference
New insights into autophagy in inflammatory subtypes of asthma
10.3389/fimmu.2023.1156086 · 2023 · External reference
Inflammatory biomarkers on an LPS-induced RAW 264.7 cell model: A systematic review and meta-analysis
10.1007/s00011-022-01584-0 · 2022 · External reference
T1-T2 interplay in the complex immune landscape of severe asthma
10.1111/imr.70011 · 2025 · External reference
A review of the ephedra genus: Distribution, ecology, ethnobotany, phytochemistry and pharmacological properties
10.3390/molecules25143283 · 2020 · External reference
The molecular basis of nutrient sensing and signalling by mTORC1 in metabolism regulation and disease
10.1038/s41580-023-00641-8 · 2023 · External reference
Simvastatin alleviates airway inflammation and remodelling through up-regulation of autophagy in mouse models of asthma
10.1111/resp.12926 · 2017 · External reference
The presence and pathogenic roles of M(IL-33 + IL-2) macrophages in allergic airway inflammation
10.1111/all.16430 · 2025 · External reference
Best practice in research – overcoming common challenges in phytopharmacological research
10.1016/j.jep.2019.112230 · 2020 · External reference
Memory-type pathogenic TH2 cells and ILC2s in type 2 allergic inflammation
10.1016/j.jaci.2021.02.006 · 2021 · External reference
Exposure to ephedrine attenuates Th1/Th2 imbalance underlying OVA-induced asthma through airway epithelial cell-derived exosomal lnc-TRPM2-AS
10.1016/s1875-5364(24)60554-6 · 2024 · External reference
Decoding the role of DNA methylation in allergic diseases: from pathogenesis to therapy
10.1186/s13578-024-01270-0 · 2024 · External reference
Anti-inflammatory activities of guang-pheretima extract in lipopolysaccharide-stimulated RAW 264.7 murine macrophages
10.1186/s12906-018-2086-z · 2018 · External reference
The role of autophagy in the function of CD4+ T cells and the development of chronic inflammatory diseases
10.3389/fphar.2022.860146 · 2022 · External reference
Epithelial IL-6 trans-signaling defines a new asthma phenotype with increased airway inflammation
10.1016/j.jaci.2018.05.026 · 2019 · External reference
Tectorigenin inhibits oxidative stress by activating the Keap1/Nrf2/HO-1 signaling pathway in Th2-mediated allergic asthmatic mice
10.1016/j.freeradbiomed.2023.12.031 · 2024 · External reference
Pi-pa-run-fei-tang alleviates lung injury by modulating IL-6/JAK2/STAT3/IL-17 and PI3K/AKT/NF-κB signaling pathway and balancing Th17 and treg in murine model of OVA-induced asthma
10.1016/j.jep.2023.116719 · 2023 · External reference
STIM1 is a core trigger of airway smooth muscle remodeling and hyperresponsiveness in asthma
2022 · External reference
Cis- and trans-eQTM analysis reveals novel epigenetic and transcriptomic immune markers of atopic asthma in airway epithelium
10.1016/j.jaci.2023.05.018 · 2023 · External reference
Cellular and molecular mechanisms of allergic asthma
10.1016/j.mam.2021.100995 · 2022 · External reference
The immunology of asthma
10.1038/s41590-025-02212-9 · 2025 · External reference
Macrophages acquire a TNF-dependent inflammatory memory in allergic asthma
10.1016/j.jaci.2021.11.026 · 2022 · External reference
Mechanisms of DNA Methylation Regulatory Function and Crosstalk with Histone Lysine Methylation
10.1016/j.jmb.2023.168394 · 2024 · External reference
A critical role for Dnmt1 and DNA methylation in T cell development, function, and survival
10.1016/s1074-7613(01)00227-8 · 2001 · External reference
Loss of splicing factor SRSF3 impairs lipophagy through ubiquitination and degradation of Syntaxin17 in hepatocytes
10.1016/j.jlr.2023.100342 · 2023 · External reference
Allergen-induced dendritic cell autophagy drives immune imbalance in asthma
2026 · External reference
Programmed cell death in asthma: Apoptosis, autophagy, pyroptosis, ferroptosis, and necroptosis
10.2147/jir.s417801 · 2023 · External reference
Autophagy: Regulator of cell death
10.1038/s41419-023-06154-8 · 2023 · External reference
DNA methyltransferase inhibitor promotes human CD4+CD25hFOXP3+ regulatory T lymphocyte induction under suboptimal TCR stimulation
10.3389/fimmu.2016.00488 · 2016 · External reference
DNMT1: Catalytic and non-catalytic roles in different biological processes
10.2217/epi-2022-0035 · 2022 · External reference
Co-stimulation with opposing macrophage polarization cues leads to orthogonal secretion programs in individual cells
10.1038/s41467-020-20540-2 · 2021 · External reference
Exposure to traffic-related air pollution and changes in exhaled nitric oxide and DNA methylation in arginase and nitric oxide synthase in children with asthma
2021 · External reference
Dose translation between laboratory animals and human in preclinical and clinical phases of drug development
10.1002/ddr.21461 · 2018 · External reference
Genetics and epigenetics in asthma
10.3390/ijms22052412 · 2021 · External reference
