Research graph
References from Icaritin ameliorates diabetes-associated cognitive dysfunction by attenuating ferroptosis through PPARα/CPT1A-associated fatty acid oxidative regulation. Local targets link to admitted publications; unresolved targets remain external evidence.
Loss of ferroportin induces memory impairment by promoting ferroptosis in Alzheimer's disease
10.1038/s41418-020-00685-9 · 2021 · External reference
Anti-inflammatory and immunoregulatory effects of icariin and icaritin
10.1016/j.biopha.2022.113180 · 2022 · External reference
Gut microbiota regulate Alzheimer's disease pathologies and cognitive disorders via PUFA-associated neuroinflammation
10.1136/gutjnl-2021-326269 · 2022 · External reference
Mechanisms underlying cognitive impairment and management strategies in type 2 diabetes
10.3389/fendo.2025.1655768 · 2025 · External reference
Type 2 diabetes mellitus and cognitive function: understanding the connections
10.1097/med.0000000000000783 · 2023 · External reference
Ferroptosis: an iron-dependent form of nonapoptotic cell death
10.1016/j.cell.2012.03.042 · 2012 · External reference
Pharmacological inhibition of cystine–glutamate exchange induces endoplasmic reticulum stress and ferroptosis
10.7554/elife.02523 · 2014 · External reference
ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition
10.1038/nchembio.2239 · 2017 · External reference
Kuwanon G protects HT22 cells from advanced glycation end product-induced damage
10.3892/etm.2021.9869 · 2021 · External reference
Global, regional, and national burden of diabetes from 1990 to 2021, with projections of prevalence to 2050: a systematic analysis for the global Burden of Disease Study 2021
10.1016/s0140-6736(23)01301-6 · 2023 · External reference
11th edition of the IDF Diabetes Atlas: global, regional, and national diabetes prevalence estimates for 2024 and projections for 2050
10.1016/s2213-8587(25)00299-2 · 2026 · External reference
Exploring the effect and mechanism of action of Jinlida granules (JLD) in the treatment of diabetes-associated cognitive impairment based on network pharmacology with experimental validation
10.1080/07853890.2024.2445181 · 2025 · External reference
Icaritin: a phytomolecule with enormous pharmacological values
10.1016/j.phytochem.2023.113772 · 2023 · External reference
Shenling Kaixin granules attenuate depression via multi-target mechanisms: evidence from CSDS model and cellular studies
10.1016/j.phymed.2025.157547 · 2025 · External reference
Reprogramming astrocytic NDRG2/NF-κB/C3 signaling restores the diabetes-associated cognitive dysfunction
10.1016/j.ebiom.2023.104653 · 2023 · External reference
SGK1 drives hippocampal demyelination and diabetes-associated cognitive dysfunction in mice
10.1038/s41467-025-56854-2 · 2025 · External reference
Icariin alleviates diabetes-associated cognitive dysfunction through modulation of LCN2–MEK/ERK signaling-associated neuroinflammation
10.1002/cns.71008 · 2026 · External reference
Oxidized arachidonic and adrenic PEs navigate cells to ferroptosis
10.1038/nchembio.2238 · 2017 · External reference
An endoscopic real-time, in situ assessment of intestinal permeability in type 2 diabetes: links to microbiota and hyperglycemia
10.1007/s00535-025-02325-w · 2026 · External reference
Oxidative stress: the nexus of obesity and cognitive dysfunction in diabetes
2023 · External reference
Mitochondrial CPT1A: insights into structure, function, and basis for drug development
10.3389/fphar.2023.1160440 · 2023 · External reference
Ferroptosis in diabetes-associated cognitive dysfunction: mechanisms and therapeutic potential
2026 · External reference
Gut microbiota mediates intermittent-fasting alleviation of diabetes-induced cognitive impairment
10.1038/s41467-020-14676-4 · 2020 · External reference
Type 2 diabetes mellitus-associated cognitive dysfunction: advances in potential mechanisms and therapies
10.1016/j.neubiorev.2022.104642 · 2022 · External reference
PPAR control of metabolism and cardiovascular functions
10.1038/s41569-021-00569-6 · 2021 · External reference
The gut microbiota–brain axis in behaviour and brain disorders