IL-4/IL-13 axis as therapeutic targets in allergic rhinitis and asthma
10.7717/peerj.13444 · 2022 · External reference
Pharmacological inhibition of DNMT1 restores macrophage autophagy and M2 polarization in western diet-induced nonalcoholic fatty liver disease
10.1016/j.jbc.2023.104779 · 2023 · External reference
A current perspective of allergic asthma: From mechanisms to management
10.1007/164_2021_483 · 2022 · External reference
Exposure to NO2, CO, and PM2.5 is linked to regional DNA methylation differences in asthma
10.1186/s13148-017-0433-4 · 2018 · External reference
Allergic Asthma in the Era of Personalized Medicine
10.3390/jpm12071162 · 2022 · External reference
Immunometabolism in the pathogenesis of asthma
10.1111/imm.13688 · 2024 · External reference
CLDN6 suppresses c-MYC-mediated aerobic glycolysis to inhibit proliferation by TAZ in breast cancer
10.3390/ijms23010129 · 2021 · External reference
Indicaxanthin induces autophagy in intestinal epithelial cancer cells by epigenetic mechanisms involving DNA methylation
10.3390/nu15153495 · 2023 · External reference
Ziziphus mauritiana lam attenuates inflammation via downregulating NFκB pathway in LPS-stimulated RAW 264.7 macrophages & OVA-induced airway inflammation in mice models
10.1016/j.jep.2022.115445 · 2022 · External reference
Autophagy regulation by signaling
10.1016/j.ceb.2025.102595 · 2025 · External reference
Targeting IL-13 and IL-4 in asthma: Therapeutic implications on airway remodeling in severe asthma
10.1007/s12016-025-09045-2 · 2025 · External reference
Epigenetic and post-translational modifications in autophagy: Biological functions and therapeutic targets
10.1038/s41392-022-01300-8 · 2023 · External reference
DNMT1-mediated DNA methylation in toll-like receptor 4 (TLR4) inactivates NF-κB signal pathway-triggered pyroptotic cell death and cellular inflammation to ameliorate lipopolysaccharides (LPS)-induced osteomyelitis
10.1016/j.mcp.2023.101922 · 2023 · External reference
Involvement of autophagy in exacerbation of eosinophilic airway inflammation in a murine model of obese asthma
10.1080/15548627.2022.2025571 · 2022 · External reference
Epigenetic regulation of T-helper cell differentiation, memory, and plasticity in allergic asthma
10.1111/imr.12560 · 2017 · External reference
Epigenetic signatures of asthma: A comprehensive study of DNA methylation and clinical markers
10.1186/s13148-024-01765-0 · 2024 · External reference
A multi-omics mendelian randomization identifies putatively causal genes and DNA methylation sites for asthma
10.1016/j.waojou.2024.101008 · 2024 · External reference
Inhibitory effect of zanthoxylum bungeanum seed oil on ovalbumin-induced lung inflammation in a murine model of asthma
10.3892/mmr.2016.5050 · 2016 · External reference
Active ingredients from chinese medicine plants as therapeutic strategies for asthma: Overview and challenges
2021 · External reference
Epigenetic regulation of airway epithelial barrier dysfunction in pediatric asthma: Mechanistic insights and therapeutic potential
2025 · External reference
Epigenetic reprogramming of dendritic cells by DNMT1 inhibition attenuates Th2 skewing in allergic airway inflammation
10.1186/s12964-025-02467-7 · 2025 · External reference
The translational regulation in mTOR pathway
10.3390/biom12060802 · 2022 · External reference
Oncogenic DNA methyltransferase 1 activates the PI3K/AKT/mTOR signalling by blocking the binding of HSPB8 and BAG3 in melanoma
10.1080/15592294.2023.2239607 · 2023 · External reference
Epigenetic therapy: Research progress of decitabine in the treatment of solid tumors
10.1016/j.bbcan.2023.189066 · 2024 · External reference
Efficacy of shegan mahuang decoction for asthma: A systematic review and meta-analysis protocol
10.1097/md.0000000000017845 · 2019 · External reference
DNA methylation-driven gene FAM3D promotes colorectal cancer growth via the ATF4-SESN2-mTORC1 pathway
10.18632/aging.206115 · 2024 · External reference
Traditional uses, phytochemistry, pharmacology, and toxicology of belamcanda chinensis: A review
10.3390/plants14233688 · 2025 · External reference
Inhibition of DNA methyltransferase DNMT1 reverses Th2 response polarisation and alleviates allergic rhinitis
10.1111/1440-1681.70015 · 2025 · External reference
Short-Term Effect of Shemazhichuan Liquid on Asthma and Its Related Mechanism
2000 · External reference
Effect of Shemazhichuan liquid on pulmonary function in asthma patients
2005 · External reference
Exploration of Irigenin Interfering with Airway Inflammation Based on the COX-2/Nrf2/HO-1 Signalling Pathway and Regulating Intestinal Flora to Improve AllergicAsthma in Mice
2025 · External reference
Study on mechanism of Shema Zhichuan Liquid for improving airway remodeling by inhibiting airway epithelial cell EMT in asthma through NF-κB/VEGFA signaling pathway
2024 · External reference
Unresolved reference
External reference