10.1038/s41579-020-00460-0 · 2021 · External reference
Fatty acid oxidation organizes mitochondrial supercomplexes to sustain astrocytic ROS and cognition
10.1038/s42255-023-00835-6 · 2023 · External reference
Ferroptosis is controlled by the coordinated transcriptional regulation of glutathione and labile iron metabolism by the transcription factor BACH1
10.1074/jbc.ra119.009548 · 2020 · External reference
MMD collaborates with ACSL4 and MBOAT7 to promote polyunsaturated phosphatidylinositol remodeling and susceptibility to ferroptosis
10.1016/j.celrep.2023.113023 · 2023 · External reference
Characterization of gut microbiota composition in type 2 diabetes patients: a population-based study
10.3390/ijerph192315913 · 2022 · External reference
Phospholipids with two polyunsaturated fatty acyl tails promote ferroptosis
10.1016/j.cell.2024.01.030 · 2024 · External reference
Xanthoceras sorbifolium oil ameliorates neuroinflammation and learning and memory impairment in Alzheimer's disease mice by regulating gut microbiota and unsaturated fatty acid metabolism
2026 · External reference
Emerging mechanisms and disease relevance of ferroptosis
10.1016/j.tcb.2020.02.009 · 2020 · External reference
Mitochondrial fatty acid oxidase CPT1A ameliorates postoperative cognitive dysfunction by regulating astrocyte ferroptosis
10.1016/j.brainres.2024.149424 · 2025 · External reference
Metformin alleviates glucolipotoxicity-induced pancreatic β cell ferroptosis through regulation of the GPX4/ACSL4 axis
10.1016/j.ejphar.2023.175967 · 2023 · External reference
Caveolin-1 alleviates diabetes-associated cognitive dysfunction through modulating neuronal ferroptosis-mediated mitochondrial homeostasis
10.1089/ars.2021.0233 · 2022 · External reference
FTH1 inhibits ferroptosis through ferritinophagy in the 6-OHDA model of Parkinson's disease
10.1007/s13311-020-00929-z · 2020 · External reference
Prenylated flavonoids icariin and icaritin for drug discovery: structural modifications and bioactivity studies
10.1007/s00044-025-03426-0 · 2025 · External reference
Exogenous H2S initiating Nrf2/GPx4/GSH pathway through promoting Syvn1-Keap1 interaction in diabetic hearts
10.1038/s41420-023-01690-w · 2023 · External reference
Berberine modulates gut microbiota to attenuate cerebral ferroptosis induced by ischemia-reperfusion in mice
10.1016/j.ejphar.2023.175782 · 2023 · External reference
Integrative microbiomics, proteomics and lipidomics studies unraveled the preventive mechanism of Shouhui Tongbian Capsules on cerebral ischemic stroke injury
10.1016/j.jep.2024.118874 · 2025 · External reference
Activated AMPK mitigates diabetes-related cognitive dysfunction by inhibiting hippocampal ferroptosis
10.1016/j.bcp.2022.115374 · 2023 · External reference
PPARα alleviates iron overload-induced ferroptosis in mouse liver
10.15252/embr.202052280 · 2022 · External reference
Icaritin ameliorates hepatic steatosis via promoting fatty acid β-oxidation and insulin sensitivity
10.1016/j.lfs.2020.119000 · 2021 · External reference
High glucose- or AGE-induced oxidative stress inhibits hippocampal neuronal mitophagy through the Keap1–Nrf2–PHB2 pathway in diabetic encephalopathy
2024 · External reference
Melatonin impedes NCOA4/ACSL4-dependent ferroptosis by targeting STING to ameliorate diabetic cognitive dysfunction
10.1016/j.bioorg.2025.109357 · 2026 · External reference
Lipid peroxidation inhibition by icaritin and its glycosides as a strategy to combat iron overload-induced osteoporosis in zebrafish
10.1016/j.foodres.2025.115900 · 2025 · External reference
Ferroptosis: death by lipid peroxidation
10.1016/j.tcb.2015.10.014 · 2016 · External reference
Gut microbial ammonia as a mediator of PFOS neurotoxicity and its remediation by the flavonoid icaritin
10.1080/19490976.2026.2620125 · 2026 · External reference
Fecal microbiota transplantation protects rotenone-induced Parkinson's disease mice via suppressing inflammation mediated by the lipopolysaccharide-TLR4 signaling pathway through the microbiota-gut-brain axis
10.1186/s40168-021-01107-9 · 2021 · External reference